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1. 发明申请

US20080021027A1 Novel benzimidazole derivatives 失效
标题翻译：新型苯并咪唑衍生物
公开(公告)号：US20080021027A1
公开(公告)日：2008-01-24
申请号：US11821265
申请日：2007-06-22
申请人： Gregory Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer Martin , Eric Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Warot , Matthew Wright , Minmin Yang
发明人： Gregory Benson , Konrad Bleicher , Alexander Chucholowski , Henrietta Dehmlow , Uwe Grether , Bernd Kuhn , Rainer Martin , Eric Niesor , Narendra Panday , Hans Richter , Franz Schuler , Xavier Warot , Matthew Wright , Minmin Yang
IPC分类号： A61K31/4184 , A61K31/41 , A61K31/422 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/47 , A61K31/5377 , A61P1/16 , C07D211/12 , C07D215/20 , C07D235/26 , C07D257/04 , C07D261/12 , C07D285/06 , C07D401/04 , C07D413/10 , C07D413/14
CPC分类号： C07D235/18 , C07D235/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D413/04 , C07D417/06
摘要： The invention is concerned with novel benzimidazole derivatives of formula (I) wherein R1 to R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to Farnesoid-X-receptors (FXR) and can be used to treat diseases which are modulated by FXR agonists such as diabetes and dyslipidemia.
摘要翻译：本发明涉及式（I）的新的苯并咪唑衍生物，其中R 1至R 8如在说明书和权利要求书中所定义，以及生理上可接受的盐及其酯。这些化合物与法呢型-X受体（FXR）结合，可用于治疗由FXR激动剂如糖尿病和血脂异常调节的疾病。

2. 发明授权

US08271271B2 Method for bias compensation for cepstro-temporal smoothing of spectral filter gains 失效
标题翻译：用于频谱滤波器增益的频谱平滑的偏置补偿方法
公开(公告)号：US08271271B2
公开(公告)日：2012-09-18
申请号：US12504887
申请日：2009-07-17
申请人： Colin Breithaupt , Timo Gerkmann , Rainer Martin
发明人： Colin Breithaupt , Timo Gerkmann , Rainer Martin
IPC分类号： G10L11/04
CPC分类号： H04R25/505 , G10L21/0208 , H04R2225/43
摘要： A method for modification of a cepstro-temporally smoothed gain function of a gain function resulting in a bias compensated spectral gain function is provided. The cepstro-temporal smoothing increases the quality of an enhanced output signal, as it affects only spectral outliers caused by estimation errors, while the speech characteristics are well preserved. However, due to the cepstral transform, the temporal smoothing is done in the logarithmic domain rather than the linear domain, and hence results in a certain bias. Thus, the method for a general bias compensation for a cepstro-temporal smoothing of spectral filter gain functions that is only dependent on the lower limit of the spectral filter-gain function.
摘要翻译：提供了一种用于修改产生偏置补偿光谱增益功能的增益函数的后台平滑增益函数的方法。尖端时间平滑增加了增强的输出信号的质量，因为它仅影响由估计误差引起的频谱异常值，同时语音特征被良好地保留。然而，由于倒谱变换，在对数域而不是线性域中进行时间平滑，因此导致一定的偏差。因此，用于频谱滤波器增益函数的频谱平滑的通用偏置补偿的方法仅取决于频谱滤波器增益函数的下限。

3. 发明授权

US08026365B2 4,4-disubstituted piperidine derivatives 失效
标题翻译： 4,4-二取代哌啶衍生物
公开(公告)号：US08026365B2
公开(公告)日：2011-09-27
申请号：US12111230
申请日：2008-04-29
申请人： Andreas Christ , Rainer Martin , Peter Mohr
发明人： Andreas Christ , Rainer Martin , Peter Mohr
IPC分类号： A61K31/438 , C07D471/10
CPC分类号： C07D471/10 , C07D211/66 , C07D401/12
摘要： This invention relates to 4,4-disubstituted piperidine derivatives of the formula wherein A and R1 to R5 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译：本发明涉及下式的4,4-二取代哌啶衍生物，其中A和R 1至R 5如说明书中所定义，及其药学上可接受的盐。本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

4. 发明授权

US07448274B2 Pressure sensor having a pressure measuring cell with a platform and a measuring membrane 有权
标题翻译：压力传感器具有带有平台和测量膜的压力测量单元
公开(公告)号：US07448274B2
公开(公告)日：2008-11-11
申请号：US10566364
申请日：2004-07-16
申请人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
发明人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
IPC分类号： G01L7/00
CPC分类号： G01L19/003
摘要： A pressure sensor including: A pressure measuring cell having an end face loadable with the medium; a housing having a media opening and a ring-shaped, axial bearing surface, which surrounds the media opening; a clamping apparatus; and a ring-shaped sealing arrangement. The pressure measuring cell is positioned in the housing and the sealing arrangement is positioned between the bearing surface and the end face, and the sealing arrangement, as well as the pressure measuring cell, are axially clamped between the bearing surface and the clamping apparatus. The sealing arrangement includes, a decoupling ring, as well as a first and a second, ring-shaped sealing element. The first sealing element lies against the end face, the second sealing element lies against the bearing surface, and the decoupling ring is axially clamped between the first and the second sealing elements.
摘要翻译：一种压力传感器，包括：压力测量单元，其具有可与介质一起装载的端面; 壳体，其具有介质开口和围绕介质开口的环形的轴向支承表面; 夹紧装置; 和环形密封装置。压力测量单元位于壳体中，并且密封装置位于支承表面和端面之间，并且密封装置以及压力测量单元被轴向地夹紧在支承表面和夹紧装置之间。密封装置包括脱钩环以及第一和第二环形密封元件。第一密封元件靠在端面上，第二密封元件位于支承表面上，并且解耦环被轴向夹紧在第一和第二密封元件之间。

5. 发明授权

US5750899A Capacitive pressure sensor with sensing element mechanically isolated from the casing 失效
标题翻译：电容式压力传感器，其传感元件与外壳机械隔离
公开(公告)号：US5750899A
公开(公告)日：1998-05-12
申请号：US929030
申请日：1997-09-15
申请人： Frank Hegner , Elke Maria Schmidt , Ulfert Drewes , Rainer Martin
发明人： Frank Hegner , Elke Maria Schmidt , Ulfert Drewes , Rainer Martin
IPC分类号： G01L9/12 , G01L9/00 , G01L19/04 , G01L19/14 , G01L7/00 , G01L7/08
CPC分类号： G01L19/14 , G01L9/0075
摘要： To provide a flush-mounted and corrosion-resistant pressure sensor for measuring the pressure of a medium which, on the one hand, is very rugged and, on the other hand, has a casing (2) mechanically isolated from the sensing element (1) as perfectly as possible, and whose measured values exhibit little temperature dependence and little hysteresis, the casing (2) has an internal space (21) and is preferably pot-shaped for receiving the sensing element (1). An annular, particularly annular-disk-shaped, flexible connecting element (3), disposed between the casing (2) and the sensing element (1), and the sensing element close the interior space (21) toward the medium to be measured, and a liquid (4) fills the enclosed interior space (21).
摘要翻译：为了提供一种用于测量介质的压力的嵌入式和耐腐蚀的压力传感器，其一方面非常坚固，另一方面具有与传感元件（1）机械隔离的壳体（2）），并且其测量值显示出很小的温度依赖性和很小的滞后，所以壳体（2）具有内部空间（21），并且优选地是盆形以用于接收感测元件（1）。设置在壳体（2）和感测元件（1）之间的环形的，特别是环形的盘形的柔性连接元件（3），并且感测元件朝向要测量的介质关闭内部空间（21）并且液体（4）填充封闭的内部空间（21）。

6. 发明授权

US5572621A Speech signal processing device with continuous monitoring of signal-to-noise ratio 失效
标题翻译：具有连续监测信噪比的语音信号处理装置
公开(公告)号：US5572621A
公开(公告)日：1996-11-05
申请号：US308768
申请日：1994-09-19
申请人： Rainer Martin
发明人： Rainer Martin
IPC分类号： G10L15/00 , G10L15/20 , G10L21/02 , H04B7/26 , H04M1/00 , H04M1/60 , G10L3/02
CPC分类号： G10L21/0208 , G10L2021/02166
摘要： A mobile radio set includes a speech processing device for processing digital samples (x(i)) of speech signals which have noise components as well as speech components. Such device includes a control unit for continuously forming estimates of the signal-to-noise ratio of the speech signals by determining and smoothing the power values of the samples thereof, and determining the minimum of each successive group of L smoothed power values. The groups uninterruptedly succeed each other and each contains a sufficient number of smoothed power values so that all the values of a single group associated with a random phoneme of the speech signal can be combined. An estimate of the present signal-to-noise ratio is formed based on the present smoothed power value and the most recently determined minimum successive smoothed power value.
摘要翻译：移动无线电设备包括用于处理具有噪声分量以及语音分量的语音信号的数字样本（x（i））的语音处理设备。这种设备包括一个控制单元，用于通过确定和平滑其样本的功率值并确定每个连续的L个平滑功率值组的最小值来连续地形成语音信号的信噪比的估计。这些组不间断地相互成功，并且每个包含足够数量的平滑功率值，使得可以组合与语音信号的随机音素相关联的单个组的所有值。基于当前平滑功率值和最近确定的最小连续平滑功率值形成当前信噪比的估计。

7. 发明申请

US20130136805A1 FOAMABLE COMPOSITIONS OF STABILIZED CHLORITE 审中-公开
标题翻译：稳定化氯化物的可燃组合物
公开(公告)号：US20130136805A1
公开(公告)日：2013-05-30
申请号：US13816056
申请日：2011-08-12
申请人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin
发明人： Servet Buyuktimkin , Nadir Buyuktimkin , Edward T. Kisak , John M. Newsam , Dominic King-Smith , Jagat Singh , Rainer Martin
IPC分类号： A61K9/12
CPC分类号： A61K9/122 , A61K9/0014 , A61K33/00 , A61K47/02 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38
摘要： The present application relates to foamable compositions and foams comprising stabilized chlorite, including stabilized chlorite solutions such as Oxovasin™, and to medical uses thereof, in particular for wound healing. The foamable compositions comprise at least one foaming agent, stabilized chlorite, water and optionally, a buffering agent.
摘要翻译：本发明涉及可发泡组合物和包含稳定的亚氯酸盐的泡沫，包括稳定的亚氯酸盐溶液，例如Oxovasin TM，以及其医疗用途，特别是用于伤口愈合。可发泡组合物包含至少一种发泡剂，稳定的亚氯酸盐，水和任选的缓冲剂。

8. 发明授权

US08208666B2 Method for determining unbiased signal amplitude estimates after cepstral variance modification 失效
标题翻译：倒谱方差修正后确定无偏信号幅度估计的方法
公开(公告)号：US08208666B2
公开(公告)日：2012-06-26
申请号：US12684147
申请日：2010-01-08
申请人： Timo Gerkmann , Rainer Martin
发明人： Timo Gerkmann , Rainer Martin
IPC分类号： H04R25/00
CPC分类号： G10L21/0208 , G10L25/24
摘要： A method for determining unbiased signal amplitude estimates () after cepstral variance modification of a discrete time domain signal (s(t)), wherein the cepstrally-modified spectral amplitudes () of the discrete time domain signal (s(t)) are χ-distributed with 2{tilde over (μ)} degrees of freedom. A bias reduction factor (r) is determined using the equation r 2 = μ μ ~ ⁢ ⅇ ψ ⁡ ( μ ~ ) - ψ ⁡ ( μ ) , where 2μ are the degrees of freedom of the χ-distributed spectral amplitudes of the discrete time domain signal (s(t)) and ψ ⁡ ( x ) = - 0.5772 - ∑ n = 0 ∞ ⁢ ( 1 x + n - 1 1 + n ) ; then the unbiased signal amplitude estimates () are determined by multiplying the cepstrally-modified spectral amplitudes () with the bias reduction factor (r) according to the equation =r. A method for speech enhancement and a hearing aid use the method for determining unbiased signal amplitude estimates () in order to offer the advantage of spectral modification, such as smoothing, of spectral quantities without affecting their signal power.
摘要翻译：一种用于确定离散时域信号（s（t））的倒谱方差修正后的无偏信号幅度估计（）的方法，其中离散时域信号（s（t））的经频谱修正的频谱幅度（χ）为χ 分布为2（波形）超过（μ）}自由度。使用等式r 2 =μμ〜ψψ（μ〜）-ψ⁡（μ）确定偏置约简因子（r），其中2μ是离散时间的χ分布频谱幅度的自由度域信号（s（t））和ψ⁡（x）= - 0.5772 - Σn = 0∞（1 x + n - 1 1 + n）那么无偏信号幅度估计（）通过将倒频修正的频谱幅度（）与偏置简化因子（r）相乘来确定，方程式= r。用于语音增强和助听器的方法使用用于确定无偏信号幅度估计（）的方法，以便提供频谱修改的优点，例如频谱量化的平滑，而不影响其信号功率。

9. 发明申请

US20070028696A1 Pressure sensor 有权
标题翻译：压力传感器
公开(公告)号：US20070028696A1
公开(公告)日：2007-02-08
申请号：US10566364
申请日：2004-07-16
申请人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
发明人： Ulfert Drewes , Karl Floegel , Frank Hegner , Thomas Uehlin , Rainer Martin
IPC分类号： G01L7/00
CPC分类号： G01L19/003
摘要： A pressure sensor including: A pressure measuring cell having an end face loadable with the medium; a housing having a media opening and a ring-shaped, axial bearing surface, which surrounds the media opening; a clamping apparatus; and a ring-shaped sealing arrangement. The pressure measuring cell is positioned in the housing and the sealing arrangement is positioned between the bearing surface and the end face, and the sealing arrangement, as well as the pressure measuring cell, are axially clamped between the bearing surface and the clamping apparatus. The sealing arrangement includes, a decoupling ring, as well as a first and a second, ring-shaped sealing element. The first sealing element lies against the end face, the second sealing element lies against the bearing surface, and the decoupling ring is axially clamped between the first and the second sealing elements.
摘要翻译：一种压力传感器，包括：压力测量单元，其具有可与介质一起装载的端面; 壳体，其具有介质开口和围绕介质开口的环形的轴向支承表面; 夹紧装置; 和环形密封装置。压力测量单元位于壳体中，并且密封装置位于支承表面和端面之间，并且密封装置以及压力测量单元被轴向地夹紧在支承表面和夹紧装置之间。密封装置包括脱钩环以及第一和第二环形密封元件。第一密封元件靠在端面上，第二密封元件位于支承表面上，并且解耦环被轴向夹紧在第一和第二密封元件之间。

10. 发明授权

US5835607A Mobile radiotelephone with handsfree device 失效
标题翻译：手机无线电话免提设备
公开(公告)号：US5835607A
公开(公告)日：1998-11-10
申请号：US424257
申请日：1995-06-12
申请人： Rainer Martin , Kees Janse , Charles Knibbler , Walter Kellermann
发明人： Rainer Martin , Kees Janse , Charles Knibbler , Walter Kellermann
IPC分类号： H04M1/02 , H04M1/19 , H04M1/60 , H04R3/00 , H04R3/04 , H04B15/00
CPC分类号： H04M1/6075 , H04M1/19 , H04R3/005 , H04R3/04 , H04R2499/13
摘要： A mobile radio transceiver comprising a hands-free facility, which hands-free facility combines at least two acoustic input signals to produce an output signal, and an adaptive filter is provided for filtering the combined output signal. To achieve an improved speech quality, a high-pass filter is provided for filtering the acoustic input signals.
摘要翻译： PCT No.PCT / IB94 / 00265 Sec。 371日期：1995年6月12日 102（e）1995年6月12日PCT PCT 1994年9月7日PCT公布。公开号WO95 / 07597 日期1995年3月16日一种包括免提设施的移动无线电收发机，其免提设施组合至少两个声输入信号以产生输出信号，并且提供自适应滤波器以对组合的输出信号进行滤波。为了实现改进的语音质量，提供了用于对声输入信号进行滤波的高通滤波器。

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