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    • 5. 发明申请
    • Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production
    • 用于生产适合疫苗生产的血液生物和寄生虫的装置和方法
    • US20070169209A1
    • 2007-07-19
    • US11726622
    • 2007-03-21
    • Stephen HoffmanThomas Luke
    • Stephen HoffmanThomas Luke
    • A01K67/033C12N1/10
    • A01K67/033
    • Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of Plasmodium species sporozoites in Anopheles species mosquitoes specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.
    • 公开了通常在血虫中生产减毒无菌寄生虫的装置和方法,特别是在按蚊种中产生疟原虫种子孢子; 用于生产具有所需性质如低致敏性或超感染性的血液昆虫菌株的装置和方法; 生产能够在接近冷冻的温度下耐受静脉保存的寄生虫菌株的方法; 用于注射减毒寄生虫疫苗的装置和方法; 生产不受不需要的生物制剂污染的寄生虫和血液昆虫; 用于无菌地重建复杂寄生生命周期的装置,以避免寄生虫或昆虫载体宿主与不想要的生物制剂的污染。