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1. 发明授权

US07341652B2 Stationary capillary electrophoresis system 失效
标题翻译：固定毛细管电泳系统
公开(公告)号：US07341652B2
公开(公告)日：2008-03-11
申请号：US10601181
申请日：2003-06-20
申请人： George E. Barringer, Jr.
发明人： George E. Barringer, Jr.
IPC分类号： G01N27/447
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N27/44704 , Y10T436/25375 , B01D2311/12 , B01D2311/16 , B01D2311/2603
摘要： A system and method for capillary electrophoresis are provided for analyzing a macromolecule prepared from a complex liquid mixture. In particular applications, methods and apparatus are provided for separating and analyzing a solution containing a denatured macromolecule by employing a stationary capillary electrophoresis apparatus. An apparatus for capillary electrophoresis includes an inlet chamber and a capillary electrophoresis column. One end of the column is fixed at the interior of the inlet chamber. The column has a length of at least about 20 centimeters. Also included is a liquid source adapted for automatic control. The liquid source supplies a liquid sample through an input valve into the inlet chamber so that the sample is in fluid communication with the end of the column. A method for capillary electrophoresis includes automatically supplying the liquid sample to the apparatus.
摘要翻译：提供毛细管电泳的系统和方法，用于分析由复合液体混合物制备的大分子。特别是应用中，提供了一种使用固定式毛细管电泳装置分离和分析含有变性大分子的溶液的方法和装置。毛细管电泳装置包括入口室和毛细管电泳柱。塔的一端固定在入口室的内部。该柱具有至少约20厘米的长度。还包括适用于自动控制的液体源。液体源通过输入阀将液体样品提供到入口室中，使得样品与柱的端部流体连通。毛细管电泳的方法包括将液体样品自动供应给设备。

2. 发明授权

US07955843B2 Fluid interface for bioprocessor systems 失效
标题翻译：生物处理系统的流体界面
公开(公告)号：US07955843B2
公开(公告)日：2011-06-07
申请号：US11604440
申请日：2006-11-27
申请人： George E. Barringer, Jr.
发明人： George E. Barringer, Jr.
IPC分类号： C12M1/26 , C12M3/00 , G01N1/20 , G01N1/16
CPC分类号： G01N35/1097 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N27/44704 , Y10T137/4259 , Y10T137/4266 , B01D2311/12 , B01D2311/16
摘要： An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for automatic control and is coupled to a biofluid process site. A trap is at the sampling conduit. A waste valve, adapted for automatic control, is located at a waste conduit extending from the sampling conduit to a waste site. Also included is a wash fluid source that is coupled to at least one of the inlet or outlet valves. In the method, the sample is automatically directed to the biofluid process site by opening the outlet valve, and closing the waste valve. Also included is isolating the biofluid sites by closing the inlet and outlet valves, and opening the waste valve to drain biofluid from the trap to the waste site. Another step is cleaning the sampling conduit before sample collection by directing the wash fluid through at least one valve selected from the inlet and outlet valves, and subsequently through the waste valve to the waste site.
摘要翻译：提供了用于生物处理系统之间的无菌流体界面的装置和方法。该装置包括适于自动控制的入口阀，其连接到生物流体源部位。取样导管从入口阀延伸到出口阀。出口阀适用于自动控制，并连接到生物流体过程现场。陷阱位于采样管道处。适用于自动控制的废气阀位于从采样管道延伸到废物处所的废料管道处。还包括与至少一个入口阀或出口阀联接的洗涤流体源。在该方法中，通过打开出口阀并关闭废气阀，将样品自动导向生物流体过程现场。还包括通过关闭入口和出口阀来隔离生物流体位置，并打开废气阀以将生物流体从捕集器排出到废物处。另一步骤是在采样之前通过将洗涤流体引导至少一个选自入口阀和出口阀的阀，然后通过废气阀到废物部位来清洗取样管。

3. 发明授权

US07601545B2 Automated macromolecule sample preparation system 失效
标题翻译：自动化大分子样品制备系统
公开(公告)号：US07601545B2
公开(公告)日：2009-10-13
申请号：US10601277
申请日：2003-06-20
申请人： George E. Barringer, Jr.
发明人： George E. Barringer, Jr.
IPC分类号： G01N1/18 , B01D24/46 , B01D21/00 , B01L11/00 , G01N33/53
CPC分类号： G01N35/1097 , B01D61/14 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N1/4077 , G01N27/44704 , Y10S436/808 , Y10T436/25 , Y10T436/25375 , B01D2311/16 , B01D2311/18
摘要： An apparatus for preparing a macromolecule sample from a complex liquid mixture includes a hydraulic system adapted for control by an automated controller, comprising a pump and one or more valves. The hydraulic system can be controlled by an automated controller to apply the liquid mixture to one or more filters with a pressure differential across each filter. The filters include a rough filter selected to separate, from a macromolecule in a liquid mixture, at least a portion of one or more rough components in the mixture that are larger than the macromolecule. Further included is a fine filter selected to separate from the macromolecule at least a portion of one or more fine components in the mixture that are smaller than the macromolecule. A method for preparing a macromolecule sample includes automatically acquiring a liquid mixture, the mixture including a macromolecule. At least a portion of the other components in the mixture are automatically separated from the macromolecule by applying the mixture to each of one or more filters, with a pressure differential across each filter.
摘要翻译：用于从复杂液体混合物制备大分子样品的装置包括适于由自动控制器控制的液压系统，包括泵和一个或多个阀。液压系统可以由自动控制器控制，以将液体混合物施加到一个或多个过滤器上，并在每个过滤器上具有压差。过滤器包括粗选择的过滤器，其选择为从液体混合物中的大分子中分离混合物中大于大分子的一种或多种粗组分的至少一部分。进一步包括精选过滤器，其被选择为与大分子分离混合物中的一种或多种细小成分的至少一部分小于大分子。制备高分子样品的方法包括自动获取液体混合物，该混合物包括大分子。通过将混合物施加到一个或多个过滤器中的每一个上，通过每个过滤器上的压力差，将混合物中的至少一部分其它组分自动地与大分子分离。

4. 发明授权

US07169599B2 Fluid interface for bioprocessor systems 失效
标题翻译：生物处理系统的流体界面
公开(公告)号：US07169599B2
公开(公告)日：2007-01-30
申请号：US10601083
申请日：2003-06-20
申请人： George E. Barringer, Jr.
发明人： George E. Barringer, Jr.
IPC分类号： C12M1/36 , C12M1/38 , C12M3/00 , C12M1/26 , G01N1/20
CPC分类号： G01N35/1097 , B01D61/142 , B01D61/16 , B01D61/18 , B01D2311/04 , G01N1/2035 , G01N27/44704 , Y10T137/4259 , Y10T137/4266 , B01D2311/12 , B01D2311/16
摘要： An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for automatic control and is coupled to a biofluid process site. A trap is at the sampling conduit. A waste valve, adapted for automatic control, is located at a waste conduit extending from the sampling conduit to a waste site. Also included is a wash fluid source that is coupled to at least one of the inlet or outlet valves. In the method, the sample is automatically directed to the biofluid process site by opening the outlet valve, and closing the waste valve Also included is isolating the biofluid sites by closing the inlet and outlet valves, and opening the waste valve to drain biofluid from the trap to the waste site. Another step is cleaning the sampling conduit before sample collection by directing the wash fluid through at least one valve selected from the inlet and outlet valves, and subsequently through the waste valve to the waste site.
摘要翻译：提供了用于生物处理系统之间的无菌流体界面的装置和方法。该装置包括适于自动控制的入口阀，其连接到生物流体源部位。取样导管从入口阀延伸到出口阀。出口阀适用于自动控制，并连接到生物流体过程现场。陷阱位于采样管道处。适用于自动控制的废气阀位于从采样管道延伸到废物处所的废料管道处。还包括与至少一个入口阀或出口阀联接的洗涤流体源。在该方法中，通过打开出口阀并关闭废气阀，样品自动导向生物流体过程现场还包括通过关闭入口和出口阀来隔离生物流体位置，并打开废气阀以从生物流体排出生物流体陷入废物场地。另一步骤是在采样之前通过将洗涤流体引导至少一个选自入口阀和出口阀的阀，然后通过废气阀到废物部位来清洗取样管。

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