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1. 发明申请

US20070075010A1 Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system 有权
$Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system$
标题翻译：在微流体系统中实施微流体组分，包括分子分馏装置
公开(公告)号：US20070075010A1
公开(公告)日：2007-04-05
申请号：US11479125
申请日：2006-06-30
申请人： John Gilbert , Manish Deshpande , Jaishree Trikha
发明人： John Gilbert , Manish Deshpande , Jaishree Trikha
IPC分类号： B01D63/00 , G01N33/00 , C02F1/40
CPC分类号： B01D63/087 , B01D63/088 , B01D67/0034 , B01D67/0062 , B01D2313/13 , B01D2313/40 , B01D2325/028 , B01D2325/12 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C02F2209/36 , C30B7/00 , C30B29/58 , G01N27/44743 , G01N27/44773 , Y10S977/786 , Y10T156/10
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
摘要翻译：用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。封盖模块包括用于执行微流控功能的微流体元件。封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。微流体元件可以包含对样品中选定分子具有亲和性的基质。该基质与所选择的分子结合，反应和/或保留，而不影响样品中的其它分子。

2. 发明申请

US20060269446A1 Unitary cartridge for particle processing 有权
标题翻译：用于颗粒处理的单一墨盒
公开(公告)号：US20060269446A1
公开(公告)日：2006-11-30
申请号：US11295183
申请日：2005-12-05
申请人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
发明人： John Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： B01L9/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

3. 发明授权

US07153699B2 Microfabricated two-pin system for biomolecule crystallization 有权
公开(公告)号：US07153699B2
公开(公告)日：2006-12-26
申请号：US10328932
申请日：2002-12-23
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
IPC分类号： G01N1/10 , G01N1/00 , G01N1/40 , B01L3/02
CPC分类号： C40B50/08 , B01L3/0244 , B01L3/0248 , B01L3/0255 , B01L3/06 , B01L3/5088 , B01L2200/142 , B01L2200/143 , B01L2200/147 , B01L2300/1822 , B01L2400/0439 , C40B40/10 , G01N2035/1037 , Y10T436/25 , Y10T436/2575
摘要： A two-pin liquid handling system for crystallizing biomolecules comprises a pair of interacting pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The two-pin liquid handling system includes a temperature and humidity control element for controlling the temperature of the sample acquisition region to cause transpiration of water to and from a droplet of biomolecule solution to promote crystallization of the biomolecule.

4. 发明申请

US20050112774A1 Microfluidic chip or biomolecule crystallization 审中-公开
标题翻译：微流控芯片或生物分子结晶
公开(公告)号：US20050112774A1
公开(公告)日：2005-05-26
申请号：US10973138
申请日：2004-10-25
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
IPC分类号： B01L3/00 , B01L3/06 , C30B7/00
CPC分类号： C30B7/00 , B01L3/0248 , B01L3/06 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/0678 , B01L2300/0681 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C30B29/58 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译：用于结晶蛋白质和其他生物分子的系统包括用于输送含有待结晶的生物分子的溶液的流动通道和与沿流动通道形成的结晶过程相关的一个或多个变电站。该系统通过使生物分子溶液流过流动通道，然后在微量级上进行透析以设定结晶条件来操作。透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。可以从流动通道观察并收获形成的晶体。

5. 发明申请

US20070054408A1 Microfabricated two-pin system for biomolecule crystallization 审中-公开
标题翻译：用于生物分子结晶的微型双引脚系统
公开(公告)号：US20070054408A1
公开(公告)日：2007-03-08
申请号：US11595543
申请日：2006-11-10
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
IPC分类号： G01N33/00
CPC分类号： C30B29/58 , C30B7/00
摘要： A two-pin liquid handling system for crystallizing biomolecules comprises a pair of interacting pins for holding a droplet of liquid therebetween. Each pin includes a tip spaced predetermined distance from the other pin to define a sample acquisition region. The two-pin liquid handling system includes a temperature and humidity control element for controlling the temperature of the sample acquisition region to cause transpiration of water to and from a droplet of biomolecule solution to promote crystallization of the biomolecule.
摘要翻译：用于结晶生物分子的双针液体处理系统包括一对用于在其间保持液滴的相互作用的销。每个引脚包括与另一个引脚间隔预定距离的尖端以限定采样区域。双针液体处理系统包括温度和湿度控制元件，用于控制样品采集区域的温度，以使水与生物分子溶液液滴一起蒸发以促进生物分子的结晶。

6. 发明授权

US06849459B2 Microfluidic chip for biomolecule crystallization 失效
标题翻译：用于生物分子结晶的微流控芯片
公开(公告)号：US06849459B2
公开(公告)日：2005-02-01
申请号：US10328931
申请日：2002-12-23
申请人： John Gilbert , Jaishree Trikha
发明人： John Gilbert , Jaishree Trikha
IPC分类号： B01L3/00 , B01L3/06 , C30B7/00 , G01N33/00
CPC分类号： C30B7/00 , B01L3/0248 , B01L3/06 , B01L3/502715 , B01L3/502723 , B01L3/502753 , B01L2200/0678 , B01L2300/0681 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C30B29/58 , Y10T436/25 , Y10T436/2525 , Y10T436/255
摘要： A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
摘要翻译：用于结晶蛋白质和其他生物分子的系统包括用于输送含有待结晶的生物分子的溶液的流动通道和与沿流动通道形成的结晶过程相关的一个或多个变电站。该系统通过使生物分子溶液流过流动通道，然后在微量级上进行透析以设定结晶条件来操作。透析后，通过从生物分子溶液中除去水或溶剂来改变生物分子溶液的浓度，以促进在流动通道的段中形成晶体。可以从流动通道观察并收获形成的晶体。

7. 发明授权

US08567608B2 Method and apparatus for sorting particles 有权
公开(公告)号：US08567608B2
公开(公告)日：2013-10-29
申请号：US12499254
申请日：2009-07-08
申请人： Manish Deshpande , John Gilbert
发明人： Manish Deshpande , John Gilbert
IPC分类号： B07C5/00
CPC分类号： B07C5/36 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0652 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , B07C5/02 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0019 , F16K99/0028 , F16K99/0046 , F16K99/0048 , G01N15/10 , G01N15/14 , G01N2015/1075 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

8. 发明申请

US20080030865A1 Optical detector for a particle sorting system 有权
标题翻译：用于粒子分选系统的光学检测器
公开(公告)号：US20080030865A1
公开(公告)日：2008-02-07
申请号：US11906621
申请日：2007-10-03
申请人： John Gilbert , Edward Sinofsky , Manish Deshpande
发明人： John Gilbert , Edward Sinofsky , Manish Deshpande
IPC分类号： G02B27/14
CPC分类号： G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6452 , G01N2015/1081
摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.
摘要翻译：用于从空间通道阵列获取快速光谱的光学系统包括用于产生穿过微流体芯片或待监测通道的光束的光源，用于在相互作用之后捕获来自光源的光的一个或多个透镜或光纤微流体通道中的颗粒或化学物质，以及一个或多个检测器。可以包括光放大元件的检测器检测每个光信号并将光信号转换成电子信号。每个表示光信号强度的电子信号从每个检测器传递到电子数据采集系统进行分析。光放大元件可以包括耦合到光电二极管检测器阵列的光管阵列，多子光电管或基于多通道板的图像增强器。

9. 发明申请

US20060285983A1 Electromagnetic pump 审中-公开
公开(公告)号：US20060285983A1
公开(公告)日：2006-12-21
申请号：US11362411
申请日：2006-02-23
申请人： Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
发明人： Bernard Bunner , Manish Deshpande , Sebastian Bohm , Richard Day , John Gilbert
IPC分类号： F04B17/00
CPC分类号： F04B43/025 , F04B43/04 , F04B43/043 , Y10S977/963
摘要： An electromagnetic micropump for pumping small volumes of liquids and gases comprises a magnetic actuator assembly, a flexible membrane and a housing defining a chamber and a plurality of valves. The magnetic actuator assembly comprises a coil and a permanent magnet for deflecting the membrane to effect pumping of the fluid. A plurality of micropumps may be stacked together to increase pumping capacity.

10. 发明申请

US20050128479A1 Optical detector for a particle sorting system 有权
标题翻译：用于粒子分选系统的光学检测器
公开(公告)号：US20050128479A1
公开(公告)日：2005-06-16
申请号：US10915016
申请日：2004-08-09
申请人： John Gilbert , Edward Sinofsky , Manish Deshpande
发明人： John Gilbert , Edward Sinofsky , Manish Deshpande
IPC分类号： G01N15/14 , G01N21/00 , G01N21/64 , G01N21/88 , H01L20060101
CPC分类号： G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6452 , G01N2015/1081
摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.
摘要翻译：用于从空间通道阵列获取快速光谱的光学系统包括用于产生穿过微流体芯片或待监测通道的光束的光源，用于在相互作用之后捕获来自光源的光的一个或多个透镜或光纤微流体通道中的颗粒或化学物质，以及一个或多个检测器。可以包括光放大元件的检测器检测每个光信号并将光信号转换成电子信号。每个表示光信号强度的电子信号从每个检测器传递到电子数据采集系统进行分析。光放大元件可以包括耦合到光电二极管检测器阵列的光管阵列，多子光电管或基于多通道板的图像增强器。

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