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1. 发明授权

US5766231A Implantable growth tissue stimulator and method of operation 失效
标题翻译：植入式生长组织刺激器及其操作方法
公开(公告)号：US5766231A
公开(公告)日：1998-06-16
申请号：US730493
申请日：1996-10-11
申请人： John H. Erickson , John C. Tepper , Ike C. Thacker , Gregg Turi , Anthony J. Varrichio , Arthur A. Pilla , Mark A. Bettin , William C. Brosche
发明人： John H. Erickson , John C. Tepper , Ike C. Thacker , Gregg Turi , Anthony J. Varrichio , Arthur A. Pilla , Mark A. Bettin , William C. Brosche
IPC分类号： A61N1/05 , A61N1/08 , A61N1/18 , A61N1/32 , A61N1/36
CPC分类号： A61N1/3605 , A61N1/05 , A61N1/08 , A61N1/326 , Y10S128/903
摘要： A hand-held programmer/monitor (500) for programming and monitoring an implantable tissue growth stimulator (10) is provided. The stimulator (10) includes circuitry (46) for implementing selected operations in response to a down-link signal transmitted by the programmer/monitor (500). The stimulator (10) also includes circuitry (14) for transmitting up-link signals to the programmer/monitor (500). The programmer/monitor (500) includes a control circuit (518) for generating the down-link signal. The control circuit (518) also processes the up-link signal to monitor the status of the implantable tissue growth stimulator (10). The programmer/monitor (500) also includes a transmit/receive circuit (514) for transmitting the down-link signal to and for receiving the up-link signal from the implantable tissue growth stimulator (10). The transmit/receive circuit (514) also couples the up-link signal to the control circuit (518).
摘要翻译：提供了一种用于编程和监测植入式组织生长刺激器（10）的手持编程器/监视器（500）。刺激器（10）包括用于响应于由编程器/监视器（500）发送的下行链路信号来实现所选择的操作的电路（46）。刺激器（10）还包括用于向编程器/监视器（500）发送上行链路信号的电路（14）。编程器/监视器（500）包括用于产生下行链路信号的控制电路（518）。控制电路（518）还处理上行链路信号以监视可植入组织生长刺激器（10）的状态。编程器/监视器（500）还包括发送/接收电路（514），用于将下行链路信号发送到可植入组织生长刺激器（10）并用于从可植入组织生长刺激器（10）接收上行链路信号。发射/接收电路（514）还将上行链路信号耦合到控制电路（518）。

2. 发明授权

US5441527A Implantable bone growth stimulator and method of operation 失效
标题翻译：植入式骨生长刺激剂及其操作方法
公开(公告)号：US5441527A
公开(公告)日：1995-08-15
申请号：US186230
申请日：1994-01-24
申请人： John H. Erickson , John C. Tepper , Ike C. Thacker , Gregg Turi , Anthony J. Varrichio , Arthur A. Pilla
发明人： John H. Erickson , John C. Tepper , Ike C. Thacker , Gregg Turi , Anthony J. Varrichio , Arthur A. Pilla
IPC分类号： A61N1/05 , A61N1/18 , A61N1/32 , A61N1/36
CPC分类号： A61N1/3605 , A61N1/05 , A61N1/326 , A61N1/37211
摘要： A method for the therapeutic stimulation of bone growth of a bone site is disclosed comprising the steps of implanting first and second electrodes into the tissue near the base site. The electrodes are coupled to a bone growth stimulator which generates an alternating current.
摘要翻译：公开了一种治疗性刺激骨骼部位骨生长的方法，包括将第一和第二电极植入基部附近的组织中的步骤。电极耦合到产生交流电的骨生长刺激器。

3. 发明授权

US5565005A Implantable growth tissue stimulator and method operation 失效
标题翻译：植入式生长组织刺激器和方法操作
公开(公告)号：US5565005A
公开(公告)日：1996-10-15
申请号：US18944
申请日：1993-02-17
申请人： John H. Erickson , John C. Tepper , Ike C. Thacker , Greg Turi , Anthony J. Varrichio , Arthur A. Pilla , Mark A. Bettin , William C. Brosche
发明人： John H. Erickson , John C. Tepper , Ike C. Thacker , Greg Turi , Anthony J. Varrichio , Arthur A. Pilla , Mark A. Bettin , William C. Brosche
IPC分类号： A61N1/05 , A61N1/08 , A61N1/18 , A61N1/32 , A61N1/36
CPC分类号： A61N1/3605 , A61N1/05 , A61N1/08 , A61N1/326 , Y10S128/903
摘要： A hand-held programmer/monitor (500) for programming and monitoring an implantable tissue growth stimulator (10) is provided. The stimulator (10) includes circuitry (46) for implementing selected operations in response to a down-link signal transmitted by the programmer/monitor (500). The stimulator (10) also includes circuitry (46) for transmitting up-link signals to the programmer/monitor (500). The programmer/monitor (500) includes a control circuit (518) for generating the down-link signal. The control circuit (518) also processes the up-link signal to monitor the status of the implantable tissue growth stimulator (10). The programmer/monitor (500) also includes a transmit/receive circuit (514) for transmitting the down-link signal to and for receiving the up-link signal from the implantable tissue growth stimulator (10). The transmit/receive circuit (514) also couples the up-link signal to the control circuit (518).
摘要翻译：提供了一种用于编程和监测植入式组织生长刺激器（10）的手持编程器/监视器（500）。刺激器（10）包括用于响应于由编程器/监视器（500）发送的下行链路信号来实现所选择的操作的电路（46）。刺激器（10）还包括用于向编程器/监视器（500）发送上行链路信号的电路（46）。编程器/监视器（500）包括用于产生下行链路信号的控制电路（518）。控制电路（518）还处理上行链路信号以监视可植入组织生长刺激器（10）的状态。编程器/监视器（500）还包括发送/接收电路（514），用于将下行链路信号发送到可植入组织生长刺激器（10）并用于从可植入组织生长刺激器（10）接收上行链路信号。发射/接收电路（514）还将上行链路信号耦合到控制电路（518）。

4. 发明申请

US20140221726A1 APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT OF NEURODEGENERATIVE CONDITIONS 有权
标题翻译：用于电磁疗法治疗神经营养因子的装置及方法
公开(公告)号：US20140221726A1
公开(公告)日：2014-08-07
申请号：US14171613
申请日：2014-02-03
申请人： Arthur A. Pilla , Andre' A. DiMino , Iyer Viswanathan , Diana Casper , Berish Strauch
发明人： Arthur A. Pilla , Andre' A. DiMino , Iyer Viswanathan , Diana Casper , Berish Strauch
IPC分类号： A61N2/00 , A61N2/02
CPC分类号： A61N2/006 , A61N1/36014 , A61N1/36025 , A61N2/008 , A61N2/02
摘要： Described herein are methods of treating neurological injury and conditions, in particular neurodegenerative conditions. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.
摘要翻译：本文描述了治疗神经损伤和病症，特别是神经变性病症的方法。这些处理方法可以包括从脉冲电磁场源产生脉冲电磁场并将脉冲电磁场施加到目标区域附近的步骤。

5. 发明授权

US08343027B1 Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant 有权
标题翻译：在含有金属的植入物的存在下提供电磁处理的方法和装置
公开(公告)号：US08343027B1
公开(公告)日：2013-01-01
申请号：US13361797
申请日：2012-01-30
申请人： Andre' A. DiMino , Matthew E. Drummer , Arthur A. Pilla
发明人： Andre' A. DiMino , Matthew E. Drummer , Arthur A. Pilla
IPC分类号： A61N1/00
CPC分类号： A61N1/40
摘要： Methods and devices for providing electromagnetic field treatment to a subject having a metal-containing implant or prosthesis at or near the treatment site. These treatment methods can include calibrating the treatment devices such that the treatment field provided is not distorted or affected by the presence of metal in the target location. Additionally, embodiments of the invention provide for wearable and adjustable electromagnetic treatment devices with reinforcing support members to maintain the structure of flexible metal applicators, which generate the therapeutic electromagnetic field.
摘要翻译：用于向在处理部位处或附近具有含金属的植入物或假体的受试者提供电磁场治疗的方法和装置。这些处理方法可以包括校准处理装置，使得所提供的治疗场不会由于目标位置中的金属的存在而变形或影响。此外，本发明的实施例提供了具有加强支撑构件的耐磨和可调节的电磁治疗装置，以维持产生治疗电磁场的柔性金属敷设器的结构。

6. 发明申请

US20110112352A1 APPARATUS AND METHOD FOR ELECTROMAGNETIC TREATMENT 审中-公开
标题翻译：电磁治疗装置及方法
公开(公告)号：US20110112352A1
公开(公告)日：2011-05-12
申请号：US12819956
申请日：2010-06-21
申请人： Arthur A. Pilla , Andre' A. DiMino , Iyer Viswanathan
发明人： Arthur A. Pilla , Andre' A. DiMino , Iyer Viswanathan
IPC分类号： A61N2/04
CPC分类号： A61N2/02 , A61N1/40 , A61N2/008
摘要： Described herein are electromagnetic treatment devices for treatment of tissue. In particular, described herein are lightweight, wearable, low-energy variations that are specifically configured to specifically and sufficiently apply energy within a specific bandpass of frequencies of a target biological pathway, such as the binding of Calcium to Calmodulin, and thereby regulate the pathway. Methods and systems for treating biological tissue are also described.
摘要翻译：本文描述了用于治疗组织的电磁治疗装置。特别地，本文描述的是轻质的，可穿戴的，低能量的变化，其特别地被配置为具体地并且充分地将能量施加在目标生物学途径的频率的特定带通中，例如钙与钙调蛋白的结合，从而调节通路。还描述了用于治疗生物组织的方法和系统。

7. 发明授权

US07896797B2 Electromagnetic field treatment apparatus and method for using same 有权
标题翻译：电磁场处理装置及其使用方法
公开(公告)号：US07896797B2
公开(公告)日：2011-03-01
申请号：US12082944
申请日：2008-04-14
申请人： Arthur A. Pilla , Andre' DiMino , David J. Muehsam
发明人： Arthur A. Pilla , Andre' DiMino , David J. Muehsam
IPC分类号： A61N1/00
CPC分类号： A61N2/02 , A61N2/004 , A61N2/06
摘要： Larmor Precession makes specific predictions about bound ion dynamics, based upon specific combinations of AC and DC magnetic fields. Especially significant is the fact that the external magnetic field environment determines the overall qualities of resonances or particular changes in bio-effects. Given a target with a particular gyromagnetic ratio, Larmor Precession makes predictions that are determined solely by a magnetic field environment itself. An embodiment according to the present invention comprises specific combinations of AC and DC magnetic fields configured to produce specific bio-effects. Preferably an embodiment according to the present invention comprises using Larmor Precession to develop Electromagnetic Field environments targeted towards enhancing or diminishing specific biological processes, including tumor growth, bone and tissue repair, and biological processes and using Larmor Precession to generate magnetic field conditions that take advantage of specific behaviors, including resonances conditions.
摘要翻译：根据AC和DC磁场的特定组合，Larmor进动对结合离子动力学做出具体的预测。特别重要的是，外部磁场环境决定了共振的整体质量或生物效应的特定变化。给定具有特定回旋比的目标，Larmor进动使得仅由磁场环境本身确定的预测。根据本发明的实施例包括配置成产生特定生物效应的AC和DC磁场的特定组合。优选地，根据本发明的实施例包括使用Larmor进动来开发旨在增强或减少特定生物过程（包括肿瘤生长，骨和组织修复和生物过程）的电磁场环境，并且使用Larmor进动来产生有利的磁场条件具体行为，包括谐振条件。

8. 发明申请

US20090069626A1 Electromagnetic field treatment apparatus and method for using same 有权
标题翻译：电磁场处理装置及其使用方法
公开(公告)号：US20090069626A1
公开(公告)日：2009-03-12
申请号：US12082944
申请日：2008-04-14
申请人： Arthur A. Pilla , Andre DiMino , David J. Muehsam
发明人： Arthur A. Pilla , Andre DiMino , David J. Muehsam
IPC分类号： A61N2/02
CPC分类号： A61N2/02 , A61N2/004 , A61N2/06
摘要： Larmor Precession makes specific predictions about bound ion dynamics, based upon specific combinations of AC and DC magnetic fields. Especially significant is the fact that the external magnetic field environment determines the overall qualities of resonances or particular changes in bio-effects. Given a target with a particular gyromagnetic ratio, Larmor Precession makes predictions that are determined solely by a magnetic field environment itself. An embodiment according to the present invention comprises specific combinations of AC and DC magnetic fields configured to produce specific bio-effects. Preferably an embodiment according to the present invention comprises using Larmor Precession to develop Electromagnetic Field environments targeted towards enhancing or diminishing specific biological processes, including tumor growth, bone and tissue repair, and biological processes and using Larmor Precession to generate magnetic field conditions that take advantage of specific behaviors, including resonances conditions.
摘要翻译：根据AC和DC磁场的特定组合，Larmor进动对结合离子动力学做出具体的预测。特别重要的是，外部磁场环境决定了共振的整体质量或生物效应的特定变化。给定具有特定回旋比的目标，Larmor进动使得仅由磁场环境本身确定的预测。根据本发明的实施例包括配置成产生特定生物效应的AC和DC磁场的特定组合。优选地，根据本发明的实施例包括使用Larmor进动来开发旨在增强或减少特定生物过程（包括肿瘤生长，骨和组织修复和生物过程）的电磁场环境，并且使用Larmor进动来产生有利的磁场条件具体行为，包括谐振条件。

9. 发明授权

US09656096B2 Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans 有权
公开(公告)号：US09656096B2
公开(公告)日：2017-05-23
申请号：US13285761
申请日：2011-10-31
申请人： Arthur A. Pilla
发明人： Arthur A. Pilla
IPC分类号： A61N1/02 , A61N2/02 , A61N1/40 , A01G7/04 , A61N2/00
CPC分类号： A61N2/02 , A01G7/04 , A61N1/40 , A61N2/008
摘要： Apparatus and methods for delivering electromagnetic signals configured specifically to accelerate the asymmetrical kinetics of the binding of intracellular ions to their respective intracellular buffers, to enhance the biochemical signaling pathways plant animal and human molecules, cells, tissues, organs, portions of entire organisms and entire organisms employ for growth, repair and maintenance. Described herein are devices and methods that utilize repetitive bursts of waveforms configured to maximize the bound concentration of intracellular ions at their associated molecular buffers to enhance the biochemical signaling pathways living systems employ for growth, repair and maintenance. For example the systems and methods described herein may drive the binding of calcium to calmodulin (CaM), thereby enhancing the CaM-dependent nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway.

10. 发明授权

US07611453B2 Apparatus and method for static magnetic field treatment of tissue, organs, cells, and molecules 有权
标题翻译：用于组织，器官，细胞和分子的静态磁场处理的装置和方法
公开(公告)号：US07611453B2
公开(公告)日：2009-11-03
申请号：US11009878
申请日：2004-12-11
申请人： Arthur A. Pilla , David John Muehsam , Charles Zablotsky , Ted Zablotsky
发明人： Arthur A. Pilla , David John Muehsam , Charles Zablotsky , Ted Zablotsky
IPC分类号： A61N1/00
CPC分类号： A61N2/008 , A61N2/06
摘要： An apparatus and method for static magnetic field treatment of plants, animals, and humans comprising the steps of configuring at least one composite static magnetic field by combining at least one of a bipolar static magnetic field and an axial static magnetic field, optimizing spatial distribution and amplitude of the composite static magnetic field at a target pathway structure by satisfying a mathematical model, and coupling the at least one optimized composite static magnetic field to the target pathway structure using a composite static magnetic device.
摘要翻译：用于植物，动物和人的静态磁场处理的装置和方法包括以下步骤：通过组合双极静磁场和轴向静磁场中的至少一个来配置至少一个复合静态磁场，优化空间分布和通过满足数学模型在目标通路结构处的复合静态磁场的振幅，以及使用复合静磁装置将至少一个优化的复合静态磁场耦合到目标通路结构。

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