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1. 发明申请

US20070037897A1 Method for making contact lenses 审中-公开
标题翻译：隐形眼镜的制作方法
公开(公告)号：US20070037897A1
公开(公告)日：2007-02-15
申请号：US11500721
申请日：2006-08-08
申请人： Guigui Wang , Dawn Smith , Juergen Vogt , John Lally , Brian Devlin
发明人： Guigui Wang , Dawn Smith , Juergen Vogt , John Lally , Brian Devlin
IPC分类号： B29D11/00 , G02B1/04
CPC分类号： B29C33/60 , B29C33/62 , B29D11/00134 , B29D11/00192 , G02B1/043
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a non-crosslinkable hydrophilic polymer into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the non-crosslinkable hydrophilic polymer and to provide a disparity of about 10 N or less in mold separation force. The non-crosslinkable hydrophilic polymer has a limited miscibility with the lens-forming material low enough to successfully and timely form an intact interfacial film with a sufficient thickness at an interface between the mold and the fluid composition therein, and has a structure that minimizes entanglement of the non-crosslinkable hydrophilic polymer in the interfacial film with the polymer matrix of the formed lens.
摘要翻译：本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。本发明的方法包括将不可交联的亲水性聚合物添加到包含透镜形成材料的流体组合物中，该透镜形成材料的量足以将平均的模具分离力减小至少约40％，与没有不可交联的亲水性并且在模具分离力中提供约10N或更小的差异。不可交联的亲水性聚合物与透镜形成材料的混溶性有限，足够低以在模具和其中的流体组合物之间的界面处成功地及时地形成具有足够厚度的完整界面膜，并且具有最小化缠结的结构的界面膜中的不可交联的亲水聚合物与形成的透镜的聚合物基体。

2. 发明申请

US20050013842A1 Antimicrobial medical devices 有权
标题翻译：抗微生物医疗器械
公开(公告)号：US20050013842A1
公开(公告)日：2005-01-20
申请号：US10891407
申请日：2004-07-14
申请人： Yongxing Qiu , John Lally
发明人： Yongxing Qiu , John Lally
IPC分类号： A61L27/54 , G02B1/04 , A61F2/00
CPC分类号： G02B1/043 , A01N59/16 , A61L12/088 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/442 , A61L2300/624 , B29D11/00038 , B82Y30/00
摘要： The present invention provides methods for making an antimicrobial medical device, preferably an antimicrobial ophthalmic device, more preferably an antimicrobial extended-wear contact lens, which contains silver nano-particles distributed uniformly therein. The antimicrobial medical device can exhibit antimicrobial activity over an extended period of time.
摘要翻译：本发明提供了制备抗微生物医疗器械，优选抗微生物眼科装置，更优选抗微生物延长耐磨隐形眼镜的方法，该隐形眼镜含有均匀分布的银纳米颗粒。抗微生物医疗装置可以在长时间内显示出抗菌活性。

3. 发明申请

US20070032869A1 Method and apparatus for applying a coating to an ophthalmic lens 审中-公开
标题翻译：将涂层施加到眼科镜片的方法和装置
公开(公告)号：US20070032869A1
公开(公告)日：2007-02-08
申请号：US11543695
申请日：2006-10-05
申请人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
发明人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
IPC分类号： A61F2/16
CPC分类号： B29D11/00317 , B29D11/00903 , G02B1/10
摘要： The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.
摘要翻译：本发明提供了一种将涂层施加到眼用透镜或用于制造眼科镜片或除眼镜之外的医疗装置的模具的方法。该方法包括使用选自空气辅助雾化和分配过程，超声波辅助雾化和分配过程，压电辅助雾化和分配过程的喷雾方法将至少一层涂布液体喷涂到眼科镜片上工艺，机电喷射印刷工艺，压电喷墨印刷工艺，静压喷射印刷工艺的压电和热喷涂印刷工艺。涂层可以包括性质/功能性图案或彩色图像或两者的组合。

4. 发明申请

US20060251696A1 Ophthalmic devices for sustained delivery of active compounds 有权
标题翻译：用于持续递送活性化合物的眼科装置
公开(公告)号：US20060251696A1
公开(公告)日：2006-11-09
申请号：US11416260
申请日：2006-05-02
申请人： Lynn Winterton , John Lally
发明人： Lynn Winterton , John Lally
IPC分类号： A61F13/00
CPC分类号： G02B1/043 , A61K9/0051 , B29D11/00038 , B29D11/00865 , C08L29/04
摘要： The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.
摘要翻译：本发明涉及具有以时间控制释放方式输送客体材料（例如润滑剂或药物）的能力的眼用产品。本发明还提供了制备本发明的眼用产品的方法。此外，本发明提供了药物或润滑剂的时间控制递送的方法。

5. 发明申请

US20050076831A1 Method and apparatus for applying a coating to an ophthalmic lens 审中-公开
标题翻译：将涂层施加到眼科镜片的方法和装置
公开(公告)号：US20050076831A1
公开(公告)日：2005-04-14
申请号：US10937140
申请日：2004-09-09
申请人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
发明人： Allen Gilliard , Lynn Winterton , Rafael Andino , John Lally
IPC分类号： G02C7/04 , B29D11/00 , G02B1/10 , B05D5/06 , B05C5/00
CPC分类号： B29D11/00317 , B29D11/00903 , G02B1/10
摘要： The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.
摘要翻译：本发明提供了一种将涂层施加到眼用透镜或用于制造眼科镜片或除眼镜之外的医疗装置的模具的方法。该方法包括使用选自空气辅助雾化和分配过程，超声波辅助雾化和分配过程，压电辅助雾化和分配过程的喷雾方法将至少一层涂布液体喷涂到眼科镜片上工艺，机电喷射印刷工艺，压电喷墨印刷工艺，静压喷射印刷工艺的压电和热喷涂印刷工艺。涂层可以包括性质/功能性图案或彩色图像或两者的组合。

6. 发明申请

US20080063898A1 Materials containing multiple layers of vesicles 有权
标题翻译：含有多层囊泡的材料
公开(公告)号：US20080063898A1
公开(公告)日：2008-03-13
申请号：US11981208
申请日：2007-10-31
申请人： John Lally , Nicholas Kotov
发明人： John Lally , Nicholas Kotov
IPC分类号： B05D7/00 , B32B9/00
CPC分类号： G02B1/043 , A61K9/127
摘要： The present invention provides a composite material, preferably an ophthalmic device, more preferably a contact lens, which comprises a vesicle-containing coating including at least one layer of a vesicle and one layer of a polyionic material having charges opposite the charges of the vesicle. Such composite material can find use in biomedical applications, for example, a device for localized drug delivery and an in vivo analyte sensor such as glucose sensing contact lens. By lifting off the vesicle-containing coating from a substrate, a self-standing membrane (film) capable of encapsulating a wide variety of guest materials can be prepared. In addition, the invention provides methods for making vesicle-containing composite and film materials of the present invention.
摘要翻译：本发明提供一种复合材料，优选眼科装置，更优选隐形眼镜，其包括含囊泡的涂层，其包含至少一层囊泡和一层具有与囊泡的电荷相反的电荷的聚离子材料。这种复合材料可用于生物医学应用，例如用于局部药物递送的装置和体内分析物传感器，例如葡萄糖感测隐形眼镜。通过从基材上取出含囊泡的涂层，可以制备能够包封各种客体材料的自立膜（膜）。另外，本发明提供了制造本发明的含囊泡复合材料和薄膜材料的方法。

7. 发明申请

US20050196520A1 Method for applying a coating to a medical device 有权
公开(公告)号：US20050196520A1
公开(公告)日：2005-09-08
申请号：US11029619
申请日：2005-01-05
申请人： Yongxing Qiu , Lynn Winterton , John Lally , Yasuo Matsuzawa , Rafael Andino , Allen Gilliard
发明人： Yongxing Qiu , Lynn Winterton , John Lally , Yasuo Matsuzawa , Rafael Andino , Allen Gilliard
IPC分类号： A61L27/34 , B05D1/18 , G02B1/10 , B05D5/06 , B05D3/00
CPC分类号： G02B1/10 , A61L27/34 , B05D1/18 , B29D11/00865 , Y10S134/901
摘要： This invention provides a method for efficiently applying a coating to each of a plurality of objects selected from the group consisting of ophthalmic lenses, molds for making ophthalmic lenses, and other medical devices, the method comprising dipping the plurality of objects into a coating bath containing a coating solution having a coating material; and creating with a means a convective current flow and thereby forcing a coating solution flowing over and under each of the plurality of ophthalmic lenses. In a preferred embodiment, the plurality of objects are held in baskets which are pre-conditioned to have a first layer of polyelectrolytes and a second layer of aqueous solution or have a mixed layer of polyelectrolytes and aqueous solution on the surfaces of the baskets.

8. 发明申请

US20050058844A1 Method for making medical devices having antimicrobial coatings thereon 有权
标题翻译：制造其上具有抗微生物涂层的医疗装置的方法
公开(公告)号：US20050058844A1
公开(公告)日：2005-03-17
申请号：US10732543
申请日：2003-12-10
申请人： Michael Rubner , Sung Yang , Yongxing Qiu , Lynn Winterton , John Lally
发明人： Michael Rubner , Sung Yang , Yongxing Qiu , Lynn Winterton , John Lally
IPC分类号： A61L27/34 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , G02B1/04 , B32B15/04
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having —COOAg groups and/or silver nanoparticles formed by reducing Ag+ ions associated with the —COO− groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译：本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， -COOAg基团和/或银纳米颗粒通过还原与负电聚合物材料的-COO - 基团相关的Ag +离子而形成。此外，本发明提供了根据本发明的方法制备的医疗装置。

9. 发明授权

US06811805B2 Method for applying a coating 有权
标题翻译：施加涂层的方法
公开(公告)号：US06811805B2
公开(公告)日：2004-11-02
申请号：US10154249
申请日：2002-05-22
申请人： Allen Gilliard , Lynn Cook Winterton , Rafael Victor Andino , John Lally
发明人： Allen Gilliard , Lynn Cook Winterton , Rafael Victor Andino , John Lally
IPC分类号： A61L5103
CPC分类号： B29D11/00317 , B29D11/00903 , G02B1/10
摘要： The invention provide a method for applying a coating to an ophthalmic lens or a mold for making the ophthalmic lens or a medical device other than ophthalmic lens. The method comprises spraying at least one layer of a coating liquid onto an ophthalmic lens using a spraying process selected from the group consisting of an air-assisted atomization and dispensing process, an ultrasonic-assisted atomization and dispensing process, a piezoelectric assisted atomization and dispensing process, an electro-mechanical jet printing process, a piezo-electric jet printing process, a piezo-electric with hydrostatic pressure jet printing process, and a thermal jet printing process. The coating can comprise a property/functionality pattern or a color image or combination of both.
摘要翻译：本发明提供了一种将涂层施加到眼用透镜或用于制造眼科镜片或除眼镜之外的医疗装置的模具的方法。该方法包括使用选自空气辅助雾化和分配过程，超声波辅助雾化和分配过程，压电辅助雾化和分配过程的喷雾方法将至少一层涂布液体喷涂到眼科镜片上工艺，机电喷射印刷工艺，压电喷墨印刷工艺，静压喷射印刷工艺的压电和热喷涂印刷工艺。涂层可以包括性质/功能性图案或彩色图像或两者的组合。

10. 发明授权

US06217171B1 Composite ophthamic lens 失效
标题翻译：复合光电透镜
公开(公告)号：US06217171B1
公开(公告)日：2001-04-17
申请号：US09084656
申请日：1998-05-26
申请人： Richard Dale Auten , John Lally , Xiao-Xiao Zhang
发明人： Richard Dale Auten , John Lally , Xiao-Xiao Zhang
IPC分类号： G02C704
CPC分类号： G02C7/02 , A61F2/142 , A61F2/145 , A61F2/16 , A61F2/1648 , A61F2250/0053 , B29D11/00048 , G02B1/043 , G02C7/041 , G02C7/049 , G02C7/12 , G02C2202/16 , G02C2202/20
摘要： The invention provides a molded ophthalmic lens having at least first and second optical components, wherein the first optical component is cast molded to encapsulate the second optical component such that the first optical component provides an optical function and the second optical component provides an additional optical function. The invention additionally provides a process for producing a molded composite ophthalmic lens.
摘要翻译：本发明提供一种具有至少第一和第二光学部件的模制眼科镜片，其中第一光学部件被铸造以封装第二光学部件，使得第一光学部件提供光学功能，并且第二光学部件提供附加的光学功能。本发明另外提供了一种用于生产模制复合眼科镜片的方法。

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