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1. 发明申请

US20180036408A1 ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS 审中-公开
公开(公告)号：US20180036408A1
公开(公告)日：2018-02-08
申请号：US15786046
申请日：2017-10-17
申请人： Immunolight, LLC , Duke University
发明人： Frederic A. BOURKE , Tuan VO DINH
IPC分类号： A61K41/00 , A61K47/55 , A61K31/4427 , A61N5/06
CPC分类号： A61N5/062 , A61K31/4427 , A61K31/7052 , A61K31/7056 , A61K41/008 , A61K47/55 , A61K47/551
摘要： The present invention relates to methods for treating cell proliferation disorders comprising: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated; (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder; and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes; a kit and a computer implemented system for performing the method; a pharmaceutical composition useful in the method; and a method for causing an autovaccine effect in a subject using the method.

2. 发明申请

US20140343479A1 ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS 有权
标题翻译：用于治疗细胞增殖障碍的先进方法和系统
公开(公告)号：US20140343479A1
公开(公告)日：2014-11-20
申请号：US14256550
申请日：2014-04-18
申请人： Immunolight, LLC , Duke University
发明人： Frederic A. BOURKE , Tuan Vo Dinh
IPC分类号： A61N5/06 , A61K31/7056
CPC分类号： A61N5/062 , A61K31/4427 , A61K31/7052 , A61K31/7056 , A61K41/008 , A61K47/55 , A61K47/551
摘要： The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes
摘要翻译：本发明涉及治疗细胞增殖紊乱的方法，其包括（1）向受试者施用至少一种能够同时进行两个光子吸收事件激活并可被激活时实现预定的细胞变化的可活化药剂，（2）向所述受试者施用至少一种等离子体激动剂活性剂，和（3）将来自起始能量源的引发能量施用于所述受试者，其中所述等离子体激活剂增强或改变所施加的引发能量，使得所述增强或修饰的引发能量通过原位同步双光子吸收事件激活可激活的药剂，从而导致发生预定的细胞变化，其中所述预定的细胞变化处理细胞增殖相关病症，以及使用等离子体激元增强光谱疗法（PEPST）和离开 - 增效光疗法（EPEP）治疗va 细胞增殖紊乱，PEPST和EPEP试剂和探针

3. 发明申请

US20190184190A1 PHOSPHOR-CONTAINING DRUG ACTIVATOR ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE, SYSTEM CONTAINING THE ACTIVATOR, AND METHODS FOR USE 审中-公开
公开(公告)号：US20190184190A1
公开(公告)日：2019-06-20
申请号：US16322178
申请日：2017-08-01
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Harold WALDER , Frederic A. BOURKE , Zakaryae FATHI , Wayne BEYER , Mark OLDHAM , Justus ADAMSON , Paul YOON
IPC分类号： A61N5/06 , A61N5/10 , A61P35/00 , A61K41/00
CPC分类号： A61N5/062 , A61K33/42 , A61K41/00 , A61K41/0057 , A61N5/10 , A61N2005/1098 , A61P35/00
摘要： A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays, wherein a distribution of the phosphors in the diseased target site is based on a Monte Carlo derived x-ray dose distribution. A system for treating a disease in a subject in need thereof, includes the drug activator and a photoactivatable drug, one or more devices which infuse the photoactivatable drug and the activator including the pharmaceutically acceptable carrier into a diseased site in the subject; and an x-ray source which is controlled to deliver the Monte Carlo derived x-ray exposure to the subject for production of ultraviolet and visible light inside the subject to activate the photoactivatable drug and induce a persistent therapeutic response, the dose comprising a pulsed sequence of x-rays delivering from 0.5-2 Gy to the tumor.

4. 发明申请

US20180311355A1 METHODS FOR RADIOTHERAPY TO TRIGGER LIGHT ACTIVATION DRUGS 审中-公开
公开(公告)号：US20180311355A1
公开(公告)日：2018-11-01
申请号：US15770926
申请日：2016-10-26
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Mark OLDHAM , Justus ADAMSON , Mark W. DEWHIRST , Paul YOON , Harold WALDER , Frederic A. BOURKE , Zakaryae FATHI , Wayne F. BEYER
IPC分类号： A61K41/00 , A61N5/06 , A61K33/24 , A61N5/10
CPC分类号： A61K31/655 , A61K31/352 , A61K31/403 , A61K31/409 , A61K31/525 , A61K33/02 , A61K41/0066 , A61N5/062 , A61N5/0624 , A61N2005/065 , A61N2005/1095 , A61N2005/1098 , Y02A50/393
摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.

5. 发明申请

US20170050046A1 TUMOR IMAGING WITH X-RAYS AND OTHER HIGH ENERGY SOURCES USING AS CONTRAST AGENTS PHOTON-EMITTING PHOSPHORS HAVING THERAPEUTIC PROPERTIES 审中-公开
标题翻译：使用X射线和其他高能量源进行肿瘤成像使用作为对照剂的具有治疗性质的发光磷光体
公开(公告)号：US20170050046A1
公开(公告)日：2017-02-23
申请号：US15307766
申请日：2015-04-22
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY , NORTH CAROLINA STATE UNIVERSITY
发明人： Harold WALDER , Frederic A. BOURKE , Zakaryae FATHI , Wayne F. BEYER , Mark W. DEWHIRST , Mark OLDHAM , Justus ADAMSON , Michael NOLAN
IPC分类号： A61N5/06 , A61B6/00 , A61N5/10 , A61K9/00 , A61K49/04 , A61K41/00 , A61K39/00 , A61B6/03 , A61N5/02
CPC分类号： A61N5/062 , A61K39/0011 , A61K41/0019 , A61K41/0066 , A61K49/0423 , A61K2039/585 , A61N5/022 , A61N5/10 , A61N5/1081 , A61N2005/0627 , A61N2005/0659 , A61N2005/0661 , A61N2005/0662 , A61N2005/1089 , A61N2005/1098
摘要： A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are capable of emitting ultraviolet or visible light into the body and which provide x-ray contrast. The system includes one or more devices which infuse a diseased site with a photo-activatable drug and the pharmaceutical carrier, an initiation energy source comprising an x-ray or high energy source which irradiates the diseased site with at least one of x-rays, gamma rays, or electrons to thereby initiate emission of said ultraviolet or visible light into the body, and a processor programmed to at least one of 1) produce images of the diseased site or 2) control a dose of said x-rays, gamma rays, or electrons to the diseased site for production of said ultraviolet or visible light at the diseased site to activate the photoactivatable drug.
摘要翻译：用于在人或动物体内成像或治疗疾病的系统和方法。该系统向人体或动物体提供包含能够将紫外线或可见光发射到体内并提供x射线对比度的一种或多种磷光体的药物载体。该系统包括一个或多个装置，其将病变部位注入可光活化药物和药物载体，引发能量源包括用X射线或高能量源照射患病部位的x射线，伽马射线或电子，从而开始将所述紫外线或可见光发射到体内;以及处理器，被编程为以下中的至少一个：1）产生患病部位的图像，或2）控制所述X射线，γ射线的剂量或电子到病变部位，以在病变部位产生所述紫外线或可见光，以活化可光活化药物。

6. 发明申请

US20170154866A1 IMPROVED ADHESIVE BONDING COMPOSITION AND METHOD OF USE 审中-公开
公开(公告)号：US20170154866A1
公开(公告)日：2017-06-01
申请号：US15322928
申请日：2015-06-29
申请人： IMMUNOLIGHT, LLC
发明人： Zakaryae FATHI , Frederic A. BOURKE , Harold WALDER
IPC分类号： H01L23/00 , B32B7/06 , C09J133/00 , B32B38/00 , C09J11/06 , B32B7/12 , B32B37/12
CPC分类号： H01L24/83 , B32B5/02 , B32B5/18 , B32B5/26 , B32B7/06 , B32B7/12 , B32B9/025 , B32B9/04 , B32B9/043 , B32B17/00 , B32B18/00 , B32B21/042 , B32B25/045 , B32B27/08 , B32B27/16 , B32B27/302 , B32B27/304 , B32B27/308 , B32B27/32 , B32B27/322 , B32B27/34 , B32B27/36 , B32B37/12 , B32B38/0008 , B32B2037/1253 , B32B2255/26 , B32B2305/18 , B32B2307/202 , B32B2307/204 , B32B2307/21 , B32B2307/3065 , B32B2307/41 , B32B2307/412 , B32B2307/422 , B32B2307/50 , B32B2307/546 , B32B2307/548 , B32B2307/552 , B32B2307/706 , B32B2307/72 , B32B2307/748 , B32B2307/75 , B32B2310/0806 , B32B2439/00 , B32B2439/70 , B32B2439/80 , B32B2457/14 , B32B2479/00 , B32B2605/003 , B32B2605/08 , C09J11/06 , C09J133/00 , C09J133/06 , H01L24/00 , H01L24/03 , H01L24/05 , H01L24/27 , H01L24/29 , H01L24/32 , H01L24/94 , H01L2224/0383 , H01L2224/03831 , H01L2224/04026 , H01L2224/05791 , H01L2224/05887 , H01L2224/2711 , H01L2224/2732 , H01L2224/27334 , H01L2224/27416 , H01L2224/27418 , H01L2224/27436 , H01L2224/27618 , H01L2224/27622 , H01L2224/29083 , H01L2224/2919 , H01L2224/2929 , H01L2224/29291 , H01L2224/293 , H01L2224/29387 , H01L2224/32145 , H01L2224/32225 , H01L2224/32245 , H01L2224/83009 , H01L2224/83591 , H01L2224/83687 , H01L2224/83851 , H01L2224/83855 , H01L2224/83868 , H01L2224/83874 , H01L2224/94 , H01L2924/00012 , H01L2224/83 , H01L2924/00014 , H01L2924/07802 , H01L2924/0781
摘要： A method of and system for adhesive bonding. The method and system a) treat a surface of an element to be bonded to provide an adherent structure including one or more rubber compounds on the surface; b) place a polymerizable adhesive composition, including at least one photoinitiator and at least one energy converting material, in contact with the adherent structure and two or more components to be bonded to form an assembly, c) irradiated the assembly with radiation at a first wavelength, capable of conversion by the at least one energy converting material, to a second wavelength capable of activating the at least one photoinitiator to produce from the polymerizable adhesive composition a cured adhesive composition; and d) adhesively join the two or more components by way of the adherent structure and the cured adhesive composition.

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