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1. 发明申请

US20180147392A9 MEDICAL GUIDE ELEMENT WITH DIAMETER TRANSITION 审中-公开
公开(公告)号：US20180147392A9
公开(公告)日：2018-05-31
申请号：US14970531
申请日：2015-12-15
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61M25/06 , A61M25/09 , A61M29/02
CPC分类号： A61M25/0606 , A61M25/09 , A61M29/00 , A61M29/02 , A61M2025/09083 , A61M2025/09125 , A61M2025/09175 , A61M2210/1021 , A61M2210/1078 , A61M2210/122 , A61M2210/125
摘要： Improved methods for percutaneously creating, entering and/or dilating an opening in the wall of a blood vessel or other anatomic structure. The improvement comprises deploying a guide element having a proximal segment and a distal segment, the diameter of said distal segment being greater than the diameter of said proximal segment at their juncture, and which at said juncture forms an abrupt circumferential step comprising a proximally-facing surface. Said proximally-facing surface abuts the catheter's tip and shields said tip, thereby facilitating passage of said catheter as it enters and passes through said opening in said wall of a blood vessel or other anatomic structure.

2. 发明授权

US09238124B2 Medical guide element with diameter transition 有权
公开(公告)号：US09238124B2
公开(公告)日：2016-01-19
申请号：US13918906
申请日：2013-06-15
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61B1/00 , A61M25/09 , A61M29/00
CPC分类号： A61M25/0606 , A61M25/09 , A61M29/00 , A61M29/02 , A61M2025/09083 , A61M2025/09125 , A61M2025/09175 , A61M2210/1021 , A61M2210/1078 , A61M2210/122 , A61M2210/125
摘要： Improved medical filaments for use with dilators to be inserted into a patient, for example into the vascular lumen, are provided, as well as combinations of filaments and dilators. Methods for use of such filaments and filament-dilator combinations are also described. The filament includes a proximal segment and a distal segment. The diameter of the distal segment is greater than the diameter of the proximal segment. The change in diameter is abrupt, providing a discrete step transition at a point along the filament which presents a proximally-facing surface on the distal segment. When the proximal segment of the filament is fully inserted into a dilator having a distal tip adapted for insertion into a patient, the dilator distal tip firmly abuts the proximally-facing end surface of the distal segment. The relative dimensions of the dilator tip and the discrete stepped transition of the filament provides full shielding or over shielding of the dilator tip, thereby facilitating passage of the dilator tip along the tissue track, through the puncture hole and into the orifice.

3. 发明授权

US09149186B2 Configuration of cables for monitoring systems 有权
标题翻译：监控系统电缆配置
公开(公告)号：US09149186B2
公开(公告)日：2015-10-06
申请号：US13337034
申请日：2011-12-23
申请人： Joseph Grayzel , Jeffrey Grayzel
发明人： Joseph Grayzel , Jeffrey Grayzel
IPC分类号： A61B5/00 , A61B5/0428 , A61B5/0205 , A61B5/021
CPC分类号： A61B5/002 , A61B5/00 , A61B5/02055 , A61B5/021 , A61B5/0402 , A61B5/04286 , A61B5/0476 , A61B8/00 , A61B2562/221 , A61B2562/222 , A61B2562/223 , A61B2562/224 , A61B2562/225 , A61B2562/247
摘要： A physical configuration of cables connecting a monitoring apparatus to a human patient, where said patient and his immediate surroundings define a potentially infectious contaminated zone. The configuration provides for the monitor and main trunk cable to lie outside of the contamination zone, and one or more serial cables connect to the trunk cable and enter the contamination zone to provide contact with the patient. This physical configuration prevents contamination of the monitor and trunk cable, so they may be reused on successive patients, while lightweight and inexpensive serial cables contacting the patient and his contamination zone may be disposable. Examples of monitoring various physiological variables are provided to exemplify the universal concept of such physical configuration. Adaptation for wireless transmission is also described.
摘要翻译：将监测装置连接到人类患者的电缆的物理结构，其中所述患者及其直接周围环境限定潜在的感染性污染区域。该配置提供监视器和主干线电缆位于污染区域之外，并且一个或多个串行电缆连接到干线电缆并进入污染区域以提供与患者的接触。这种物理配置可以防止监视器和中继电缆的污染，因此它们可以在连续的病人身上重复使用，而与患者和他的污染区域接触的轻便和便宜的串联电缆可能是一次性的。提供了监测各种生理变量的示例以例示这种物理配置的通用概念。还描述了用于无线传输的适配。

4. 发明申请

US20110213401A1 METHODS FOR CONFIGURING EXPANDABLE DEVICES 审中-公开
标题翻译：用于配置可扩展设备的方法
公开(公告)号：US20110213401A1
公开(公告)日：2011-09-01
申请号：US13022503
申请日：2011-02-07
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/22061 , A61F2/958 , A61F2002/9583 , A61M2025/1079 , A61M2025/1084 , A61M2025/1086 , A61M2025/109
摘要： The present invention pertains to a stiffened balloon which can be used in angioplasty, endovascular, and valvuloplasty procedures or as a delivery balloon to deliver a stent or a stent-graft. Longitudinally discontinuous stiffening members connected to the expandable balloon stiffen the balloon but allow it to be navigated through curved passages. Projections on the stiffening members may engage, incise, crush, fracture, or pierce occlusions or retain a stent or stent-graft. Radio-opaque portions may be referenced to determine orientation. Longitudinally continuous stiffening members bearing projections and connected to the balloon perform in a similar manner.
摘要翻译：本发明涉及一种可用于血管成形术，血管内和瓣膜成形术程序的加强球囊，或用作输送支架或支架移植物的输送球囊。连接到可膨胀气囊的纵向不连续加强构件使球囊变硬，但允许其通过弯曲的通道导航。加强构件上的突出物可能啮合，切开，挤压，断裂或刺穿闭塞或保留支架或支架移植物。可以参考无线电不透明部分来确定取向。轴承突起并连接到气球的纵向连续加强构件以类似的方式进行。

5. 发明授权

US10086169B2 Medical guide element with diameter transition 有权
公开(公告)号：US10086169B2
公开(公告)日：2018-10-02
申请号：US14970531
申请日：2015-12-15
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61B17/14 , A61B17/32 , A61M25/06 , A61M25/09 , A61M29/02 , A61M29/00
摘要： Improved methods for percutaneously creating, entering and/or dilating an opening in the wall of a blood vessel or other anatomic structure. The improvement comprises deploying a guide element having a proximal segment and a distal segment, the diameter of said distal segment being greater than the diameter of said proximal segment at their juncture, and which at said juncture forms an abrupt circumferential step comprising a proximally-facing surface. Said proximally-facing surface abuts the catheter's tip and shields said tip, thereby facilitating passage of said catheter as it enters and passes through said opening in said wall of a blood vessel or other anatomic structure.

6. 发明授权

US08485969B2 Medical guide element with diameter transition 有权
标题翻译：医疗导向元件直径过渡
公开(公告)号：US08485969B2
公开(公告)日：2013-07-16
申请号：US12233272
申请日：2008-09-18
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61B1/00
CPC分类号： A61M25/0606 , A61M25/09 , A61M29/00 , A61M29/02 , A61M2025/09083 , A61M2025/09125 , A61M2025/09175 , A61M2210/1021 , A61M2210/1078 , A61M2210/122 , A61M2210/125
摘要： Improved medical filaments for use with dilators to be inserted into a patient, for example into the vascular lumen, are provided, as well as combinations of filaments and dilators. Methods for use of such filaments and filament-dilator combinations are also described. The filament includes a proximal segment and a distal segment. The diameter of the distal segment is greater than the diameter of the proximal segment. The change in diameter is abrupt, providing a discrete step transition at a point along the filament which presents a proximally-facing surface on the distal segment. When the proximal segment of the filament is fully inserted into a dilator having a distal tip adapted for insertion into a patient, the dilator distal tip firmly abuts the proximally-facing end surface of the distal segment. The relative dimensions of the dilator tip and the discrete stepped transition of the filament provides full shielding or over shielding of the dilator tip, thereby facilitating passage of the dilator tip along the tissue track, through the puncture hole and into the orifice.
摘要翻译：提供了用于扩张器插入患者例如血管腔的改进的医用长丝，以及丝和扩张器的组合。还描述了使用这种细丝和细丝扩张器组合的方法。细丝包括近端段和远端段。远端段的直径大于近端段的直径。直径的变化是突然的，在沿着细丝的点处提供离散的台阶过渡，其在远端段上呈现面向近侧的表面。当细丝的近端段完全插入到具有适于插入患者体内的远侧末端的扩张器中时，扩张器远侧末端牢固地抵靠远侧段的面向近端的端表面。扩张器尖端的相对尺寸和细丝的离散阶跃转变提供了扩张器尖端的完全屏蔽或过度屏蔽，从而便于扩张器尖端沿着组织轨道通过穿孔并进入孔中。

7. 发明申请

US20100069880A1 MEDICAL GUIDE ELEMENT WITH DIAMETER TRANSITION 有权
标题翻译：医疗指导元件与直径转换
公开(公告)号：US20100069880A1
公开(公告)日：2010-03-18
申请号：US12233272
申请日：2008-09-18
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61M25/09 , A61M29/02
CPC分类号： A61M25/0606 , A61M25/09 , A61M29/00 , A61M29/02 , A61M2025/09083 , A61M2025/09125 , A61M2025/09175 , A61M2210/1021 , A61M2210/1078 , A61M2210/122 , A61M2210/125
摘要： Improved medical filaments for use with dilators to be inserted into a patient, for example into the vascular lumen, are provided, as well as combinations of filaments and dilators. Methods for use of such filaments and filament-dilator combinations are also described. The filament includes a proximal segment and a distal segment. The diameter of the distal segment is greater than the diameter of the proximal segment. The change in diameter is abrupt, providing a discrete step transition at a point along the filament which presents a proximally-facing surface on the distal segment. When the proximal segment of the filament is fully inserted into a dilator having a distal tip adapted for insertion into a patient, the dilator distal tip firmly abuts the proximally-facing end surface of the distal segment. The relative dimensions of the dilator tip and the discrete stepped transition of the filament provides full shielding or over shielding of the dilator tip, thereby facilitating passage of the dilator tip along the tissue track, through the puncture hole and into the orifice.
摘要翻译：提供了用于扩张器插入患者例如血管腔的改进的医用长丝，以及丝和扩张器的组合。还描述了使用这种细丝和细丝扩张器组合的方法。细丝包括近端段和远端段。远端段的直径大于近端段的直径。直径的变化是突然的，在沿着细丝的点处提供离散的台阶过渡，其在远端段上呈现面向近侧的表面。当细丝的近端段完全插入到具有适于插入患者体内的远侧末端的扩张器中时，扩张器远侧末端牢固地抵靠远侧段的面向近端的端表面。扩张器尖端的相对尺寸和细丝的离散阶跃转变提供了扩张器尖端的完全屏蔽或过度屏蔽，从而便于扩张器尖端沿着组织轨道通过穿孔并进入孔中。

8. 发明申请

US20080154298A1 Instrument fingers 失效
标题翻译：手指手指
公开(公告)号：US20080154298A1
公开(公告)日：2008-06-26
申请号：US12072603
申请日：2008-02-27
申请人： Jeffrey Grayzel , Joseph Grayzel , William Allen , Fred Karl , Alan Bachman , Ray Adams
发明人： Jeffrey Grayzel , Joseph Grayzel , William Allen , Fred Karl , Alan Bachman , Ray Adams
IPC分类号： A61B17/00
CPC分类号： A61B17/02 , A61B17/0057 , A61B17/2812 , A61B17/282 , A61B17/3403 , A61B17/3439 , A61B2017/00424 , A61B2017/00654 , A61B2017/00778 , A61B2017/320044 , A61B2017/3405 , A61B2090/062 , A61B2090/306
摘要： The instrument has a pair of instrument arms, an angled instrument finger is attached to each arm, and the respective bottom surfaces of the distal ends of the angled instrument fingers are substantially parallel to the plane of the instrument arms.
摘要翻译：仪器具有一对仪器臂，倾斜的乐器指状物附接到每个臂，并且倾斜乐器指的远端的相应底表面基本上平行于乐器臂的平面。

9. 发明申请

US20180085562A1 STIFFENED BALLOON APPARATUS 审中-公开
公开(公告)号：US20180085562A1
公开(公告)日：2018-03-29
申请号：US15799184
申请日：2017-10-31
申请人： Jeffrey Grayzel , Joseph Grayzel
发明人： Jeffrey Grayzel , Joseph Grayzel
IPC分类号： A61M25/10 , A61F2/958 , A61B17/3207 , A61B17/22
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/22061 , A61F2/958 , A61F2002/9583 , A61M2025/1079 , A61M2025/1084 , A61M2025/1086 , A61M2025/109
摘要： A stiffened balloon apparatus for use in angioplasty. Elongate stiffening members disposed longitudinally on the expandable balloon stiffen the membrane of said balloon. The stiffening members possess sufficient rigidity to resist local deformation of the wall of said expandable balloon upon expansion of said balloon and upon contact of said stiffening member with a local deformation within an anatomical passage or target lumen. Projections and/or raised surfaces on a stiffening member may engage, incise, crush, fracture, or pierce occlusions and/or the inner surface of the passage or target lumen in which it is being operated. Associated method for use to incise the inner surface of a target lumen or incise the stenosis that may be located therein.

10. 发明授权

US08690904B2 Percutaneous access conduit 有权
标题翻译：经皮导管
公开(公告)号：US08690904B2
公开(公告)日：2014-04-08
申请号：US11893853
申请日：2007-08-18
申请人： Jeffrey Grayzel , Joseph Grayzel , William Allen , Fred Karl , Alan Bachman , Ray Adams
发明人： Jeffrey Grayzel , Joseph Grayzel , William Allen , Fred Karl , Alan Bachman , Ray Adams
IPC分类号： A61B17/32 , A61F11/00
CPC分类号： A61B17/02 , A61B17/0057 , A61B17/2812 , A61B17/282 , A61B17/3403 , A61B17/3439 , A61B2017/00424 , A61B2017/00654 , A61B2017/00778 , A61B2017/320044 , A61B2017/3405 , A61B2090/062 , A61B2090/306
摘要： A tubular conduit is used to access blood vessels or other structures in the human body. The conduit has a distal tip angled to match the angle of entry into the body and an end contour adapted for the surface of the target vessel or organ. The contour may be curved to match the curve on the outer surface of the vessel or organ. The conduit's angled and contoured distal end may be adapted to engage, and align the conduit with, the surface of the vessel or organ. The conduit bears a longitudinal groove along its lower, inner surface. When the conduit is appropriately aligned, the groove may be used to guide a needle tip to the desired location, for example, the mid-line of the vessel or organ.
摘要翻译：管状导管用于进入人体内的血管或其他结构。导管具有成角度的远端以匹配进入体内的角度以及适于目标血管或器官表面的端部轮廓。轮廓可以弯曲以匹配血管或器官的外表面上的曲线。导管的成角度和轮廓的远端可以适于将导管与容器或器官的表面接合并对齐。导管沿其下部内表面具有纵向凹槽。当导管适当地对准时，凹槽可用于将针尖引导到所需位置，例如容器或器官的中线。

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