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1. 发明申请

US20050260727A1 Crystal structure of the mitochondrial protoporphyrinogen IX oxidase 审中-公开
标题翻译：线粒体原卟啉原IX氧化酶的晶体结构
公开(公告)号：US20050260727A1
公开(公告)日：2005-11-24
申请号：US11078991
申请日：2005-03-11
申请人： Jorg Freigang , Michael Koch , Constanze Breithaupt , Reiner Kiefersauer , Albrecht Messerschmidt , Robert Huber
发明人： Jorg Freigang , Michael Koch , Constanze Breithaupt , Reiner Kiefersauer , Albrecht Messerschmidt , Robert Huber
IPC分类号： C12N9/02 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N9/001 , C07K2299/00 , C12Y103/03004
摘要： The present invention relates to crystals of a protoporphyrinogen IX oxidase, to processes for preparing crystals of a protoporphyrinogen IX oxidase, to processes for determining the structure of protoporphyrinogen IX oxidases alone or complexed with a ligand, and to processes for identifying ligands of the mitochondrial protoporphyrinogen IX oxidase, which may be used as herbicides. The present invention also relates to the use of the crystal structure described here of the Nicotiana tabacum mitochondrial protoporphyrinogen IX oxidase for generating protein models of related enzymes and to the identification of inhibitors of related proteins.
摘要翻译：本发明涉及原卟啉原IX氧化酶的晶体，用于制备原卟啉原IX氧化酶的晶体的方法，用于确定单独或与配体络合的原卟啉原IX氧化酶的结构的方法，以及用于鉴定线粒体原卟啉原配体的方法 IX氧化酶，可用作除草剂。本发明还涉及这里描述的烟草线粒体原卟啉原IX氧化酶的晶体结构用于产生相关酶的蛋白质模型和鉴定相关蛋白质的抑制剂。

2. 发明申请

US20070110901A1 Method for identifying weakly binding molecule fragments having ligand properties, whereby the molecule fragments are applied in the form of microdrops of a corresponding solution to the crystal 审中-公开
标题翻译：用于鉴定具有配体性质的弱结合分子片段的方法，其中分子片段以相应溶液的微滴形式施加到晶体
公开(公告)号：US20070110901A1
公开(公告)日：2007-05-17
申请号：US10567522
申请日：2004-08-06
申请人： Torsten Neuefeind , Hans Brandstetter , Reiner Kiefersauer
发明人： Torsten Neuefeind , Hans Brandstetter , Reiner Kiefersauer
IPC分类号： B05D3/04
CPC分类号： G01N33/6803 , C30B7/00 , C30B33/00 , G01N33/68
摘要： The present invention relates to a method for treating a crystal with a solution, wherein the solution contains one or more molecule species and wherein the molecules of the molecule species typically have a molecular weight of
摘要翻译：本发明涉及用溶液处理晶体的方法，其中溶液含有一种或多种分子物质，其中分子物质的分子通常具有<500Da的分子量。通过该方法，可以鉴定与靶结构弱结合的小分子或分子片段，并且可以通过随后的X射线晶体学检查来确定其结合位置。

3. 发明授权

US07281669B2 Apparatus and method for generating a defined environment for particle-shaped samples 失效
标题翻译：用于产生颗粒状样品的限定环境的装置和方法
公开(公告)号：US07281669B2
公开(公告)日：2007-10-16
申请号：US11035769
申请日：2005-01-13
申请人： Torsten Neuefeind , Reiner Kiefersauer , Holger Venzke , Martin Still
发明人： Torsten Neuefeind , Reiner Kiefersauer , Holger Venzke , Martin Still
IPC分类号： F24F11/00 , F24F3/14 , G05D22/02
CPC分类号： G01N23/20025 , G01N1/22 , G01N23/20
摘要： An apparatus for generating a defined environment for particle-shaped samples, comprises a support element with a rest end for a particle-shaped sample and an apparatus for generating a humid gas flow at a mouth end thereof. The mouth end is directed to the rest end. A gas provider provides gas having a first dew-point temperature. A cooler cools the gas to a cooler temperature under condensation of moisture to adjust a second dew-point temperature of the gas. A guide guides the gas with the second dew-point temperature to the mouth end, preventing condensation of moisture from the gas. A controller adjusts the relative humidity of the gas at the mouth end by adjusting the cooler temperature and adjusting the temperature of the gas at the mouth end.
摘要翻译：一种用于产生颗粒状样品的限定环境的装置，包括具有用于颗粒状样品的其余端的支撑元件和用于在其端部产生湿气流的装置。嘴端指向其余的端。燃气供应商提供具有第一露点温度的气体。冷却器将冷却器冷却至较冷的温度，以调节气体的第二露点温度。引导件将气体以第二露点温度引导到嘴端，防止水分从气体中冷凝。控制器通过调节冷却器温度和调节口端部气体的温度来调节口端部气体的相对湿度。

4. 发明申请

US20070160501A1 Device and method for treating a crystal by applying microdrops thereto 审中-公开
标题翻译：通过向其施加微滴来处理晶体的装置和方法
公开(公告)号：US20070160501A1
公开(公告)日：2007-07-12
申请号：US10567193
申请日：2004-08-06
申请人： Torsten Neuefeind , Hans Brandstetter , Reiner Kiefersauer
发明人： Torsten Neuefeind , Hans Brandstetter , Reiner Kiefersauer
IPC分类号： B01L3/00
CPC分类号： C30B33/00 , C30B7/00 , C30B19/12 , C30B29/58 , G01N33/68 , G01N2500/04
摘要： The invention relates to a device for treating a crystal with a liquid having a holder for fixing the crystal and a micro dosage system, which, in relation to the holder, is arranged in such a way that it allows applying microdrops of the liquid onto the crystal fixed in the holder. Furthermore, the invention relates to a method for treating a crystal with a liquid, wherein the crystal is fixed and microdrops of the liquid are applied onto the crystal. The invention is particularly useful for gently treating protein crystals with specific substances. Thus, for example, ligands or inhibitors, which are contained in the liquid, can be applied onto the crystal by means of a piezo pipette. Herein, the crystal is preferably located in a defined gas atmosphere, to which an evaporated solubilizer for the ligand or inhibitor can be added.
摘要翻译：本发明涉及一种用液体处理晶体的装置，该装置具有用于固定晶体的保持器和一个微量剂量系统，该微量剂量系统相对于保持器以这样一种方式排列，使得其允许将液滴的微滴水晶固定在支架上。此外，本发明涉及一种用液体处理晶体的方法，其中晶体是固定的，液体的微滴被施加到晶体上。本发明特别适用于用特定物质轻轻地处理蛋白质晶体。因此，例如，可以通过压电移液管将包含在液体中的配体或抑制剂施加到晶体上。这里，晶体优选位于限定的气体气氛中，可以加入用于配体或抑制剂的蒸发增溶剂。

5. 发明申请

US20050183518A1 Apparatus and method for generating a defined environment for particle-shaped samples 失效
标题翻译：用于产生颗粒状样品的限定环境的装置和方法
公开(公告)号：US20050183518A1
公开(公告)日：2005-08-25
申请号：US11035769
申请日：2005-01-13
申请人： Torsten Neuefeind , Reiner Kiefersauer , Holger Venzke , Martin Still
发明人： Torsten Neuefeind , Reiner Kiefersauer , Holger Venzke , Martin Still
IPC分类号： C07K1/14 , G01N1/00 , G01N1/28 , G01N23/20 , G01N1/42
CPC分类号： G01N23/20025 , G01N1/22 , G01N23/20
摘要： The present invention provides an apparatus for generating a defined environment for particle-shaped samples, comprising a support element with a rest end for a particle-shaped sample and an apparatus for generating a humid gas flow at a mouth end thereof, wherein the mouth end is directed to the rest end. The apparatus for generating the humid gas flow includes means for providing gas having a first temperature and a first relative humidity, so that the gas has a first dew-point temperature. Furthermore, a cooler for cooling the gas to a cooler temperature under condensation of moisture is provided to adjust a second dew-point temperature of the gas corresponding to the cooler temperature. Means for guiding the gas with the second dew-point temperature to the mouth end, preventing condensation of moisture from the gas, and means for adjusting the relative humidity of the gas at the mouth end by adjusting the cooler temperature and the temperature of the gas at the mouth end are also provided.
摘要翻译：本发明提供了一种用于产生颗粒状样品的限定环境的装置，包括：具有用于颗粒状样品的休息端的支撑元件和在其端部产生湿气流的装置，其中，所述口端是针对休息的。用于产生湿气流的装置包括用于提供具有第一温度和第一相对湿度的气体的装置，使得气体具有第一露点温度。此外，提供了一种用于在气体冷凝下将气体冷却至较冷温度的冷却器，以调节对应于较冷温度的气体的第二露点温度。用于将具有第二露点温度的气体引导到嘴端的装置，防止水分与气体的冷凝，以及用于通过调节气体的冷却器温度和气体来调节口部的气体的相对湿度的装置在嘴端还提供。

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