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1. 发明申请

US20060136182A1 Three dimensional construct for the design and fabrication of physiological fluidic networks 有权
标题翻译：用于设计和制造生理流体网络的三维构造
公开(公告)号：US20060136182A1
公开(公告)日：2006-06-22
申请号：US10528737
申请日：2003-09-23
申请人： Joseph Vacanti , Jeffrey Borenstein , Mohammad Kaazempur-Mofrad , Eli Weinberg
发明人： Joseph Vacanti , Jeffrey Borenstein , Mohammad Kaazempur-Mofrad , Eli Weinberg
IPC分类号： G06G7/48 , G06G7/58
CPC分类号： C12N5/0062 , B01L3/5027 , B33Y80/00 , C12M25/14 , G06F19/00 , G16H50/50 , Y10T137/206 , Y10T137/212
摘要： The present invention relates to methods for the design and fabrication of biological constructs, such as organ simulants or organ replacements, which contain complex microfluidic architecture. Designs of the present invention provide increased space in the lateral dimension, enabling a large number of small channels for small vessels.
摘要翻译：本发明涉及用于设计和制造包含复杂微流体结构的生物构建体如器官模拟物或器官替代物的方法。本发明的设计在横向尺寸上提供了增加的空间，使得能够为小型容器提供大量的小通道。

2. 发明申请

US20050202557A1 Micromachined bilayer unit of engineered tissues 有权
标题翻译：工程组织的微加工双层单元
公开(公告)号：US20050202557A1
公开(公告)日：2005-09-15
申请号：US10983213
申请日：2004-11-05
申请人： Jeffrey Borenstein , Eli Weinberg , Brian Orrick , Eleanor Pritchard , Edward Barnard , Nicholas Krebs , Theodore Marentis , Joseph Vacanti , Mohammad Kaazempur-Mofrad
发明人： Jeffrey Borenstein , Eli Weinberg , Brian Orrick , Eleanor Pritchard , Edward Barnard , Nicholas Krebs , Theodore Marentis , Joseph Vacanti , Mohammad Kaazempur-Mofrad
IPC分类号： C12M1/34 , C12N5/08
CPC分类号： A61M1/1678 , Y10T436/25375 , Y10T436/255
摘要： Methods and materials for making an apparatus which duplicates the functionality of a physiological system id provided.
摘要翻译：用于制造复制所提供的生理系统标识的功能的装置的方法和材料。

3. 发明申请

US20070281353A1 Microfabricated Compositions and Processes for Engineering Tissues Containing Multiple Cell Types 有权
标题翻译：用于包含多种细胞类型的工程组织的微型组合物和方法
公开(公告)号：US20070281353A1
公开(公告)日：2007-12-06
申请号：US10557081
申请日：2004-05-21
申请人： Joseph Vacanti , Jeffrey Borenstein , Eli Weinberg
发明人： Joseph Vacanti , Jeffrey Borenstein , Eli Weinberg
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： C12N5/0068 , B33Y80/00 , C12N5/0062 , C12N5/0697 , C12N2533/40
摘要： The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.
摘要翻译：本发明涉及一种三维体系及其组合物，其中系统的各层包括通过中心定位的膜纵向分成两个隔室的通道，并且其中每个隔室可包括不同的细胞类型。

4. 发明授权

US08147562B2 Three dimensional construct for the design and fabrication of physiological fluidic networks 有权
标题翻译：用于设计和制造生理流体网络的三维构造
公开(公告)号：US08147562B2
公开(公告)日：2012-04-03
申请号：US10528737
申请日：2003-09-23
申请人： Joseph P. Vacanti , Jeffrey Borenstein , Mohammad R. Kaazempur-Mofrad , Eli Weinberg
发明人： Joseph P. Vacanti , Jeffrey Borenstein , Mohammad R. Kaazempur-Mofrad , Eli Weinberg
IPC分类号： A61F2/02
CPC分类号： C12N5/0062 , B01L3/5027 , B33Y80/00 , C12M25/14 , G06F19/00 , G16H50/50 , Y10T137/206 , Y10T137/212
摘要： The present invention relates to methods for the design and fabrication of biological constructs, such as organ simulants or organ replacements, which contain complex microfluidic architecture. Designs of the present invention provide increased space in the lateral dimension, enabling a large number of small channels for small vessels.
摘要翻译：本发明涉及用于设计和制造包含复杂微流体结构的生物构建体如器官模拟物或器官替代物的方法。本发明的设计在横向尺寸上提供了增加的空间，使得能够为小型容器提供大量的小通道。

5. 发明申请

US20070148139A1 Fabrication of vascularized tissue using microfabricated two-dimensional molds 审中-公开
标题翻译：使用微细二维模具制造血管化组织
公开(公告)号：US20070148139A1
公开(公告)日：2007-06-28
申请号：US11591984
申请日：2006-11-02
申请人： Joseph Vacanti , Jeffrey Borenstein , Homer Pien , Brian Cunningham
发明人： Joseph Vacanti , Jeffrey Borenstein , Homer Pien , Brian Cunningham
IPC分类号： A61K35/14 , A61K9/70
CPC分类号： A61L27/3604 , A61K35/12 , A61K35/44 , A61L27/38 , B33Y70/00 , C12N5/0671 , C12N5/0697 , C12N2502/14 , C12N2502/28 , C12N2535/10
摘要： A method and materials to create complex vascularized living tissue in three dimensions from a two-dimension microfabricated mold has been developed. The method involved creating a two dimensional surface having a branching structure etched into the surface. The pattern begins with one or more large channels which serially branch into a large array of channels as small as individual capillaries, then converge to one or more large channels. The etched surface serves a template within a mold formed with the etched surface for the circulation of an individual tissue or organ. Living vascular cells are then seeded onto the mold, where they form living vascular channels based on the pattern etched in the mold. Once formed and sustained by their own matrix, the top of the mold is removed. The organ or tissue specific cells are then added to the etched surface, where they attach and proliferate to form a thin, vascularized sheet of tissue. The tissue can then be gently lifted from the mold using techniques such as fluid flow and other supporting material, as necessary. The tissue can then be systematically folded and compacted into a three-dimensional vascularized structure. This structure can then be implanted into animals or patients by directly connecting the blood vessels to flow into and out of the device. Immediate perfusion of oxygenated blood occurs, which allows survival and function of the entire living mass.
摘要翻译：已经开发了从二维微加工模具在三维中产生复杂血管化活组织的方法和材料。该方法涉及创建具有蚀刻到表面中的分支结构的二维表面。该模式从一个或多个大的通道开始，该通道串行地分支成与单个毛细管一样小的通道的大阵列，然后收敛到一个或多个大通道。被蚀刻的表面在形成有蚀刻表面的模具内形成模板，用于各个组织或器官的循环。然后将活的血管细胞接种到模具上，基于在模具中蚀刻的图案形成活血管通道。一旦通过自己的矩阵形成并维持，模具的顶部被移除。然后将器官或组织特异性细胞加入到蚀刻的表面中，在那里它们附着和增殖以形成薄的，血管化的组织片。然后可以根据需要使用诸如流体流动和其它支撑材料的技术从模具中轻轻地提起组织。然后可以将组织系统地折叠并压实成三维血管结构。然后可以通过直接连接血管流入和流出装置将该结构植入动物或患者体内。发生氧合血液的立即灌注，这允许整个生物体的存活和功能。

6. 发明申请

US20070266801A1 Reversible Sealing of Microfluidic Arrays 审中-公开
标题翻译：微流体阵列的可逆密封
公开(公告)号：US20070266801A1
公开(公告)日：2007-11-22
申请号：US11612142
申请日：2006-12-18
申请人： Alireza Khademhosseini , Jeffrey Borenstein , George Eng , Judy Yeh , Robert Langer
发明人： Alireza Khademhosseini , Jeffrey Borenstein , George Eng , Judy Yeh , Robert Langer
IPC分类号： G01N1/20
CPC分类号： B01L3/5025 , B01J19/0046 , B01J2219/00317 , B01J2219/00418 , B01J2219/0043 , B01J2219/00585 , B01J2219/00743 , B01L3/0293 , B01L3/5027 , B01L3/50853 , B01L3/563 , B01L2200/0642 , B01L2300/041 , B01L2300/046 , B01L2300/0819 , B01L2300/0829 , B01L2300/0864 , B01L2400/0487 , G01N35/1074 , G01N2035/00158
摘要： Channel arrays are reversibly disposed over an array of microwells to deliver materials, for example, cells, to the microwells.
摘要翻译：通道阵列可逆地设置在微孔阵列上，以将材料（例如，细胞）输送到微孔。

7. 发明申请

US20060283246A1 Tuning fork gyroscopes, accelerometers, and other sensors with improved scale factor 有权
标题翻译：调谐叉式陀螺仪，加速度计和其他具有改进的比例因子的传感器
公开(公告)号：US20060283246A1
公开(公告)日：2006-12-21
申请号：US11153664
申请日：2005-06-15
申请人： Marc Weinberg , Jonathan Bernstein , Jeffrey Borenstein , Richard Elliott , Gregory Kirkos , Anthony Kourepenis
发明人： Marc Weinberg , Jonathan Bernstein , Jeffrey Borenstein , Richard Elliott , Gregory Kirkos , Anthony Kourepenis
IPC分类号： G01P15/08
CPC分类号： G01C19/5733 , G01P15/125
摘要： A tuning fork gyroscope design where at least one proof mass is supported above a substrate. At least one drive electrode is also supported above the substrate adjacent the proof mass. Typically, the proof mass and the drive electrode include interleaved electrode fingers. A sense plate or shield electrode on the substrate beneath the proof mass extends completely under the extent of the electrode fingers of proof mass.
摘要翻译：音叉陀螺仪设计，其中至少一个检测质量被支撑在基板上方。至少一个驱动电极也被支撑在与基体相邻的衬底上。通常，检测质量块和驱动电极包括交错的电极指。在证明物质下方的基板上的感应板或屏蔽电极在证明质量的电极指的范围内完全延伸。

8. 发明申请

US20060167435A1 Transscleral drug delivery device and related methods 审中-公开
标题翻译：经巩膜给药装置及相关方法
公开(公告)号：US20060167435A1
公开(公告)日：2006-07-27
申请号：US10545726
申请日：2004-02-17
申请人： Anthony Adamis , Joan Miller , Mark Mescher , Evangelos Gragoudas , Jeffrey Borenstein
发明人： Anthony Adamis , Joan Miller , Mark Mescher , Evangelos Gragoudas , Jeffrey Borenstein
IPC分类号： A61M31/00
CPC分类号： A61F9/0017
摘要： The invention provides a low-profile, dome-shaped body for attachment to a scleral surface of an eye and defining an internal cavity for receiving a drug or other pharmaceutically active agent. The device has an opening for controllably delivering the drug into the eye at therapeutically effective concentrations over a prolonged period of time. When attached, the device does not affect or otherwise restrict movement of the eye. Features of the invention include an optional drug inlet port and puncture guard, both designed for refilling the device while preventing a needle inserted through the inlet port from contacting the sclera.
摘要翻译：本发明提供了一种用于附着到眼睛的巩膜表面并限定用于接收药物或其它药物活性剂的内腔的低角度圆顶形体。该装置具有用于在长时间内以治疗有效浓度可控地将药物输送到眼睛中的开口。安装时，设备不会影响或限制眼睛的运动。本发明的特征包括可选的药物入口和穿刺保护装置，两者设计用于在防止穿过入口插入的针头接触巩膜的同时重新填充装置。

9. 发明申请

US20110021965A1 ADHESIVE ARTICLES 有权
标题翻译：胶粘剂
公开(公告)号：US20110021965A1
公开(公告)日：2011-01-27
申请号：US12743817
申请日：2008-11-19
申请人： Jeffrey Karp , Mahdavi Alborz , Lino Ferreira , David Carter , Andreas Zumbuehl , Jeffrey Borenstein , Edwin Chan , Christopher Bettinger , Robert Langer
发明人： Jeffrey Karp , Mahdavi Alborz , Lino Ferreira , David Carter , Andreas Zumbuehl , Jeffrey Borenstein , Edwin Chan , Christopher Bettinger , Robert Langer
IPC分类号： A61F13/02
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
摘要翻译：粘合剂制品包括具有表面的生物相容性和至少部分可生物降解的基材; 以及从表面延伸的多个突起。突起包括生物相容性和至少部分可生物降解的材料，并且具有小于约1,000微米的平均高度。

10. 发明申请

US20070062283A9 A METHOD FOR FABRICATING A TUNING FORK GYROSCOPE 有权
标题翻译：一种用于制作调音机陀螺仪的方法
公开(公告)号：US20070062283A9
公开(公告)日：2007-03-22
申请号：US10970067
申请日：2004-10-21
申请人： Marc Weinberg , Anthony Kourepenis , William Sawyer , Jeffrey Borenstein , James Connelly , Amy Duwel , Christopher Lento , James Cousens
发明人： Marc Weinberg , Anthony Kourepenis , William Sawyer , Jeffrey Borenstein , James Connelly , Amy Duwel , Christopher Lento , James Cousens
IPC分类号： G01P15/08
CPC分类号： H01L21/6835 , G01C19/5719 , H01L2924/19041 , H01L2924/30105 , H01L2924/3025
摘要： A method for reducing errors in a tuning fork gyroscope includes determining a first distance, gt, between an upper sense plate and a proof mass and a second distance, gb, between a lower sense plate and the proof mass. The method further includes applying a first voltage, Vt, to the upper sense plate and a second voltage, Vb, to the lower sense plate, wherein the ratio of the first voltage and the second voltage is a function of the first distance and the second distance.
摘要翻译：一种用于减少音叉陀螺仪中的误差的方法包括确定上感测板和检测质量之间的第一距离g i，以及第二距离g b，在下感测板和检测质量之间。所述方法还包括向所述下感测板施加第一电压V sub至所述上感测板，并将第二电压V SUB施加到所述下感测板，其中，第一电压和第二电压是第一距离和第二距离的函数。

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