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1. 发明申请

US20100139368A1 MICRO-OPTICAL-MECHANICAL SYSTEM PHOTOACOUSTIC SPECTROMETER 有权
标题翻译：微光机械系统光电光谱仪
公开(公告)号：US20100139368A1
公开(公告)日：2010-06-10
申请号：US12628952
申请日：2009-12-01
申请人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
发明人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
IPC分类号： G01H9/00 , G01N21/00 , G01N29/02
CPC分类号： G01N21/1702 , G01N33/0016 , G01N2021/1704
摘要： All-optical photoacoustic spectrometer sensing systems (PASS system) and methods include all the hardware needed to analyze the presence of a large variety of materials (solid, liquid and gas). Some of the all-optical PASS systems require only two optical-fibers to communicate with the opto-electronic power and readout systems that exist outside of the material environment. Methods for improving the signal-to-noise are provided and enable mirco-scale systems and methods for operating such systems.
摘要翻译：全光学光声光谱仪传感系统（PASS系统）和方法包括分析各种材料（固体，液体和气体）的存在所需的所有硬件。全光学PASS系统中的一些只需要两根光纤与存在于材料环境之外的光电和读出系统进行通信。提供了改善信噪比的方法，并且实现了用于操作这种系统的微小规模系统和方法。

2. 发明授权

US08342005B2 Micro-optical-mechanical system photoacoustic spectrometer 有权
标题翻译：微光机械系统光声光谱仪
公开(公告)号：US08342005B2
公开(公告)日：2013-01-01
申请号：US12628952
申请日：2009-12-01
申请人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
发明人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
IPC分类号： G01N21/00
CPC分类号： G01N21/1702 , G01N33/0016 , G01N2021/1704
摘要： All-optical photoacoustic spectrometer sensing systems (PASS system) and methods include all the hardware needed to analyze the presence of a large variety of materials (solid, liquid and gas). Some of the all-optical PASS systems require only two optical-fibers to communicate with the opto-electronic power and readout systems that exist outside of the material environment. Methods for improving the signal-to-noise are provided and enable mirco-scale systems and methods for operating such systems.
摘要翻译：全光学光声光谱仪传感系统（PASS系统）和方法包括分析各种材料（固体，液体和气体）的存在所需的所有硬件。全光学PASS系统中的一些只需要两根光纤与存在于材料环境之外的光电和读出系统进行通信。提供了改善信噪比的方法，并且实现了用于操作这种系统的微小规模系统和方法。

3. 发明授权

US09170028B1 Methods and compositions for rapid thermal cycling 有权
标题翻译：快速热循环的方法和组成
公开(公告)号：US09170028B1
公开(公告)日：2015-10-27
申请号：US13267767
申请日：2011-10-06
申请人： Neil Reginald Beer , William J. Benett , James M. Frank , Joshua R. Deotte , Christopher Spadaccini
发明人： Neil Reginald Beer , William J. Benett , James M. Frank , Joshua R. Deotte , Christopher Spadaccini
IPC分类号： F24H1/00 , F24H1/10 , H05B3/78
CPC分类号： F24H1/00 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2200/12 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1827 , C12M29/00 , C12M41/12 , C12M41/18 , C12M41/48 , F24H1/10
摘要： The rapid thermal cycling of a material is targeted. A microfluidic heat exchanger with an internal porous medium is coupled to tanks containing cold fluid and hot fluid. Fluid flows alternately from the cold tank and the hot tank into the porous medium, cooling and heating samples contained in the microfluidic heat exchanger's sample wells. A valve may be coupled to the tanks and a pump, and switching the position of the valve may switch the source and direction of fluid flowing through the porous medium. A controller may control the switching of valve positions based on the temperature of the samples and determined temperature thresholds. A sample tray for containing samples to be thermally cycled may be used in conjunction with the thermal cycling system. A surface or internal electrical heater may aid in heating the samples, or may replace the necessity for the hot tank.
摘要翻译：材料的快速热循环是目标。具有内部多孔介质的微流体热交换器耦合到容纳冷流体和热流体的罐。流体从冷箱和热罐交替地流入多孔介质，冷却和加热微流体换热器样品孔中包含的样品。阀可以联接到罐和泵，并且切换阀的位置可以切换流过多孔介质的流体的源和方向。控制器可以基于样品的温度和确定的温度阈值来控制阀位置的切换。用于包含热循环样品的样品盘可以与热循环系统一起使用。表面或内部电加热器可能有助于加热样品，也可能取代热水箱的必要性。

4. 发明授权

US08202566B2 Method of producing an electronic unit having a polydimethylsiloxane substrate and circuit lines 有权
标题翻译：制备具有聚二甲基硅氧烷衬底和电路线的电子单元的方法
公开(公告)号：US08202566B2
公开(公告)日：2012-06-19
申请号：US11243302
申请日：2005-10-03
申请人： James Courtney Davidson , Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Armando R. Tovar
发明人： James Courtney Davidson , Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Armando R. Tovar
IPC分类号： B05D5/12
CPC分类号： H01L23/145 , H01L23/5387 , H01L2924/0002 , H01L2924/1433 , H05K1/0272 , H05K1/0283 , H05K1/032 , H05K1/0393 , H05K1/095 , H05K3/101 , H05K3/12 , H05K3/1216 , H05K3/1258 , H05K3/1275 , H05K2201/0162 , H05K2203/0108 , H05K2203/0126 , H05K2203/082 , Y10S428/901 , Y10T428/24917 , H01L2924/00
摘要： A system of metalization in an integrated polymer microsystem. A flexible polymer substrate is provided and conductive ink is applied to the substrate. In one embodiment the flexible polymer substrate is silicone. In another embodiment the flexible polymer substrate comprises poly(dimethylsiloxane).
摘要翻译：一体化聚合物微系统中的金属化系统。提供柔性聚合物基底，并将导电油墨施加到基底上。在一个实施方案中，柔性聚合物基材是硅酮。在另一个实施方案中，柔性聚合物基材包含聚（二甲基硅氧烷）。

5. 发明授权

US07744604B2 Shape memory polymer medical device 有权
标题翻译：形状记忆聚合物医疗器械
公开(公告)号：US07744604B2
公开(公告)日：2010-06-29
申请号：US11172668
申请日：2005-06-30
申请人： Duncan Maitland , William J. Benett , Jane P. Bearinger , Thomas S. Wilson , Ward Small, IV , Daniel L. Schumann , Wayne A. Jensen , Jason M. Ortega , John E. Marion, III , Jeffrey M. Loge
发明人： Duncan Maitland , William J. Benett , Jane P. Bearinger , Thomas S. Wilson , Ward Small, IV , Daniel L. Schumann , Wayne A. Jensen , Jason M. Ortega , John E. Marion, III , Jeffrey M. Loge
IPC分类号： A61F11/00
CPC分类号： A61B17/221 , A61B2017/00867 , A61B2017/22034 , A61B2017/2215 , A61B2017/2217
摘要： A system for removing matter from a conduit. The system includes the steps of passing a transport vehicle and a shape memory polymer material through the conduit, transmitting energy to the shape memory polymer material for moving the shape memory polymer material from a first shape to a second and different shape, and withdrawing the transport vehicle and the shape memory polymer material through the conduit carrying the matter.
摘要翻译：用于从管道中去除物质的系统。该系统包括将运输车辆和形状记忆聚合物材料通过导管的步骤，将能量传递到形状记忆聚合物材料，以将形状记忆聚合物材料从第一形状移动到第二形状和不同形状，并且将运送车辆和形状记忆聚合物材料通过导管携带物质。

6. 发明申请

US20090074628A1 Thermal cycler 有权
标题翻译：热循环仪
公开(公告)号：US20090074628A1
公开(公告)日：2009-03-19
申请号：US11901787
申请日：2007-09-18
申请人： William J. Benett , John T. Andreski , John M. Dzenitis , Anthony J. Makarewicz , Dean R. Hadley , Satinderpall S. Pannu
发明人： William J. Benett , John T. Andreski , John M. Dzenitis , Anthony J. Makarewicz , Dean R. Hadley , Satinderpall S. Pannu
IPC分类号： B01J19/00 , B21D53/02 , C12M1/38 , B01L7/00
CPC分类号： B01L7/52 , B01L3/50851 , B01L7/525 , B01L2200/02 , B01L2200/147 , B01L2300/1805 , B01L2300/1827 , C12M41/14 , C12Q1/6844 , Y10T29/4935
摘要： A thermalcycler includes a first thermalcycler body section having a first face and a second thermalcycler body section having a second face. A cavity is formed by the first face and the second face. A thermalcycling unit is positioned in the cavity. A heater trace unit is connected to a support section, to the first thermalcycler body section, to the second thermalcycler body section, and to the thermalcycling unit. The first thermalcycler body section and the second thermalcycler body section are positioned together against the support section to enclose the thermalcycling unit and the heater trace unit.
摘要翻译：热循环器包括具有第一面的第一热循环器主体部分和具有第二面的第二热循环器主体部分。空腔由第一面和第二面形成。热循环装置位于空腔中。加热器跟踪单元连接到支撑部分，连接到第一热循环器主体部分，连接到第二热循环器主体部分，并连接到热循环单元。第一热循环器主体部分和第二热循环器主体部分一起被放置在支撑部分上以包围热循环单元和加热器跟踪单元。

7. 发明授权

US06991963B2 Electronic unit integrated into a flexible polymer body 有权
公开(公告)号：US06991963B2
公开(公告)日：2006-01-31
申请号：US10835226
申请日：2004-04-28
申请人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
发明人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
IPC分类号： H01L21/44
CPC分类号： A61N1/0456 , A61B2560/0412 , A61N1/0452 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/0534 , H01L23/5387 , H01L25/065 , H01L2924/0002 , H01L2924/09701 , H05K1/0313 , H05K1/0393 , H05K2201/0162 , H05K2201/09118 , H01L2924/00
摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

8. 发明授权

US06878643B2 Electronic unit integrated into a flexible polymer body 有权
公开(公告)号：US06878643B2
公开(公告)日：2005-04-12
申请号：US10323219
申请日：2002-12-18
申请人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
发明人： Peter A. Krulevitch , Mariam N. Maghribi , William J. Benett , Julie K. Hamilton , Klint A. Rose , James Courtney Davidson , Mark S. Strauch
IPC分类号： A61N1/04 , A61N1/05 , H01L23/538 , H01L25/065 , H05K1/00 , H05K1/03 , H01L21/31
CPC分类号： A61N1/0456 , A61B2560/0412 , A61N1/0452 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/0534 , H01L23/5387 , H01L25/065 , H01L2924/0002 , H01L2924/09701 , H05K1/0313 , H05K1/0393 , H05K2201/0162 , H05K2201/09118 , H01L2924/00
摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

9. 发明授权

US6059815A Microfabricated therapeutic actuators and release mechanisms therefor 失效
标题翻译：微型治疗执行器及其释放机制
公开(公告)号：US6059815A
公开(公告)日：2000-05-09
申请号：US67824
申请日：1998-04-28
申请人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
发明人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
IPC分类号： A61B17/00 , A61B17/12 , A61M25/16 , A61B17/28
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00867 , A61B2017/00871 , A61B2017/12068 , A61B2017/12077
摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a retaining/release actuator for the delivery of material, such as embolic coils, for example, through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use. The SMP microtubing can be positioned around or within an end of a deposit material. Various heating arrangements can be utilized with the SMP release mechanism, and the SMP microtubing can include a metallic coating for enhanced light absorption.
摘要翻译：使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。通过使用这种SMP材料，SMP微管可用作用于例如通过导管穿入动脉瘤等物质输送的保持/释放致动器。微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。 SMP微管可以定位在沉积材料的周围或内部。 SMP释放机构可以使用各种加热装置，并且SMP微管可以包括用于增强光吸收的金属涂层。

10. 发明授权

US5985217A Microfabricated instrument for tissue biopsy and analysis 失效
标题翻译：用于组织活检和分析的微型仪器
公开(公告)号：US5985217A
公开(公告)日：1999-11-16
申请号：US895786
申请日：1997-07-17
申请人： Peter A. Krulevitch , Abraham P. Lee , M. Allen Northrup , William J. Benett
发明人： Peter A. Krulevitch , Abraham P. Lee , M. Allen Northrup , William J. Benett
IPC分类号： G01N1/06 , G01N1/31 , B01L11/00
CPC分类号： G01N1/31 , G01N1/06 , Y10T83/222 , Y10T83/9493
摘要： A microfabricated biopsy/histology instrument which has several advantages over the conventional procedures, including minimal specimen handling, smooth cutting edges with atomic sharpness capable of slicing very thin specimens (approximately 2 .mu.m or greater), micro-liter volumes of chemicals for treating the specimens, low cost, disposable, fabrication process which renders sterile parts, and ease of use. The cutter is a "cheese-grater" style design comprising a block or substrate of silicon and which uses anisotropic etching of the silicon to form extremely sharp and precise cutting edges. As a specimen is cut, it passes through the silicon cutter and lies flat on a piece of glass which is bonded to the cutter. Microchannels are etched into the glass or silicon substrates for delivering small volumes of chemicals for treating the specimen. After treatment, the specimens can be examined through the glass substrate. For automation purposes, microvalves and micropumps may be incorporated. Also, specimens in parallel may be cut and treated with identical or varied chemicals. The instrument is disposable due to its low cost and thus could replace current expensive microtome and histology equipment.
摘要翻译：微生物活检/组织学仪器具有优于常规方法的几个优点，包括最小的样品处理，具有能够切割非常薄的样品（约2微米或更大）的原子清晰度的平滑切割边缘，微量体积的用于处理标本，低成本，一次性，制造过程，使无菌部件和易于使用。切割器是包括硅块或硅衬底的“干酪磨”式设计，其使用硅的各向异性蚀刻来形成非常清晰和精确的切割边缘。当样品被切割时，它通过硅切割器并且平坦地放置在粘合到切割器上的一块玻璃上。将微通道蚀刻到玻璃或硅衬底中，用于递送少量用于处理样品的化学品。处理后，可以通过玻璃基板检查样品。为了自动化，可以并入微阀和微型泵。此外，可以用相同或不同的化学物质来切割并处理标本。该仪器由于成本低，因此可以替代当前昂贵的切片机和组织学设备。

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