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    • 3. 发明授权
    • Resealable medical transfer set
    • US06681946B1
    • 2004-01-27
    • US09665859
    • 2000-09-20
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • B65D3900
    • A61J1/1406A61J1/201A61J1/2096B65D51/002Y10S215/03
    • A transfer set for transferring fluid, including drugs, vaccines, medicaments, solutions and the like, between a first container, such as a conventional vial, and a second container, such as a conventional syringe having a unique multipurpose resealable member. The transfer set assembly includes an elastomeric tubular fluid transfer and resealable valve member preferably including an open end mounted on the pierceable closure or stopper of a vial and a generally closed distal end having a longitudinal slit and a piercing member is telescopically received within the fluid transfer valve member having a piercing end opposite the pierceable closure. The fluid transfer valve member is preferably formed of silicone and is surrounded by a generally tubular luer connector member having an open end mounted on the pierceable closure and a distal end having male luer threads. This assembly is enclosed within a cup-shaped closure and the assembly is retained to the first container or vial by a collar preferably secured to the vial by crimping. Upon removal of the cup-shaped closure, fluid communication between the vial and a second container, such as a syringe, is achieved by threading the luer connector of the syringe on the luer threads of the tubular luer connector member, which drives the tip through the slit of the elastomeric fluid transfer valve member against the distal end of the piercing member, driving the piercing end through the pierceable closure. In the preferred embodiment, the piercing member includes a generally longitudinal channel which establishes communication between the vial and the syringe through the tubular fluid transfer valve member.
    • 4. 发明授权
    • Transfer set for vials and medical containers
    • 转瓶套和医疗容器
    • US06209738B1
    • 2001-04-03
    • US09420998
    • 1999-10-20
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • B65D3900
    • A61J1/2089A61J1/10A61J1/1406A61J1/1475A61J1/201A61J1/2013A61J1/2051A61J1/2096B65D51/002Y10S215/03
    • A transfer set assembly for transferring fluids between a first container, such as a conventional medical vial, having a sealed open end and a second container such as a conventional IV infusion bag. The transfer set includes a collar having a proximate tubular end portion for securement to the container, a needle cannula and holder assembly, which is telescopically received in a distal tubular portion of the collar, and a closure including a tubular body portion having an open proximate end which is telescopically received over the needle cannula and holder assembly and the distal tubular portion of the collar, a closed distal end portion and an inner tubular portion which is integral with the closed distal end. The inner tubular portion includes a free end having spiral camming surfaces which mate with spiral camping surfaces on the inside surface of the tubular distal portion of the needle cannula holder. The tubular body portion of the closure includes lateral slots which receive projections on the collar and contiguous camming surface which extends toward the proximate open end of the closure. Rotation of the closure relative to the collar first drives the mating spiral camming surfaces of the closure and holder together, thereby driving the needle cannula and holder assembly axially to pierce the seal of the container. Continued rotation of the closure drives the projections on the collar against the contiguous angled camming surface, driving the closure from the collar and providing access to the needle cannula for transfer of fluids to a second container, such as an IV infusion bag.
    • 一种用于在具有密封开口端的第一容器(例如常规医用小瓶)和诸如常规IV输液袋的第二容器之间传送流体的转移组件。 转移组件包括具有用于固定到容器的近端管状端部的套环,套管和保持器组件,其可伸缩地容纳在套环的远端管状部分中,以及封闭件,该封闭件包括管状本体部分, 其可伸缩地容纳在针插管和保持器组件以及套环的远端管状部分,封闭的远端部分和与封闭的远端一体的内部管状部分。 内部管状部分包括具有螺旋形凸轮表面的自由端,其与针管保持器的管状远端部分的内表面上的螺旋形露营表面配合。 封闭件的管状主体部分包括横向狭槽,其接收套环上的凸起和朝向闭合件的近端开口端延伸的邻接凸轮表面。 闭合件相对于套环的旋转首先将闭合件和保持器的配合的螺旋凸轮表面驱动到一起,从而轴向地驱动针插管和保持器组件以刺穿容器的密封。 闭合件的继续旋转驱动套环上的凸起抵靠邻接的倾斜的凸轮表面,从套环驱动闭合件,并提供对针管的通路,以将流体传送到第二容器,例如IV输液袋。
    • 6. 发明授权
    • Method of sealing a medical container with a plastic closure
    • 用塑料盖封住医疗容器的方法
    • US06681475B2
    • 2004-01-27
    • US09732538
    • 2000-12-08
    • Jean-Claude ThibaultHubert JansenVolker Niermann
    • Jean-Claude ThibaultHubert JansenVolker Niermann
    • B21D3900
    • A61J1/1406A61J1/201A61J1/2096B65B7/285B65D51/002Y10T29/49915Y10T29/49918
    • A method of sealing a medical container such as a vial with a polymeric closure, wherein the polymeric enclosure includes a tubular collar portion and an integral radial portion, which includes disposing the tubular collar portion over the radial rim portion of the container to surround the reduced diameter neck portion and radially deforming the tubular collar portion adjacent its free end into the reduced diameter neck portion and against the adjacent radial rim portion and, wherein the polymer selected for the closure is sufficiently malleable to permit radial deformation, yet sufficiently rigid to retain its shape following deformation and sufficiently resistant to creep to maintain a seal between the plastic closure and the container following radial deformation. In the preferred embodiment of the method, the crimping tool or tools include an inclined surface having a gradually decreasing angle of inclination, which is driven against the tubular collar portion adjacent the free end and the container and vial assembly and crimping tool are relatively rotated. In the most preferred embodiment of the method of this invention, the crimping tool includes an inclined surface or surfaces, which may be separate surfaces or a continuously inclined surface, to gradually and progressively deform the tubular collar portion into the reduced diameter neck portion and against the adjacent radial rim portion in a cold forming process.
    • 一种密封具有聚合物封闭物的小瓶的医疗容器的方法,其中所述聚合物外壳包括管状套环部分和整体的径向部分,其包括将所述管状套环部分设置在所述容器的所述径向边缘部分上以包围所述减小的 直径的颈部并且将管状套环部分与其自由端相邻地径向地变形成直径减小的颈部并抵靠相邻的径向边缘部分,并且其中为封闭件选择的聚合物具有足够的延展性,以允许径向变形,但足够刚性以保持其 形状跟随变形,并且充分抵抗蠕变以在径向变形之后保持塑料盖和容器之间的密封。 在该方法的优选实施例中,压接工具或工具包括具有逐渐减小的倾斜角度的倾斜表面,该倾斜表面被驱动抵靠靠近自由端的管状套环部分,并且容器和小瓶组件以及压接工具相对旋转。 在本发明方法的最优选实施例中,压接工具包括可以是分离表面或连续倾斜表面的倾斜表面或逐渐变形以使管状套环部分逐渐变形成直径缩小的颈部并抵抗 相邻的径向边缘部分在冷成型过程中。
    • 7. 发明授权
    • Transfer set
    • 转移集
    • US06626309B1
    • 2003-09-30
    • US09684123
    • 2000-10-05
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • B65D3900
    • A61J1/2096A61J1/14A61J1/1406A61J1/1425A61J1/201A61J1/2086B65D51/002Y10S215/03
    • A transfer set for transferring fluid from a first container, such as a conventional sealed vial, to. a second container, such as a conventional syringe having a luer connector without a needle canula. The transfer set includes a tubular housing member having a proximate end adapted to be attached to the first container open end, a tubular transfer member located within the tubular housing member, a piercing member telescopically supported in the tubular transfer member, and a cap or closure which in the preferred embodiments releasably retains the distal end of the piercing member prior to removal of the cap. The cap includes a central portion having a tubular connector portion which receives and releasably retains the distal end of the piercing member.
    • 用于将流体从诸如常规密封小瓶的第一容器传送到的传送装置。 第二容器,例如具有无针管的鲁尔连接器的常规注射器。 传送组包括管状壳体构件,其具有适于附接到第一容器开口端的近端,位于管状壳体构件内的管状传送构件,可伸缩地支撑在管状传送构件中的穿刺构件,以及帽或盖 在优选实施例中,在移除盖之前可释放地保持穿孔构件的远端。 盖包括具有管状连接器部分的中心部分,该管状连接器部分接收并可释放地保持穿孔构件的远端。
    • 8. 发明授权
    • Transfer set for vials and medical containers
    • 转瓶套和医疗容器
    • US06571837B2
    • 2003-06-03
    • US09767791
    • 2001-01-23
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • B65B104
    • A61J1/2089A61J1/10A61J1/1406A61J1/1475A61J1/201A61J1/2013A61J1/2051A61J1/2096B65D51/002Y10S215/03
    • A transfer set assembly for transferring fluids between a first container, such as a conventional medical vial, having a sealed open end and a second container such as a conventional IV infusion bag. The transfer set includes a collar having a proximate tubular end portion for securement to the container, a needle cannula and holder assembly, which is telescopically received in a distal tubular portion of the collar, and a closure including a tubular body portion having an open proximate end which is telescopically received over the needle cannula and holder assembly and the distal tubular portion of the collar, a closed distal end portion and an inner tubular portion which is integral with the closed distal end. The inner tubular portion includes a free end having spiral camming surfaces which mate with spiral camping surfaces on the inside surface of the tubular distal portion of the needle cannula holder. The tubular body portion of the closure includes lateral slots which receive projections on the collar and contiguous camming surface which extends toward the proximate open end of the closure. Rotation of the closure relative to the collar first drives the mating spiral camming surfaces of the closure and holder together, thereby driving the needle cannula and holder assembly axially to pierce the seal of the container. Continued rotation of the closure drives the projections on the collar against the contiguous angled camming surface, driving the closure from the collar and providing access to the needle cannula for transfer of fluids to a second container, such as an IV infusion bag.
    • 一种传送组件,用于在具有密封开口端的第一容器(例如常规医用小瓶)和诸如常规IV输液袋的第二容器之间传送流体。 转移组件包括具有用于固定到容器的近端管状端部的套环,套管和保持器组件,其可伸缩地容纳在套环的远端管状部分中,以及封闭件,该封闭件包括管状本体部分, 其可伸缩地容纳在针插管和保持器组件以及套环的远端管状部分,封闭的远端部分和与封闭的远端一体的内部管状部分。 内部管状部分包括具有螺旋形凸轮表面的自由端,其与针管保持器的管状远端部分的内表面上的螺旋形露营表面配合。 封闭件的管状主体部分包括横向狭槽,其接收套环上的凸起和朝向闭合件的近端开口端延伸的邻接凸轮表面。 闭合件相对于套环的旋转首先将闭合件和保持器的配合的螺旋凸轮表面驱动到一起,从而轴向地驱动针插管和保持器组件以刺穿容器的密封。 闭合件的继续旋转驱动套环上的凸起抵靠邻接的倾斜的凸轮表面,从套环驱动闭合件,并提供对针插管的通路,以将流体传送到第二容器,例如IV输液袋。
    • 9. 发明授权
    • Resealable medical transfer set
    • 可再密封医疗转移套
    • US06945417B2
    • 2005-09-20
    • US10723531
    • 2003-11-26
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • A61J1/00A61J1/14A61J1/20B65D51/00B65D39/00B65D41/10B65D47/04
    • A61J1/1406A61J1/201A61J1/2096B65D51/002Y10S215/03
    • A transfer set for transferring fluid, including drugs, vaccines, medicaments, solutions and the like, between a first container, such as a conventional vial, and a second container, such as a conventional syringe having a unique multipurpose resealable member. The transfer set assembly includes an elastomeric tubular fluid transfer and resealable valve member preferably including an open end mounted on the pierceable closure or stopper of a vial and a generally closed distal end having a longitudinal slit and a piercing member is telescopically received within the fluid transfer valve member having a piercing end opposite the pierceable closure. The fluid transfer valve member is preferably formed of silicone and is surrounded by a generally tubular luer connector member having an open end mounted on the pierceable closure and a distal end having male luer threads. This assembly is enclosed within a cup-shaped closure and the assembly is retained to the first container or vial by a collar preferably secured to the vial by crimping. Upon removal of the cup-shaped closure, fluid communication between the vial and a second container, such as a syringe, is achieved by threading the luer connector of the syringe on the luer threads of the tubular luer connector member, which drives the tip through the slit of the elastomeric fluid transfer valve member against the distal end of the piercing member, driving the piercing end through the pierceable closure. In the preferred embodiment, the piercing member includes a generally longitudinal channel which establishes communication between the vial and the syringe through the tubular fluid transfer valve member.
    • 用于在诸如常规小瓶的第一容器和具有独特的多用途可再密封构件的常规注射器的第二容器之间传送流体的转移装置,包括药物,疫苗,药物,溶液等。 传送组件包括弹性体管状流体传送和可重新密封的阀构件,其优选地包括安装在小瓶的可刺穿的封闭件或塞子上的开口端,以及具有纵向狭缝的通常封闭的远端,并且穿孔构件可伸缩地容纳在流体传递 阀构件具有与可刺破的封闭件相对的穿刺端。 流体转移阀构件优选地由硅树脂形成,并且由通常管状的鲁尔连接器构件围绕,该连接器构件具有安装在可刺穿闭合件上的开口端和具有阳性鲁尔螺纹的远端。 该组件被封闭在杯形封闭件内,并且组件通过优选通过卷曲固定到小瓶的套环而保持在第一容器或小瓶中。 在移除杯形封闭件时,小瓶和第二容器(例如注射器)之间的流体连通通过将注射器的鲁尔连接器穿过管状鲁尔连接器构件的鲁尔螺纹上来实现,该管路式鲁尔连接器构件驱动尖端通过 弹性体流体转移阀构件的狭缝抵靠穿孔构件的远端,将刺穿端驱动穿过可刺穿的闭合件。 在优选实施例中,刺穿构件包括大致纵向通道,其通过管状流体转移阀构件在小瓶和注射器之间建立连通。
    • 10. 发明授权
    • Transferset for vials and other medical containers
    • US06601721B2
    • 2003-08-05
    • US10060628
    • 2002-01-30
    • Hubert JansenJean-Claude Thibault
    • Hubert JansenJean-Claude Thibault
    • B65D3900
    • A61J1/2096A61J1/14A61J1/1406A61J1/1425A61J1/201A61J1/2086B65D51/002Y10S215/03
    • An improved transferset assembly for transferring fluids between a first container, such as a medicament vial and a second container, such as a syringe, which includes an integral polymeric transfer assembly having a tubular collar portion, a radial portion overlying the rim of the first container, an outer tubular portion and an inner tubular portion which is integrally joined to the outer tubular portion by a radial intermediate web portion, a piercing member telescopically received in the inner tubular portion having a piercing end to pierce the closure sealing the open end of the first container and a removable closure which seals the open ends of the outer and inner tubular portions of the transfer assembly. The tubular collar portion, which may be separate from the inner and outer tubular portions, is formed of composite polymer including a relatively soft polymer and a relatively rigid polymer, such that the free end of the collar portion may be deformed radially inwardly or crimped into the neck of the first container, yet sufficiently rigid to retain its shape following deformation and resistant to creep to maintain a seal between the transfer assembly and the first container. The proximate end of the inner tubular portion includes a sharp edge which seals against the closure of the first container. The preferred embodiment of the closure is frangibly connected to the free end of the outer tubular portion of the transfer assembly and provides a biological seal.