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1. 发明授权

US11826163B2 Systems, methods and devices for achieving glycemic balance 有权
公开(公告)号：US11826163B2
公开(公告)日：2023-11-28
申请号：US16918489
申请日：2020-07-01
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： A61B5/00 , A61B5/145 , A61M5/172 , G16H20/17 , G16H20/10 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/1723 , G16H20/10 , G16H20/17 , A61B5/0002 , A61M5/142 , A61M2205/50 , A61M2205/507 , A61M2205/52
摘要： Systems, methods and/or devices for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen. Also disclosed are systems, methods and/or devices for treating a patient's diabetes by providing treatment guidance, wherein the patient's current glycemic state is determined relative to a desired balance point; and determining from at least one of a plurality of the data corresponding to the patient's blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen to get closer to the patient's desired balance point; wherein the desired balance point is the patient's lowest blood glucose-level within a predetermined range achievable before increasing the frequency of hypoglycemic events above a predetermined threshold.

2. 发明申请

US20180146920A1 Apparatus and System for Diabetes Management 审中-公开
公开(公告)号：US20180146920A1
公开(公告)日：2018-05-31
申请号：US15878050
申请日：2018-01-23
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： A61B5/00 , A61M5/172 , G16H10/40 , G16H40/63 , A61B5/145 , A61M5/168 , G16H20/17 , A61M5/315 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/1684 , A61M5/1723 , A61M5/31571 , A61M2005/14208 , A61M2205/502 , A61M2205/507 , A61M2205/52 , G06F19/3456 , G06F19/3468 , G16H10/40 , G16H20/10 , G16H20/17 , G16H40/63
摘要： An apparatus and system diabetes management. The apparatus comprises a body which houses: (i) at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; (ii) a processor operatively connected to the at least first memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen; (iii) a display screen operatively connected to the processor, (iv) a quantity of insulin; (v) a needle communicating with the quantity of insulin for delivering insulin to the patient; (vi) means for effecting delivery of a portion of the quantity of insulin to the patient via the needle; and (vii) metering means for controlling the portion of the quantity of insulin delivered to the patient via the needle.

3. 发明公开

US20240071591A1 Apparatus for Optimizing A Patient's Insulin Dosage Regimen 审中-公开
公开(公告)号：US20240071591A1
公开(公告)日：2024-02-29
申请号：US18229420
申请日：2023-08-02
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： G16H20/17 , A61B5/145 , A61M5/172 , G16H10/00 , G16H20/10
CPC分类号： G16H20/17 , A61B5/14532 , A61M5/1723 , G16H10/00 , G16H20/10 , A61B5/0002
摘要： An apparatus for optimizing a patient's insulin dosage regimen over time, comprising: at least a first computer-readable memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; a processor operatively connected to the at least first computer-readable memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range; and a display operative to display information corresponding to at least the patient's present insulin dosage regimen.

4. 发明授权

US11723592B2 Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus 有权
公开(公告)号：US11723592B2
公开(公告)日：2023-08-15
申请号：US16817161
申请日：2020-03-12
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： A61B5/00 , A61M5/172 , A61B5/145 , G16H20/17 , G16H10/40
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/7275 , A61M5/1723 , G16H10/40 , G16H20/17 , A61B5/0002 , A61B5/4842
摘要： Systems, methods and/or devices for treating diabetes mellitus by alleviating glucotoxicity and restoring pancreatic beta-cell function, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the components of the patient's present insulin dosage regimen. Also disclosed are systems, methods, and/or devices for alleviating glucotoxicity and restoring pancreatic beta-cell function, comprising establishing the patient's current glycemic state relative to a desired glycemic range and determining from at least one of a plurality of the data corresponding to the patient's blood glucose-level measurements whether and by how much to adjust at least one of the components in the patient's present insulin dosage regimen.

5. 发明授权

US10335546B2 Apparatus for optimizing a patient's insulin dosage regimen 有权
公开(公告)号：US10335546B2
公开(公告)日：2019-07-02
申请号：US14067479
申请日：2013-10-30
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： G01N33/48 , A61M5/172 , A61B5/145 , G06F19/00 , A61B5/00 , A61M5/142
摘要： An apparatus for optimizing a patient's insulin dosage regimen over time, comprising: at least a first computer-readable memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen and the patient's blood-glucose-level measurements determined at a plurality of times; a processor operatively connected to the at least first computer-readable memory, the processor programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components of the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range; and a display operative to display information corresponding to at least the patient's present insulin dosage regimen.

6. 发明申请

US20160224751A1 Apparatus and Methods for Taking Blood Glucose Measurements and Recommending Insulin Doses 有权
标题翻译：血糖检测仪器及方法推荐胰岛素剂量
公开(公告)号：US20160224751A1
公开(公告)日：2016-08-04
申请号：US15094634
申请日：2016-04-08
申请人： Hygieia, Inc.
发明人： Holly Bielawa , Carissa Demetris , James Goebel , Carol Treat Morton , Michelle Pomorski , Thomas Puricelli , Jim Rodgers , Eran Bashan , Israel Hodish , John R. Hindinger
IPC分类号： G06F19/00
CPC分类号： G16H40/63 , A61B5/14532 , G01N21/8483 , G01N27/3271 , G01N27/3273 , G01N33/48792 , G06F19/00 , G06F19/3406 , G06F19/3456 , G06F19/366 , G16H10/40 , G16H20/10
摘要： The present disclosure related to an apparatus that may be used for taking blood glucose measurements and providing individualized insulin dose recommendations wherein the apparatus is easy to use and facilitates improved diabetes control in patients. Also disclosed are related methods.
摘要翻译：本公开涉及可用于进行血糖测量并提供个体化胰岛素剂量建议的装置，其中该装置易于使用并且有助于改善患者的糖尿病控制。还公开了相关方法。

7. 发明公开

US20240156400A1 Systems, Methods and Devices for Achieving Glycemic Balance 审中-公开
公开(公告)号：US20240156400A1
公开(公告)日：2024-05-16
申请号：US18488675
申请日：2023-10-17
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： A61B5/00 , A61B5/145 , A61M5/172 , G16H20/10 , G16H20/17
CPC分类号： A61B5/4839 , A61B5/14532 , A61M5/1723 , G16H20/10 , G16H20/17 , A61B5/0002 , A61M5/142
摘要： Systems, methods and/or devices for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen. Also disclosed are systems, methods and/or devices for treating a patient's diabetes by providing treatment guidance, wherein the patient's current glycemic state is determined relative to a desired balance point; and determining from at least one of a plurality of the data corresponding to the patient's blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen to get closer to the patient's desired balance point; wherein the desired balance point is the patient's lowest blood glucose-level within a predetermined range achievable before increasing the frequency of hypoglycemic events above a predetermined threshold.

8. 发明授权

US11826142B2 Apparatus and method for taking blood glucose measurements and recommending insulin doses 有权
公开(公告)号：US11826142B2
公开(公告)日：2023-11-28
申请号：US16863027
申请日：2020-04-30
申请人： Hygieia, Inc.
发明人： Holly Bielawa , Carissa Demetris , James Goebel , Carol Treat Morton , Michelle Pomorski , Thomas Puricelli , Jim Rogers , Eran Bashan , Israel Hodish , John Hindinger
IPC分类号： A61B5/145 , A61B5/00 , A61M5/168 , A61M5/172 , G01N33/487 , G16H10/40 , G16H20/10 , G01N27/327 , G16H20/17 , G16H20/60 , G16H40/63 , A61M5/315 , A61M5/142 , G01N21/84
CPC分类号： A61B5/14532 , A61B5/4839 , A61M5/1684 , A61M5/1723 , G01N33/48792 , G16H10/40 , G16H20/10 , G16H20/17 , G16H20/60 , G16H40/63 , A61M5/31571 , A61M2005/14208 , A61M2205/502 , A61M2205/507 , A61M2205/52 , G01N21/8483 , G01N27/3271 , G01N27/3273
摘要： The present disclosure related to an apparatus that may be used for taking blood glucose measurements and providing individualized insulin dose recommendations wherein the apparatus is easy to use and facilitates improved diabetes control in patients. Also disclosed are related methods.

9. 发明授权

US10736562B2 Systems, methods and devices for achieving glycemic balance 有权
公开(公告)号：US10736562B2
公开(公告)日：2020-08-11
申请号：US14946259
申请日：2015-11-19
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： A61B5/00 , A61B5/145 , A61M5/172 , G06F19/00 , A61M5/142
摘要： Systems, methods and/or devices for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen. Also disclosed are systems, methods and/or devices for treating a patient's diabetes by providing treatment guidance, wherein the patient's current glycemic state is determined relative to a desired balance point; and determining from at least one of a plurality of the data corresponding to the patient's blood glucose-level measurements whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen to get closer to the patient's desired balance point; wherein the desired balance point is the patient's lowest blood glucose-level within a predetermined range achievable before increasing the frequency of hypoglycemic events above a predetermined threshold.

10. 发明授权

US10272198B2 System for optimizing a patient's insulin dosage regimen 有权
公开(公告)号：US10272198B2
公开(公告)日：2019-04-30
申请号：US13868612
申请日：2013-04-23
申请人： Hygieia, Inc.
发明人： Eran Bashan , Israel Hodish
IPC分类号： G01N33/48 , A61M5/172 , A61B5/145 , G06F19/00 , A61B5/00 , A61M5/142
摘要： A system for optimizing a patient's insulin dosage regimen over time, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the one or more components in the patient's present insulin dosage regimen in order to maintain the patient's future blood-glucose-level measurements within a predefined range.

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