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    • 1. 发明授权
    • Cryogenic medical device with high pressure resistance tip
    • 具有高耐压端头的低温医疗器械
    • US06589234B2
    • 2003-07-08
    • US09965208
    • 2001-09-27
    • Jean-Pierre LalondeMarwan AbboudConstantin Bogdan Ciobotaru
    • Jean-Pierre LalondeMarwan AbboudConstantin Bogdan Ciobotaru
    • A61B1818
    • A61B18/02A61B2018/0212A61B2018/0268
    • The present invention provides a medical device to cold treat desired regions. An injection tube with an open distal end is disposed inside of a catheter tube, defining a return lumen therein. A supply of cryogenic fluid, regulated by a controller mechanism coupled to the device, flows through the injection tube and into the distal tip portion of the catheter tube, whereupon the fluid is returned from the catheter through the return lumen. The expansion and evaporation of cryogenic fluid inside the device serves to cool the surrounding areas external to and proximate the distal end of the device. An additional restriction tube is provided in the length of the catheter tube to regulate the pressure of the flow of cryogen therethrough so as to create higher operating pressures in the distal end of the device and thereby enhance the cooling power and temperature stability of the device at a lower range of fluid flow rates without reaching the triple point of the cryogenic fluid.
    • 本发明提供一种用于冷处理所需区域的医疗装置。 具有开口远端的注射管设置在导管管内部,在其中限定回流腔。 由连接到装置的控制器机构调节的低温流体的供应流过注射管并进入导管管的远侧末端部分,于是流体从导管通过返回内腔返回。 装置内的低温流体的膨胀和蒸发用于冷却装置的远端外部和附近的周围区域。 在导管的长度上设置一个附加的限制管,用于调节制冷剂流过的压力,从而在装置的远端产生更高的操作压力,从而提高装置的冷却功率和温度稳定性 较低的流体流速范围,而不达到低温流体的三重点。
    • 4. 发明授权
    • Closed loop catheter coolant system
    • 闭环导管冷却系统
    • US08454587B2
    • 2013-06-04
    • US11948321
    • 2007-11-30
    • Jean-Pierre LalondeMarwan Abboud
    • Jean-Pierre LalondeMarwan Abboud
    • A61B18/18A61F7/00A61B18/02A61F7/12
    • A61B18/02A61B2017/00092A61B2017/00119A61B2018/0212A61B2018/0262A61F7/12
    • A coolant system for a cryoablation or treatment probe that includes a compressor and condenser having a low pressure inlet side and a high pressure outlet side, wherein the outlet side passes through a heat exchanger and is cooled by the inlet side and conditioned for injection to a catheter inlet. A vacuum return system connectable to the catheter outlet draws thermally expended coolant from the catheter and returns it to the low pressure inlet side. A motorized pressure regulator between the heat exchanger and the catheter inlet determines the pressure of coolant passing into the catheter, regulating the cooling rate for a selected mapping or ablation regimen. A coolant reservoir feeds into the low pressure inlet side and receives a return flow of excess fluid from a branch off the outlet side of the compressor.
    • 一种用于冷冻消融或处理探针的冷却剂系统,其包括具有低压入口侧和高压出口侧的压缩机和冷凝器,其中出口侧通过热交换器并且被入口侧冷却并被调节为注入 导管入口。 可连接到导管出口的真空返回系统从导管吸出热消耗的冷却剂并将其返回到低压入口侧。 在热交换器和导管入口之间的电动压力调节器确定冷却剂通过导管的压力,调节所选择的绘图或消融方案的冷却速率。 冷却剂储存器进入低压入口侧并接收来自压缩机出口侧的分支的多余流体的回流。
    • 9. 发明授权
    • Closed loop catheter coolant system
    • 闭环导管冷却系统
    • US06383180B1
    • 2002-05-07
    • US09489646
    • 2000-01-24
    • Jean-Pierre LalondeMarwan Abboud
    • Jean-Pierre LalondeMarwan Abboud
    • A61B1818
    • A61B18/02A61B2017/00092A61B2017/00119A61B2018/0212A61B2018/0262A61F7/12
    • A coolant system for a cryoablation or treatment probe such as a mapping or ablation catheter, or a treatment wand, includes a compressor and condenser having a low pressure inlet side and a high pressure outlet side, wherein the outlet side passes through a heat exchanger and is cooled by the inlet side and conditioned for injection to a catheter inlet. A vacuum return system connectable to the catheter outlet draws thermally expended coolant from the catheter and returns it to the low pressure inlet side. A motorized pressure regulator between the heat exchanger and the catheter inlet determines the pressure of coolant passing into the catheter and thus regulates the cooling rate for a selected mapping or ablation regimen. The low pressure compressor inlet supply preferentially conditions the pressurized coolant to ambient temperature or lower before injection into the catheter, allowing the coolant to travel through the body at ambient before expansion in the tip. In a preferred embodiment, a coolant reservoir feeds into the low pressure inlet side and receives a return flow of excess fluid from a branch off the outlet side of the compressor. The vacuum return assures that coolant does not leak into the blood stream, and preferably various check valves and bypass valves operate in the event of pressure buildup to return fluid to either the inlet or supply from different points along the loop. The coolant mixture preferably has a boiling point of approximately −60° Fahrenheit at about 1-2 bar, and may be compressed to several hundred psi. The entire system is amenable to microprocessor control for providing ablation cooling cycles to operate the catheter tip in accordance with a selected protocol, and for effecting system functions such as recharging and venting of the supply, and shutting down during nonuse or upon occurrence of a fault condition.
    • 用于冷冻消融或治疗探针如冷凝或消融导管或治疗棒的冷却剂系统包括具有低压入口侧和高压出口侧的压缩机和冷凝器,其中出口侧通过热交换器和 通过入口侧冷却并调节注射到导管入口。 可连接到导管出口的真空返回系统从导管吸出热消耗的冷却剂并将其返回到低压入口侧。 热交换器和导管入口之间的电动压力调节器确定冷却剂通过导管的压力,从而调节所选择的定位或消融方案的冷却速率。 低压压缩机入口供应优选地将加压的冷却剂调节到环境温度或更低温度,然后注入导管,允许冷却剂在环境温度下在尖端中膨胀之前穿过身体。 在优选实施例中,冷却剂储存器进入低压入口侧并接收来自压缩机出口侧的分支的多余流体的回流。 真空回流确保冷却剂不会泄漏到血液中,并且优选地,在压力累积的情况下,各种止回阀和旁通阀操作,以将流体从沿着回路的不同点返回到入口或供应源。 冷却剂混合物优选在约1-2巴下具有约-60华氏度的沸点,并且可以压缩至几百磅/平方英寸。 整个系统适于微处理器控制,以根据所选择的方案提供消融冷却循环来操作导管尖端,并且用于实现系统功能,例如电源的再充电和排气,以及在不使用或发生故障时关闭。 条件。