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1. 发明授权

US5700478A Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity 失效
标题翻译：水溶性压敏粘膜粘附剂及其装置用于置于粘膜内衬体腔内
公开(公告)号：US5700478A
公开(公告)日：1997-12-23
申请号：US505185
申请日：1995-08-03
申请人： James E. Biegajski , Subbu S. Venkatraman , Ann M. Scott
发明人： James E. Biegajski , Subbu S. Venkatraman , Ann M. Scott
IPC分类号： A61K9/70 , A61F6/06 , A61F13/00 , A61F13/02 , A61K6/00 , A61K9/00 , C08K5/10 , C09J9/00 , C09J101/08 , C09J103/00 , C09J103/02 , C09J105/00 , C09J107/00 , C09J129/04 , C09J133/02 , C09J137/00 , C09J139/06 , C09J171/00 , C09J171/02 , C09J189/00 , C09J193/00 , C09J201/00 , A61F9/02 , A61K47/30
CPC分类号： C09J139/06 , A61F13/023 , A61F13/0253 , A61F6/06 , A61K9/006 , C08K5/10 , C09J201/00 , A61F2013/00642 , A61F2013/00685 , A61F2013/0071 , A61F2013/00714 , A61F2013/00906 , A61F2013/0091 , A61F2013/00914 , C09J2201/606
摘要： Water-soluble pressure-sensitive adhesives include a water-soluble polymer that is made tacky at room temperature by addition of a water-soluble plasticizer that is miscible with the polymer. Suitable polymers are solid at room temperature; and have a hydrophilicity as measured by water uptake greater than about 25%; they are liquid at room temperature and have a boiling point higher than about 80.degree. C. The adhesives according to the invention may conveniently be provided in dry film form. Preferred water-soluble pressure-sensitive adhesives of the invention adhere both to mucosal surfaces and to a variety of materials that may constitute a part of a device or prosthesis to be held in a body cavity that has a mucosal lining. Also, a laminated device for the controlled release of a substance within a mucosa-lined body cavity includes the substance dissolved or dispersed in either or both of a water-soluble pressure-sensitive adhesive layer and optionally one or more water-soluble polymer layers. Also, devices for administering a substance over an extended time for relief of sore throat or cough, or for administering a breath freshening agent, particularly a mint odorant, include a water soluble polymer film layer containing the active ingredient, and a water soluble pressure sensitive mucoadhesive layer.
摘要翻译： PCT No.PCT / US94 / 09305 Sec。 371日期：1995年8月3日 102（e）日期1995年8月3日PCT 1994年8月19日PCT PCT。出版物WO95 / 05416 日期1995年2月23日水溶性压敏粘合剂包括水溶性聚合物，其通过加入与聚合物混溶的水溶性增塑剂在室温下变粘。合适的聚合物在室温下为固体; 并且具有通过吸水率大于约25％测量的亲水性; 它们在室温下为液体，沸点高于约80℃。根据本发明的粘合剂可以方便地以干膜形式提供。本发明优选的水溶性压敏粘合剂既粘附到粘膜表面，也可以粘附到可以构成待保持在具有粘膜衬里的体腔中的装置或假体的一部分的各种材料。而且，用于在粘膜内衬的体腔中控制释放物质的层压装置包括溶解或分散在水溶性压敏粘合剂层和任选的一种或多种水溶性聚合物层之一或两者中的物质。此外，用于延长时间用于缓解喉咙痛或咳嗽或用于施用呼吸清新剂，特别是薄荷味剂的物质的装置包括含有活性成分的水溶性聚合物膜层和水溶性压敏粘膜粘附层。

2. 发明授权

US5079300A Method of curing organpolysiloxane compositions and compositions and articles therefrom 失效
标题翻译：固化有机硅氧烷组合物及其组合物及其制品的方法
公开(公告)号：US5079300A
公开(公告)日：1992-01-07
申请号：US488806
申请日：1990-03-05
申请人： Robert S. Dubrow , Subbu S. Venkatraman , Albert J. Highe , Frank W. Mercer , Christian A. Debbaut
发明人： Robert S. Dubrow , Subbu S. Venkatraman , Albert J. Highe , Frank W. Mercer , Christian A. Debbaut
IPC分类号： C08G77/04 , C08K5/14 , C08L83/04 , H01B3/46
CPC分类号： H01B3/46 , C08K5/14 , C08L83/04 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/26 , C08G77/70
摘要： The present invention provides curable gel compositions and also cured gel compositions which possess unexpectedly superior combinations of physical properties and aging resistance. These compositions are particularly useful for environmentally protecting substrates especially electrical conductors, connectors and splices and for sealing around jacketed cables, for example, where they enter splice cases.
摘要翻译：本发明提供可固化的凝胶组合物和固化的凝胶组合物，其具有意想不到的优异的物理性能和耐老化性的组合。这些组合物特别可用于环境保护基材，特别是电导体，连接器和接头以及用于围绕夹套电缆的密封，例如，在它们进入接合情况下。

3. 发明授权

US5273756A Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset 失效
标题翻译：透皮给药装置使用膜保护微孔膜实现延迟发作
公开(公告)号：US5273756A
公开(公告)日：1993-12-28
申请号：US748935
申请日：1991-08-23
申请人： Renee A. Fallon , Subbu S. Venkatraman , Gary W. Cleary
发明人： Renee A. Fallon , Subbu S. Venkatraman , Gary W. Cleary
IPC分类号： A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61K9/7084
摘要： A delayed onset transdermal drug delivery device exhibiting a delay period of at least eight hours comprising a laminated composite of (12) a top backing layer; (13) a pressure rupturable layer underlying (12); (14) a reservoir of a solution of drug in al liquid vehicle between (12) and (13); (16) a wick layer underlying (13) for dispersing the drug once (13) is ruptured; (17) a first adhesive layer underlying (16) that is permeable to the drug; (18) a first polymer membrane that is permeable to drug but substantially impermeable to the adhesive of (17); (19) a microporous membrane underlying (18) which is itself impermeable to the drug and whose pores are unfilled; (20) a second polymer membrane that underlies the microporous membrane that is permeable to drug but substantially impermeable to the adhesive of (21) below; and (21) a second adhesive layer underlying (20) that is permeable to the drug.
摘要翻译：延迟发作的透皮药物递送装置显示至少8小时的延迟时间，其包括层压复合材料（12）顶层背衬层; （13）位于（12）下面的压力破裂层; （14）在（12）和（13）之间的液体载体中的药物溶液的储存器; （16）用于分散药物（13）的（13）下方的芯层破裂; （17）对药物是可渗透的第一粘合剂层（16）; （18）第一聚合物膜，其对于药物是可渗透的但对（17）的粘合剂基本上不可渗透; （19）下面的微孔膜（18），其本身对于药物是不透气的，并且其孔未填充; （20）第二聚合物膜，其位于可渗透药物但基本上不渗透下面的（21）的粘合剂的微孔膜之下; 和（21）可渗透药物的第二粘合剂层（20）。

4. 发明授权

US5246705A Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use 失效
标题翻译：透皮药物递送系统中的闭塞弹性体背衬材料，以及相关的制造和使用方法
公开(公告)号：US5246705A
公开(公告)日：1993-09-21
申请号：US865140
申请日：1992-04-08
申请人： Subbu S. Venkatraman , Scott E. Smith
发明人： Subbu S. Venkatraman , Scott E. Smith
IPC分类号： A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/7053 , A61F13/023 , A61K9/7076 , A61F2013/00578 , A61F2013/00885 , Y10T428/28 , Y10T428/2915
摘要： Improved transdermal drug delivery systems are provided which contain an occlusive, elastomeric backing layer which is preferably liquid-resistant. The systems contain as a backing layer a single homogeneous sheet of an elastomeric material having a moisture vapor transmission rate ("MVTR") in the range of about 0.1 to 20 g/m.sup.2 /hr and a Young's modulus in the range of about 10.sup.4 to 10.sup.9 dynes/cm.sup.2. Methods for making and using transdermal drug delivery devices containing such backing layers are provided as well.
摘要翻译：提供了改进的透皮药物递送系统，其包含优选耐液体的封闭的弹性体背衬层。该系统包含作为背衬层的单一均匀的弹性体材料片，其水分蒸气透过率（“MVTR”）在约0.1-20g / m 2 / hr的范围内，杨氏模量在约104〜 109达因/平方厘米。还提供了制备和使用含有这种背衬层的透皮药物递送装置的方法。

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