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1. 发明申请

US20050274885A1 Maldi sample plate 有权
标题翻译：马尔迪样品板
公开(公告)号：US20050274885A1
公开(公告)日：2005-12-15
申请号：US11196820
申请日：2005-08-03
申请人： Jeff Brown , Dominic Gostick , Edouard Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
发明人： Jeff Brown , Dominic Gostick , Edouard Bouvier , John Charles Gebler , Peter Jeng Jong Lee , James Ian Langridge , Emmanuelle Claude , Weibin Chen
IPC分类号： H01J49/04 , H01J49/16 , H01J49/40 , A01N43/40
CPC分类号： H01J49/0418 , B01L3/5088
摘要： A MALDI sample plate 1 is disclosed which comprises a metallic substrate 2 having a circular groove or moat 3. A hydrophobic polytetrafluoroethylene layer 4 is applied to the substrate 2 and a central portion 5 of the substrate 2 is laser etched which roughens the surface of the substrate 2. A thin polystyrene layer is then applied to the polytetrafluoroethylene layer 4 and the central portion 5.
摘要翻译：公开了一种MALDI样品板1，其包括具有圆形槽或护城河3的金属基板2.将疏水性聚四氟乙烯层4施加到基板2上，并且激光蚀刻基板2的中心部分5，其粗糙化表面然后将薄聚苯乙烯层施加到聚四氟乙烯层4和中心部分5。

2. 发明申请

US20050087685A1 Desalting plate for maldi mass spectrometry 有权
标题翻译：用于maldi质谱的脱盐板
公开(公告)号：US20050087685A1
公开(公告)日：2005-04-28
申请号：US10478399
申请日：2002-05-24
申请人： Edouard Bouvier , Bruce Compton , Dominic Gostick , Jeffrey Brown
发明人： Edouard Bouvier , Bruce Compton , Dominic Gostick , Jeffrey Brown
IPC分类号： G01N27/62 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/0418 , G01N1/405 , Y10T436/24 , Y10T436/25
摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.
摘要翻译：描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）脱盐样品支撑板。所述板包括样品呈现表面，其中所述样品呈现表面包括吸收层的至少一个接收表面，其中所述吸收层将选定的分子保持在所述接收表面上。还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

3. 发明申请

US20080073512A1 METHODS, COMPOSITIONS AND DEVICES FOR PERFORMING IONIZATION DESORPTION ON SILICON DERIVATIVES 审中-公开
标题翻译：用于对硅衍生物进行离子沉淀的方法，组合物和装置
公开(公告)号：US20080073512A1
公开(公告)日：2008-03-27
申请号：US11829170
申请日：2007-07-27
申请人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
发明人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
IPC分类号： C01B33/113 , C07F7/02 , H01J49/16
CPC分类号： B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/12 , H01J49/0418
摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1, or O—SiR1, R2, R3 wherein R1, R2, and R3 are selected from the group consisting of alkyl, alkenyl, alkynyl, aromatic, amino alkyl, amino alkenyl, amino alkynyl, pyridinyl, pyrridonyl, and carbonyl, alcohol and carboxylic acid derivatives thereof having one to twenty five atoms, and hydroxyl, amino, amide, carboxyl, ester, carbonyl, sulfhydryl, sulfonyl, phosphoral, bromo, iodo, chloro and fluoro derivatives. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.
摘要翻译：本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基或-OR 1，或O-SiR 1，R 2，R 3，其中R 1， R 1，R 2，R 3和R 3选自烷基，烯基，炔基，芳族，氨基烷基，氨基烯基，氨基炔基，吡啶基，吡咯基和羰基，具有一至二十五个原子的醇和羧酸衍生物，以及羟基，氨基，酰胺，羧基，酯，羰基，巯基，磺酰基，磷酰基，溴，碘，氯和氟衍生物。字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

4. 发明申请

US20050133424A1 Water-wettable chromatographic media for solid phase extraction 审中-公开
标题翻译：用于固相萃取的水润湿色谱介质
公开(公告)号：US20050133424A1
公开(公告)日：2005-06-23
申请号：US10911389
申请日：2004-08-04
申请人： Edouard Bouvier , Randy Meirowitz , Patrick McDonald
发明人： Edouard Bouvier , Randy Meirowitz , Patrick McDonald
IPC分类号： G01N30/00 , B01D15/00 , B01D15/08 , B01J20/26 , C08F26/06 , C08L101/00 , G01N30/14
CPC分类号： G01N30/482 , B01D15/00 , B01D15/08 , B01J20/285 , B01J2220/54 , B01J2220/62 , B01J2220/64
摘要： A method for removing an organic solute from a solution comprises contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.
摘要翻译：从溶液中除去有机溶质的方法包括使溶液与通过共聚一种或多种疏水单体和一种或多种亲水单体形成的聚合物接触，由此将溶质吸附到聚合物上。溶液可以包含极性溶剂如极性有机溶剂或水或水性缓冲液。疏水性单体可以是例如二乙烯基苯。亲水性单体可以是例如杂环单体，例如乙烯基吡啶或N-乙烯基吡咯烷酮。

5. 发明申请

US20060163162A1 Device for solid phase extraction and method for purifying samples prior to analysis 有权
标题翻译：固相萃取装置和分析前样品的纯化方法
公开(公告)号：US20060163162A1
公开(公告)日：2006-07-27
申请号：US11393076
申请日：2006-03-30
申请人： Raymond Fisk , Pamela Iraneta , Yuri Tuvim , Edouard Bouvier , Jonathan Belanger , Martin Gilar
发明人： Raymond Fisk , Pamela Iraneta , Yuri Tuvim , Edouard Bouvier , Jonathan Belanger , Martin Gilar
IPC分类号： B01D15/08
CPC分类号： B01L3/5085 , B01D15/203 , B01D15/22 , B01D15/424 , B01J2220/64 , B01L3/50255 , B01L2200/0631 , B01L2300/0681 , B01L2300/0829 , B01L2300/12 , G01N1/405 , G01N30/6004 , G01N30/6065 , G01N35/028 , G01N2030/009 , G01N2030/062 , G01N2035/1053 , Y10T436/25375 , Y10T436/255 , G01N30/603
摘要： A solid phase extraction (SPE) device having a reservoir with an opening; a well comprising an internally tapered wall, the well having a wider interior diameter at an end closest to the opening than at an exit spout; a first filter within the well; a bed of sorbent particles within the well below the first filter; and a second filter having a diameter smaller than the first filter within the well below the bed of sorbent particles and above the exit spout is provided. A method of performing SPE using the device is also provided.
摘要翻译：固相萃取（SPE）装置，其具有带有开口的储存器; 一个包括内部锥形壁的井，该井在最靠近开口的一端具有比在出口处出口处更宽的内径; 井内的第一个过滤器; 在第一过滤器下面的井内的吸附剂颗粒床; 并且提供具有小于第一过滤器的第二过滤器，该第二过滤器位于吸附剂颗粒床之下的井内以及排出口上方。还提供了使用该装置执行SPE的方法。

6. 发明申请

US20060157648A1 Methods, compositions and devices for performing ionization desorption on silicon derivatives 审中-公开
标题翻译：用于在硅衍生物上进行电离解吸的方法，组合物和装置
公开(公告)号：US20060157648A1
公开(公告)日：2006-07-20
申请号：US11288590
申请日：2005-11-29
申请人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
发明人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
IPC分类号： H01J49/00
CPC分类号： H01J49/0418 , B01L3/5085 , B01L3/5088 , B01L2300/069 , B01L2300/0819 , B01L2300/0829 , B01L2300/12 , G01N1/22
摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1 or O—SiR1,R2,R3 wherein R1,R2, and R3 are selected from the group consisting C1 to C6 straight, cyclic, or branched alkyl, aryl, or alkoxy group, a hydroxyl group, or a siloxane group, and R6 may be a C1 to C36 straight, cyclic, or branched alkyl (e.g., C18, cyanopropyl), aryl, or alkoxy group, where the groups of R6 are unsubstituted or substituted with one or more moieties such as halogen, cyano, amino, diol, nitro, ether, carbonyl, epoxide, sulfonyl, cation exchanger, anion exchanger, carbamate, amide, urea, peptide, protein, carbohydrate, and nucleic acid functionalities. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.
摘要翻译：本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基或-OR 1或O-SiR 1，R 2，R 3，其中R 1 R 2，R 3和R 3选自C 1至C 6 - ， - 直链，环状或支链烷基，芳基或烷氧基，羟基或硅氧烷基，R 6可以是C 1〜 36个直链，环状或支链烷基（例如C 18，氰基丙基），芳基或烷氧基，其中R 6基团是未取代的或被一个或多个部分取代，例如卤素，氰基，氨基，二醇，硝基，醚，羰基，环氧化物，磺酰基，阳离子交换剂，阴离子交换剂，氨基甲酸酯，酰胺，脲，肽，蛋白质，碳水化合物和核酸功能。字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

7. 发明申请

US20060057659A1 Destructible surfactants and uses thereof 有权
公开(公告)号：US20060057659A1
公开(公告)日：2006-03-16
申请号：US10516418
申请日：2003-05-30
申请人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
发明人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
摘要： The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

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