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1. 发明申请

US20050196345A1 Compressed air inhaler for pulmonary application of liposomal powder aerosols and powder aerosols 审中-公开
标题翻译：用于肺部应用脂质体粉末气溶胶和粉末气溶胶的压缩空气吸入器
公开(公告)号：US20050196345A1
公开(公告)日：2005-09-08
申请号：US11111589
申请日：2005-04-21
申请人： Julia Diederichs , Wolfgang Koch , Hubert Lodding , Regina Reszka , Horst Windt
发明人： Julia Diederichs , Wolfgang Koch , Hubert Lodding , Regina Reszka , Horst Windt
IPC分类号： A61K9/00 , A61K9/127 , A61K9/51 , A61M11/06 , A61M15/00 , B05B7/00 , B05B7/06 , A61L9/04 , A61M11/00
CPC分类号： A61K9/0075 , A61K9/0078 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61M11/001 , A61M11/06 , A61M15/0086 , B05B7/0012 , B05B7/066
摘要： The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention, providing an inhaler with which the pulmonary application of, in particular, liposomes carrying active agent is enabled without forced breathing manoeuvres and with which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping, is solved by the compressed air inhaler for the pulmonary application of a liposomal powder aerosol entailing a receptacle 20 for a watery liposome dispersion, in which the liposomes carrying the active agent are dispersed in water, which is connected via a liquid dosing device 19 with an atomiser nozzle 1 and with a drying unit 17 such as an atomising chamber for the spray drying of the liposomes, to which said drying unit an exit 18 such as a mouthpiece is connected, in which the atomiser nozzle 1 has separate supply channels 14,16 for the compressed air and the liposome dispersion-FIG. 1-. The aim of the invention is further a new kind of powder aerosol comprising liposomes or nano-particles.
摘要翻译：本发明涉及用于肺部施用携带活性剂或不带电的脂质体粉末气溶胶的压缩空气吸入器。本发明的目的是提供一种吸入器，其具有特别是携带活性剂的脂质体的肺部应用，而无需强制呼吸机动，并且活性剂可以以足够的量转移到所需的作用位置，而没有通过压缩空气吸入器解决了用于肺部施用脂质体粉末气溶胶的溶剂，所述脂质体粉末气溶胶带有用于水性脂质体分散体的容器20，其中携带活性剂的脂质体分散在水中，其通过液体剂量装置19具有雾化器喷嘴1和干燥单元17，例如用于喷雾干燥脂质体的雾化室，所述干燥单元连接诸如接口的出口18，其中雾化器喷嘴1具有单独的供应用于压缩空气和脂质体分散体的通道14,16。 1 - 。本发明的目的是进一步的一种新型的包含脂质体或纳米颗粒的粉末气溶胶。

2. 发明申请

US20060039978A1 Self-forming phospholipidic gels 审中-公开
标题翻译：自形成磷脂凝胶
公开(公告)号：US20060039978A1
公开(公告)日：2006-02-23
申请号：US10534746
申请日：2003-11-24
申请人： Julia Diederichs
发明人： Julia Diederichs
IPC分类号： A61K9/14 , A61K31/56 , A61K31/192
CPC分类号： A61K9/0014 , A61K47/24
摘要： A phospholipid gel is spontaneously formed when combining a first phospholipid, a second phospholipid, and water, wherein the first phospholipid is a neutral phospholipid and the second phospholipid is a negatively charged phospholipid. The first and second phospholipids are of natural origin, semi-synthetic origin, or synthetic origin. Preferably, they are di(C8-C22 acyl) phosphatidyl choline and di(C8-C22 acyl) phosphatidyl glycerol. The total phospholipid concentration is within a range of 6-40% by weight.
摘要翻译：当组合第一磷脂，第二磷脂和水时，磷脂凝胶是自发形成的，其中第一种磷脂是中性磷脂，而第二种磷脂是带负电荷的磷脂。第一和第二磷脂是天然来源，半合成来源或合成来源的。优选地，它们是二（C 8 -C 22酰基）磷脂酰胆碱和二（C 8 -C 22 -C 22 >酰基）磷脂酰甘油。总磷脂浓度在6-40重量％的范围内。

3. 发明申请

US20100179226A1 Topical Dosage Form Comprising Tri-Substituted Glycerol Compounds 有权
标题翻译：包含三取代甘油化合物的局部剂量形式
公开(公告)号：US20100179226A1
公开(公告)日：2010-07-15
申请号：US12520368
申请日：2007-11-09
申请人： Julia Diederichs , Wolfgang Richter , Lutz Weber
发明人： Julia Diederichs , Wolfgang Richter , Lutz Weber
IPC分类号： A61K31/14 , C07C211/63 , A61P35/00
CPC分类号： A61K31/662 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/685 , C07F9/091
摘要： The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.
摘要翻译：本发明涉及用于局部给药的药物剂型，其包含三取代的甘油化合物或其药学上可接受的盐。本发明还涉及制备这种剂型的相应方法以及它们作为用于治疗癌症和免疫疾病的药物的用途。

4. 发明授权

US08653138B2 Calcium salts of compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents 有权
标题翻译：化合物的钙盐作为抗炎，免疫调节和抗增殖剂
公开(公告)号：US08653138B2
公开(公告)日：2014-02-18
申请号：US13174899
申请日：2011-07-01
申请人： Aldo Ammendola , Julia Diederichs , Johann Leban , Daniel Vitt
发明人： Aldo Ammendola , Julia Diederichs , Johann Leban , Daniel Vitt
IPC分类号： A61K31/195 , A61K31/19 , C07C229/00
CPC分类号： C07D333/38 , C07C233/59 , C07C233/60 , C07C255/60 , C07C2601/10 , C07D307/30 , C07D333/58
摘要： The present invention relates to calcium salts of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group; Y is a monocyclic or bicyclic substituted or unsubstituted 6-9 membered ring system which may contain one or more heteroatoms selected from N or S and which contains at least one aromatic ring; n is 0 or 1, and q is 0 or 1; with the proviso that compounds wherein X═CH2, q=0, Y=unsubstituted phenyl and E=unsubstituted phenylene are excluded; or a hydrate thereof.
摘要翻译：本发明涉及通式（I）化合物的盐，其中X选自CH 2，S或O; D为O或S; R8是氢或烷基; E是任选取代的亚苯基; Y是单环或双环取代或未取代的6-9元环系，其可含有一个或多个选自N或S的杂原子并且含有至少一个芳环; n为0或1，q为0或1; 条件是其中X = CH 2，q = 0，Y =未取代的苯基和E =未取代的亚苯基的化合物被排除; 或其水合物。

5. 发明授权

US08637688B2 Topical dosage form comprising tri-substituted glycerol compounds 有权
标题翻译：包含三取代甘油化合物的局部剂型
公开(公告)号：US08637688B2
公开(公告)日：2014-01-28
申请号：US12520368
申请日：2007-11-09
申请人： Julia Diederichs , Wolfgang Richter , Lutz Weber
发明人： Julia Diederichs , Wolfgang Richter , Lutz Weber
IPC分类号： C07F9/10 , C11D1/28 , A61K31/685 , C07C305/02
CPC分类号： A61K31/662 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/685 , C07F9/091
摘要： The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.
摘要翻译：本发明涉及用于局部给药的药物剂型，其包含三取代的甘油化合物或其药学上可接受的盐。本发明还涉及制备这种剂型的相应方法以及它们作为用于治疗癌症和免疫疾病的药物的用途。

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