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1. 发明申请

US20090047685A1 ULTRAHIGHLY SENSITIVE DETERMINATION REAGENT FOR C-REACTIVE PROTEIN AND DETERMINATION METHOD 审中-公开
标题翻译：用于C反应蛋白的超声敏感性测定试剂和测定方法
公开(公告)号：US20090047685A1
公开(公告)日：2009-02-19
申请号：US12095429
申请日：2006-06-02
申请人： Hideki Kohno , Masahiro Ogawa
发明人： Hideki Kohno , Masahiro Ogawa
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/54313 , G01N33/569 , G01N33/6893 , G01N2333/4737 , G01N2800/08 , G01N2800/24
摘要： The present invention is related to an ultrahighly sensitive determination reagent for C-reactive protein (CRP) for use in determination of CRP in a test sample with high sensitivity; and a CRP determination method using the reagent. A reagent for determining C-reactive protein containing an insoluble carrier particle loading an antibody directed to the C-reactive protein via an amino acid; and a method for determining a C-reactive protein including the steps of reacting the reagent with an antigenic substance in a test sample, and determining a resulting aggregate.
摘要翻译：本发明涉及一种高灵敏度的用于C-反应蛋白（CRP）的超高灵敏度测定试剂，用于测定样品中CRP的灵敏度; 和使用该试剂的CRP测定方法。一种用于测定含有通过氨基酸负载针对C反应蛋白的抗体的不溶性载体颗粒的C-反应蛋白的试剂; 以及用于测定C反应蛋白的方法，包括在试样中使试剂与抗原物质反应的步骤，并测定所得的骨料。

2. 发明授权

US5109197A Nuclear magnetic resonance multi-echo imaging method and apparatus 失效
标题翻译：核磁共振多重成像方法和装置
公开(公告)号：US5109197A
公开(公告)日：1992-04-28
申请号：US578766
申请日：1990-09-07
申请人： Takashi Onodera , Hidemi Shiono , Hideki Kohno
发明人： Takashi Onodera , Hidemi Shiono , Hideki Kohno
IPC分类号： A61B5/055 , G01R33/48 , G01R33/565
CPC分类号： G01R33/56554
摘要： A nuclear magnetic resonance multi-echo imaging method and an apparatus therefor in which gradient field pulses having predetermined products of intensity and time are applied on both sides of an inversion pulse in at least two of three directions which are orthogonal to each other to dephase components of a magnetization vector which leads to an artifact signal and an error signal, whereby only a normal echo signal can be sampled to form a correct image.

3. 发明授权

US4937201A Latex reagent for detection of the toxin of clostridium difficile 失效
标题翻译：用于检测艰难梭菌毒素的乳胶试剂
公开(公告)号：US4937201A
公开(公告)日：1990-06-26
申请号：US495487
申请日：1983-05-17
申请人： Kazue Ueno , Hideki Kohno , Satoshi Tsutsui
发明人： Kazue Ueno , Hideki Kohno , Satoshi Tsutsui
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/54393 , G01N33/54313 , G01N33/56916 , Y10S435/842
摘要： Latex particles are sensitized with Immunoglobulin G obtained from the antiserum collected from a laboratory animal which has been immunized with a toxin extracted from pathogenic enterobacterium. The IgG-sensitized latex is useful for diagnosis of diseases caused by pathogenic enterobacteria.
摘要翻译：用从用从病原性肠杆菌提取的毒素免疫的实验室动物中收集的抗血清获得的免疫球蛋白G使乳胶颗粒致敏。 IgG致敏乳胶可用于诊断由致病肠杆菌引起的疾病。

4. 发明授权

US4791369A Method of measuring magnetic field error of an NMR imaging apparatus and of correcting distortion caused by the error 失效
标题翻译：测量NMR成像设备的磁场误差并校正由误差引起的失真的方法
公开(公告)号：US4791369A
公开(公告)日：1988-12-13
申请号：US72035
申请日：1987-07-10
申请人： Etsuji Yamamoto , Hideki Kohno
发明人： Etsuji Yamamoto , Hideki Kohno
IPC分类号： A61B5/055 , A61B10/00 , G01R33/24 , G01R33/48 , G01R33/565 , G01R33/20
CPC分类号： G01R33/24 , G01R33/56563 , G01R33/56518
摘要： A method of finding error distribution in the static magnetic field and distribution of deviations from straight lines in the gradient magnetic fields of an NMR imaging apparatus which employs the applied spin-warp method. A phantom whose shape has been known is measured in the read-out gradient magnetic fields having different polarities to obtain two spin density distribution images. The two images are then compared with the shape of said phantom to measure the distortion distributions of the images. Error in the static magnetic field and deviations of the gradient magnetic fields from the straight lines are analyzed from the distortion distributions. From the thus obtained error distribution, furthermore, distortion induced in imaging the object is estimated, and the distortion contained in the image that is reconstructed from the spin density of the object by the spin-warp method is corrected using the thus estimated value.
摘要翻译：在使用所采用的旋转翘曲方法的NMR成像装置的梯度磁场中找到静态磁场中的误差分布和偏离直线偏差的方法。在具有不同极性的读出梯度磁场中测量其形状已知的体模，以获得两个自旋密度分布图像。然后将两个图像与所述体模的形状进行比较，以测量图像的失真分布。从失真分布中分析静态磁场的误差和梯度磁场与直线的偏差。此外，根据这样得到的误差分布，估计在物体成像时引起的失真，并且使用这样估计的值来校正通过旋转扭曲方法从物体的自旋密度重构的图像中包含的失真。

5. 发明授权

US4777443A Inspection apparatus based on nuclear magnetic resonance 失效
标题翻译：基于核磁共振的检测装置
公开(公告)号：US4777443A
公开(公告)日：1988-10-11
申请号：US119489
申请日：1987-11-12
申请人： Masao Yabusaki , Etsuji Yamamoto , Takashi Onodera , Yukiko Ogura , Hideaki Nakane , Shigeru Matsui , Hideki Kohno
发明人： Masao Yabusaki , Etsuji Yamamoto , Takashi Onodera , Yukiko Ogura , Hideaki Nakane , Shigeru Matsui , Hideki Kohno
IPC分类号： G01R33/035 , G01R33/36 , G01R33/20
CPC分类号： G01R33/326 , G01R33/0358
摘要： Disclosed in a nuclear magnetic resonance (NMR) based inspection apparatus using an SQUID flux meter for detecting a small NMR signal, in which a receiving coil for receiving the NMR signal from an object is connected to a mixer, which mixes a reference high-frequency signal with the NMR signal so that the NMR signal is reduced to a low-frequency signal having a differential component of frequencies of both signals, and the low-frequency signal is applied to the input coil of the SQUID flux meter so that it is converted into a voltage signal. The mixer circuit includes Schottky diodes operative at a liquid helium temperature or Josephson junctions, and the portions of apparatus from the reception coil up to the SQUID flux meter are operated in a superconductive state at a liquid helium temperature.
摘要翻译：在使用SQUID通量计检测小型NMR信号的基于核磁共振（NMR）的检查装置中公开了一种用于从物体接收NMR信号的接收线圈连接到混频器，该混频器将参考高频用NMR信号进行信号，使得NMR信号被减少到具有两个信号的频率的差分分量的低频信号，并且低频信号被施加到SQUID通量计的输入线圈，使得其被转换变成电压信号。混频器电路包括以液氦温度或约瑟夫逊结操作的肖特基二极管，并且从接收线圈到SQUID通量计的装置部分在液氦温度下处于超导状态。

6. 发明授权

US4689568A NMR chemical shift imaging method 失效
标题翻译： NMR化学位移成像方法
公开(公告)号：US4689568A
公开(公告)日：1987-08-25
申请号：US750475
申请日：1985-07-01
申请人： Shigeru Matsui , Kensuke Sekihara , Hideki Kohno , Takashi Onodera , Hidemi Shiono
发明人： Shigeru Matsui , Kensuke Sekihara , Hideki Kohno , Takashi Onodera , Hidemi Shiono
IPC分类号： G01R33/44 , A61B5/055 , A61B10/00 , G01R33/48 , G01R33/485 , G01R33/561 , G01R33/20
CPC分类号： G01R33/485 , G01R33/5616
摘要： An NMR imaging method which provides a three-dimensional image representative of the two-dimensional distribution of nuclear spin species resolved by chemical shift or the local spectra resolved by two-dimensional location. After the excitation of nuclear spins and the phase-encoding by application of a field gradient G.sub.y, a periodically inverting field gradient G.sub.x is generated to yield a continuous echo train. The echo train is sampled and separated into data of odd-numbered echoes and data of even-numbered echoes which data are in turn reconstructed into two-dimensional data arrays, respectively. The data thus reconstructed are three-dimensional Fourier-transformed.
摘要翻译：提供表示通过化学位移分解的核自旋物质的二维分布的三维图像的NMR成像方法或通过二维位置解析的局部光谱。在核自旋的激励和通过施加场梯度Gy的相位编码之后，产生周期性反转场梯度Gx以产生连续的回波串。回波串被采样并分离成奇数回波的数据和偶数回波的数据，数据又分别被重建成二维数据阵列。这样重建的数据是三维傅里叶变换的。

7. 发明授权

US4683433A Imaging method and apparatus using nuclear magnetic resonance 失效
标题翻译：使用核磁共振的成像方法和装置
公开(公告)号：US4683433A
公开(公告)日：1987-07-28
申请号：US636995
申请日：1984-08-02
申请人： Etsuji Yamamoto , Hideki Kohno , Masao Kuroda , Shigeru Matsui , Hidemi Shiono
发明人： Etsuji Yamamoto , Hideki Kohno , Masao Kuroda , Shigeru Matsui , Hidemi Shiono
IPC分类号： G01R33/20 , A61B5/055 , A61B10/00 , G01R33/48 , G01R33/54 , G01R33/56
CPC分类号： G01R33/482 , G01R33/56
摘要： An NMR imaging apparatus and method for detecting a nuclear spin resonance signal from an object, which is placed in a magnetic field, to produce images of the object. At an instant when the spins come into phase after the signal detection by a first spin excitation, RF magnetic field pulses are applied for rotating the direction of the spin to that opposite to the initial state. After that, the spin excitation and the signal direction of second time are conducted to measure the data which are different in the effect of the relaxation time from the first measurements. By repeating these sequences, it is possible to produce a plurality of images such as an intensity image or a relaxation time enhanced image.
摘要翻译：一种用于检测放置在磁场中的物体的核自旋共振信号的NMR成像设备和方法，以产生物体的图像。在通过第一自旋激发在信号检测之后自旋进入相位的瞬间，施加RF磁场脉冲以将旋转方向旋转到与初始状态相反的方向。之后，进行自旋激励和第二次的信号方向，以测量与第一次测量相比，松弛时间的影响不同的数据。通过重复这些序列，可以产生多个图像，例如强度图像或弛豫时间增强图像。

8. 发明授权

US4625170A NMR imaging method and apparatus 失效
标题翻译： NMR成像方法和装置
公开(公告)号：US4625170A
公开(公告)日：1986-11-25
申请号：US635154
申请日：1984-07-27
申请人： Etsuji Yamamoto , Shigeru Matsui , Masuo Kuroda , Hideki Kohno
发明人： Etsuji Yamamoto , Shigeru Matsui , Masuo Kuroda , Hideki Kohno
IPC分类号： G01R33/20 , A61B5/055 , A61B10/00 , G01R33/48 , G01R33/565
CPC分类号： G01R33/56518
摘要： An NMR imaging method and apparatus of the type in which a 180-degree RF pulse is applied to generate a spin echo after the selective excitation of a spin by a 90-degree RF pulse. A dummy gradient field, which has the same direction and intensity as those of a gradient field to be applied when the spin echo is observed, is applied between said 90-degree RF pulse and said 180-degree RF pulse so that the instant of starting the application of the gradient field for signal observation is advanced to the extent corresponding to said dummy gradient field.
摘要翻译：一种NMR成像方法和装置，其中施加180度RF脉冲以在旋转选择性激发90度RF脉冲之后产生自旋回波。在所述90度RF脉冲和所述180度RF脉冲之间，施加与观察到自旋回波时要施加的梯度场相同的方向和强度的虚拟梯度场，使得起始时刻将用于信号观察的梯度场的应用提前到对应于所述虚拟梯度场的程度。

9. 发明授权

US4607164A Radiation detecting apparatus 失效
标题翻译：辐射检测装置
公开(公告)号：US4607164A
公开(公告)日：1986-08-19
申请号：US517402
申请日：1983-07-26
申请人： Shigeo Kubota , Minoru Yoshida , Toshio Takahashi , Hideki Kohno , Takayuki Hayakawa , Sadao Matuoka , Shigeo Kato , Takaji Suzuki
发明人： Shigeo Kubota , Minoru Yoshida , Toshio Takahashi , Hideki Kohno , Takayuki Hayakawa , Sadao Matuoka , Shigeo Kato , Takaji Suzuki
IPC分类号： G01T1/164 , G01T1/20 , G01T1/202
CPC分类号： G01T1/202 , G01T1/1644 , G01T1/2018
摘要： A radiation detecting apparatus includes a pair of substrates disposed face to face in such a manner that a plurality of grooves provided in one of the facing surfaces at a predetermined interval face a plurality of grooves provided in the other of the facing surfaces at the predetermined interval. Radiation shielding plates are inserted at both ends thereof into a facing pair of grooves to be held by both of the substrates, scintillators are mounted on a corresponding one of the radiation shielding plates, and photodetectors are fixed to either one of the facing surfaces of the substrates between adjacent grooves so that a plurality of facing pairs of photodetectors are juxtaposed.
摘要翻译：放射线检测装置包括一对基板，以这样一种方式设置，使得以预定间隔设置在一个相对表面中的多个凹槽面对设置在另一个相对表面中的预定间隔的多个凹槽。辐射屏蔽板的两端插入到由两个基板保持的面对的一对沟槽中，闪烁体安装在相应的一个辐射屏蔽板上，光电检测器固定在相邻槽之间的衬底，使得多个面对的光电检测器对并置。

10. 发明授权

US4472683A Imaging apparatus using nuclear magnetic resonance 失效
标题翻译：使用核磁共振成像设备
公开(公告)号：US4472683A
公开(公告)日：1984-09-18
申请号：US420303
申请日：1982-09-20
申请人： Kensuke Sekihara , Etsuji Yamamoto , Hideki Kohno , Shinji Yamamoto
发明人： Kensuke Sekihara , Etsuji Yamamoto , Hideki Kohno , Shinji Yamamoto
IPC分类号： A61B10/00 , A61B5/055 , G01R33/48 , G01R33/54 , G01R33/08
CPC分类号： G01R33/4833
摘要： An imaging apparatus using nuclear magnetic resonance is disclosed in which both an image corresponding to the projection of a nuclear spin distribution in a to-be-inspected object on a two-dimensional plane and a display mark indicating a desired measuring position are displayed on a display face of a display device such as a CRT display, the display mark is freely moved on the display face to be set at a desired position on the display face, and magnetic field generating means for generating a static magnetic field, linear gradient field, or radio frequency magnetic field is controlled on the basis of the desired position of the display mark to obtain an image of that cross section of the object which is located at a position indicated by the display mark.
摘要翻译：公开了一种使用核磁共振的成像装置，其中在二维平面上的被检查物体中的核自旋分布的投影和指示期望的测量位置的显示标记的图像都显示在 CRT显示器等显示装置的显示面，在显示面上自由移动显示标记，将其设定在显示面上的期望位置，产生静磁场，线性梯度场，或者基于显示标记的期望位置来控制射频磁场，以获得位于由显示标记指示的位置处的对象的该横截面的图像。

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