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1. 发明申请

US20170079813A1 METHODS OF PROVIDING OPTIMIZED DRUG-ELUTING STENT ASSEMBLIES 审中-公开
公开(公告)号：US20170079813A1
公开(公告)日：2017-03-23
申请号：US15366703
申请日：2016-12-01
申请人： InspireMD, Ltd.
发明人： Eli BAR , Asher HOLZER , Ofir PAZ
IPC分类号： A61F2/90 , A61L31/16 , A61L31/10 , A61L31/02 , A61L31/04 , A61L31/06 , A61F2/07 , A61L31/14
CPC分类号： A61F2/90 , A61F2/0063 , A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/0086 , A61F2002/075 , A61F2002/823 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L31/022 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , A61L2420/02 , C08G63/00 , C08G63/06 , C08G63/08 , C08G63/40 , C08G73/02 , C08G79/04 , Y10T29/49964
摘要： Methods of providing a stent assembly that includes a stent jacket formed from an expansible mesh structure having apertures and that includes a fiber having a diameter of about 7 micrometers and about 40 micrometers, and an expansible stent operatively associated with the stent jacket. The method further comprises administering to the subject an active pharmaceutical ingredient (API) eluted from the stent assembly.

2. 发明申请

US20180185177A1 STENT THERMOFORMING APPARATUS AND METHODS 审中-公开
公开(公告)号：US20180185177A1
公开(公告)日：2018-07-05
申请号：US15725908
申请日：2017-10-05
申请人： InspireMD, Ltd.
发明人： Eli BAR , Nimrod MELLER , Dror HAZAN
IPC分类号： A61F2/82 , G01M3/32 , A61F2/958 , B29C49/28 , B29C49/64 , B29C49/78 , B29C49/80 , A61F2/95 , B29L31/00
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2002/9583 , B29C49/28 , B29C49/64 , B29C49/6409 , B29C49/783 , B29C49/786 , B29C49/80 , B29C2049/4838 , B29C2949/78151 , B29C2949/78294 , B29C2949/78436 , B29C2949/78663 , B29C2949/78949 , B29K2101/12 , B29K2905/00 , B29K2995/0013 , B29L2031/7543 , B29L2031/7546 , G01M3/3218 , G01M3/36
摘要： A medical stent mold includes a tube having an interior passage sized and dimensioned to receive a stent assembly disposed at least partially about a central portion of a stent balloon. The medical stent mold may also include a housing forming a chamber through which the tube extends. The tube may include a thermally conductive material and may have a body portion that extends within the chamber and an end portion that is proximate the body portion and that extends away from the housing. Forced convection may be used to quickly heat and cool the tube. Methods of increasing retention of an expandable stent assembly on a stent balloon and of detecting a leak in a stent balloon are also included.

3. 发明申请

US20160058589A1 INTRAVASCULAR ANEURYSM TREATMENT DEVICE AND METHODS 审中-公开
标题翻译：血管内血栓治疗装置及方法
公开(公告)号：US20160058589A1
公开(公告)日：2016-03-03
申请号：US14935339
申请日：2015-11-06
申请人： INSPIREMD, LTD.
发明人： Eli BAR , Asher HOLZER , Ofir PAZ
IPC分类号： A61F2/90 , A61F2/00
CPC分类号： A61F2/90 , A61F2/0063 , A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/0086 , A61F2002/075 , A61F2002/823 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L31/022 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , A61L2420/02 , C08G63/00 , C08G63/06 , C08G63/08 , C08G63/40 , C08G73/02 , C08G79/04 , Y10T29/49964
摘要： An intravascular device configured to treat an aneurysm that includes a support structure including metal struts configured to be positioned in a body lumen and defining a central fluid passage that extends axially along the support structure, and a knitted mesh cover disposed over an exterior thereof and across a radial arc and along a length of the support structure sufficient to exceed an opening of an aneurysm to be treated, and the cover includes a polymer fiber having a diameter of at least 40 nanometers to 30 microns and apertures therethrough, the apertures being sized to prevent blood from passing through the device to prevent further expansion of the aneurysm. Devices including apertures that are at least 20 microns and sized to minimize or prevent an aneurysm-filling material from exiting the aneurysm through the knitted mesh cover and support structure, and methods of stenting, are also encompassed.
摘要翻译：一种血管内装置，其构造成治疗动脉瘤，所述动脉瘤包括支撑结构，所述支撑结构包括配置成定位在体腔中的金属支柱，并且限定沿所述支撑结构轴向延伸的中心流体通道，以及布置在其外部和横跨径向弧并且沿支撑结构的长度足以超过要治疗的动脉瘤的开口，并且所述盖包括直径为至少40纳米至30微米的聚合物纤维和穿过其的孔，所述孔的尺寸设定为防止血液通过装置，以防止动脉瘤进一步扩张。还包括包括孔径至少为20微米并且尺寸适于最小化或防止动脉瘤填充材料通过针织网罩和支撑结构离开动脉瘤的装置以及支架置入方法的装置。

4. 发明申请

US20170100265A1 STENT THERMOFORMING APPARATUS AND METHODS 有权
公开(公告)号：US20170100265A1
公开(公告)日：2017-04-13
申请号：US15386936
申请日：2016-12-21
申请人： InspireMD, Ltd.
发明人： Eli BAR , Nimrod MELLER , Dror HAZAN
IPC分类号： A61F2/82 , B29C49/64 , A61F2/958 , B29C49/80 , G01M3/32 , B29C49/28 , B29C49/78
CPC分类号： A61F2/82 , A61F2/958 , A61F2002/9522 , A61F2002/9583 , B29C49/28 , B29C49/64 , B29C49/6409 , B29C49/783 , B29C49/786 , B29C49/80 , B29C2049/4838 , B29C2949/78151 , B29C2949/78294 , B29C2949/78436 , B29C2949/78663 , B29C2949/78949 , B29K2101/12 , B29K2905/00 , B29K2995/0013 , B29L2031/7543 , B29L2031/7546 , G01M3/3218 , G01M3/36
摘要： A medical stent mold includes a tube having an interior passage sized and dimensioned to receive a stent assembly disposed at least partially about a central portion of a stent balloon. The medical stent mold may also include a housing forming a chamber through which the tube extends. The tube may include a thermally conductive material and may have a body portion that extends within the chamber and an end portion that is proximate the body portion and that extends away from the housing. Forced convection may be used to quickly heat and cool the tube. Methods of increasing retention of an expandable stent assembly on a stent balloon and of detecting a leak in a stent balloon are also included.

5. 发明申请

US20150230953A1 STENT WITH SHEATH AND METAL WIRE AND METHODS 审中-公开
标题翻译：与管和金属线和方法的STENT
公开(公告)号：US20150230953A1
公开(公告)日：2015-08-20
申请号：US14705871
申请日：2015-05-06
申请人： INSPIREMD, LTD
发明人： Eli BAR , Zeev Asher Holzer , Ofir Paz
IPC分类号： A61F2/90
摘要： A stent assembly includes a stent and a fiber mesh sleeve covering the stent. A wire runs along the stent over the sleeve and fastened to the stent at multiple points so as to attach the sleeve to the stent. Methods of making the stent assembly are included.
摘要翻译：支架组件包括支架和覆盖支架的纤维网套筒。电线沿着支架在套管上延伸并且在多个点处固定到支架上，以将套筒附接到支架上。包括制造支架组件的方法。

6. 发明申请

US20140309723A1 STENT WITH SHEATH AND METAL WIRE 审中-公开
标题翻译：与钢丝和金属丝连接
公开(公告)号：US20140309723A1
公开(公告)日：2014-10-16
申请号：US14315001
申请日：2014-06-25
申请人： INSPIREMD, LTD.
发明人： Eli BAR , Asher HOLZER , Ofir PAZ
IPC分类号： A61F2/07 , D04B1/22
CPC分类号： A61F2/07 , A61F2/852 , A61F2/90 , A61F2/91 , A61F2002/0086 , A61F2002/075 , A61F2220/0058 , A61F2250/0063 , B23K11/11 , D04B1/225 , D10B2509/06 , Y10T29/49826
摘要： A stent assembly includes a stent and a fiber mesh sleeve covering the stent. A wire runs along the stent over the sleeve and fastened to the stent at multiple points so as to attach the sleeve to the stent.
摘要翻译：支架组件包括支架和覆盖支架的纤维网套管。电线沿着支架在套管上延伸并且在多个点处固定到支架上，以将套筒附接到支架上。

7. 发明申请

US20180338847A1 OPTIMIZED STENT JACKET HAVING SINGLE FIBER MESH 审中-公开
公开(公告)号：US20180338847A1
公开(公告)日：2018-11-29
申请号：US16052301
申请日：2018-08-01
申请人： INSPIREMD, LTD.
发明人： Asher HOLZER , Eli BAR , Ofir PAZ
IPC分类号： A61F2/90 , C08G79/04 , C08G73/02 , A61F2/00 , A61F2/07 , A61F2/82 , A61L31/02 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , C08G63/00 , C08G63/40 , C08G63/08 , C08G63/06 , A61F2/89
CPC分类号： A61F2/90 , A61F2/0063 , A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/0086 , A61F2002/075 , A61F2002/823 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61L31/022 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , A61L2420/02 , C08G63/00 , C08G63/06 , C08G63/08 , C08G63/40 , C08G73/02 , C08G79/04 , Y10T29/49964
摘要： An intravascular device configured to treat an aneurysm that includes a support structure including metal struts configured to be positioned in a body lumen and defining a central fluid passage that extends axially along the support structure, and a knitted mesh cover disposed over an exterior thereof and across a radial arc and along a length of the support structure sufficient to exceed an opening of an aneurysm to be treated, and the cover includes a polymer fiber having a diameter of at least 40 nanometers to 30 microns and apertures therethrough, the apertures being sized to prevent blood from passing through the device to prevent further expansion of the aneurysm. Devices including apertures that are at least 20 microns and sized to minimize or prevent an aneurysm-filling material from exiting the aneurysm through the knitted mesh cover and support structure, and methods of stenting, are also encompassed.

8. 发明申请

US20170216066A1 DEFORMABLE TIP FOR STENT DELIVERY AND METHODS OF USE 审中-公开
公开(公告)号：US20170216066A1
公开(公告)日：2017-08-03
申请号：US15419437
申请日：2017-01-30
申请人： InspireMD, Ltd.
发明人： Eli BAR , Dror HAZAN
IPC分类号： A61F2/966 , A61F2/91 , A61F2/958 , A61F2/86
CPC分类号： A61F2/966 , A61F2/852 , A61F2/86 , A61F2/91 , A61F2/958 , A61F2210/0004 , A61F2210/0014 , A61F2250/001 , A61F2250/0067
摘要： A stent-delivery assembly that includes a catheter; an expandable stent that is movable, relative to the catheter, from a first position to a second position; and a guidewire assembly extending through a longitudinal passage of the catheter and a longitudinal passage of the stent, the guidewire assembly being movable, relative to the catheter, from a third position to a fourth position. While the expandable stent is in the first position and while the guidewire assembly is in the third position, the stent-delivery assembly has an a-traumatic shape. While the expandable stent is in the second position and while the guidewire assembly is in the fourth position, the guidewire assembly is capable of passing through the stent to allow for retrieval of the stent-delivery assembly. Methods of use and manufacture are also included.

9. 发明申请

US20150032197A1 CAROTID STENT ASSEMBLY AND METHODS FOR TREATMENT VIA BODY LUMENS 审中-公开
标题翻译： CAROTID STENT ASSEMBLY AND METHODS FOR THEATMENT VIA BODY LUMENS
公开(公告)号：US20150032197A1
公开(公告)日：2015-01-29
申请号：US14500759
申请日：2014-09-29
申请人： INSPIREMD, LTD
发明人： Eli BAR , Zeev Asher HOLZER , Ofir PAZ
IPC分类号： A61F2/92 , A61L31/10 , A61F2/958
CPC分类号： A61F2/92 , A61F2/07 , A61F2/89 , A61F2/958 , A61F2002/075 , A61F2002/077 , A61F2230/0054 , A61F2230/0067 , A61F2250/0023 , A61F2250/0039 , A61L31/10 , A61L2300/20
摘要： A stent assembly adapted to carotid arterial placement that includes a self-expanding support element comprising metal struts constructed to be positioned in a body lumen and expanded from a retracted state to an expanded state, and a knitted cover disposed over an exterior of the support element and along an entire length thereof, wherein the knitted cover comprises a single polymer fiber having a diameter of at least 40 nanometers to 30 microns, wherein the self-expanding support element and knitted cover together have apertures sized 20 microns to smaller than 100 microns in diameter to block larger debris when the stent assembly is placed in a carotid artery and expanded to the expanded state. Methods of stenting a carotid artery by applying the stent assembly to the carotid artery of a patient in need of treatment and expanding the stent assembly in situ are disclosed.
摘要翻译：一种适于颈动脉置入的支架组件，其包括自扩张支撑元件，所述自扩张支撑元件包括被构造成定位在体腔中并且从缩回状态扩展到扩张状态的金属支柱，以及布置在所述支撑元件的外部上的针织盖并且沿着其整个长度，其中编织覆盖物包括直径为至少40纳米至30微米的单一聚合物纤维，其中自膨胀支撑元件和编织覆盖物一起具有尺寸为20微米至小于100微米的孔直径以在支架组件放置在颈动脉中并扩张至扩张状态时阻挡较大的碎屑。公开了通过将支架组件应用于需要治疗和扩大支架组件的患者的颈动脉来支架颈动脉的方法。

10. 发明申请

US20190070028A1 STENT ASSEMBLY AND METHODS FOR TREATMENT VIA BODY LUMENS 审中-公开
公开(公告)号：US20190070028A1
公开(公告)日：2019-03-07
申请号：US16113752
申请日：2018-08-27
申请人： InspireMD, Ltd.
发明人： Eli BAR , Zeev Asher HOLZER , Ofir PAZ
IPC分类号： A61F2/90 , A61F2/92 , A61L31/10 , A61F2/958 , A61F2/07
摘要： Various stent assemblies for placement in a body lumen that includes a support element comprising metal struts constructed to be positioned in a body lumen, and a knitted layer or cover disposed over an interior, an exterior, or both, of the support element and along an entire length thereof, wherein the knitted layer or cover comprises a single polymer fiber or metal wire having a diameter of at least 40 nanometers to 30 microns, wherein the support element and knitted cover together have apertures sized 100 microns to 300 microns in diameter, or alternatively from 200 microns to 1500 microns, to block larger debris when the stent assembly is properly placed in a body lumen. Methods of stenting a body lumen by applying the stent assembly to a patient in need of treatment and expanding the stent assembly in situ are disclosed.

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