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1. 发明授权

US08562791B2 System for decontaminating water and generating water vapor 有权
标题翻译：净化水和产生水蒸气的系统
公开(公告)号：US08562791B2
公开(公告)日：2013-10-22
申请号：US12488750
申请日：2009-06-22
申请人： John D. Riley , Dana L. Johnson
发明人： John D. Riley , Dana L. Johnson
IPC分类号： C02F1/04 , C02F103/00 , B01D3/42 , F01K17/00
CPC分类号： C02F1/043 , B01D1/225 , C02F1/048 , C02F1/08 , C02F1/18 , C02F2103/08 , C02F2209/02 , C02F2209/42 , F22B3/06 , Y02A20/109 , Y02A20/128 , Y02W10/37 , Y10S159/39 , Y10S159/901
摘要： A system and method for decontaminating water and generating water vapor includes introducing contaminated water in to a vessel. The water is moved through a series of rotating trays alternately separated by stationary baffles so as to swirl and heat the water to effect the vaporization thereof to produce a vapor having at least some of the contaminants separated therefrom. The vapor is removed from the vessel for condensing apart from the separated contaminants and the remaining water. The vapor may be passed through a turbine connected to an electric generator. Sensors in a controller may be employed to adjust the speed of rotation of the trays or water input into the vessel in response to the sensed conditions. The treated water may be recirculated and reprocessed through the vessel to increase the purification thereof.
摘要翻译：用于净化水和产生水蒸汽的系统和方法包括将污染的水引入到容器中。水通过一系列由固定挡板交替分离的旋转托盘移动，以便旋转和加热水以实现其蒸发，以产生至少部分污染物与之分离的蒸汽。蒸汽从容器中取出，用于与分离的污染物和剩余的水冷凝。蒸气可以通过连接到发电机的涡轮机。可以使用控制器中的传感器来响应于感测到的条件来调节托盘或输入到容器中的水的旋转速度。经处理的水可以再循环并通过容器再加工以增加其纯化。

2. 发明申请

US20120267232A1 SYSTEM FOR DECONTAMINATING WATER AND GENERATING WATER VAPOR 有权
标题翻译：消除水和生成水蒸气的系统
公开(公告)号：US20120267232A1
公开(公告)日：2012-10-25
申请号：US13536581
申请日：2012-06-28
申请人： John D. Riley , Dana L. Johnson
发明人： John D. Riley , Dana L. Johnson
IPC分类号： B01D3/30 , C02F1/06
CPC分类号： C02F1/06 , B01D1/0082 , B01D1/225 , B01D3/30 , B01D3/42 , C02F1/048 , C02F1/08 , C02F1/18 , C02F2103/08 , C02F2209/02 , C02F2209/42 , F22B3/06 , Y02A20/109 , Y02A20/128 , Y02W10/37
摘要： A system and method for processing a fluid, including decontaminating water and generating water vapor includes introducing the fluid into a vessel. The fluid is moved through a series of rotating trays alternately separated by stationary baffles so as to swirl and heat the fluid to effect the vaporization thereof to produce a vapor having at least some of the contaminants separated therefrom. The vapor is removed from the vessel for condensing apart from the separated contaminants and the remaining water. The vapor may be passed through a turbine connected to an electric generator. Sensors in a controller may be employed to adjust the speed of rotation of the trays or fluid input into the vessel in response to the sensed conditions. The treated fluid may be recirculated and reprocessed through the vessel to increase the purification thereof.
摘要翻译：用于处理流体的系统和方法，包括净化水和产生水蒸汽包括将流体引入容器中。流体通过一系列由固定挡板交替分离的旋转托盘移动，以便旋流和加热流体以实现其蒸发，以产生具有与其分离的至少一些污染物的蒸气。蒸汽从容器中取出，用于与分离的污染物和剩余的水冷凝。蒸气可以通过连接到发电机的涡轮机。可以使用控制器中的传感器来响应于感测到的条件来调节托盘或输入到容器中的流体的旋转速度。经处理的流体可以再循环并通过容器再加工以增加其纯化。

3. 发明申请

US20090313996A1 SYSTEM FOR DECONTAMINATING WATER AND GENERATING WATER VAPOR 有权
标题翻译：消除水和生成水蒸气的系统
公开(公告)号：US20090313996A1
公开(公告)日：2009-12-24
申请号：US12488750
申请日：2009-06-22
申请人： John D. Riley , Dana L. Johnson
发明人： John D. Riley , Dana L. Johnson
IPC分类号： F01K17/00 , B01D3/42 , B01D3/00 , C02F1/04 , F02C1/00
CPC分类号： C02F1/043 , B01D1/225 , C02F1/048 , C02F1/08 , C02F1/18 , C02F2103/08 , C02F2209/02 , C02F2209/42 , F22B3/06 , Y02A20/109 , Y02A20/128 , Y02W10/37 , Y10S159/39 , Y10S159/901
摘要： A system and method for decontaminating water and generating water vapor includes introducing contaminated water in to a vessel. The water is moved through a series of rotating trays alternately separated by stationary baffles so as to swirl and heat the water to effect the vaporization thereof to produce a vapor having at least some of the contaminants separated therefrom. The vapor is removed from the vessel for condensing apart from the separated contaminants and the remaining water. The vapor may be passed through a turbine connected to an electric generator. Sensors in a controller may be employed to adjust the speed of rotation of the trays or water input into the vessel in response to the sensed conditions. The treated water may be recirculated and reprocessed through the vessel to increase the purification thereof.
摘要翻译：用于净化水和产生水蒸汽的系统和方法包括将污染的水引入到容器中。水通过一系列由固定挡板交替分离的旋转托盘移动，以便旋转和加热水以实现其蒸发，以产生至少部分污染物与之分离的蒸汽。蒸汽从容器中取出，用于与分离的污染物和剩余的水冷凝。蒸气可以通过连接到发电机的涡轮机。可以使用控制器中的传感器来响应于感测到的条件来调节托盘或输入到容器中的水的旋转速度。经处理的水可以再循环并通过容器再加工以增加其纯化。

4. 发明授权

US09102545B2 System for decontaminating water and generating water vapor 有权
标题翻译：净化水和产生水蒸气的系统
公开(公告)号：US09102545B2
公开(公告)日：2015-08-11
申请号：US13536581
申请日：2012-06-28
申请人： John D. Riley , Dana L. Johnson
发明人： John D. Riley , Dana L. Johnson
IPC分类号： C02F1/06 , B01D3/30 , F22B3/06 , B01D1/00 , B01D1/22 , C02F1/04 , C02F1/08 , C02F1/18 , C02F103/08
CPC分类号： C02F1/06 , B01D1/0082 , B01D1/225 , B01D3/30 , B01D3/42 , C02F1/048 , C02F1/08 , C02F1/18 , C02F2103/08 , C02F2209/02 , C02F2209/42 , F22B3/06 , Y02A20/109 , Y02A20/128 , Y02W10/37
摘要： A system and method for processing a fluid, including decontaminating water and generating water vapor includes introducing the fluid into a vessel. The fluid is moved through a series of rotating trays alternately separated by stationary baffles so as to swirl and heat the fluid to effect the vaporization thereof to produce a vapor having at least some of the contaminants separated therefrom. The vapor is removed from the vessel for condensing apart from the separated contaminants and the remaining water. The vapor may be passed through a turbine connected to an electric generator. Sensors in a controller may be employed to adjust the speed of rotation of the trays or fluid input into the vessel in response to the sensed conditions. The treated fluid may be recirculated and reprocessed through the vessel to increase the purification thereof.
摘要翻译：用于处理流体的系统和方法，包括净化水和产生水蒸汽包括将流体引入容器中。流体通过一系列由固定挡板交替分离的旋转托盘移动，以便旋流和加热流体以实现其蒸发，以产生具有与其分离的至少一些污染物的蒸气。蒸汽从容器中取出，用于与分离的污染物和剩余的水冷凝。蒸气可以通过连接到发电机的涡轮机。可以使用控制器中的传感器来响应于感测到的条件来调节托盘或输入到容器中的流体的旋转速度。经处理的流体可以再循环并通过容器再加工以增加其纯化。

5. 发明授权

US07196110B2 N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders 有权
标题翻译： N-取代的三环3-氨基吡唑作为治疗细胞增殖性疾病的抑制剂
公开(公告)号：US07196110B2
公开(公告)日：2007-03-27
申请号：US10438152
申请日：2003-05-14
申请人： Chih Yung Ho , Bengt Anders Brunmark , Stuart Emanuel , Robert A. Galemmo, Jr. , Dana L. Johnson , Donald W. Ludovici , Umar Maharoof , Jay M. Mei , Jan L. Sechler , Eric D. Strobel , Robert W. Tuman , Hwa Kwo Yen
发明人： Chih Yung Ho , Bengt Anders Brunmark , Stuart Emanuel , Robert A. Galemmo, Jr. , Dana L. Johnson , Donald W. Ludovici , Umar Maharoof , Jay M. Mei , Jan L. Sechler , Eric D. Strobel , Robert W. Tuman , Hwa Kwo Yen
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07F9/65038 , C07D231/54 , C07D231/56 , C07D233/64 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D491/04 , C07D495/04
摘要： The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.
摘要翻译：本发明涉及可用作血小板衍生生长因子受体（PDGF-R）激酶抑制剂的N-取代三环3-氨基吡唑衍生物，以及制备所述衍生物的方法。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如肿瘤和其它细胞增殖性疾病的病症的方法。

6. 发明授权

US5767078A Agonist peptide dimers 失效
标题翻译：激动肽二聚体
公开(公告)号：US5767078A
公开(公告)日：1998-06-16
申请号：US484135
申请日：1995-06-07
申请人： Dana L. Johnson , Robert A. Zivin
发明人： Dana L. Johnson , Robert A. Zivin
IPC分类号： A61K38/00 , A61K38/22 , A61K38/28 , C07K1/107 , C07K14/505 , C07K2/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/505 , C07K1/1072 , A61K38/00
摘要： The present invention is directed to the dimerization of agonists and antagonists of cell surface receptors and particularly to peptide dimers which behave as cell surface receptor agonists in their dimeric form. Such receptors belong to the dimerization-mediated activation class often observed among receptors for growth and differentiation factors. The agonists of this class of receptors is understood to effect dimerization of the receptor and thus signal initiation. The present invention exemplifies dimers of erythropoietin (EPO) agonists and antagonists comprising a core amino acid sequence of X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO: 1) wherein each amino acid is indicated by standard one letter abbreviation; X.sub.3 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc; X.sub.4 can be R, H, L or W; X.sub.5 can be M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids; X.sub.7 can be D, E, I, L or V; and X.sub.8 can be C, A, .alpha.-amino-.gamma.-bromobutyric acid or Hoc, provided that either X.sub.3 or X.sub.8 is C or Hoc.
摘要翻译：本发明涉及细胞表面受体的激动剂和拮抗剂的二聚，特别涉及作为其二聚体形式的细胞表面受体激动剂的肽二聚体。这种受体属于通常在生长和分化因子的受体中观察到的二聚化介导的活化类别。这类受体的激动剂被理解为影响受体的二聚化，从而使信号起始。本发明例示了包含X3X4X5GPX6TWX7X8（SEQ ID NO：1）的核心氨基酸序列的促红细胞生成素（EPO）激动剂和拮抗剂的二聚体，其中每个氨基酸由标准的一个字母的缩写表示; X3可以是C，A，α-氨基-γ-溴丁酸或Hoc; X4可以是R，H，L或W; X5可以是M，F或I; X6独立地选自20个遗传编码的L-氨基酸或立体异构体D-氨基酸中的任一个; X7可以是D，E，I，L或V; X 8可以是C，A，α-氨基-γ-溴丁酸或Hoc，条件是X3或X8为C或Hoc。

7. 发明授权

US08513229B2 4-Azetidinyl-1-phenyl-cyclohexane antagonists of CCR2 有权
标题翻译： CCR2的4-氮杂环丁烷基-1-苯基 - 环己烷拮抗剂
公开(公告)号：US08513229B2
公开(公告)日：2013-08-20
申请号：US13280690
申请日：2011-10-25
申请人： Xuqing Zhang , Heather Rae Hufnagel , Cuifen Hou , Dana L. Johnson , Zhihua Sui
发明人： Xuqing Zhang , Heather Rae Hufnagel , Cuifen Hou , Dana L. Johnson , Zhihua Sui
IPC分类号： A61K31/397 , C07D205/00
CPC分类号： C07D205/04 , C07D403/08 , C07D403/10 , C07D405/08 , C07D413/08 , C07D417/08
摘要： The present invention comprises compounds of Formula (I): wherein: X, R1, R2, R3, and R4 are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
摘要翻译：本发明包括式（I）的化合物：其中：X，R 1，R 2，R 3和R 4如说明书中所定义。本发明还包括预防，治疗或改善综合征，病症或疾病的方法，其中所述综合征，病症或疾病是II型糖尿病，肥胖症和哮喘。本发明还包括通过施用治疗有效量的至少一种式（I）化合物来抑制哺乳动物CCR2活性的方法。

8. 发明授权

US08173654B2 Triazolopyridazine compounds 有权
标题翻译：三唑并哒嗪化合物
公开(公告)号：US08173654B2
公开(公告)日：2012-05-08
申请号：US12187524
申请日：2008-08-07
申请人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
发明人： Tianbao Lu , Richard Alexander , Richard W. Connors , Maxwell D. Cummings , Robert A. Galemmo , Heather Rae Hufnagel , Dana L. Johnson , Ehab Khalil , Kristi A. Leonard , Thomas P. Markotan , Anna C. Maroney , Jan L. Sechler , Jeremy M. Travins , Robert W. Tuman
IPC分类号： A61K31/4985 , C07D487/04 , A61P3/10 , A61P17/06 , A61P25/18 , A61P19/02 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的三唑并哒嗪化合物：其中R 1，R 5，R 6，R 7，R 8和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及使用的这样的化合物以减少或抑制细胞或受试者中c-Met的激酶活性，并调节细胞或受试者中的c-Met表达，以及这些化合物在受试者中预防或治疗细胞增殖性病症和 /或与c-Met有关的障碍。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

9. 发明授权

US07662824B2 Acylhydrazones as kinase modulators 有权
标题翻译：酰腙作为激酶调节剂
公开(公告)号：US07662824B2
公开(公告)日：2010-02-16
申请号：US11377077
申请日：2006-03-16
申请人： Kristi Leonard , Tianbao Lu , Robert W. Tuman , Dana L. Johnson , Anna C. Maroney , Jan L. Sechler , Richard W. Connors , Richard S. Alexander , Maxwell D. Cummings , Robert A. Galemmo , Thomas P. Markotan
发明人： Kristi Leonard , Tianbao Lu , Robert W. Tuman , Dana L. Johnson , Anna C. Maroney , Jan L. Sechler , Richard W. Connors , Richard S. Alexander , Maxwell D. Cummings , Robert A. Galemmo , Thomas P. Markotan
IPC分类号： A61K31/496 , A61K31/404 , C07D405/14 , C07D405/12 , C07D407/14
CPC分类号： C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12
摘要： The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的酰腙化合物：其中R 1，R 2和A如本文所定义，使用这些化合物作为蛋白质酪氨酸激酶调节剂，特别是c-Met的抑制剂，以及使用这些化合物来减少或抑制 c-Met在细胞或受试者中的激酶活性和调节细胞或受试者中的c-Met表达，以及这些化合物用于预防或治疗受试者的细胞增殖性病症和/或与c- 遇见本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

10. 发明授权

US5003248A Probability density histogram display 失效
标题翻译：概率密度直方图显示
公开(公告)号：US5003248A
公开(公告)日：1991-03-26
申请号：US539285
申请日：1990-06-15
申请人： Dana L. Johnson
发明人： Dana L. Johnson
IPC分类号： G01R13/28 , G01R13/34
CPC分类号： G01R13/28 , G01R13/345
摘要： Disclosed is a probability density histogram display for a digital oscilloscope which shows a probability density histogram display of an input signal waveform alongside the conventional voltage-versus-time time-domain display of the waveform. The histogram shows the relative frequency of occurrence of voltage amplitude levels of the waveform. The histogram is optional and shown simultaneously with the time-domain display of the waveform.
摘要翻译：公开了用于数字示波器的概率密度直方图显示，该数字示波器示出了与常规的波形对时间时域显示相关的输入信号波形的概率密度直方图显示。直方图显示了波形的电压幅度电平的出现相对频率。直方图是可选的，与波形的时域显示同时显示。

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