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1. 发明授权

US11440971B2 Fc-region variants with modified FcRn-binding and methods of use 有权
公开(公告)号：US11440971B2
公开(公告)日：2022-09-13
申请号：US16868972
申请日：2020-05-07
申请人： Hoffmann-La Roche Inc.
发明人： Ekkehard Moessner , Tilman Schlothauer
IPC分类号： C07K16/46 , C07K16/00
摘要： Herein is reported an IgG class Fc-region comprising a first variant Fc-region polypeptide and a second variant Fc-region polypeptide, wherein a) the first variant Fc-region polypeptide is derived from a first parent IgG class Fc-region polypeptide and the second variant Fc-region polypeptide is derived from a second parent IgG class Fc-region polypeptide, whereby the first parent IgG class Fc-region polypeptide is identical to or different from the second parent IgG class Fc-region polypeptide, and b) the first variant Fc-region polypeptide differs from the second variant Fc-region polypeptide in one or more amino acid residues other than those amino acid residues in which the first parent IgG class Fc-region polypeptide differs from the second parent IgG class Fc-region polypeptide, and c) the IgG class Fc-region comprising the first variant Fc-region polypeptide and the second variant Fc-region polypeptide has an affinity to a human Fc-receptor that is different than that of an IgG class Fc-region comprising the first parent IgG class Fc-region polypeptide of a) and the second parent IgG class Fc-region polypeptide of a), wherein either the first Fc-region polypeptide or the second Fc-region polypeptide or both Fc-region polypeptides comprise independently of each other one of the following mutations or combination of mutations: T307H, or Q311H, or E430H, or N434H, or T307H and Q311H, or T307H and E430H, or T307H and N434A, or T307H and N434H, or T307Q and Q311H, or T307Q and E430H, or T307Q and N434H, or T307H and Q311H and E430H and N434A, or T307H and Q311H and E430H and N434H, or T307H and Q311H and E430H and N434Y, or T307Q and Q311H and E430H and N434A, or T307Q and Q311H and E430H and N434H, or T307Q and Q311H and E430H and N434Y, or T307Q and V308P and N434Y and Y436H, or T307H and M252Y and S254T and T256E, or T307Q and M252Y and S254T and T256E, or Q311H and M252Y and S254T and T256E, or E430 H and M252Y and S254T and T256E, or N434H and M252Y and S254T and T256E, or T307H and Q311H and M252Y and S254T and T256E, or T307H and E430H and M252Y and S254T and T256E, or T307H and N434A and M252Y and S254T and T256E, or T307H and N434H and M252Y and S254T and T256E, or T307Q and Q311H and M252Y and S254T and T256E, or T307Q and E430H and M252Y and S254T and T256E, or T307Q and N434H and M252Y and S254T and T256E, or T307H and Q311H and E430H and N434A and M252Y and S254T and T256E, or T307H and Q311H and E430H and N434H and M252Y and S254T and T256E, or T307H and Q311H and E430H and N434Y and M252Y and S254T and T256E, or T307Q and Q311H and E430H and N434A and M252Y and S254T and T256E, or T307Q and Q311H and E430H and N434H and M252Y and S254T and T256E, or T307Q and Q311H and E430H and N434Y and M252Y and S254T and T256E, or T307Q and V308P and N434Y and Y436H and M252Y and S254T and T256E.

2. 发明申请

US20220267395A1 ANTIGEN BINDING MOLECULES COMPRISING A TRIMERIC TNF FAMILY LIGAND 有权
公开(公告)号：US20220267395A1
公开(公告)日：2022-08-25
申请号：US17455617
申请日：2021-11-18
申请人： Hoffmann-La Roche Inc.
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Pablo Umana
IPC分类号： C07K14/525 , C07K16/40 , C07K16/28 , C07K14/705 , C07K16/30 , A61K39/395
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) a polypeptide comprising three ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by peptide linkers and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

3. 发明授权

US11286300B2 Humanized anti-human CD19 antibodies and methods of use 有权
公开(公告)号：US11286300B2
公开(公告)日：2022-03-29
申请号：US15763868
申请日：2016-09-30
申请人： Hoffmann-La Roche Inc.
发明人： Claudia Ferrara Koller , Guy Georges , Alexander Haas , Hubert Kettenberger , Ekkehard Moessner , Tilman Schlothauer , Michael Molhoj , Laurent Lariviere
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K16/28 , C07K1/00
摘要： Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.

4. 发明授权

US11267903B2 Antigen-binding molecules comprising a tumor necrosis factor (TNF) family ligand trimer 有权
公开(公告)号：US11267903B2
公开(公告)日：2022-03-08
申请号：US16522412
申请日：2019-07-25
申请人： Hoffmann-La Roche Inc.
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/28 , C07K14/705 , A61K39/395 , A61K38/00 , C07K16/40 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

5. 发明申请

US20210139571A1 HUMANIZED ANTI-TAU(PS422) ANTIBODIES AND METHODS OF USE 有权
公开(公告)号：US20210139571A1
公开(公告)日：2021-05-13
申请号：US17023963
申请日：2020-09-17
申请人： Hoffmann-La Roche Inc.
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.

6. 发明申请

US20210054021A1 STABILIZED IMMUNOGLOBULIN DOMAINS 有权
公开(公告)号：US20210054021A1
公开(公告)日：2021-02-25
申请号：US16943067
申请日：2020-07-30
申请人： Hoffmann-La Roche Inc.
发明人： Laura Deak Codarri , Stefan Dengl , Jens Fischer , Thomas Hofer , Laurent Lariviere , Ekkehard Moessner , Stefan Seeber , Pablo Umana , Anne-Claire Zagdoun
IPC分类号： C07K1/04 , C07K16/30 , C07K16/28 , C07K16/40
摘要： The invention relates autonomous VH domains (aVH) with cysteines in positions 52a and 71 or in positions 33 and 52 in order to stabilize the autonomous VH domains. Said cysteines are capable of forming a disulfide bond and/or form a disulfide bond under suitable conditions. The invention further relates to aVH libraries.

7. 发明授权

US10766967B2 Bispecific T cell activating antigen binding molecules 有权
公开(公告)号：US10766967B2
公开(公告)日：2020-09-08
申请号：US15281484
申请日：2016-09-30
申请人： Hoffmann-La Roche Inc.
发明人： Marina Bacac , Tanja Fauti , Sabine Imhof-Jung , Christian Klein , Stefan Klostermann , Ekkehard Moessner , Michael Molhoj , Christiane Neumann , Joerg Thomas Regula , Wolfgang Schaefer , Pablo Umana
IPC分类号： A61K39/00 , C07K16/30 , C07K16/28 , C07K16/46
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

8. 发明授权

US10745470B2 Modified anti-tenascin antibodies and methods of use 有权
公开(公告)号：US10745470B2
公开(公告)日：2020-08-18
申请号：US16186418
申请日：2018-11-09
申请人： Hoffmann-La Roche Inc.
发明人： Ralf Hosse , Ekkehard Moessner , Pablo Umana
IPC分类号： A61P35/00 , C07K16/18 , C12N15/85 , A61K38/00
摘要： The present invention relates to improved antibodies specific for Tenascin-C (TnC), in particular domain specific anti-TnC antibodies with improved cross-species reactivity. In addition, the invention relates to polynuleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies and methods of using them in the treatment of disease.

9. 发明申请

US20190382507A1 ANTIGEN BINDING MOLECULES COMPRISING A TNF FAMILY LIGAND TRIMER 审中-公开
公开(公告)号：US20190382507A1
公开(公告)日：2019-12-19
申请号：US16522412
申请日：2019-07-25
申请人： Hoffmann-La Roche Inc.
发明人： Maria Amann , Peter Bruenker , Christina Claus , Claudia Ferrara Koller , Sandra Grau-Richards , Christian Klein , Viktor Levitski , Ekkehard Moessner , Joerg Thomas Regula , Pablo Umana
IPC分类号： C07K16/40 , C07K16/28 , C07K14/705 , A61K39/395 , C07K16/30
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) at least one moiety capable of specific binding to a target cell antigen and (b) a first and a second polypeptide that are linked to each other by a disulfide bond, characterized in that the first polypeptide comprises two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and in that the second polypeptide comprises only one ectodomain of said TNF ligand family member or a fragment thereof.

10. 发明申请

US20190248916A1 Antibodies binding To HLA-A2/WT1 审中-公开
公开(公告)号：US20190248916A1
公开(公告)日：2019-08-15
申请号：US16228102
申请日：2018-12-20
申请人： Hoffmann-La Roche Inc.
发明人： Joerg Benz , Christian Klein , Stefan Klostermann , Ekkehard Moessner , Johannes Sam , Pablo Umaña , Lydia Jasmin Hanisch , Alexander Bujotzek , Wei Xu
IPC分类号： C07K16/30 , C07K16/28 , A61K35/00
CPC分类号： C07K16/3038 , A61K35/00 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K16/2833 , C07K16/32 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present invention generally relates to antibodies that bind to HLA-A2/WT1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

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