会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 6. 发明申请
    • Chemical Process
    • 化学工艺
    • US20070219371A1
    • 2007-09-20
    • US10599377
    • 2005-03-29
    • Ulf LarssonKajsa Radevik
    • Ulf LarssonKajsa Radevik
    • C07D239/46
    • C07D239/47
    • The present invention provides a process for the preparation of a compound of formula (I): wherein X is halogen; Y is ZR1; Z is oxygen or sulphur; and R1 is C1-6 alkyl, C1-6 haloalkyl or C3-7 cycloalkyl; the process comprising either: a. hydrogenating a compound of formula (II): with a suitable transition metal catalyst in a C1-6 aliphatic alcohol, an ether, an ester or a hydrocarbon as solvent; or, b. conducting a one-pot hydrogenation of a compound of formula (III): wherein R2 is phenyl optionally substituted by chloro, C1-6 alkyl, C1-6 alkoxy or (C1-6 alkyl)2N; i. firstly at about 20° C. to form a compound of formula (IV): ii. and then at about 40° C.; both steps (i) and (ii) being carried out in the presence of a suitable catalyst and in the presence of a suitable solvent.
    • 本发明提供制备式(I)化合物的方法:其中X是卤素; Y是ZR <1; Z是氧或硫; 且R 1是C 1-6烷基,C 1-6 - 卤代烷基或C 3-7环烷基; 该过程包括:a。 将式(II)化合物用适合的过渡金属催化剂在C 1-6脂族醇,醚,酯或烃作溶剂中氢化; 或者,b。 进行式(III)化合物的一锅氢化:其中R 2是任选被氯,C 1-6烷基,C 1〜 -6个烷氧基或(C 1-6烷基)2 N; 一世。 首先在约20℃下形成式(IV)的化合物:ii。 然后在约40℃。 步骤(i)和(ii)都在合适的催化剂存在下和在合适的溶剂存在下进行。