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1. 发明授权

US06640805B2 Metering valve for a metered dose inhaler having improved flow 失效
公开(公告)号：US06640805B2
公开(公告)日：2003-11-04
申请号：US10100641
申请日：2002-03-19
申请人： Gustavo H. Castro , Thomas Herdtle , Cathleen M. Arsenault , Antony J. Davis
发明人： Gustavo H. Castro , Thomas Herdtle , Cathleen M. Arsenault , Antony J. Davis
IPC分类号： A61M1100
CPC分类号： B65D83/54 , A61M15/0065
摘要： A novel metering valve having improved flow for delivery of an aerosol formulation is disclosed. Methods of delivering an aerosol formulation using a device comprising the novel metering valve are also disclosed.

2. 发明授权

US08764279B2 Y-cross mixers and fluid systems including the same 有权
标题翻译： Y交叉混合器和包括其的流体系统
公开(公告)号：US08764279B2
公开(公告)日：2014-07-01
申请号：US13054130
申请日：2009-07-15
申请人： Gustavo H. Castro , Christopher R. Kokaisel
发明人： Gustavo H. Castro , Christopher R. Kokaisel
IPC分类号： B81B1/00
CPC分类号： B01F5/0645 , B01F13/0059
摘要： Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing.
摘要翻译：包含一个或多个静态混合器的静态混合器和流体系统。静态混合器包括在体内形成的混合结构，其中流过混合结构的流体通过混合结构限定下游方向。混合结构包括一系列Y形通道，其交叉以提供导致有效混合的流动路径。

3. 发明申请

US20110179887A1 SAMPLE ACQUISITION DEVICE 审中-公开
标题翻译：样本获取设备
公开(公告)号：US20110179887A1
公开(公告)日：2011-07-28
申请号：US12867100
申请日：2009-02-12
申请人： Paul J. Cobian , G. Marco Bommarito , Bernard A. Gonzalez , Tushar A. Kshirsagar , Patrick A. Mach , Tera M. Nordby , Gustavo H. Castro , Joseph J. Stoffel , Murat Okcay , Scott A. Burton
发明人： Paul J. Cobian , G. Marco Bommarito , Bernard A. Gonzalez , Tushar A. Kshirsagar , Patrick A. Mach , Tera M. Nordby , Gustavo H. Castro , Joseph J. Stoffel , Murat Okcay , Scott A. Burton
IPC分类号： G01N1/10
CPC分类号： A61B10/0291 , A61B10/0051 , A61B17/32002 , A61B2010/0054 , A61B2010/0208 , A61B2017/320008
摘要： A sample acquisition device includes a body comprising a plurality of sample acquisition regions defined by at least a first wall and a second wall oriented nonparallel to the first wall. In some embodiments, the body defines a plurality of apertures that define a plurality of sample acquisition regions. In other embodiments, the walls extend from the body, and the sample acquisition regions are defined between the walls. The sample acquisition regions may be configured in some embodiments such that a user may acquire a sample by rotating the body in a first direction relative to a sample source and may release the sample by rotating the body in a second direction that is substantially opposite to the first direction. When rotated in the first direction, at least one of the first or second walls defines a surface that is inclined into a sample acquisition region.
摘要翻译：样品采集装置包括主体，其包括由至少第一壁和不平行于第一壁定向的第二壁限定的多个样品采集区域。在一些实施例中，主体限定了限定多个样本采集区域的多个孔。在其他实施例中，壁从主体延伸，并且样品采集区域被限定在壁之间。可以在一些实施例中配置样本采集区域，使得用户可以通过相对于样本源沿第一方向旋转身体来获取样本，并且可以通过沿与第二方向基本上相反的第二方向旋转身体来释放样本第一个方向当沿第一方向旋转时，第一或第二壁中的至少一个限定了倾斜成样品采集区域的表面。

4. 发明申请

US20110097814A1 DETECTION DEVICES AND METHODS 审中-公开
标题翻译：检测装置和方法
公开(公告)号：US20110097814A1
公开(公告)日：2011-04-28
申请号：US12743522
申请日：2008-11-20
申请人： G. Marco Bommarito , Joseph J. Stoffel , Vinod P. Menon , Brinda B. Lakshmi , Timothy J. Diekmann , Gustavo H. Castro , Paul J. Cobian , Raj Rajagopal , Patrick A. Mach
发明人： G. Marco Bommarito , Joseph J. Stoffel , Vinod P. Menon , Brinda B. Lakshmi , Timothy J. Diekmann , Gustavo H. Castro , Paul J. Cobian , Raj Rajagopal , Patrick A. Mach
IPC分类号： G01N21/00 , B01J19/00
CPC分类号： B01L3/5027 , B01L3/5023 , B01L2200/0684 , B01L2300/0825 , B01L2300/0867 , B01L2300/0887 , B01L2400/0406 , B01L2400/0487 , G01N33/542 , G01N33/54366
摘要： The application discloses embodiments of detection devices including a sensor component in a flow path between a first flow path portion and a second flow path portion. In embodiments described, the sensor component includes a receptor in a polymerized composition. The receptor is configured to bind with an analyte in a test sample. Upon binding the sensor component undergoes a detectable change in response to interaction of the analyte with the receptor.
摘要翻译：本申请公开了一种检测装置的实施例，其包括在第一流路部分和第二流路部分之间的流动路径中的传感器部件。在所描述的实施方案中，传感器组分包括聚合组合物中的受体。受体被配置为与测试样品中的分析物结合。当结合时，传感器组件响应于分析物与受体的相互作用而经历可检测的变化。

5. 发明申请

US20110176965A1 Y-CROSS MIXERS AND FLUID SYSTEMS INCLUDING THE SAME 有权
标题翻译： Y-CROSS MIXERS和流体系统，包括它们
公开(公告)号：US20110176965A1
公开(公告)日：2011-07-21
申请号：US13054130
申请日：2009-07-15
申请人： Gustavo H. Castro , Christopher R. Kokaisel
发明人： Gustavo H. Castro , Christopher R. Kokaisel
IPC分类号： B01F5/06 , G01N33/53
CPC分类号： B01F5/0645 , B01F13/0059
摘要： Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include a mixing structure formed within a body, wherein fluid flowing through the mixing structure defines a downstream direction through the mixing structure. The mixing structure includes a series of Y-shaped channels that cross to provide flowpaths that result in efficient mixing.
摘要翻译：包含一个或多个静态混合器的静态混合器和流体系统。静态混合器包括在体内形成的混合结构，其中流过混合结构的流体通过混合结构限定下游方向。混合结构包括一系列Y形通道，其交叉以提供导致有效混合的流动路径。

6. 发明申请

US20110158852A1 OFFSET PATH MIXERS AND FLUID SYSTEMS INCLUDNG THE SAME 审中-公开
标题翻译：偏差路径混合器和流体系统包括相同
公开(公告)号：US20110158852A1
公开(公告)日：2011-06-30
申请号：US13054129
申请日：2009-07-15
申请人： Gustavo H. Castro , Paul J. Cobian
发明人： Gustavo H. Castro , Paul J. Cobian
IPC分类号： G01N30/00 , B01F5/06
CPC分类号： B01F13/0059 , B01F5/0641 , B01F5/0682 , B01F5/0688
摘要： Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers include one or more channels that provide a fluid path through a body, wherein fluid flowing through each channel defines a downstream direction through the channel. The channel includes two or more sets of concatenated mixing elements arranged adjacent to each other across the width of the channel, wherein two sets of the mixing elements are offset from each other along the downstream direction of the channel.
摘要翻译：包含一个或多个静态混合器的静态混合器和流体系统。静态混合器包括提供通过主体的流体路径的一个或多个通道，其中流过每个通道的流体限定通过通道的下游方向。通道包括跨越通道的宽度彼此相邻布置的两组或更多组连接的混合元件，其中两组混合元件沿着通道的下游方向彼此偏移。

7. 发明申请

US20110146419A1 SAMPLE ACQUISITION DEVICE 失效
标题翻译：样本获取设备
公开(公告)号：US20110146419A1
公开(公告)日：2011-06-23
申请号：US12867146
申请日：2009-02-10
申请人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
发明人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： G01N1/02 , A61B10/0045 , G01N2001/028
摘要： A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.
摘要翻译：样品采集装置包括毛细管阵列，该毛细管阵列构造成吸取样品并通过毛细管作用保留样品。毛细管阵列可以耦合到细长构件，例如杆或中空管，其限定沿第一方向延伸的纵向轴线。在一些实施例中，毛细管阵列限定沿与第一方向不同的第二方向延伸的主要样本采集表面。可以选择毛细管阵列保留的主要样品采集表面积与最大体积的比率以使毛细管阵列和样品之间的物理结合最小化。在一些实施例中，装置可以包括反馈机构，以指示使用样本采集装置施加到样本源的相对压力。此外，在一些实施例中，样品采集装置可以包括抽吸源以帮助将样品吸入毛细管阵列。

8. 发明授权

US06245007B1 Blood pump 有权
标题翻译：血泵
公开(公告)号：US06245007B1
公开(公告)日：2001-06-12
申请号：US09239440
申请日：1999-01-28
申请人： William Bedingham , Bernard A. Gonzalez , Gustavo H. Castro
发明人： William Bedingham , Bernard A. Gonzalez , Gustavo H. Castro
IPC分类号： A61M112
CPC分类号： A61M1/102 , A61M1/1008 , A61M1/101 , A61M1/1012 , A61M1/1017 , A61M1/1034 , A61M1/122 , A61M1/125
摘要： A blood pump comprising a pump mechanism having an outer sleeve, an inner sleeve, and an impeller. The pump mechanism is movable between a closed and preferably retracted position wherein one or both of an inlet port and an outlet port are sealed by the inner and/or outer sleeve for inserting the pump mechanism into the heart, and an open and preferably extended position wherein the inlet and outlet ports are open to allow the impeller to pump blood through the ports. The pump mechanism preferably retracts so that it has less length and is more readily maneuvered when it is in its closed position. Also disclosed are a bearing portion received within a cap of the impeller with a flow of lubricating liquid between the bearing portion and cap, and a method of using the pump.
摘要翻译：一种血泵，包括具有外套筒，内套筒和叶轮的泵机构。泵机构可以在闭合和优选缩回位置之间移动，其中入口端口和出口端口中的一个或两个由内部和/或外部套筒密封，用于将泵机构插入到心脏中，并且打开且优选地延伸的位置其中入口和出口是敞开的，以允许叶轮泵送血液通过端口。泵机构优选地缩回，使得其具有较小的长度并且当其处于其关闭位置时更容易操纵。还公开了一种容纳在叶轮的盖中的轴承部分，其具有在轴承部分和盖之间的润滑液流，以及使用该泵的方法。

9. 发明授权

US08677843B2 Sample acquisition device 失效
标题翻译：样品采集装置
公开(公告)号：US08677843B2
公开(公告)日：2014-03-25
申请号：US12867146
申请日：2009-02-10
申请人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
发明人： Bernard A. Gonzalez , G. Marco Bommarito , Paul J. Cobian , Tera M. Nordby , Tushar A. Kshirsagar , Scott A. Burton , Joseph J. Stoffel , Patrick A. Mach , Gustavo H. Castro
IPC分类号： G01N1/10
CPC分类号： G01N1/02 , A61B10/0045 , G01N2001/028
摘要： A sample acquisition device includes a capillary array configured to draw in a sample and retain the sample by capillary action. The capillary array may be coupled to an elongated member, such as a stem or a hollow tube, which defines a longitudinal axis extending in a first direction. In some embodiments, the capillary array defines a major sample acquisition surface that extends in a second direction different than the first direction. A ratio of the major sample acquisition surface area to maximum volume retained by the capillary array may be selected to minimize physical binding between the capillary array and sample. In some embodiments, the device may include a feedback mechanism to indicate the relative pressure applied to a sample source with the sample acquisition device. In addition, in some embodiments, the sample acquisition device may include a suction source to help draw the sample into the capillary array.
摘要翻译：样品采集装置包括毛细管阵列，该毛细管阵列构造成吸取样品并通过毛细管作用保留样品。毛细管阵列可以耦合到细长构件，例如杆或中空管，其限定沿第一方向延伸的纵向轴线。在一些实施例中，毛细管阵列限定沿与第一方向不同的第二方向延伸的主要样本采集表面。可以选择毛细管阵列保留的主要样品采集表面积与最大体积的比率以使毛细管阵列和样品之间的物理结合最小化。在一些实施例中，装置可以包括反馈机构，以指示使用样本采集装置施加到样本源的相对压力。此外，在一些实施例中，样品采集装置可以包括抽吸源以帮助将样品吸入毛细管阵列。

10. 发明申请

US20110150703A1 TORTUOUS PATH STATIC MIXERS AND FLUID SYSTEMS INCLUDING THE SAME 审中-公开
标题翻译：压缩机静态混合器和流体系统，包括它们
公开(公告)号：US20110150703A1
公开(公告)日：2011-06-23
申请号：US13054126
申请日：2009-07-15
申请人： Gustavo H. Castro , Paul J. Cobian
发明人： Gustavo H. Castro , Paul J. Cobian
IPC分类号： B01F5/06 , G01N33/00
CPC分类号： B01F5/061 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F2005/0621 , B01F2005/0636
摘要： Static mixers and fluid systems incorporating one or more of the static mixers. The static mixers may include one or more channels that provide a tortuous path through a body, wherein fluid flowing through each channel defines a downstream direction through the tortuous path created within the channel. The tortuous path of the channel is preferably formed by a set of flow obstacles protruding into the channel and a set of flow restrictions positioned along the channel between the inlet and the outlet. Each flow restriction has a downstream length over which the open cross-sectional area of the channel decreases and then increases when moving in the downstream direction.
摘要翻译：包含一个或多个静态混合器的静态混合器和流体系统。静态混合器可以包括提供通过主体的曲折路径的一个或多个通道，其中流过每个通道的流体限定通过在通道内产生的曲折路径的下游方向。通道的曲折路径优选地由突出到通道中的一组流动障碍物和沿入口和出口之间的通道定位的一组流动限制形成。每个流动限制具有下游长度，通道的开放截面积减小，然后在沿下游方向移动时增加。

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