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1. 发明授权

US5558737A Method of welding a tip to a catheter 失效
标题翻译：将尖端焊接到导管的方法
公开(公告)号：US5558737A
公开(公告)日：1996-09-24
申请号：US116349
申请日：1993-09-03
申请人： Joe E. Brown , Matt D. Pursley , D. Joe Clark
发明人： Joe E. Brown , Matt D. Pursley , D. Joe Clark
IPC分类号： A61M25/00 , A61M25/01 , B29C47/02 , B29C59/00 , B29C65/02
CPC分类号： A61M25/0012 , A61M25/0023 , A61M25/005 , B29C47/0016 , B29C47/0023 , B29C47/003 , B29C47/0033 , B29C47/023 , B29C47/027 , A61M2025/0062 , A61M25/001 , A61M25/0053 , B29C47/0026 , B29K2105/101 , B29L2023/18 , B29L2024/003 , B29L2031/7542 , Y10T156/1023 , Y10T156/1057 , Y10T156/1064
摘要： A method of manufacturing, extruding, milling and welding a high torque, thin monolithic walled guiding catheter having resilient reinforcement material (8, 23, 29, 70, 73) integrally spiralled or braided into monolithic walls (21) of flexible material. A solid lubricant, also referred to as dry lubricant, comprised of either special fluorine containing materials or polymeric organic silicon compounds is embedded into interior and exterior wall surfaces of the catheters. Smooth interior walls (11) are channeled (10) to decrease friction resistance, to trap resistance particles and to dissipate friction heat in the high ratio of surface area to cross-sectional area of small catheters. Number of spirals or braids of reinforcement strands per unit of length, number of layers of strands of the catheters, catheter diameter and progressiveness thereof are designedly different for separate portions of particular catheters. Catheter tips (6) arc machinable immediately adjacent to select density of strands of reinforcement material. Perfusion ports are machinable where desired. Directional bends (7) are positional selectively at distal ends (5) of the catheters (1).
摘要翻译：一种制造，挤压，铣削和焊接具有弹性增强材料（8,23,29,70,73）的高扭矩，薄整体壁导向导管的方法，其一体地螺旋化或编织成柔性材料的整体壁（21）。由特殊含氟材料或聚合有机硅化合物组成的固体润滑剂也称为干性润滑剂，被嵌入导管的内壁和外壁表面。平滑的内壁（11）被引导（10）以降低摩擦阻力，捕获电阻颗粒并以高比例的表面积与小导管的横截面面积消散摩擦热。每单位长度的增强线的螺旋或编织物的数量，导管的股数，导管直径和进行性的数量对于特定导管的分开的部分设计上是不同的。导管尖端（6）可立即切割加工，以选择强化材料股线的密度。灌注口可根据需要加工。定向弯头（7）在导管（1）的远端（5）处有选择性地位置。

2. 发明授权

US06402736B1 Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents 失效
标题翻译：用于过滤血管内液体和递送诊断和治疗剂的装置和方法
公开(公告)号：US06402736B1
公开(公告)日：2002-06-11
申请号：US09558078
申请日：2000-04-25
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61M2500
CPC分类号： A61M25/0017 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M25/0021 , A61M25/0041 , A61M25/0108 , A61M25/0662 , A61M2025/0057 , A61N2005/1021
摘要： An apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents intravascularly is disclosed in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy, and that deploy filtration devices intravascularly for removing particulate matter from body fluid. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the filtering and delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：公开了一种用于过滤血管内液体和用于输送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的内腔注入诊断和治疗剂，该内腔以可溶性涂层的形式递送试剂，其循环或容纳用于血管内放射治疗的放射性物质的预加载电荷，并且部署过滤用于从体液中去除颗粒物的血管内装置。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将过滤和递送装置部署到容器中并用于防止辐射暴露的各种部署系统。

3. 发明授权

US6053900A Apparatus and method for delivering diagnostic and therapeutic agents intravascularly 有权
标题翻译：血管内递送诊断和治疗药物的装置和方法
公开(公告)号：US6053900A
公开(公告)日：2000-04-25
申请号：US168133
申请日：1998-10-07
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61M25/00 , A61M25/01 , A61M25/06 , A61N5/10 , A61K9/22
CPC分类号： A61M25/0041 , A61M25/0017 , A61M25/0021 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61M2025/0057 , A61M25/0108 , A61M25/0662 , A61N2005/1021
摘要： An apparatus and method for delivering diagnostic and therapeutic agents intravascularly in which the apparatus has a shape defined by a preset shape of a resilient fiber core. The resilient fiber core is covered by a soft polymer tubing or other polymer material to form a delivery apparatus that takes the shape of the resilient fiber core. Various shapes and structures are disclosed that infuse diagnostic and therapeutic agents through a lumen of the polymer tubing, that deliver the agents in the form of a soluble coating, and that circulate or contain a preloaded charge of radioactive material for intravascular radiotherapy. The resilient fiber core and soft polymer material permit the construction of a very small apparatus that can be removed easily following treatment. Various deployment systems are disclosed for deploying the delivery apparatuses into a vessel and for protecting against radiation exposure.
摘要翻译：用于递送血管内的诊断和治疗剂的装置和方法，其中该装置具有由弹性纤维芯的预设形状限定的形状。弹性纤维芯被软聚合物管或其它聚合物材料覆盖以形成呈弹性纤维芯形状的输送装置。公开了各种形状和结构，其通过聚合物管的管腔输注诊断和治疗剂，其以可溶性涂层的形式递送药剂，并且循环或容纳用于血管内放射治疗的放射性物质的预加载电荷。弹性纤维芯和软质聚合物材料允许构造非常小的装置，其可以在处理后容易地除去。公开了用于将输送装置部署到容器中并用于防止辐射暴露的各种部署系统。

4. 发明授权

US08784439B1 Percutaneous medical procedures and devices for closing vessels using mechanical closures 失效
标题翻译：经皮医疗程序和关闭使用机械闭合的血管的装置
公开(公告)号：US08784439B1
公开(公告)日：2014-07-22
申请号：US13413156
申请日：2012-03-06
申请人： Stephen V. Ward , Kenneth Salce , Matt D. Pursley , Joe E. Brown
发明人： Stephen V. Ward , Kenneth Salce , Matt D. Pursley , Joe E. Brown
IPC分类号： A61B17/12 , A61B17/064 , A61B17/06 , A61B17/00 , A61B17/03
CPC分类号： A61B17/12172 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0487 , A61B17/06066 , A61B17/06109 , A61B17/0644 , A61B17/068 , A61B17/12013 , A61B17/12031 , A61B17/12036 , A61B17/12109 , A61B17/12131 , A61B2017/00526 , A61B2017/00778 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0437 , A61B2017/0445 , A61B2017/0448 , A61B2017/0464 , A61B2017/0472 , A61B2017/06052 , A61B2017/0608 , A61B2017/06095 , A61B2017/061 , A61B2017/0641 , A61B2017/0645 , A61B2017/0649 , A61B2017/12054
摘要： Percutaneous medical procedures are provided, which use endovascular instruments to install mechanical closures for closing vessels, such as veins. The mechanical closures can be one or more sutures that are anchored to the vessel walls and then cinched to closed the vessel. The mechanical closures can also be resilient clips or stents that are expanded within the vessel to pierce the vessel walls, and are then contracted to pull the vessel closed. Various techniques for installing the mechanical closures are also described.
摘要翻译：提供经皮医学程序，其使用血管内仪器来安装用于封闭血管（如静脉）的机械闭合件。机械闭合件可以是一个或多个缝合线，其被锚定到血管壁上，然后固定以封闭血管。机械闭合件也可以是在容器内膨胀以刺穿血管壁的弹性夹子或支架，然后收缩以使容器闭合。还描述了用于安装机械闭合件的各种技术。

5. 发明授权

US5603694A Infusion coil apparatus and method for delivering fluid-based agents intravascularly 失效
标题翻译：输液管线装置及血管内给药液的方法
公开(公告)号：US5603694A
公开(公告)日：1997-02-18
申请号：US602424
申请日：1996-02-16
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88 , A61M25/00 , A61N5/10 , A61M31/00
CPC分类号： A61M25/0021 , A61M25/0041 , A61F2/88 , A61F2250/0067 , A61F2250/0098 , A61N2005/1021
摘要： An infusion coil apparatus and method for delivering fluid-based diagnostic and therapeutic agents intravascularly in which an infusion coil is placed in an artery or other vessel at a diseased location, and then fluid-based agents are delivered through the infusion coil to that specific location. The infusion coil apparatus includes a resilient fiber core enclosed in a soft, hollow polymer tubing. The resilient fiber core has a preshaped coil at one end that overcomes the susceptibility of the infusion coil to become uncoiled, while permitting a construction of the infusion coil having a very small diameter. The polymer tubing is radiopaque and has a soft surface for engaging the inside of a vessel. The infusion coil is deployed by a deployment device at a specific site in a vessel to be treated. Once at the delivery site, the deployment device ejects the infusion coil out of a delivery sheath into the vessel. The infusion coil is perforated so that fluid-based agents can be delivered through the infusion coil to the site adjacent the wall of the vessel. Variations in the shape of the coil and in the deployment devices are disclosed.
摘要翻译：一种输液线圈装置和方法，用于输送血液内流体的诊断和治疗剂，其中将输注线圈放置在患病位置的动脉或其他血管中，然后将基于流体的药剂通过输注线圈输送到该特定位置。输注线圈装置包括封装在柔软的中空聚合物管中的弹性纤维芯。弹性纤维芯在一端具有预成型线圈，其克服了输注线圈变得未卷曲的易感性，同时允许具有非常小直径的输注线圈的构造。聚合物管是不透射线的，并且具有用于接合容器内部的柔软表面。输注线圈由待处理的容器中的特定部位的展开装置展开。一旦在分娩地点，展开装置就将输液线圈从输送鞘排出到容器中。输注线圈是穿孔的，使得流体基剂可以通过输注线圈输送到邻近容器壁的位置。公开了线圈形状和展开装置的变化。

6. 发明授权

US5334169A Reinforced catheter with thin monolithic walls 失效
标题翻译：加强导管与薄的整体墙
公开(公告)号：US5334169A
公开(公告)日：1994-08-02
申请号：US881422
申请日：1992-05-11
申请人： Joe E. Brown , Matt D. Pursley
发明人： Joe E. Brown , Matt D. Pursley
IPC分类号： A61M25/00 , A61M25/01 , B29C47/02
CPC分类号： A61M25/0012 , A61M25/0023 , A61M25/005 , B29C47/0016 , B29C47/0023 , B29C47/003 , B29C47/0033 , B29C47/023 , B29C47/027 , A61M2025/0062 , A61M25/001 , A61M25/0053 , B29C47/0026 , B29K2105/101 , B29L2023/18 , B29L2024/003 , B29L2031/7542 , Y10T156/1023 , Y10T156/1057 , Y10T156/1064
摘要： A high torque, thin walled guiding catheter has resilient reinforcement material (8, 23, 29, 70, 73) integrally spiraled or braided into monolithic walls (21) of flexible material. A solid lubricant, also referred to as dry lubricant, comprised of either special fluorine containing materials or polymeric organic silicon compounds is embedded into interior and exterior wall surfaces of the catheters. Smooth interior walls (11) are channeled (10) to decrease friction resistance, to trap resistance particles and to dissipate friction heat in the high ratio of surface area to cross-sectional area of small catheters. Number of spirals or braids of reinforcement strands per unit of length, number of layers of strands of the catheters, catheter diameter and progressiveness thereof are designedly different for separate portions of particular catheters. Catheter tips (6) are weldable immediately adjacent to select density of strands of reinforcement material. Perfusion ports are weldable where desired. Directional bends (7) are positional selectively at distal ends (5) of the catheters (1). Methods for manufacture and modification with co-extrusion, miniature milling and welding while maintaining structural integrity with monolithic wall structure are described.
摘要翻译：高扭矩薄壁引导导管具有一体地螺旋化或编织成柔性材料的整体壁（21）的弹性增强材料（8,23,29,70,73）。由特殊含氟材料或聚合有机硅化合物组成的固体润滑剂也称为干性润滑剂，被嵌入导管的内壁和外壁表面。平滑的内壁（11）被引导（10）以降低摩擦阻力，捕获电阻颗粒并且以高比例的表面积与小导管的横截面面积消散摩擦热。每单位长度的增强线的螺旋或编织物的数量，导管的股数，导管直径和进行性的数量对于特定导管的分开的部分设计上是不同的。导管尖端（6）可直接焊接，以选择密度增强材料的股线。灌注口可以焊接在需要的地方。定向弯头（7）在导管（1）的远端（5）处有选择性地位置。描述了通过共挤出，微型铣削和焊接进行制造和改进的方法，同时保持具有整体壁结构的结构完整性。

7. 发明授权

US08109953B1 Catheter device, hub assembly and method for traversing total occlusions 有权
标题翻译：导管装置，轮毂组件和穿过全部闭塞的方法
公开(公告)号：US08109953B1
公开(公告)日：2012-02-07
申请号：US11838313
申请日：2007-08-14
申请人： Spencer B. King, III , Matt D. Pursley
发明人： Spencer B. King, III , Matt D. Pursley
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/22 , A61B2017/22044 , A61B2017/22049 , A61B2017/22069 , A61B2017/22094 , A61B2090/034 , A61M25/0097 , A61M25/0152 , A61M2025/0681 , A61M2025/09125
摘要： A medical device for traversing an occlusion in a vessel includes a straightening sleeve positioned at a distal aspect of a catheter, a steering sleeve having an arcuate distal end, and a guidewire disposed through the steering sleeve. The steering sleeve has a first position in which the arcuate distal end is straightened within the straightening sleeve, and a second position in which the steering sleeve extends distally past the straightening sleeve to expose the arcuate distal end. The tip of the arcuate distal end of the steering sleeve or the guidewire can be used to pierce the occlusion. An arrangement of hub assemblies with locking mechanisms and motion limiting structures facilitates adjusting and locking the relative positions of the straightening sleeve, the steering sleeve, and the guidewire. Detent mechanisms are associated with the motion limiting structures for providing controlled incremental movement of the sleeves and the guidewire.
摘要翻译：用于穿过容器中的闭塞的医疗装置包括定位在导管的远侧方面的矫直套筒，具有弓形远端的转向套管和穿过转向套筒的导丝。转向套筒具有第一位置，其中弓形远端在矫直套筒内矫直，以及第二位置，转向套筒向远侧延伸穿过矫直套筒以暴露弓形远端。转向套筒或导丝的弓形远端的尖端可用于刺穿闭塞。具有锁定机构和运动限制结构的轮毂组件的布置有助于调节和锁定矫直套筒，转向套筒和导丝的相对位置。止动机构与运动限制结构相关联，用于提供套筒和导丝的受控的增量运动。

8. 发明授权

US09301828B1 Multi lumen IVC filter retrieval device 有权
标题翻译：多腔IVC过滤器检索装置
公开(公告)号：US09301828B1
公开(公告)日：2016-04-05
申请号：US14214344
申请日：2014-03-14
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M29/00 , A61F2/01 , A61B17/50
CPC分类号： A61F2/01 , A61B17/50 , A61F2002/011 , A61F2002/016
摘要： A device for retrieving items endovascularly includes a sheath having a first lumen containing a snare that can be deployed out a distal end of the sheath and retracted back into the sheath for pulling an IVC filter into the sheath. The sheath has a second lumen that opens through a sidewall of the sheath proximal of the distal end. The second lumen contains a removal assist device that can be deployed through the sidewall and used to dislodge and/or cut an item to be retrieved from a vein wall. The removal assist device includes a catheter, a cutting head, and a pull wire. The pull wire has a proximal portion protruding from a proximal end of the catheter and a distal end connected to the cutting head. The pull wire is movable within the catheter to selectively extend and retract the cutting head from the distal end of the catheter.
摘要翻译：用于血管内检索物品的装置包括具有第一内腔的护套，所述第一腔容纳有可以从所述护套的远端展开并缩回到护套中的圈套，用于将IVC过滤器拉入鞘中。护套具有通过远端的近侧的护套的侧壁开口的第二管腔。第二管腔包含去除辅助装置，其可以通过侧壁部署并用于移除和/或切割要从静脉壁取回的物品。移除辅助装置包括导管，切割头和拉丝。拉线具有从导管的近端突出的近端部分和连接到切割头的远端。拉线可在导管内移动以选择性地从导管的远端延伸和缩回切割头。

9. 发明授权

US08192403B1 Side port catheter device and method for accessing side branch occlusions 有权
标题翻译：侧端口导管装置及其方法
公开(公告)号：US08192403B1
公开(公告)日：2012-06-05
申请号：US12890353
申请日：2010-09-24
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M5/178 , A61M25/00 , A61B5/00
CPC分类号： A61M25/01 , A61M25/0029 , A61M25/04 , A61M25/09041 , A61M25/10 , A61M25/1002 , A61M2025/0175 , A61M2025/0177 , A61M2025/018 , A61M2025/0183 , A61M2025/1056 , A61M2025/1063
摘要： A medical device and method are provided for accessing a side branch in an artery. The device includes a catheter having a sidewall, an internal lumen, and a side port formed through the sidewall. A perforating guide wire has a proximal portion within the internal lumen and a distal portion arranged to be movable out of the side port. The guide wire can be delivered through the side port to a side branch artery when the catheter is deployed to a location with the side port aligned with the side branch artery. In another embodiment, the catheter has inner and outer telescoping tubes with offset exit ports formed therein. The telescoping tubes can be used to change the degree of deflection of the perforating guide wire by changing the relative positions of the offset exit ports.
摘要翻译：提供了用于进入动脉侧支的医疗装置和方法。该装置包括具有侧壁，内腔和通过侧壁形成的侧端口的导管。穿孔导线具有在内腔内的近端部分和远侧部分，该远端部分布置成可移出外侧端口。当导管部署到具有与侧分支动脉对准的侧端的位置时，导丝可以通过侧端口被输送到侧分支动脉。在另一个实施例中，导管具有形成有偏移出口的内外伸缩管。伸缩管可用于通过改变偏移出口的相对位置来改变穿孔导丝的偏转程度。

10. 发明申请

US20110137282A1 METHOD AND APPARATUS FOR CURVING A CATHETER 有权
标题翻译：用于弯曲导管的方法和装置
公开(公告)号：US20110137282A1
公开(公告)日：2011-06-09
申请号：US13019962
申请日：2011-02-02
申请人： Matt D. Pursley
发明人： Matt D. Pursley
IPC分类号： A61M25/00
CPC分类号： A61M25/0152
摘要： An apparatus and method for curving a catheter after deployment include a catheter having a primary lumen, a secondary lumen, and a resilient fiber contained within the secondary lumen. The resilient fiber and the secondary lumen have corresponding, preformed curve shapes when the catheter is in a straight, unstressed condition. The resilient fiber is slidable within the secondary lumen to create a desired curve shape in the catheter as the curved portion of the resilient fiber slides into an originally straight portion of the secondary lumen. In another embodiment, the preformed curve shape of the resilient fiber is held in a straight condition within a stiff, marker ring segment of the catheter until after the catheter is deployed. Once deployed, the resilient fiber is slid out of the marker ring segment, and the preformed curve shape of the resilient fiber creates a corresponding curve shape in the catheter.
摘要翻译：用于在展开后弯曲导管的装置和方法包括具有主腔，辅管腔和包含在次腔内的弹性纤维的导管。当导管处于直的不受应力状态时，弹性纤维和次内腔具有相应的预成型曲线形状。当弹性纤维的弯曲部分滑入第二内腔的原始直线部分时，弹性纤维可以在次内腔内滑动以在导管中产生期望的曲线形状。在另一个实施例中，将弹性纤维的预成型曲线形状保持在导管刚性的标记环段内的直线状态，直到导管部署之后。一旦部署，弹性纤维从标记环段滑出，并且弹性纤维的预成型曲线形状在导管中产生相应的曲线形状。

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