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1. 发明授权

US4529608A Honey powder preserving its natural aroma components 失效
标题翻译：蜂蜜粉保存其天然香气成分
公开(公告)号：US4529608A
公开(公告)日：1985-07-16
申请号：US549205
申请日：1983-11-04
申请人： Jozsef Szejtli , Marta Tardy nee Lengyel
发明人： Jozsef Szejtli , Marta Tardy nee Lengyel
IPC分类号： A23L1/00 , A23L1/08 , A23L1/22
CPC分类号： A23L27/77 , A23L21/25 , A23L27/70 , A23P10/43
摘要： A process for the preparation of honey powder preserving its natural aroma substances comprises(a) kneading 1 part by weight of honey, 0.8 part by weight of starch, pre-hydrolyzed starch or flour and 0.1-0.3 part by weight of cyclodextrin to yield a homogeneous mixture, subjecting the mixture thus obtained to thermal treatment at 100.degree. C. for 20 minutes, disintegrating the hot product obtained after thermal treatment, drying the product at a temperature of 50.degree.-55.degree. C., for 10-50 hours, adding 0.01-1.0% by weight of hydrophobic colloidal silicic acid or alkali earth stearate and grinding it to a powder; or(b) admixing 1 part by weight of honey with 6 parts by weight of a hot saturated aqueous cyclodextrin solution, freezing the homogeneous solution thus obtained, subjecting the product to lyphilization, adding 0.01-1.0% by weight of hydrophobic colloidal silicic acid or alkali earth stearate to the lyophilized product and grinding it to a powder.The advantage of the invention is that the aroma substances of honey are preserved and set free only during consumption.
摘要翻译：制备保存其天然芳香物质的蜂蜜粉的方法包括（a）捏合1重量份蜂蜜，0.8重量份淀粉，预水解淀粉或面粉和0.1-0.3重量份环糊精，得到均匀混合，将得到的混合物在100℃下热处理20分钟，将热处理后得到的热产物分解，在50-55℃的温度下干燥产物10-50小时，加入0.01-1.0重量％的疏水性胶体硅酸或碱土金属硬脂酸盐，并研磨成粉末; 或（b）将1重量份蜂蜜与6重量份热饱和水性环糊精溶液混合，冷却由此获得的均匀溶液，使产物进行裂解，加入0.01-1.0重量％的疏水胶体硅酸或碱土金属硬脂酸盐加入到冻干产品中并研磨成粉末。本发明的优点是蜂蜜的芳香物质被保存并且仅在消费期间释放。

2. 发明申请

US20100056476A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN 审中-公开
标题翻译：药物组合物包含肾上腺皮质激素
公开(公告)号：US20100056476A1
公开(公告)日：2010-03-04
申请号：US12617074
申请日：2009-11-12
申请人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
发明人： Lajos Szente , Jozsef Szejtli , Laszio Jicsinszky , Georg Ludwig Kis , Christian Scnoch
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种包含环戊二烯环糊精，药物和载体的药物组合物，以使用环戊二烯环糊精作为药物转运增强剂（例如渗透促进剂），以及在制备药物组合物中使用环糊精协同辅助系统。

3. 发明授权

US07189798B2 Composition containing mixture of dihydroxybutane sulfonates 有权
标题翻译：含有二羟基丁烷磺酸盐混合物的组合物
公开(公告)号：US07189798B2
公开(公告)日：2007-03-13
申请号：US10601877
申请日：2003-06-24
申请人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
发明人： Charles M. Buchanan , Steven N. Falling , Juanelle L. Lambert , Shannon E. Large , Jozsef Szejtli , Lajos Szente , Laszlo Jicsinszky
IPC分类号： C08G63/688 , C07C309/04 , C07C309/08
CPC分类号： G01N30/482 , B01D15/3833 , B01J20/262 , B01J20/265 , B01J20/285 , B01J20/29 , B01J2220/54 , C07C309/08 , C08B37/0012 , C08B37/0015 , C08G63/6884
摘要： This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
摘要翻译：本发明涉及新的环糊精衍生物，制备这些环糊精衍生物的方法，以及由新的环糊精衍生物和客体分子组成的包合配合物，以及制备这些材料的方法及相关材料及其使用方法。

4. 发明授权

US5298496A Inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof, and pharmaceutical compositions containing the same 失效
标题翻译： 3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物
公开(公告)号：US5298496A
公开(公告)日：1994-03-29
申请号：US793389
申请日：1992-01-02
申请人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
发明人： Maaria Vikmon , Jozsef Szejtli , Lajos Szente , Jozsef Gaal , Hermecz: Istvan , Agnes Horvath , Katalin Marmarosi , Gabor Horvath , Iren Munkacsi
IPC分类号： A61K31/41 , A61K31/4245 , A61K31/535 , A61K31/5375 , A61K47/40 , A61K47/48 , A61P9/08 , A61P9/10 , C07D265/28 , C07D271/04 , C07D295/30 , C07D413/04 , C08B37/00 , C08B37/06 , C08B37/16
CPC分类号： C08B37/0015 , C07D271/04 , Y10S514/821 , Y10S514/969
摘要： The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same.The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared bya) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, orb) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.
摘要翻译： PCT No.PCT / HU91 / 00013 Sec。 371日期1992年1月2日 102（e）日期1992年1月2日PCT 1991年3月28日PCT。本发明涉及3-吗啉代 - 脱水亚胺或其盐或其互变异构体的包合物，其制备方法和含有它们的药物组合物。由环糊精衍生物形成的3-吗啉代 - 顺式亚胺或其盐的包合络合物是通过以下步骤制备的：a）使3-吗啉代 - 脱水亚胺或其盐在水性介质中与环糊精衍生物反应，并通过脱水从溶液中分离复合物，或b）3-吗啉代 - 二氢亚胺或其盐和环糊精衍生物的高能研磨。

5. 发明申请

US20120004158A1 Quaternised Ammonium Cyclodextrin Compounds 审中-公开
标题翻译：季铵化环糊精化合物
公开(公告)号：US20120004158A1
公开(公告)日：2012-01-05
申请号：US13234912
申请日：2011-09-16
申请人： Georg Ludwig Kis , Christian Schoch , Jozsef Szejtli
发明人： Georg Ludwig Kis , Christian Schoch , Jozsef Szejtli
IPC分类号： A61K38/00 , A61P31/04 , A61K31/711 , A61P31/10 , A61K31/7105 , A61K31/715 , A61P31/00
CPC分类号： A61K31/724 , A61K31/196 , A61K31/4535 , C08B37/0012
摘要： Use of a compound of formula (I): wherein the symbol cyclodextrin ]n represents a n-valent residue derived from a cyclodextrin compound by removing n of its hydroxyl groups; n is a number greater than 0 and represents the average number of substituents of formula per molecule of said compound; h is 0 or 1; R1 is a di-valent group selected from alkylene, hydroxy alkylene, halogeno alkylene, monocyclic aralkylene, cycloalkylene and phenylene; R2, R3 and R4 are each independently of one another a group selected from alkyl, cycloalkyl, aryl, aralkyl, and cycloheteryl; Xm− is a m-fold negatively charged anion; m is an integer being equal or greater than 1; and k is n/m in the preparation of an anti-infective medicament, as preservative and penetration enhancer.
摘要翻译：式（I）化合物的用途：其中符号环糊精] n表示通过除去其羟基而衍生自环糊精化合物的n价残基; n是大于0的数，表示每分子所述化合物的式的取代基的平均数; h为0或1; R1是选自亚烷基，羟基亚烷基，卤代亚烷基，单环亚芳基，亚环烷基和亚苯基的二价基团; R2，R3和R4各自独立地为选自烷基，环烷基，芳基，芳烷基和环戊基的基团; Xm-是一个m-带负电荷的阴离子; m是等于或大于1的整数; 在制备抗感染药物中，k为n / m，作为防腐剂和渗透促进剂。

6. 发明申请

US20080299166A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20080299166A1
公开(公告)日：2008-12-04
申请号：US12178934
申请日：2008-07-24
申请人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Gyorgy L. Kis , Christian Schoch
IPC分类号： A61K47/30 , A61K47/40 , A61F2/00 , A61K38/02 , A61P17/02 , A61K31/56 , A61K38/43
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

7. 发明授权

US4599327A Dibenzo[bd]pyran derivatives, process for the preparation thereof and pharmaceutical compositions containing same 失效
标题翻译：二苯并[bd]吡喃衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4599327A
公开(公告)日：1986-07-08
申请号：US557629
申请日：1983-12-02
申请人： Mihaly Nogradi , Dezso Korbonits , Agnes Gottsegen , Sandor Antus , Zsuzsa Furst , Jozsef Knoll , Jozsef Szejtli , Agnes Stadler , Gabor Kovacs , Katalin Marmarosi
发明人： Mihaly Nogradi , Dezso Korbonits , Agnes Gottsegen , Sandor Antus , Zsuzsa Furst , Jozsef Knoll , Jozsef Szejtli , Agnes Stadler , Gabor Kovacs , Katalin Marmarosi
IPC分类号： A61K31/35 , A61K31/352 , A61K31/715 , A61P1/08 , A61P23/00 , A61P23/02 , A61P25/02 , A61P25/04 , C07C43/178 , C07C43/205 , C07C43/23 , C07C59/68 , C07D221/12 , C07D311/78 , C07D311/80 , C07D311/92 , C07D493/10 , C08B37/00 , C08B37/16 , A61K31/70
CPC分类号： C07D493/10 , C07C309/00 , C07C43/1782 , C07C43/1785 , C07C43/2055 , C07C43/23 , C07C59/68 , C07D221/12 , C07D311/78 , C07D311/80 , C08B37/0015
摘要： 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.
摘要翻译：式（1a）化合物的2,6-二-O-甲基-β-环糊精复合物其中R 2'代表C 1至C 12烷基或其中R 11为C 1至C 4的式烷基; R 12是氢或C 1至C 4烷基; n为0或1; p为1〜4; r为1〜4; 和R 3'和R 4'各自为C1至C4烷基，或其药学上可接受的盐，具有止痛活性。

8. 发明授权

US4524068A Cyclodextrin inclusion complex of piperonyl butoxide 失效
标题翻译：胡椒基丁醚的环糊精包合物
公开(公告)号：US4524068A
公开(公告)日：1985-06-18
申请号：US550478
申请日：1983-11-09
申请人： Jozsef Szejtli , Zsuzsanna Budai , Erzsebet Radvany nee Hegedus , Laszlo Papp , Gyorgy Kormoczy , Gabriella Pap nee Imrenyi
发明人： Jozsef Szejtli , Zsuzsanna Budai , Erzsebet Radvany nee Hegedus , Laszlo Papp , Gyorgy Kormoczy , Gabriella Pap nee Imrenyi
IPC分类号： A01N43/30 , A61K47/48 , C07D317/54 , A61K31/73
CPC分类号： B82Y5/00 , A01N43/30 , A61K47/48969 , C07D317/54
摘要： The invention relates to new inclusion complexes of piperonyl butoxide formed with cyclodextrin.The new complex of the invention can be prepared by reacting cyclodextrin or a solution thereof formed with water and/or an organic solvent having 1-4 carbon atoms, preferably ethanol with piperonyl butoxide or a solution thereof formed with an organic solvent having 1-4 carbon atoms, preferably ethanol at a temperature between 20.degree. C. and 90.degree. C., whereby the piperonyl butoxide is used in an amount of 0.6-1.5 moles related to 1 mole of cyclodextrin.The complexes of the present invention synergize the pesticidal effect of known insecticides and fungicides to a much higher extent of known insecticides and fungicides to a much higher extent than piperonyl butoxide used per se.
摘要翻译：本发明涉及与环糊精形成的胡椒基丁醚的新的包合络合物。本发明的新配合物可以通过使环糊精或其与水和/或具有1-4个碳原子的有机溶剂，优选乙醇与胡椒基丁醚形成的溶液或其形成有有机溶剂的溶液，碳原子，优选乙醇，温度在20℃至90℃之间，其中胡椒基丁醚的用量为与1摩尔环糊精有关的0.6-1.5摩尔。本发明的配合物与已知的杀虫剂和杀真菌剂的杀虫作用相比，已知的杀虫剂和杀真菌剂的杀虫效果比本身使用的胡椒基丁醚的效果高得多。

9. 发明授权

US4357468A Sorbents of cellulose basis capable of forming inclusion complexes and a process for the preparation thereof 失效
标题翻译：能够形成包合物的纤维素基质的吸附剂及其制备方法
公开(公告)号：US4357468A
公开(公告)日：1982-11-02
申请号：US288764
申请日：1981-07-31
申请人： Jozsef Szejtli , Bela Zsadon , Eva Fenyvesi , nee Otta; Klara Horvath , Ferenc Tudos
发明人： Jozsef Szejtli , Bela Zsadon , Eva Fenyvesi , nee Otta; Klara Horvath , Ferenc Tudos
IPC分类号： C08L1/00 , C08B11/08 , C08B15/00 , C08B37/16
CPC分类号： C08B37/0012 , C08B11/08
摘要： The invention relates to new sorbents of cellulose basis capable of forming inclusion complexes, as well as to a process for the preparation thereof. The new sorbents according to the invention are cellulose derivatives containing structural units of the general formula (I), ##STR1## wherein Cell is a group derived by removing m hydroxy groups from the glucose unit of the cellulose chain,m is an integer of 1 to 3,CD is a group derived by removing one hydroxy group from the .alpha., .beta. or .gamma.-cyclodextrin molecule,n is an integer of 1 to 5, andp stands for 0 or 1, which may optionally vary even within a single chain.The cellulose derivatives according to the invention are substances of loose structure, with large specific surface area and good swelling properties, which can be applied for solving the most diverse adsorption tasks. Thus e.g. the substances can be applied for the preparation of smoke filters in cigarettes, waste water purification (de-poisoning) filters, inserts for removing solvent vapors, etc., furthermore for solving specific tasks of fractionation according to molecular dimensions.
摘要翻译：本发明涉及能够形成包合络合物的新型纤维素基质吸附剂，以及其制备方法。根据本发明的新吸附剂是含有通式（I），Cell {[OCH 2（CHOH）pCH 2] nOCD} m（I）的结构单元的纤维素衍生物，其中Cell是从葡萄糖中除去m个羟基衍生的基团纤维素链的单位，m为1〜3的整数，CD为从α，β或γ-环糊精分子除去一个羟基衍生的基团，n为1〜5的整数，p为0 或1，其可以任选地在单链内变化。根据本发明的纤维素衍生物是松散结构的物质，具有大的比表面积和良好的溶胀性能，可用于解决最多样化的吸附任务。因此，例如该物质可用于制备香烟中的烟雾过滤器，废水净化（去中毒）过滤器，用于除去溶剂蒸气的插入物等，此外用于根据分子尺寸解决特定的分馏任务。

10. 发明申请

US20120040901A1 NOVEL BIOMATERIALS, THEIR PREPARATION AND USE 审中-公开
标题翻译：新生物材料，其制备和使用
公开(公告)号：US20120040901A1
公开(公告)日：2012-02-16
申请号：US13281033
申请日：2011-10-25
申请人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , György Lajos Kis , Christian Schoch
IPC分类号： A61K38/22 , C12N9/00 , A61K31/4535 , A23L1/48 , A61K31/568 , A61K31/5575 , A61P43/00 , A01P15/00 , A01N25/00 , A61K31/12
CPC分类号： A61K9/0024 , A61K9/7015 , A61L27/20 , A61L27/54 , A61L2300/602 , A61L2300/802 , C08L5/16
摘要： The present invention relates to novel materials, particularly biomaterials, in form of a precipitate, comprising at least an anionic polymeric component which is as such soluble in water and an amphiphilic ammonium-type component, which precipitate is obtainable by a process including the following steps: 1. contacting the anionic polymeric component and an cyclodextrin component in an aqueous medium, and 2. adding to the mixture obtained in step 1 said amphiphilic ammonium-type component, wherein said components are present in amounts effective to form said precipitate, and preferably to corresponding precipitates additionally comprising said cyclodextrin component. Both types of precipitates may optionally comprise one or more further components. The precipitates are particularly useful as controlled-release depot formulations suitable for long-lasting delivery of said further components. The further components incorporated into the precipitates can be pharmaceutical compounds, pesticides, agrochemicals, colorants, diagnostics, enzymes, foodstuffs etc.
摘要翻译：本发明涉及沉淀物形式的新型材料，特别是生物材料，其包含至少一种如此可溶于水的阴离子聚合物组分和两亲性铵型组分，所述沉淀物可通过包括以下步骤 1.将阴离子聚合物组分和环糊精组分在水性介质中接触，2.向步骤1中获得的混合物中加入所述两亲性铵型组分，其中所述组分以有效形成所述沉淀物的量存在，优选到另外包含所述环糊精组分的相应沉淀物。两种类型的沉淀物可任选地包含一种或多种另外的组分。沉淀物特别适用于适用于持久递送所述其它组分的控释剂型剂型。掺入沉淀物中的其它组分可以是药物化合物，农药，农药，着色剂，诊断，酶，食品等。

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