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1. 植物专利

US20140182024P1 Populus tree named 'RRR Yellow' 有权
标题翻译：名为“RRR Yellow”的杨树
公开(公告)号：US20140182024P1
公开(公告)日：2014-06-26
申请号：US13694691
申请日：2012-12-26
申请人： Gary Banuelos , John Diener , James Prince
发明人： Gary Banuelos , John Diener , James Prince
IPC分类号： A01H5/00
CPC分类号： A01H5/00 , Y02A40/40
摘要： A new and distinctly salt and boron tolerant poplar tree cultivar named “RRR Yellow,” is particularly distinguishable by its ability to tolerate and grow in soil with high concentrations of salt, boron and selenium. The cultivar was originally discovered as a sport through stringent selection of cultivated poplar trees, and potentially from isolation of a single unique sapling or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “RRR Yellow” cultivar.
摘要翻译：一种新的明显的耐盐和耐硼杨树品种“RRR黄”，其特点是能够在高浓度盐，硼和硒的土壤中耐受和生长。该栽培品种最初是通过严格挑选栽培的杨树被发现的，并且潜在地分离出独特的树苗或运动，这种独特的树苗或运动具有高水平的盐和硼的耐受性，为生存所必需，然后传播到“RRR黄”品种。

2. 植物专利

USPP24039P3 Opuntia plant named ‘Seleno-Orange’ 有权
标题翻译：仙人掌植物“硒硒橙”
公开(公告)号：USPP24039P3
公开(公告)日：2013-11-26
申请号：US13506028
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Orange’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Orange’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Orange’ cultivar has yellow flowers, mature green cladodes without glochids, and orange fruit. When grown in a saline/selenium-laden soil, the spineless ‘Seleno-Orange’ cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒 - 橙”的仙人掌仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种特别与其在高浓度的盐，硼和含硒土壤中耐受和生长的能力是有区别的。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且可能通过分离显示生存所必需的高水平盐和硼耐受性的单一独特的分离层或运动，然后传播到“硒 - 橙” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 'Seleno-Orange'品种有黄色的花朵，成熟的绿色扁豆，没有glo ids，橙色的水果。当生长在盐渍/含硒的土壤中时，无脊椎的“硒 - 橙”品种吸收高浓度的天然硒，挥发硒，并生产富含潜在抗癌形式的有机硒的可食用的分枝杆菌和果实。

3. 植物专利

US20130254959P1 Opuntia plant named "SELENO-RED" 有权
标题翻译：名为“SELENO-RED”的仙人掌植物
公开(公告)号：US20130254959P1
公开(公告)日：2013-09-26
申请号：US13506030
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/00
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Red,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Red” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Red” cultivar has orange-red flowers, mature green cladodes without glochids, and red-purple fruit. When grown in a saline/selenium-laden soil, the spineless “Seleno-Red” cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒红”的仙人掌（Opuntia ficus-indica）的新的明显的耐盐和耐受硼的品种特别与其在高浓度盐，硼和含硒土壤中耐受和生长的能力特别区别。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且潜在地从单独独特的分离层或运动的分离中发现生存所需的高水平的盐和硼的耐受性，然后传播到“硒 - 红” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒红”品种有橙红色的花朵，成熟的绿色扁豆，无茄子，红紫色的果实。当生长在含盐/硒的土壤中时，无硒的“硒 - 红”品种吸收高浓度的天然存在的硒，挥发硒，并生产富含潜在抗癌形式的有机硒的食用的分枝杆菌和果实。

4. 植物专利

USPP24052P3 Opuntia plant named ‘Seleno-Red’ 有权
标题翻译：仙人掌植物“硒硒红”
公开(公告)号：USPP24052P3
公开(公告)日：2013-12-03
申请号：US13506030
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/00
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Red,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Red’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Red’ cultivar has orange-red flowers, mature green cladodes without glochids, and red-purple fruit. When grown in a saline/selenium-laden soil, the spineless ‘Seleno-Red’ cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒硒红”的仙人掌仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受栽培品种，特别与其在高浓度盐，硼和含硒土壤中耐受和生长的能力是有区别的。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且潜在地从单独独特的分离层或运动中分离出显示高水平的生存所需的盐和硼的耐受性，然后传播到“硒硒红” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒 - 红”品种有橙红色的花朵，成熟的绿色无花果，无紫红色的水果。当生长在盐水/硒的土壤中时，无脊椎的“硒 - 红”品种吸收高浓度的天然存在的硒，挥发硒，并生产富含潜在抗癌形式的有机硒的食用分枝杆菌和果实。

5. 植物专利

US20130254956P1 Opuntia plant named 'Seleno-Green' 有权
标题翻译：仙人掌植物“硒硒绿”
公开(公告)号：US20130254956P1
公开(公告)日：2013-09-26
申请号：US13506026
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/00
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Green,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Green” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Green” cultivar has yellow-orange flowers, mature green cladodes without glochids, and yellow-green fruit. When grown in a saline/selenium-laden soil, the spineless “Seleno-Green” cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒绿”的仙人掌仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种特别区别于其在高浓度盐，硼和含硒土壤中耐受和生长的能力。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且可能通过分离显示生存所需的高水平的盐和硼耐受性的单一独特的分离层或运动，然后传播到“硒 - 绿” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒绿”栽培品种有黄橙色花，成熟绿色无枝条，黄绿色果实。当生长在盐渍/含硒土壤中时，无硒的“硒 - 绿”品种吸收高浓度的天然硒，挥发硒，并生产富含潜在抗癌形式的有机硒的可食用的分枝杆菌和果实。

6. 植物专利

USPP24053P3 Opuntia plant named ‘Seleno-Green’ 有权
标题翻译：仙人掌植物“硒硒绿”
公开(公告)号：USPP24053P3
公开(公告)日：2013-12-03
申请号：US13506026
申请日：2012-03-21
申请人： Gary Banuelos , John Diener , John Leonard Freeman
发明人： Gary Banuelos , John Diener , John Leonard Freeman
IPC分类号： A01H5/00
CPC分类号： A01H5/00
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Green,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Green’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Green’ cultivar has yellow-orange flowers, mature green cladodes without glochids, and yellow-green fruit. When grown in a saline/selenium-laden soil, the spineless ‘Seleno-Green’ cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒硒绿”的仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种特别与其在高浓度的盐，硼和含硒土壤中耐受和生长的能力是有区别的。最初通过严格选择随机收获的分枝杆菌（修饰的茎）和潜在地从单独独特的分离层或运动的分离中发现培养物，其表现出高水平的生存所需的盐和硼耐受性，然后传播到“硒 - 绿” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒 - 绿”品种有黄橙色的花朵，成熟的绿色无枝条花，黄绿色的水果。当生长在含盐/硒的土壤中时，无毛的“硒 - 绿”品种吸收高浓度的天然硒，挥发硒，并生产富含潜在抗癌形式的有机硒的可食性分枝杆菌和果实。

7. 植物专利

US20130254957P1 Opuntia plant named "Seleno-Orange" 有权
标题翻译：仙人掌植物名为“硒橙”
公开(公告)号：US20130254957P1
公开(公告)日：2013-09-26
申请号：US13506028
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Orange,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Orange” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Orange” cultivar has yellow flowers, mature green cladodes without glochids, and orange fruit. When grown in a saline/selenium-laden soil, the spineless “Seleno-Orange” cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“Seleno-Orange”的仙人掌仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种特别与其在高浓度盐，含硼和含硒土壤中耐受和生长的能力有所区别。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且潜在地从单独独特的分子代码或体育的分离中获得生存所需的高水平的盐和硼耐受性，然后传播到“硒 - 橙” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “Seleno-Orange”品种有黄色的花朵，成熟的绿色扁豆，没有glo ids，橙色的果实。当生长在含盐/硒的土壤中时，无机的“硒 - 橙”品种吸收高浓度的天然硒，挥发硒，并生产富含潜在抗癌形式的有机硒的可食用的分枝杆菌和果实。

8. 植物专利

USPP24072P3 Opuntia plant named ‘Seleno-Purple’ 有权
标题翻译：仙人掌植物“硒硒紫”
公开(公告)号：USPP24072P3
公开(公告)日：2013-12-10
申请号：US13506029
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Purple,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Purple’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Purple’ cultivar has yellow flowers, mature green cladodes without glochids, and purple fruit. When grown in a saline/selenium-laden soil, the spineless ‘Seleno-Purple’ cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：名为“硒紫”的仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种特别与其在高浓度的盐，硼和含硒土壤中耐受和生长的能力是有区别的。最初通过严格选择随机收获的分枝杆菌（修饰茎）和潜在地从单独独特的分离层或运动的分离中发现培养物，其表现出高水平的生存所需的盐和硼的耐受性，然后传播到“硒 - 紫” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒紫”品种有黄色的花朵，成熟的绿色无花果，紫色的果实。当生长在含盐/硒的土壤中时，无脊椎的“硒 - 紫”品种吸收高浓度的天然存在的硒，挥发硒，并产生富含潜在的抗癌形式的有机硒的食用分枝杆菌和果实。

9. 植物专利

US20130254958P1 Opuntia plant named "SELENO-PURPLE" 有权
标题翻译：仙人掌植物名为“SELENO-PURPLE”
公开(公告)号：US20130254958P1
公开(公告)日：2013-09-26
申请号：US13506029
申请日：2012-03-21
申请人： Gary Banuelos , John Leonard Freeman , John Diener
发明人： Gary Banuelos , John Leonard Freeman , John Diener
IPC分类号： A01H5/00
CPC分类号： A01H5/02
摘要： A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Purple,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Purple” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Purple” cultivar has yellow flowers, mature green cladodes without glochids, and purple fruit. When grown in a saline/selenium-laden soil, the spineless “Seleno-Purple” cultivar absorbs high concentrations of natural-occurring selenium, volatilizes selenium, and produces edible cladodes and fruit enriched with potential anti-carcinogenic forms of organic selenium.
摘要翻译：一种名为“硒紫”的仙人掌（Opuntia ficus-indica）的新鲜明显的盐和硼耐受品种通过其在高浓度盐，硼和含硒土壤中耐受和生长的能力而具有特别的区别。最初通过严格选择随机收获的分枝杆菌（修饰茎）发现培养物，并且潜在地从单独独特的分离层或运动的分离中发现生存所需的高水平的盐和硼耐受性，然后传播到“硒 - 紫” 品种最初从不同的单株植物随机收获分枝杆菌，并从天然分离的野生种群或种质中筛选出来。 “硒紫”品种有黄色的花朵，成熟的绿色无花果，紫色的果实。当生长在盐渍/硒的土壤中时，无脊椎的“硒 - 紫”品种吸收高浓度的天然硒，挥发硒，并生产富含潜在抗癌形式的有机硒的食用分枝杆菌和果实。

10. 发明授权

US08598335B2 Organic compositions to treat Beta-ENaC-related diseases 有权
公开(公告)号：US08598335B2
公开(公告)日：2013-12-03
申请号：US13614836
申请日：2012-09-13
申请人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
发明人： Antonin De Fougerolles , John Diener , Emma Hickman , Gregory Hinkle , Stuart Milstein , Anne-Marie Pulichino , Andrew Griffin Sprague
IPC分类号： C07H21/04 , C07H21/02 , A61K48/00
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/111 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3513 , C12N2310/3515 , C12N2310/3517 , C12N2310/3521
摘要： The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.

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