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    • 7. 发明申请
    • STRUCTURED NON-AQUEOUS GEL-FORM CARRIER COMPOSITION
    • 结构非水凝胶形式载体组合物
    • US20130004442A1
    • 2013-01-03
    • US13583682
    • 2011-03-10
    • Hy Si BuiMohamed KanjiLiana Esposito
    • Hy Si BuiMohamed KanjiLiana Esposito
    • A61K8/90A61Q1/02C09D11/00A61Q15/00A61Q1/10A61Q5/00A61Q17/04A61Q1/06
    • A61K47/18A61K8/0229A61K8/345A61K8/442A61K8/8111A61K8/8164A61K8/90A61K9/0014A61K9/06A61Q1/06
    • Disclosed are non-aqueous carrier compositions capable of forming a gel structure, having a low molecular mass N-acyl glutamic acid diamide having a straight-chain alkyl group, a low molecular mass N-acyl glutamic acid diamide having a branched-chain alkyl group, at least one gel-promoting solvent, and at least one high molecular mass block copolymer having at least one hard segment and at least one soft segment, and at least one solvent capable of solubilizing the at least one hard segment and/or the at least one soft segment of the block copolymer, at least one oil-soluble polar modified polymer; and at least one solvent capable of solubilizing the at least one oil-soluble polar modified polymer, and optionally at least one active ingredient, wherein the composition has a hardness value ranging from about 30 to about 300 gf, a melting point of about 50° C. or higher, and does not require use of wax as a structuring agent. Methods of making and using the compositions are also disclosed.
    • 公开了能够形成凝胶结构的非水载体组合物,其具有具有直链烷基的低分子量N-酰基谷氨酸二酰胺,具有支链烷基的低分子量N-酰基谷氨酸二酰胺 ,至少一种促凝溶剂和至少一种具有至少一个硬链段和至少一个软链段的高分子量嵌段共聚物,以及至少一种能够增溶至少一个硬链段和/或至少一个软链段的溶剂 嵌段共聚物的至少一个软链段,至少一种油溶性极性改性聚合物; 和至少一种能够溶解至少一种油溶性极性改性聚合物的溶剂和任选的至少一种活性成分,其中所述组合物的硬度值为约30至约300gf,熔点为约50° C.以上,不需要使用蜡作为结构剂。 还公开了制备和使用组合物的方法。