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1. 发明授权

US06956422B2 Generation and measurement of timing delays by digital phase error compensation 失效
标题翻译：通过数字相位误差补偿生成和测量定时延迟
公开(公告)号：US06956422B2
公开(公告)日：2005-10-18
申请号：US10744834
申请日：2003-12-23
申请人： James P. Reilly , Noah P. Christian
发明人： James P. Reilly , Noah P. Christian
IPC分类号： G01R31/30 , G01R31/317 , G01R31/3193 , H03H11/26
CPC分类号： G01R31/31725 , G01R31/3016 , G01R31/31937
摘要： A circuit and method for generating a delayed event following a trigger pulse occurring at a random time between clock pulses is disclosed. The circuit includes a clock circuit, a voltage converter, an analog-to-digital converter circuit, a memory storage circuit, and a summing circuit. The method includes representing the time between the triggering pulse and a subsequent clock pulse as a voltage, converting the voltage to a stored digital value, and defining a desired delay time by adding a first time determined by counting a predetermined number of clock cycles to a second time determined by converting the stored digital value first to an analog value and then to a time value.
摘要翻译：公开了用于在时钟脉冲之后的随机时间发生的触发脉冲之后产生延迟事件的电路和方法。电路包括时钟电路，电压转换器，模数转换器电路，存储器存储电路和求和电路。该方法包括将触发脉冲和随后的时钟脉冲之间的时间表示为电压，将电压转换为存储的数字值，并通过将通过计数预定数量的时钟周期确定的第一时间添加到通过将所存储的数字值首先转换为模拟值然后再转换为时间值来确定第二次。

2. 发明授权

US06627879B2 Voltage pulser circuit 失效
标题翻译：电压脉冲发生器电路
公开(公告)号：US06627879B2
公开(公告)日：2003-09-30
申请号：US10223424
申请日：2002-08-19
申请人： James P. Reilly , Noah P. Christian
发明人： James P. Reilly , Noah P. Christian
IPC分类号： H01J4940
CPC分类号： H01J49/40 , H01J49/0009
摘要： One illustrative embodiment of a voltage pulser circuit comprises a voltage source producing a first voltage, and a thyratron tube having an anode coupled to the output of the voltage source, a cathode connected to a reference potential and a grid responsive to a grid control voltage to electrically connect the anode to the cathode to thereby cause the first thyratron tube to switch the anode between the first voltage and the reference potential. A pulse-shaping circuit may be connected to the anode of the tube to effectuate desired rise and fall times of the voltage pulses produced by the voltage pulser circuit. Such a voltage pulser circuit is particularly suited for use in connection with the operation of pulsed spectrometer instruments, such as time-of-flight mass spectrometers and the like.
摘要翻译：电压脉冲发生器电路的一个说明性实施例包括产生第一电压的电压源和具有耦合到电压源的输出的阳极的闸流管，连接到参考电位的阴极和响应于电网控制电压的电网将阳极电连接到阴极，从而使第一闸流管在第一电压和参考电位之间切换阳极。脉冲整形电路可以连接到管的阳极，以实现由电压脉冲发生器电路产生的电压脉冲的期望上升和下降时间。这种电压脉冲发生器电路特别适用于脉冲光谱仪器的操作，例如飞行时间质谱仪等。

3. 发明授权

US06437325B1 System and method for calibrating time-of-flight mass spectra 失效
标题翻译：用于校准飞行时间质谱的系统和方法
公开(公告)号：US06437325B1
公开(公告)日：2002-08-20
申请号：US09313923
申请日：1999-05-18
申请人： James P. Reilly , Noah P. Christian
发明人： James P. Reilly , Noah P. Christian
IPC分类号： H01J4940
CPC分类号： H01J49/40 , H01J49/0009
摘要： A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. Electrostatic time-of-flight calculations are conducted in conjunction with an iterative procedure, preferably a simplex optimization procedure, to thereby minimize a residual error between the electrostatic time-of-flight calculations and the measured time-of-flight data values for each of the known mass values. While conventional curve fitting mass calibration techniques are devoid of information that describe ion behavior, the mass calibration technique of the present invention, by contrast, takes into account all of the instrument operational parameters in arriving at a final calibration. Because the electrostatic TOF calculation is a description of ion behavior in an actual TOF mass spectrometer instrument rather than a polynomial representation of a curve, it is well behaved and does not contain any instabilities where unpredictable calibration errors might occur. Moreover, unlike conventional curve fitting mass calibration techniques, the mass calibration technique of the present invention maintains mass accuracy in extrapolated mass ranges.
摘要翻译：飞行时间质谱校准技术使用飞行时间质谱仪仪器操作参数和已知质量和测量的飞行时间数据对来优化所选仪器操作参数的值。静电飞行时间计算结合迭代程序，优选单纯形优化程序进行，从而最小化静电飞行时间计算之间的残余误差和测量的飞行时间数据值已知的质量值。虽然传统的曲线拟合质量校准技术没有描述离子行为的信息，但是相比之下，本发明的质量校准技术考虑到达到最终校准的所有仪器操作参数。因为静电TOF计算是对实际TOF质谱仪器中的离子行为的描述，而不是曲线的多项式表示，因此它的行为良好，并且不包含可能发生不可预测的校准误差的任何不稳定性。此外，与传统的曲线拟合质量校准技术不同，本发明的质量校准技术保持外推质量范围的质量精度。

4. 发明授权

US07253403B2 Control system for a power supply 失效
标题翻译：电源控制系统
公开(公告)号：US07253403B2
公开(公告)日：2007-08-07
申请号：US11108471
申请日：2005-04-18
申请人： James P. Reilly , Noah P. Christian
发明人： James P. Reilly , Noah P. Christian
IPC分类号： G05F1/70
CPC分类号： G05F1/70 , G05F1/66
摘要： A control system (12) for a power supply (14), such as a high voltage power supply, includes a control circuit (16) and a feedback circuit (18, 28, 30). The feedback circuit (18, 28, 30) is configured to produce a feedback signal indicative of the voltage of the power supply output. The control circuit (16) is configured to control the power supply (14) based on the feedback signal and a predetermined voltage value to maintain the output of the power supply (14) at about the predetermined voltage value. A portion of the feedback circuit (18, 28, 30) may be included in an isolation shield (88) to improve the accuracy of the feedback signal.
摘要翻译：用于诸如高压电源的电源（14）的控制系统（12）包括控制电路（16）和反馈电路（18,28,30）。反馈电路（18,28,30）被配置为产生指示电源输出的电压的反馈信号。控制电路（16）被配置为基于反馈信号和预定电压值来控制电源（14），以将电源（14）的输出维持在约预定电压值。反馈电路（18,28,30）的一部分可以包括在隔离屏蔽（88）中，以提高反馈信号的精度。

5. 发明授权

US06956208B2 Method and apparatus for controlling position of a laser of a MALDI mass spectrometer 失效
标题翻译：用于控制MALDI质谱仪的激光器位置的方法和装置
公开(公告)号：US06956208B2
公开(公告)日：2005-10-18
申请号：US10603488
申请日：2003-06-25
申请人： James P. Reilly , Kirk S. Boraas , Noah P. Christian
发明人： James P. Reilly , Kirk S. Boraas , Noah P. Christian
IPC分类号： G01N20060101 , H01J49/04 , H01J49/16 , H01S49/00
CPC分类号： H01J49/164 , H01J49/0004
摘要： A MALDI mass spectrometer directs a laser shot onto a MALDI sample to generate a sample spectrum which is analyzed to determine if the sample spectrum meets a predetermined criteria. If so, subsequent laser shots are directed to predetermined locations on the MALDI sample. In essence, if the analysis of a previous laser shot indicates that a “sweet spot” of the MALDI sample has be located, subsequent laser shots may be directed to areas proximate to the previous shot thereby allowing the sweet spot to be thoroughly sampled. A method of operating a MALDI mass spectrometer is also disclosed.
摘要翻译： MALDI质谱仪将激光射击引导到MALDI样品上以产生样品光谱，其被分析以确定样品光谱是否符合预定标准。如果是这样，随后的激光照射被引导到MALDI样品上的预定位置。实质上，如果先前的激光镜头的分析表明已经定位了MALDI样品的“最佳点”，则随后的激光照射可以被定向到接近先前镜头的区域，从而允许将甜点彻底地采样。还公开了一种操作MALDI质谱仪的方法。

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