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1. 发明授权

US07519212B2 Three-dimensional reconstructions of a breast from two X-ray mammographics 有权
标题翻译：来自两个X射线乳房摄影术的乳房三维重建
公开(公告)号：US07519212B2
公开(公告)日：2009-04-14
申请号：US10221778
申请日：2001-01-31
申请人： John Michael Brady , Ralph Highnam , Shuk Wah Margaret Yam
发明人： John Michael Brady , Ralph Highnam , Shuk Wah Margaret Yam
IPC分类号： G06K9/00 , A61B6/04 , A61B8/00
CPC分类号： G06T7/0012 , G06T7/55 , G06T2207/30068
摘要： Methods are described for the production of a three-dimensional reconstruction of a undeformed object from two different views of the object under deformation using a volume constraint and also by matching corresponding features in the two images. The volume constraint involves assuming that the deformed volume is the same as the undeformed volume, and calculating the deformed volume from one of the images. Further, the deformation of the object can be parameterised by finding corresponding image entities in the each of the images. The method is particularly applicable to breast mammograms in which case the two images are the cranio-caudal (CC) image and medio-lateral oblique (MLO) image whose angular separation varies from 35 to 60 degrees. The image entities which are detected in the two images are microcalcifications, and these are matched by detecting a value representing their volume a looking for matches in this value between the two images.
摘要翻译：描述了用于使用体积约束从变形的对象的两个不同视图以及通过匹配两个图像中的对应特征来生成未变形对象的三维重建的方法。体积约束假设变形的体积与未变形的体积相同，并且从一个图像计算变形的体积。此外，可以通过在每个图像中找到对应的图像实体来参数化对象的变形。该方法特别适用于乳房X线照片，在这种情况下，两幅图像是角度分离从35度到60度变化的颅尾（CC）图像和中 - 内倾斜（MLO）图像。在两个图像中检测到的图像实体是微钙化，并且通过检测表示它们的体积的值来匹配这些图像，以在两个图像之间的该值中寻找匹配。

2. 发明申请

US20160133033A1 A Method of Reconstruction of an Object from Projection Views 有权
标题翻译：从投影视图重建对象的方法
公开(公告)号：US20160133033A1
公开(公告)日：2016-05-12
申请号：US14895717
申请日：2014-06-06
申请人： John Michael BRADY , Ralph HIGHNAM , VOLPARA HEALTH TECHNOLOGIES LIMITED
发明人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G06T11/005 , G06T2207/10081 , G06T2207/10112 , G06T2207/30068 , G06T2207/30096 , G06T2211/436
摘要： The present invention relates to a method of reconstruction of an object from projections, more particularly to a quantitative reconstruction of an object from projection views of the object. For example, quantitative reconstruction of an image of a human breast from projection views generated by digital breast tomosynthesis (DBT), computed tomography (CT), or standard mammography, and use of the reconstruction to identify densest regions.
摘要翻译：本发明涉及一种从投影重建物体的方法，更具体地涉及从物体的投影视图对物体的定量重构。例如，通过数字乳房断层合成（DBT），计算机断层扫描（CT）或标准乳房X线照相术产生的投影视图对人乳房图像进行定量重建，以及使用重建来识别最密集区域。

3. 发明授权

US09361683B2 Imaging technique and imaging system 有权
标题翻译：成像技术和成像系统
公开(公告)号：US09361683B2
公开(公告)日：2016-06-07
申请号：US13990181
申请日：2011-11-29
申请人： Ralph Highnam , John Michael Brady
发明人： Ralph Highnam , John Michael Brady
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T7/0014 , G06T2207/10088 , G06T2207/10136 , G06T2207/30068
摘要： The present invention relates to an imaging technique and an imaging system and more particularly to an automatic assessment of quantitative measure(s)/properties(s) of an object wherein, for example, an imaging system is used to capture an image, following which image properties are quantified using image processing techniques. An imaging technique obtains an image of an object along a first axis, or by way of a first technique, and subsequently obtains an image of the object along a second axis, or by way of a second technique. One or more pixels from the first image are selected and designated as reference pixels. An automated comparison between corresponding regions of the first and second images are then performed which is based upon the reference pixels, so as to indicate regions of interest.
摘要翻译：本发明涉及成像技术和成像系统，并且更具体地涉及自动评估对象的定量测量/特性，其中例如使用成像系统来拍摄图像，随后，图像属性使用图像处理技术进行量化。成像技术获得沿着第一轴的物体的图像，或者通过第一技术获得物体的图像，并且随后通过第二轴获得物体的图像，或者通过第二技术获得物体的图像。选择来自第一图像的一个或多个像素并将其指定为参考像素。然后，基于参考像素执行第一和第二图像的相应区域之间的自动比较，以便指示感兴趣的区域。

4. 发明授权

US09865067B2 Method of reconstruction of an object from projection views 有权
公开(公告)号：US09865067B2
公开(公告)日：2018-01-09
申请号：US14895717
申请日：2014-06-06
申请人： Ralph Highnam , John Michael Brady
发明人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
IPC分类号： G06T11/00
CPC分类号： G06T11/008 , G06T11/005 , G06T2207/10081 , G06T2207/10112 , G06T2207/30068 , G06T2207/30096 , G06T2211/436
摘要： The present invention relates to a method of reconstruction of an object from projections, more particularly to a quantitative reconstruction of an object from projection views of the object. For example, quantitative reconstruction of an image of a human breast from projection views generated by digital breast tomosynthesis (DBT), computed tomography (CT), or standard mammography, and use of the reconstruction to identify densest regions.

5. 发明申请

US20110052025A1 SYSTEM FOR IMAGING PATHWAY VERIFICATION 审中-公开
标题翻译：成像路径验证系统
公开(公告)号：US20110052025A1
公开(公告)日：2011-03-03
申请号：US12848942
申请日：2010-08-02
申请人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
发明人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06T2207/10116 , G06T2207/30068
摘要： The disclosure includes computer implemented methods and devices comprising processors for inputting images and medical history into an electronic medium and analyzing x-ray images of a subject's breasts to determine density. The disclosure further contemplates using these methods and devices to generate a numerical value. The disclosure further contemplates using the numerical value to determine whether the subject should have magnetic resonance imaging of the breasts.
摘要翻译：本公开包括计算机实现的方法和装置，其包括用于将图像和病历输入到电子介质中的处理器，并且分析被检者乳房的X射线图像以确定密度。本公开进一步考虑使用这些方法和装置来产生数值。本公开进一步考虑使用数值来确定受试者是否应该具有乳房的磁共振成像。

6. 发明授权

US09008382B2 Method and system for analysing tissue from images 有权
标题翻译：用于分析图像组织的方法和系统
公开(公告)号：US09008382B2
公开(公告)日：2015-04-14
申请号：US13261165
申请日：2010-08-03
申请人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
发明人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
IPC分类号： G06K9/00 , G06T7/00 , G06T7/40
CPC分类号： G06T7/0012 , G06T7/44 , G06T2207/30068
摘要： Disclosed is a method of analyzing tissue from an image comprising providing an electronic image of tissue (100, 400, 450, 600, 800, 1100), determining a reference value from the image (1070, 1170, 1270), establishing an hint representation (500,700) of the image, and using the hint representation in analysis of the tissue to quantify the breast and compute a calibration error. Also disclosed is a system which runs an inner breast edge detection algorithm (1310) on the electronic image to detect the inner breast edge on the image (1315), and refined the inner breast edge location (1340) if a calibration error is not acceptable (1324). Also disclosed is automatic estimation of breast composition and temporal analysis of images.
摘要翻译：公开了一种从图像中分析组织的方法，包括提供组织的电子图像（100,400,450,600,800,10000），从图像（1070,1170,1270）确定参考值，建立提示表示（500,700）的图像，并且使用提示表示来分析组织以量化乳房并计算校准误差。还公开了一种在电子图像上运行内部乳房边缘检测算法（1310）以检测图像（1315）上的内乳房边缘的系统，并且如果校准误差不可接受则改善了内乳房边缘位置（1340）（1324）。还公开了对图像的乳房成分和时间分析的自动估计。

7. 发明申请

US20140010429A1 Imaging Technique and Imaging System 有权
标题翻译：成像技术与成像系统
公开(公告)号：US20140010429A1
公开(公告)日：2014-01-09
申请号：US13990181
申请日：2011-11-29
申请人： Ralph Highnam , John Michael Brady
发明人： Ralph Highnam , John Michael Brady
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/0014 , G06T2207/10088 , G06T2207/10136 , G06T2207/30068
摘要： The present invention relates to an imaging technique and an imaging system and more particularly to an automatic assessment of quantitative measure(s)/properties(s) of an object wherein, for example, an imaging system is used to capture an image, following which image properties are quantified using image processing techniques. An imaging technique obtains an image of an object along a first axis, or by way of a first technique, and subsequently obtains an image of the object along a second axis, or by way of a second technique. One or more pixels from the first image are selected and designated as reference pixels. An automated comparison between corresponding regions of the first and second images are then performed which is based upon the reference pixels, so as to indicate regions of interest.
摘要翻译：本发明涉及成像技术和成像系统，并且更具体地涉及自动评估对象的定量测量/特性，其中例如使用成像系统来拍摄图像，随后，图像属性使用图像处理技术进行量化。成像技术获得沿着第一轴的物体的图像，或者通过第一技术获得物体的图像，并且随后通过第二轴获得物体的图像，或者通过第二技术获得物体的图像。选择来自第一图像的一个或多个像素并将其指定为参考像素。然后，基于参考像素执行第一和第二图像的相应区域之间的自动比较，以便指示感兴趣的区域。

8. 发明申请

US20120189175A1 Method and system for analysing tissue from images 有权
标题翻译：用于分析图像组织的方法和系统
公开(公告)号：US20120189175A1
公开(公告)日：2012-07-26
申请号：US13261165
申请日：2010-08-03
申请人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
发明人： Ralph Highnam , John Michael Brady , Nico Karssemeijer , Martin Yaffe
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/44 , G06T2207/30068
摘要： Disclosed is a method of analysing tissue from an image comprising providing an electronic image of tissue (100, 400, 450, 600, 800, 1100), determining a reference value from the image (1070, 1170, 1270), establishing an hint representation (500,700) of the image, and using the hint representation in analysis of the tissue to quantify the breast and compute a calibration error. Also disclosed is a system which runs an inner breast edge detection algorithm (1310) on the electronic image to detect the inner breast edge on the image (1315), and refined the inner breast edge location (1340) if a calibration error is not acceptable (1324). Also disclosed is automatic estimation of breast composition and temporal analysis of images.
摘要翻译：公开了一种从图像中分析组织的方法，包括提供组织的电子图像（100,400,450,600,800,10000），从图像（1070,1170,1270）确定参考值，建立提示表示（500,700）的图像，并且使用提示表示来分析组织以量化乳房并计算校准误差。还公开了一种在电子图像上运行内部乳房边缘检测算法（1310）以检测图像（1315）上的内乳房边缘的系统，并且如果校准误差不可接受则改善了内乳房边缘位置（1340）（1324）。还公开了对图像的乳房成分和时间分析的自动估计。

9. 发明授权

US07315640B1 X-ray image processing 失效
标题翻译： X射线图像处理
公开(公告)号：US07315640B1
公开(公告)日：2008-01-01
申请号：US09914460
申请日：2000-02-21
申请人： John Michael Brady , Ralph Highnam
发明人： John Michael Brady , Ralph Highnam
IPC分类号： G06K9/00
CPC分类号： G06T5/002 , G06T5/003 , G06T2207/10116 , G06T2207/30068
摘要： A method of enhancing and normalizing x-ray images, particularly mammograms, by correcting the image for digitizer blur, glare from the intensifying screen and the anode-heel effect. The method also allows the calculation of the compressed thickness of the imaged breast and calculation of the contribution to the mammograms of the extra focal radiation. The correction of the image for glare from the intensifying screen allows the detection of noise, such as film shot noise, in the image, and in particular the differentiation between such noise and microcalcifications.
摘要翻译：通过校正数字化仪模糊的图像，来自增强屏幕的眩光和阳极 - 脚跟效应来增强和归一化X射线图像，特别是乳房X线照片的方法。该方法还允许计算成像乳房的压缩厚度并计算对额外焦点辐射的乳房X线照片的贡献。来自增强屏幕的用于眩光的图像的校正允许检测图像中的噪声，例如胶片拍摄噪声，并且特别地，这种噪声和微钙化之间的差异。

10. 发明申请

US20050078799A1 Scatter correction in scanning imaging systems 失效
标题翻译：扫描成像系统中的散射校正
公开(公告)号：US20050078799A1
公开(公告)日：2005-04-14
申请号：US10686382
申请日：2003-10-14
申请人： Bruno Ancelin , Ralph Highnam
发明人： Bruno Ancelin , Ralph Highnam
IPC分类号： A61B6/00 , A61B6/06 , G06T5/00 , G06T5/20 , G21K1/00 , H01J35/10 , H01J35/12
CPC分类号： A61B6/5282 , A61B6/06 , A61B6/502 , A61B6/508 , G06T5/003 , G06T5/20 , G06T2207/10116 , G06T2207/30068
摘要： A method of processing a radiographic image obtained with a slot-scanning radiographic system to compensate for scattering of the illuminating beam in the tissue being imaged. A conventional circularly symmetric scatter mask, for example a point spread function, is adjusted to take account of the shape of the detector and 1o time delay integration used in the slot scanning system, the presence of an air gap between the detector and the bottom of the tissue being imaged, and the collimation of the radiation beam. The result is a sharpened and shortened point spread function.
摘要翻译：一种处理通过时隙扫描放射线照相系统获得的放射照相图像以补偿被成像的组织中的照射光束的散射的方法。调整传统的圆对称散射掩模，例如点扩散函数，以考虑到检测器的形状和在槽扫描系统中使用的1o时间延迟积分，检测器和底部之间存在气隙正在成像的组织和辐射束的准直。结果是削尖和缩短点扩散功能。

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