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    • 8. 发明申请
    • POLYMERS AND NANOGEL MATERIALS AND METHODS FOR MAKING AND USING THE SAME
    • 聚合物和纳米材料及其制备和使用方法
    • US20130317131A1
    • 2013-11-28
    • US13840919
    • 2013-03-15
    • JOHNSON & JOHNSON VISION CARE, INC.
    • Charles W. ScalesKevin P. McCabeBrent Matthew Healy
    • G02B1/04
    • G02B1/043B82Y30/00C08F293/005C08J7/00C08L53/00C08L101/14C08L83/04C08L81/00
    • Provided are compositions comprising a block copolymer of the following formula: [A]-B-[Q], wherein [A] is a polymer that has an affinity for a substrate; B is a linking group comprising an optionally-substituted, polyvalent linking group having a molecular weight of no more than 1000 g/mole; and [Q] comprises a semi-crosslinked, ungelled polymer derived from copolymerization of an ethylenically unsaturated monomer with a poly-functional ethylenically unsaturated monomer. Such block copolymers are cross-linked via the [Q] segment, but not macroscopically gelled. The [Q] segment is hydrophilic and has a degree of polymerization in the range of about 10 to about 10,000. The [A] segment is located on at least one terminal end of said block copolymer, comprises between about 1 and about 200 repeating units. The block copolymer is associated, via the linear substrate associative segment with a surface comprising at least one hydrophobic site, such as a silicone hydrogel. The polymers may be incorporated into a formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post-formation.
    • 提供了包含下式的嵌段共聚物的组合物:[A] -B- [Q],其中[A]是对底物具有亲和性的聚合物; B是包含分子量不超过1000g / mol的任选取代的多价连接基团的连接基团; 和[Q]包含衍生自烯属不饱和单体与多官能烯键式不饱和单体共聚的半交联的未凝胶聚合物。 这种嵌段共聚物通过[Q]链段交联,但不是宏观胶凝的。 [Q]链段是亲水性的并且聚合度在约10至约10,000的范围内。 [A]链段位于所述嵌段共聚物的至少一个末端,包含约1至约200个重复单元。 嵌段共聚物通过线性底物缔合链段与包含至少一个疏水位点的表面如硅氧烷水凝胶缔合。 聚合物可以掺入制备硅氧烷水凝胶的制剂中,或者可与硅氧烷水凝胶后处理接触。