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1. 发明授权

US08119118B2 Helper virus-free herpesvirus amplicon particles and uses thereof 失效
标题翻译：辅助无病毒的疱疹病毒扩增子颗粒及其用途
公开(公告)号：US08119118B2
公开(公告)日：2012-02-21
申请号：US11244726
申请日：2005-10-05
申请人： Howard J. Federoff , William J. Bowers , John G. Frelinger , Richard A. Willis , Thomas G. Evans , Stephen Dewhurst , Khaled A. Tolba , Joseph D. Rosenblatt
发明人： Howard J. Federoff , William J. Bowers , John G. Frelinger , Richard A. Willis , Thomas G. Evans , Stephen Dewhurst , Khaled A. Tolba , Joseph D. Rosenblatt
IPC分类号： A01N63/00 , A61K48/00 , G09B5/04
CPC分类号： C12N15/86 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/54 , A61K2039/55522 , A61K2039/55561 , A61K2039/57 , C07K14/005 , C07K14/70575 , C12N7/00 , C12N2710/16622 , C12N2710/16643 , C12N2710/16662
摘要： The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.
摘要翻译：本发明具有新的无病毒无病毒方法，用于制备可用于免疫疗法的疱疹病毒扩增子颗粒，包括用于治疗任何数量的感染性疾病和癌症（包括慢性淋巴细胞性白血病，血细胞变为恶性的其他癌症，淋巴瘤（例如，霍奇金淋巴瘤或非霍奇金淋巴瘤）本文描述了制备无辅助病毒的HSV扩增子颗粒的方法;含有这些颗粒的细胞（例如包装细胞系或患者细胞，体内或离体感染）;产生的颗粒根据这些方法;以及根据这些方法制备的具有hf-HSV颗粒的患者的治疗方法。

2. 发明授权

US07451927B2 Multimode system and apparatus for locating lost items 有权
标题翻译：用于定位丢失物品的多模系统和装置
公开(公告)号：US07451927B2
公开(公告)日：2008-11-18
申请号：US11369162
申请日：2006-03-07
申请人： Jan R. Saperstein , Richard A. Willis
发明人： Jan R. Saperstein , Richard A. Willis
IPC分类号： G06F19/00
CPC分类号： G06Q10/087 , G06Q10/08
摘要： An apparatus for locating an item includes a mesh network communication device, a global positioning satellite chipset, a cellular telecommunications modem, a digital memory that stores a unique identification and a processor. The processor is programmed to determine the location of the item based on an input from the global positioning satellite chipset. If a mesh network connection is available, then processor transmits the unique identification and the location of the item to a requester via the mesh network, otherwise the processor registers with a wireless communication network with the cellular telecommunications modem and transmits the unique identification and the location of the item to a requester via the wireless communication network.
摘要翻译：用于定位物品的设备包括网状网络通信设备，全球定位卫星芯片组，蜂窝电信调制解调器，存储唯一标识和处理器的数字存储器。处理器被编程为基于来自全球定位卫星芯片组的输入来确定物品的位置。如果网状网络连接可用，则处理器通过网状网络将唯一标识和项目的位置发送到请求者，否则处理器向蜂窝电信调制解调器向无线通信网络注册，并且发送唯一标识和位置通过无线通信网络向请求者发送该项目。

3. 发明授权

US4984571A Collapsible tanning booth 失效
标题翻译：可折叠鞣制展位
公开(公告)号：US4984571A
公开(公告)日：1991-01-15
申请号：US370337
申请日：1989-06-22
申请人： Jack F. Springer, Jr. , Timothy S. Smith , Cathy A. Cloutier , Ben A. Marcantonio , Richard A. Willis
发明人： Jack F. Springer, Jr. , Timothy S. Smith , Cathy A. Cloutier , Ben A. Marcantonio , Richard A. Willis
IPC分类号： A61N5/06
CPC分类号： A61N5/0614 , A61N2005/0636 , A61N2005/0655 , A61N2005/0665
摘要： A collapsible tanning booth comprises at least two rear lamp units and at least two front lamp units, each of the units having a thin long casing that includes rear, side, top and bottom walls and a front panel, the front panel being of a material transmissive to ultraviolet light, a reflector panel adjacent the rear wall and lamps mounted between the reflector panel and the front panel. The rear lamp units are hinged together along their adjacent side walls so that they can be moved between a storage configuration in which they are substantially aligned transversely and a use configuration in which they are oblique transversely to each other. The laterally outermost front units are hinged along their laterally outermost side walls to the laterally outermost side walls of the rear lamp units so that the front units can be moved between a storage configuration in which they reside face to face against the rear lamp units and a use configuration in which they are disposed oblique to the rear lamp units and to each other. Two adjacent front lamp units, however, are unattached to each other to enable pivotal movement of such units about their hinges apart from each other to provide an opening for access by a person to a space defined by the units in their use configuration.
摘要翻译：可折叠的鞣制房间包括至少两个后灯单元和至少两个前灯单元，每个单元具有包括后侧，侧壁，顶壁和底壁以及前面板的薄长的外壳，前面板是材料对紫外线透射，邻近后壁的反射板和安装在反射板与前面板之间的灯。后灯单元沿其相邻的侧壁铰接在一起，使得它们可以在它们在其中基本上对准的存储构造和在它们彼此横向倾斜的使用构型之间移动。横向最外侧的前单元沿其横向最外侧的侧壁铰接到后灯单元的横向最外侧的侧壁上，使得前单元可以在它们面对面抵靠后灯单元的存储构型之间移动，并且使用它们配置成与后灯单元相互倾斜地配置。然而，两个相邻的前灯单元彼此不相连，以使得这些单元绕其铰链彼此分开地枢转运动，以提供用于人们进入由它们的使用构型中的单元限定的空间的开口。

4. 发明授权

US5316765A Use of coenzyme Q.sub.10 in combination with HMG-CoA reductase inhibitor therapies 失效
标题翻译：使用辅酶Q10与HMG-CoA还原酶抑制剂疗法组合使用
公开(公告)号：US5316765A
公开(公告)日：1994-05-31
申请号：US762312
申请日：1991-09-19
申请人： Karl A. Folkers , Per H. Langsjoen , Richard A. Willis
发明人： Karl A. Folkers , Per H. Langsjoen , Richard A. Willis
IPC分类号： A61K31/365 , A61K45/00 , A61K31/12 , A61K31/35 , A61K31/405
CPC分类号： A61K31/365 , Y10S514/922
摘要： Disclosed are methods for inhibiting the side effects attendant treatment with HMG-CoA reductase inhibitors. Treatment of a patient with and HMG-CoA reductase inhibitor in combination with coenzyme Q.sub.10 provides a reduction in patient cholesterol levels and guards against typical HMG-CoA reductase-inhibitor side effects, most notably liver dysfunction and cardiac dysfunction. The combination of lovastatin, an HMG-CoA reductase inhibitor, and coenzyme Q.sub.10 in ratios of between 1:2 to 1:29 provide significant enhancement of a patient's caridac condition. By way of example, other HMG-CoA reductase inhibitors which may be included in the claimed combinations include pravastatin, compactin, fluvastatin, dalvastatin, simvastatin, BMY 22089, GR-95030, HR-780, CI-981, SQ 33,600, and BMY 22566 and XU-62-320.
摘要翻译：公开了抑制伴随HMG-CoA还原酶抑制剂的副作用的方法。用HMG-CoA还原酶抑制剂与辅酶Q10联合治疗可降低患者胆固醇水平，防止典型的HMG-CoA还原酶抑制剂副作用，尤其是肝功能障碍和心脏功能障碍。洛伐他汀，HMG-CoA还原酶抑制剂和辅酶Q10的比例在1:2至1:29之间的组合提供了对患者的caridac病症的显着增强。作为实例，可以包括在所要求保护的组合中的其它HMG-CoA还原酶抑制剂包括普伐他汀，美伐他汀，氟伐他汀，达伐他汀，辛伐他汀，BMY 22089，GR-95030，HR-780，CI-981，SQ 33,600和BMY 22566和XU-62-320。

5. 发明授权

US4745559A Method and system for dynamically controlling the content of a local receiver data base from a transmitted data base in an information retrieval communication network 失效
标题翻译：用于在信息检索通信网络中从发送的数据库动态地控制本地接收机数据库的内容的方法和系统
公开(公告)号：US4745559A
公开(公告)日：1988-05-17
申请号：US813703
申请日：1985-12-27
申请人： Richard A. Willis , Alan Markham , Robert S. Genshaft
发明人： Richard A. Willis , Alan Markham , Robert S. Genshaft
IPC分类号： G06F17/30 , G06K15/00 , G06F15/20
CPC分类号： G06Q40/04 , G06F17/3056 , G06F17/30575
摘要： A method and system (28) are provided for dynamically controlling the content of a local receiver data base (24, 26) from a transmitter data base (20) in an information retrieval communication network (28) in which a message transmitter transmitting the transmitter data base (20) dynamically provides data base messages over a message distribution network (22) to local receivers receiving the local receiver data bases (24, 26). The transmitter data base (20) messages are used to incrementally increase and decrease the content of the local receiver data base (24, 26) on a record-by-record basis. In addition, non-data base messages may also be provided. The data base messages consist of displayable data as well as file maintenance messages. Storage templates (42) are retrievably stored at the local receiver data base (24, 26). These storage templates (42) are locally retrieved based on receipt of a unique identifier. Each stored record (40) has a unique associated storage template (42) although a storage template (42) may be corresponding to several different records (40 ). Set identifiers defining multiple field identifiers of information fields and ripple chains, which chains require a change in only one field in the ripple chain to be transmitted, are used by the local receiver data base (24, 26) in conjunction with transmitted update record data base messages (54) to reduce the communications capacity that is required.
摘要翻译：提供了一种方法和系统（28），用于在信息检索通信网络（28）中的发射机数据库（20）中动态地控制本地接收机数据库（24,26）的内容，其中发送发射机数据库（20）通过消息分发网络（22）向接收本地接收机数据库（24,26）的本地接收机动态地提供数据基消息。发射机数据库（20）消息用于逐个地增加和减少本地接收机数据库（24,26）的内容。此外，还可以提供非数据库消息。数据库消息由可显示数据和文件维护消息组成。存储模板（42）被可检索地存储在本地接收机数据库（24,26）处。这些存储模板（42）基于唯一标识符的接收被本地检索。每个存储的记录（40）具有唯一的相关联的存储模板（42），尽管存储模板（42）可以对应于几个不同的记录（40）。设置定义信息字段和纹波链的多个字段标识符的标识符，链路需要仅在要发送的纹波链中的一个字段中的改变，由本地接收机数据库（24,26）结合发送的更新记录数据使用基本消息（54）以减少所需的通信容量。

6. 发明授权

US07717338B2 Cargo hold item identification and monitoring system 有权
标题翻译：货物物品识别和监控系统
公开(公告)号：US07717338B2
公开(公告)日：2010-05-18
申请号：US11422461
申请日：2006-06-06
申请人： Jan R. Saperstein , Richard A. Willis
发明人： Jan R. Saperstein , Richard A. Willis
IPC分类号： G06K7/00
CPC分类号： G07C9/00111 , G06Q10/06 , G06Q10/08 , G06Q10/087
摘要： In an apparatus for identifying items in a cargo hold, having an entrance that is accessible by a user, each of the items includes an individual mesh network communication device and each individual mesh network communication device includes a memory that stores a unique item identification. The apparatus includes a primary mesh network communications device and a portable computational device in data communication with the primary mesh network communication device. A frame separates the primary mesh network communications device from the portable computational device at a distance that enables the user to hold the portable computational device and to direct the mesh network communications device to the entrance of the cargo hold.
摘要翻译：在用于识别货舱中的物品的设备中，具有可由用户访问的入口，每个物品包括单独的网格网络通信设备，并且每个单独的网格网络通信设备包括存储唯一的物品识别的存储器。该设备包括主网状网络通信设备和与主网状网络通信设备进行数据通信的便携式计算设备。帧将主网状网络通信设备与便携式计算设备隔开一定距离，使得用户能够保持便携式计算设备并将网状网络通信设备引导到货舱的入口。

7. 发明授权

US07416123B2 System and apparatus for locating lost items 有权
标题翻译：用于定位丢失物品的系统和设备
公开(公告)号：US07416123B2
公开(公告)日：2008-08-26
申请号：US11303791
申请日：2005-12-16
申请人： Jan R. Saperstein , Richard A. Willis
发明人： Jan R. Saperstein , Richard A. Willis
IPC分类号： G06K7/00
CPC分类号： G06Q10/087
摘要： An apparatus for locating an item at a node includes an item-specific location device disposed in association with the item and that includes a circuit that uniquely identifies the item. A fixed mesh network communication device, in communication with a computer, is in an item storage portion of the node. The computer is programmed to execute the following steps: if an item identification request is received from a requester via a global computer network including a requested item identification, then send an item identification message to the fixed mesh network communication device. If an item identified message is received from the fixed mesh network communication device indicating that the item-specific location device corresponds to the requested item identification, then transmit to the requester, via the global computer network, an item identified notification and a location identification that identifies the node.
摘要翻译：用于在节点处定位物品的装置包括与物品相关联地设置的物品特定位置装置，并且包括唯一地识别物品的电路。与计算机通信的固定网状网络通信设备位于节点的项目存储部分中。计算机被编程为执行以下步骤：如果经由包括所请求的项目标识的全局计算机网络从请求者接收到项目标识请求，则向固定网格网络通信设备发送项目标识消息。如果从固定网格网络通信设备接收到项目识别消息，指示项目特定位置设备对应于所请求的项目标识，则经由全局计算机网络向请求者发送项目识别通知和位置标识，识别节点。

8. 发明申请

US20070138274A1 Cargp Hold Item Identification and Monitoring System 有权
标题翻译：仓库物品识别和监控系统
公开(公告)号：US20070138274A1
公开(公告)日：2007-06-21
申请号：US11422461
申请日：2006-06-06
申请人： Jan R. Saperstein , Richard A. Willis
发明人： Jan R. Saperstein , Richard A. Willis
IPC分类号： G06Q30/00 , G07B15/02
CPC分类号： G07C9/00111 , G06Q10/06 , G06Q10/08 , G06Q10/087
摘要： In an apparatus for identifying items in a cargo hold, having an entrance that is accessible by a user, each of the items includes an individual mesh network communication device and each individual mesh network communication device includes a memory that stores a unique item identification. The apparatus includes a primary mesh network communications device and a portable computational device in data communication with the primary mesh network communication device. A frame separates the primary mesh network communications device from the portable computational device at a distance that enables the user to hold the portable computational device and to direct the mesh network communications device to the entrance of the cargo hold.
摘要翻译：在用于识别货舱中的物品的设备中，具有可由用户访问的入口，每个物品包括单独的网格网络通信设备，并且每个单独的网格网络通信设备包括存储唯一的物品识别的存储器。该设备包括主网状网络通信设备和与主网状网络通信设备进行数据通信的便携式计算设备。帧将主网状网络通信设备与便携式计算设备隔开一定距离，使得用户能够保持便携式计算设备并将网状网络通信设备引导到货舱的入口。

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