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1. 发明授权

US11543340B2 Autofocus systems and methods for particle analysis in blood samples 有权
公开(公告)号：US11543340B2
公开(公告)日：2023-01-03
申请号：US16574693
申请日：2019-09-18
申请人： Iris International, Inc.
发明人： Bart J. Wanders , Brett Jordan , Gregory A. Farrell , Thomas H. Adams , Warren Groner
IPC分类号： G01N15/14 , G01N33/50 , G01N15/06 , G01N21/53 , G02B7/36 , G01N33/80 , G01N33/49 , G01N15/00 , G01N15/10 , G01N21/05 , G02B21/24 , G06T7/00 , G02B7/28 , G01N1/30
摘要： Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

2. 发明授权

US11525766B2 Dynamic range extension systems and methods for particle analysis in blood samples 有权
公开(公告)号：US11525766B2
公开(公告)日：2022-12-13
申请号：US16533006
申请日：2019-08-06
申请人： Iris International, Inc.
发明人： Thomas H. Adams , Bart J. Wanders , John Roche , Harvey L. Kasdan
IPC分类号： G01N15/14 , G01N33/50 , G01N15/06 , G01N21/53 , G02B7/36 , G01N33/80 , G01N33/49 , G01N15/00 , G01N15/10 , G01N21/05 , G02B21/24 , G06T7/00 , G02B7/28 , G01N1/30
摘要： For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

3. 发明申请

US20140273068A1 AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
标题翻译：自动分析系统及其在血液样品中的分析方法
公开(公告)号：US20140273068A1
公开(公告)日：2014-09-18
申请号：US14216811
申请日：2014-03-17
申请人： IRIS International, Inc.
发明人： Bart J. Wanders , Brett Jordan , Gregory A. Farrell , Thomas H. Adams , Warren Groner
IPC分类号： G01N33/50
摘要： Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.
摘要翻译：可以通过数字图像处理器对诸如血细胞的颗粒进行分类和计数。数字显微镜照相机可以被引导到限定对称变窄的流动路径的流动池中，其中样品流在由鞘液层之间的流动和粘度参数平坦化的带中流动。在流动池上提供用于自动聚焦的对比度图案，例如在后部照明开口的边缘。图像处理器从像素数据对比度评估焦点精度。定位电机沿着光轴移动显微镜和/或流动池，用于自动聚焦在对比度图案目标上。然后，处理器将显微镜和流动池移位在对比度图案和样品流之间已知的距离，从而聚焦于样品流。从该位置收集血细胞图像，直到通过输入信号周期性重新开始自动聚焦，或当检测图像数据中的温度变化或聚焦不准确时。

4. 发明申请

US20200080926A1 AUTOFOCUS SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
公开(公告)号：US20200080926A1
公开(公告)日：2020-03-12
申请号：US16574693
申请日：2019-09-18
申请人： Iris International, Inc.
发明人： Bart J. Wanders , Brett Jordan , Gregory A. Farrell , Thomas H. Adams , Warren Groner
IPC分类号： G01N15/14 , G01N33/80 , G01N33/50 , G01N33/49 , G01N21/53 , G01N15/06 , G01N1/30
摘要： Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. A contrast pattern for autofocusing is provided on the flowcell, for example at an edge of a rear illumination opening. The image processor assesses focus accuracy from pixel data contrast. A positioning motor moves the microscope and/or flowcell along the optical axis for autofocusing on the contrast pattern target. The processor then displaces microscope and flowcell by a known distance between the contrast pattern and the sample stream, thus focusing on the sample stream. Blood cell images are collected from that position until autofocus is reinitiated, periodically, by input signal, or when detecting temperature changes or focus inaccuracy in the image data.

5. 发明申请

US20200033249A1 DYNAMIC RANGE EXTENSION SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
公开(公告)号：US20200033249A1
公开(公告)日：2020-01-30
申请号：US16533006
申请日：2019-08-06
申请人： Iris International, Inc.
发明人： Thomas H. Adams , Bart J. Wanders , John Roche , Harvey L. Kasdan
IPC分类号： G01N15/14 , G01N33/50 , G01N15/06 , G01N21/53 , G01N33/80 , G01N1/30 , G01N33/49
摘要： For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

6. 发明授权

US10060846B2 Hematology systems and methods 有权
公开(公告)号：US10060846B2
公开(公告)日：2018-08-28
申请号：US15645710
申请日：2017-07-10
申请人： Iris International, Inc.
发明人： Bart J. Wanders , Gregory A. Farrell , Thomas H. Adams , Warren Groner , Xiaodong Zhao , Brett Jordan , Jack Cremins , Carol Quon
IPC分类号： G01N15/14 , G01N33/50 , G01N33/49 , G01N21/53 , G01N1/30 , G01N33/80 , G01N21/05 , G01N15/10 , G01N15/00
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/06 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.

7. 发明申请

US20160187246A1 SHEATH FLUID SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 有权
标题翻译： SHEATH流体系统及其在血液样品中的粒子分析方法
公开(公告)号：US20160187246A1
公开(公告)日：2016-06-30
申请号：US15064129
申请日：2016-03-08
申请人： IRIS International, Inc.
发明人： Gregory A. Farrell , Bart J. Wanders , Thomas H. Adams , Warren Groner , Xiaodong Zhao
IPC分类号： G01N15/14 , G01N33/50
CPC分类号： G01N33/4915 , G01N15/1404 , G01N15/1434 , G01N15/1436 , G01N15/1459 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/05 , G01N33/5091 , G01N2015/0065 , G01N2015/0073 , G01N2015/008 , G01N2015/0084 , G01N2015/1006 , G01N2015/1037 , G01N2015/1409 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058 , G01N2201/12
摘要： Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.
摘要翻译：本公开的方面和实施方案提供用于分析样品中包含的颗粒的颗粒分析仪的颗粒和/或细胞内细胞器取向剂。示例性的颗粒和/或细胞内细胞器取向剂包括水溶液，粘度调节剂和/或缓冲液。

8. 发明申请

US20140273076A1 DYNAMIC RANGE EXTENSION SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
标题翻译：动态范围扩展系统及其在血液样品中的粒度分析方法
公开(公告)号：US20140273076A1
公开(公告)日：2014-09-18
申请号：US14217034
申请日：2014-03-17
申请人： IRIS International, Inc.
发明人： Thomas H. Adams , Bart J. Wanders , John Roche , Harvey L. Kasdan
IPC分类号： G01N33/80
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/06 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.
摘要翻译：为了分析含有至少两个类别的颗粒的样品，例如含有血细胞的样品，具有检测极限的颗粒计数器与能够鉴别颗粒数比例的分析仪（例如视觉分析仪和处理器）相结合。第一类颗粒可以存在超出检测范围限度，而第二类颗粒存在于相应的检测范围限度内。第二类颗粒的浓度由颗粒计数器确定。在分析器上确定第一类别与第二类别的计数比。基于第二类颗粒的比例和计数或浓度，在处理器上计算第一类中颗粒的浓度。

9. 发明申请

US20140273067A1 FLOWCELL SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 有权
标题翻译： FLOWCELL系统和血液样品中粒子分析的方法
公开(公告)号：US20140273067A1
公开(公告)日：2014-09-18
申请号：US14216533
申请日：2014-03-17
申请人： IRIS International, Inc.
发明人： Bart J. Wanders , Thomas H. Adams , Gregory A. Farrell , Warren Groner , Xiaodong Zhao
IPC分类号： G01N33/50
CPC分类号： G01N15/1404 , G01N1/30 , G01N15/1434 , G01N15/1463 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/53 , G01N33/49 , G01N33/4915 , G01N33/5091 , G01N33/5094 , G01N33/80 , G01N2015/0065 , G01N2015/1037 , G01N2015/1411 , G01N2015/1413 , G01N2015/1452 , G01N2015/1486 , G01N2021/058
摘要： The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. In some aspects the system comprises an analyzer which may be a visual analyzer. In one aspect, this disclosure relates to a particle imaging system comprising a flowcell through which a sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis of samples. Other compositions, methods and features of this disclosure are disclosed herein.
摘要翻译：本公开涉及用于分析含有颗粒的样品的装置，系统，组合物和方法。在一些方面，该系统包括可以是视觉分析仪的分析器。一方面，本发明涉及一种粒子成像系统，该粒子成像系统包括流过细胞，通过该流通池使含有颗粒的样品流动;以及高光学分辨率成像装置，其捕获用于样品的图像分析的图像。本公开的其它组合物，方法和特征在此公开。

10. 发明公开

US20230152203A1 DYNAMIC RANGE EXTENSION SYSTEMS AND METHODS FOR PARTICLE ANALYSIS IN BLOOD SAMPLES 审中-公开
公开(公告)号：US20230152203A1
公开(公告)日：2023-05-18
申请号：US17984116
申请日：2022-11-09
申请人： Iris International, Inc.
发明人： Thomas H. Adams , Bart J. Wanders , John Roche , Harvey L. Kasdan
IPC分类号： G01N15/14 , G01N33/50 , G01N15/06 , G01N21/53 , G02B7/36 , G01N33/80 , G01N1/30 , G01N33/49
CPC分类号： G01N15/1404 , G01N33/5094 , G01N15/06 , G01N15/1468 , G01N15/1434 , G01N15/147 , G01N15/1463 , G01N15/1475 , G01N21/53 , G01N15/1459 , G01N15/1429 , G01N15/1436 , G02B7/36 , G01N33/5091 , G01N33/80 , G01N1/30 , G01N33/49 , G01N33/4915 , G01N2015/1452 , G01N2015/0065
摘要： For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

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