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1. 发明申请

US20050261292A1 Pharmaceutical composition containing N-sulfamoyl-N'-arylpiperazines for the treatment or inhibition of obesity and related conditions 审中-公开
标题翻译：含有N-氨磺酰基-N'-芳基哌嗪的药物组合物用于治疗或抑制肥胖症及相关病症
公开(公告)号：US20050261292A1
公开(公告)日：2005-11-24
申请号：US11130268
申请日：2005-05-17
申请人： Jochen Antel , Michael Firnges , Peter-Colin Gregory , Uwe Reinecker , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche
发明人： Jochen Antel , Michael Firnges , Peter-Colin Gregory , Uwe Reinecker , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche
IPC分类号： A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/53 , C07D213/74 , C07D295/26 , C07D43/02
CPC分类号： A61K31/496 , A61K31/497 , A61K31/501 , A61K31/519 , A61K31/53 , C07D213/74 , C07D295/26
摘要： The present invention relates to the use of known and novel N-sulfamoyl-N′-arylpiperazines corresponding to Formula I and their physiologically compatible acid addition salts for the treatment or inhibition of obesity and related conditions.
摘要翻译：本发明涉及对应于式I的已知和新型N-氨磺酰基-N'-芳基哌嗪及其生理相容的酸加成盐在治疗或抑制肥胖症及相关病症中的用途。

2. 发明授权

US07772225B2 N-sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions 有权
标题翻译： N-氨磺酰基 - 哌啶酰胺，用于治疗或抑制肥胖症和相关病症
公开(公告)号：US07772225B2
公开(公告)日：2010-08-10
申请号：US11635514
申请日：2006-12-08
申请人： Jochen Antel , Michael Firnges , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche , Peter-Colin Gregory
发明人： Jochen Antel , Michael Firnges , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche , Peter-Colin Gregory
IPC分类号： A01N43/00 , A01N43/58 , A01N43/40 , A61K31/55 , A61K31/54 , A61K31/535 , A61K31/50 , A61K31/497 , A61K31/445 , C07D223/14 , C07D279/12 , C07D295/00 , C07D265/28 , C07D239/00 , C07D239/70 , C07D471/00 , C07D487/00 , C07D241/04 , C07D211/00
CPC分类号： C07D211/96 , C07D401/04 , C07D401/12 , C07D409/12 , C07D413/04
摘要： The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and its concomitant and/or secondary diseases and related or other conditions.
摘要翻译：本发明涉及式I的新型N-氨磺酰 - 哌啶酰胺及其生理上可接受的酸加成盐，包括它们的药物组合物，其制备方法及其用于治疗肥胖及其伴随和/或继发性疾病的用途，以及相关或其他条件。

3. 发明授权

US07547708B2 N-sulfamoyl-N′-benzopyranpiperidine compounds and uses thereof 有权
标题翻译： N-氨磺酰基-N'-苯并吡喃哌啶化合物及其用途
公开(公告)号：US07547708B2
公开(公告)日：2009-06-16
申请号：US11598684
申请日：2006-11-14
申请人： Jochen Antel , Harald Waldeck , Uwe Schoen , Peter-Colin Gregory , Michael Wurl , Michael Firnges , Dania Reiche , Uwe Reinecker , Holger Sann
发明人： Jochen Antel , Harald Waldeck , Uwe Schoen , Peter-Colin Gregory , Michael Wurl , Michael Firnges , Dania Reiche , Uwe Reinecker , Holger Sann
IPC分类号： A61K31/438 , C07D491/10
CPC分类号： C07D491/10
摘要： N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and related concomitant and/or secondary diseases or conditions
摘要翻译：式I的N-氨磺酰基-N'-苯并吡喃哌啶化合物及其生理上可接受的酸加成盐，包含它们的药物组合物，其制备方法及其用于治疗和/或抑制青光眼，癫痫，双相性精神障碍，偏头痛，神经性疼痛，肥胖症，II型糖尿病，代谢综合征，酒精依赖性和/或癌症，以及相关并发症和/或继发性疾病或病症

4. 发明申请

US20070149512A1 N-Sulfamoyl-piperidineamides for the treatment or inhibition of obesity and related conditions 有权
标题翻译： N-磺酰胺 - 哌啶酰胺，用于治疗或抑制肥胖症和相关病症
公开(公告)号：US20070149512A1
公开(公告)日：2007-06-28
申请号：US11635514
申请日：2006-12-08
申请人： Jochen Antel , Michael Firnges , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche , Peter-Colin Gregory
发明人： Jochen Antel , Michael Firnges , Uwe Schoen , Harald Waldeck , Michael Wurl , Dania Reiche , Peter-Colin Gregory
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号： C07D211/96 , C07D401/04 , C07D401/12 , C07D409/12 , C07D413/04
摘要： The present invention relates to novel N-sulfamoyl-piperidineamides of Formula I and their physiologically acceptable acid addition salts, to pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment of obesity and its concomitant and/or secondary diseases and related or other conditions.
摘要翻译：本发明涉及式I的新型N-氨磺酰 - 哌啶酰胺及其生理上可接受的酸加成盐，包括它们的药物组合物，其制备方法及其用于治疗肥胖及其伴随和/或继发性疾病的用途，以及相关或其他条件。

5. 发明申请

US20070117823A1 N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof 有权
标题翻译： N-氨磺酰基-N'-苯并吡喃哌啶化合物及其用途
公开(公告)号：US20070117823A1
公开(公告)日：2007-05-24
申请号：US11598684
申请日：2006-11-14
申请人： Jochen Antel , Harald Waldeck , Uwe Schoen , Peter-Colin Gregory , Michael Wurl , Michael Firnges , Dania Reiche , Uwe Reinecker
发明人： Jochen Antel , Harald Waldeck , Uwe Schoen , Peter-Colin Gregory , Michael Wurl , Michael Firnges , Dania Reiche , Uwe Reinecker
IPC分类号： A61K31/4747 , C07D491/10
CPC分类号： C07D491/10
摘要： N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and related concomitant and/or secondary diseases or conditions.
摘要翻译：式I的N-氨磺酰基-N'-苯并吡喃哌啶化合物及其生理上可接受的酸加成盐，包含它们的药物组合物，其制备方法及其用于治疗和/或抑制青光眼，癫痫，双相性精神障碍，偏头痛，神经性疼痛，肥胖症，II型糖尿病，代谢综合征，酒精依赖性和/或癌症，以及相关并发症和/或继发性疾病或病症。

6. 发明授权

US07592344B2 NK1 and NK2-antagonists and compositions and methods of using the same 有权
标题翻译： NK1和NK2拮抗剂及其组合物和使用方法
公开(公告)号：US07592344B2
公开(公告)日：2009-09-22
申请号：US11606337
申请日：2006-11-30
申请人： Jochen Antel , Daniel Jasserand , Uwe Schoen , Michael Firnges , Holger Sann , Reinhard Brueckner , Dania Reiche
发明人： Jochen Antel , Daniel Jasserand , Uwe Schoen , Michael Firnges , Holger Sann , Reinhard Brueckner , Dania Reiche
IPC分类号： A61K31/496
CPC分类号： C07D405/06 , C07D295/155 , C07D307/54 , C07D307/84 , C07D317/60 , C07D333/24 , C07D333/60 , C07D407/06 , C07D409/06
摘要： 3-cyanonaphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors, pharmaceutical compositions containing such compounds, methods of using such compounds for the treatment and/or inhibition of various diseases and disorders, processes for preparing such piperazine compounds, and intermediate products of these processes.
摘要翻译：拮抗速激肽受体的式I的3-氰基萘-1-羧酸全羟烷基甲基 - 哌嗪化合物，含有这些化合物的药物组合物，使用这些化合物治疗和/或抑制各种疾病和病症的方法，制备方法哌嗪化合物和这些方法的中间产物。

7. 发明申请

US20070149537A1 NK1 and NK2-antagonists and compositions and methods of using the same 有权
标题翻译： NK1和NK2拮抗剂及其组合物和使用方法
公开(公告)号：US20070149537A1
公开(公告)日：2007-06-28
申请号：US11606337
申请日：2006-11-30
申请人： Jochen Antel , Daniel Jasserand , Uwe Schoen , Michael Firnges , Holger Sann , Reinhard Brueckner , Dania Reiche
发明人： Jochen Antel , Daniel Jasserand , Uwe Schoen , Michael Firnges , Holger Sann , Reinhard Brueckner , Dania Reiche
IPC分类号： A61K31/496 , C07D405/02 , C07D409/02
CPC分类号： C07D405/06 , C07D295/155 , C07D307/54 , C07D307/84 , C07D317/60 , C07D333/24 , C07D333/60 , C07D407/06 , C07D409/06
摘要： 3-cyanonaphthalene-1-carboxylic acid perhydroxyalkylmethyl-piperazine compounds of formula I which are antagonistic to tachykinin receptors, pharmaceutical compositions containing such compounds, methods of using such compounds for the treatment and/or inhibition of various diseases and disorders, processes for preparing such piperazine compounds, and intermediate products of these processes.
摘要翻译：拮抗速激肽受体的式I的3-氰基萘-1-羧酸全羟烷基甲基 - 哌嗪化合物，含有这些化合物的药物组合物，使用这些化合物治疗和/或抑制各种疾病和病症的方法，制备方法哌嗪化合物和这些方法的中间产物。

8. 发明授权

US5843948A Piperazinophenyl- and piperazinophenyloxycarboxylic acid derivatives, and processes and intermediates for their preparation and pharmaceutical compositions comprising them 失效
标题翻译：哌嗪基苯基和哌嗪苯氧基羧酸衍生物，以及其制备方法和中间体以及包含它们的药物组合物
公开(公告)号：US5843948A
公开(公告)日：1998-12-01
申请号：US994754
申请日：1997-12-19
申请人： Wolfgang Kehrbach , Uwe Schoen , Jack A. J. den Hartog , Jan H. van Maarseveen , Chris G. Kruse , Jochen Antel , Jan-Hendrik Reinders , Dieter Ziegler , Gerhard-Wilhelm Bielenberg
发明人： Wolfgang Kehrbach , Uwe Schoen , Jack A. J. den Hartog , Jan H. van Maarseveen , Chris G. Kruse , Jochen Antel , Jan-Hendrik Reinders , Dieter Ziegler , Gerhard-Wilhelm Bielenberg
IPC分类号： C07D295/08 , A61K31/495 , A61P7/02 , C07D213/74 , C07D213/78 , C07D295/14 , C07D295/155 , C07D295/135 , C07D401/04
CPC分类号： C07D213/74 , C07D295/155 , Y02P20/55
摘要： Compounds having fibrinogen receptor-antagonistic activity, of the general formula I ##STR1## in which Z is oxygen or a methylene group, B is a phenyl or pyridyl radical, R.sup.1 is hydrogen or a group forming a biolabile ester, and their physiologically acceptable acid addition salts and physiologically acceptable salts of acids of formula I.
摘要翻译：具有纤维蛋白原受体拮抗活性的化合物，其中Z为氧或亚甲基的通式I ，B为苯基或吡啶基，R 1为氢或形成不可生物酯的基团及其生理学上可接受的酸式I的酸的加成盐和生理上可接受的盐。

9. 发明申请

US20110219788A1 CRYOGENIC STORAGE DEVICE 有权
标题翻译：低温储存装置
公开(公告)号：US20110219788A1
公开(公告)日：2011-09-15
申请号：US13129870
申请日：2009-11-09
申请人： Heiko Zimmermann , Uwe Schoen , Guenter R. Fuhr , Dirk Leuthold , Marianne Belke
发明人： Heiko Zimmermann , Uwe Schoen , Guenter R. Fuhr , Dirk Leuthold , Marianne Belke
IPC分类号： F25D13/06 , F25B49/00
CPC分类号： A01N1/0252 , F25B2700/04 , F25D3/102 , F25D3/11 , F25D29/001 , F25D2600/02 , F25D2700/12 , F25D2700/16 , G01N1/42 , G01N2035/00435
摘要： The invention relates to a cryogenic storage device and to a method for operating a cryogenic storage device, particularly for cryogenic storage of biological samples, comprising a sample carrying device that is set up to accommodate samples, a cryogenic container that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container can be cooled, an intermediate storage container that is set up for intermediate storage of the sample carrying device, a transport device with which the sample carrying device can be moved between the cryogenic container and the intermediate storage container and a sensor device with which at least one operating parameter of the cryogenic storage device can be registered. The transport device is set up to be activated in dependence on an output signal from the sensor device upon registering a predetermined operating condition of the cryogenic storage device, so that the sample carrying device is moved from the cryogenic container to the intermediate storage container. Additionally or alternatively, an intermediate storage cooling device that is set up for cooling the intermediate storage container can be activated in dependence on an output signal of the sensor device.
摘要翻译：本发明涉及一种低温存储装置和一种用于操作低温存储装置的方法，特别是用于生物样品的低温储存的方法，包括设置用于容纳样品的样品携带装置，设置为容纳样品运送装置，用于冷冻低温容器的容器冷却装置，设置用于样品运送装置的中间储存的中间储存容器，运送装置，使样品运送装置能够在低温容器以及可以登记低温储存装置的至少一个操作参数的中间储存容器和传感器装置。传送装置被设置为在登记低温存储装置的预定操作条件时依赖于来自传感器装置的输出信号被激活，使得样品携带装置从低温容器移动到中间储存容器。另外或替代地，可以根据传感器装置的输出信号激活设置用于冷却中间存储容器的中间存储冷却装置。

10. 发明授权

US06407106B1 N-triazolylmethyl-piperazine compounds with neurokinin-receptor antagonist activity 有权
标题翻译： N-三唑基甲基 - 哌嗪化合物与神经激肽受体拮抗剂活性
公开(公告)号：US06407106B1
公开(公告)日：2002-06-18
申请号：US09915558
申请日：2001-07-27
申请人： Daniel Jasserand , Uwe Schoen , Holger Sann , Reinhard Brueckner , Christian Eeckhout
发明人： Daniel Jasserand , Uwe Schoen , Holger Sann , Reinhard Brueckner , Christian Eeckhout
IPC分类号： A61K315377
CPC分类号： C07D403/06 , C07D403/14
摘要： N-triazolylmethyl-piperazine compounds which exhibit neurokinin receptor antagonistic activity corresponding to the formula I: wherein R1, R2 and R3 have the meanings given in the specification; pharmaceutical compositions containing these compounds; a process for preparing these compounds, and intermediate products of this process.
摘要翻译：表现出对应于式I的神经激肽受体拮抗活性的N-三唑基甲基 - 哌嗪化合物：其中R1，R2和R3具有说明书中给出的含义; 含有这些化合物的药物组合物; 制备这些化合物的方法，以及该方法的中间产物。

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