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1. 发明授权

US11793723B2 Installation for producing a medical preparation 有权
公开(公告)号：US11793723B2
公开(公告)日：2023-10-24
申请号：US17316052
申请日：2021-05-10
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Biehl , Michael Hock , Henrik Schaake , Ulla Schöbel , Holger Lenkeit , Marcel Borgward
IPC分类号： A61J3/00 , B65B3/00
CPC分类号： A61J3/002 , A61J2200/74 , B65B3/003
摘要： The invention relates to an installation for producing a medical preparation, in particular for producing a preparation for parenteral nutrition. The installation comprises a pump with which liquids can be transferred from a plurality of source containers into a target container. The installation has a modular construction and comprises a weighing module and a main module with the pump. According to a further aspect of the invention, the pump is arranged at an inclination with respect to a vertical plane. According to a further aspect of the invention, the installation comprises cascaded valve nodes.

2. 发明授权

US11077023B2 Method for producing a medical preparation using a peristaltic pump 有权
公开(公告)号：US11077023B2
公开(公告)日：2021-08-03
申请号：US16083984
申请日：2017-03-15
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Martin Biehl , Michael Hock , Henrik Schaake , Martin Bohm , Ulla Schöbel
IPC分类号： A61J3/00 , A61M1/16 , A61M1/26 , A61M1/36 , F04B43/12 , F04B53/10
摘要： The invention relates to a method and a system for synthesizing a medical preparation, a peristaltic pump being used for pumping liquid from a plurality of source containers. According to the invention, micro-amounts are extracted only in the linear region of the peristaltic pump.

3. 发明申请

US20160339451A1 DEVICE FOR PROCESSING A LIQUID MEDIUM COMPRISING CELLS 有权
标题翻译：用于处理包含细胞的液体介质的装置
公开(公告)号：US20160339451A1
公开(公告)日：2016-11-24
申请号：US15035711
申请日：2014-12-17
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Artur Meisberger , Melanie Fahrendorff , Michael Brinkmann , Martin Biehl
IPC分类号： B04B11/02 , B04B9/10 , B04B5/04 , A61M1/02 , A61M1/36
CPC分类号： B04B11/02 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
摘要翻译：本发明涉及一种用于处理初始液体介质（4）的装置，其中初始液体介质（4）包含初始浓度的单元，以便获得包含产品浓度的单元的产品液体介质（4'），该装置（2）包括分离器）适于将初始液体介质（4）分离成各种组分，用于将初始液体介质（4）供应到分离器（6）的第一供应系统（8），用于提取产物液体的第一出口系统（12）来自分离器（6）的介质（4'），适于测量与初始或产品液体介质（4,4'）中的细胞浓度相关的物理参数的传感器（22,22'），以及控制单元（24），其耦合到所述传感器（22,22'），并且适于根据由所述传感器（22,22'）测量的物理参数来控制所述设备（2）的至少一个过程。该装置的特征在于用于以给定的流量将溶液（18）供应到分离器（6）的第二供应系统（10）。基于至少一个工艺参数来确定第二供应系统（10）在供应到分离器（6）期间的溶液（18）的流量。

4. 发明申请

US20150217104A1 CONNECTOR FOR PRODUCING A FLUID CONNECTION TO A SECOND CONNECTOR, CONNECTOR SYSTEM, AND METHOD FOR PRODUCING A FLUID CONNECTION 审中-公开
标题翻译：用于生产与第二连接器，连接器系统的流体连接的连接器以及用于生产流体连接的方法
公开(公告)号：US20150217104A1
公开(公告)日：2015-08-06
申请号：US14424537
申请日：2013-08-16
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Biehl , Ilka Sternheimer
IPC分类号： A61M39/10
CPC分类号： A61M39/10 , A61M39/162 , A61M39/18 , A61M39/221 , A61M2039/1061 , A61M2039/222
摘要： A connector for producing a fluid connection to a second connector, wherein the connector can, in at least one connector area, form a weakened structure, in order to be able to break open the connector in the connector area and in this way produce a fluid connection to the second connector. A partial area of the connector area is designed in such a way that the weakened structure in the partial area can be generated by covering or spraying the connector area with a medium.
摘要翻译：一种用于产生到第二连接器的流体连接的连接器，其中连接器可以在至少一个连接器区域中形成弱化结构，以便能够在连接器区域中断开连接器，并且以这种方式产生流体连接到第二个连接器。连接器区域的部分区域被设计成使得可以通过用介质覆盖或喷射连接器区域来产生部分区域中的弱化结构。

5. 发明授权

US11000451B2 Installation for producing a medical preparation 有权
公开(公告)号：US11000451B2
公开(公告)日：2021-05-11
申请号：US16084367
申请日：2017-03-15
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Martin Biehl , Michael Hock , Henrik Schaake , Ulla Schöbel , Holger Lenkeit , Marcel Borgward
IPC分类号： A61J3/00 , B65B3/00
摘要： The invention relates to an installation for producing a medical preparation, in particular for producing a preparation for parenteral nutrition. The installation comprises a pump with which liquids can be transferred from a plurality of source containers into a target container. The installation has a modular construction and comprises a weighing module and a main module with the pump. According to a further aspect of the invention, the pump is arranged at an inclination with respect to a vertical plane. According to a further aspect of the invention, the installation comprises cascaded valve nodes.

6. 发明申请

US20200289371A1 SCALES AND INSTALLATION FOR PRODUCING A MEDICAL PREPARATION 审中-公开
公开(公告)号：US20200289371A1
公开(公告)日：2020-09-17
申请号：US16083948
申请日：2017-03-15
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Martin Biehl , Michael Hock , Ulla Schobel , Marcel Borgward , Holger Lenkeit , Dirk Lamprecht , Sebastian Maier
IPC分类号： A61J3/00 , G01G17/04 , G01G21/22 , A61J1/20
摘要： The invention relates to a set of scales and to an installation for producing a medical composition using a set of scales. The set of scales comprise interchangeable securing means for a target container, the weight thereof being measured by the set of scales.

7. 发明公开

US20240180782A1 INSTALLATION FOR PRODUCING A MEDICAL PREPARATION 审中-公开
公开(公告)号：US20240180782A1
公开(公告)日：2024-06-06
申请号：US18378607
申请日：2023-10-10
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Biehl , Michael Hock , Henrik Schaake , Ulla Schöbel , Holger Lenkeit , Marcel Borgward
IPC分类号： A61J3/00 , B65B3/00
CPC分类号： A61J3/002 , A61J2200/74 , B65B3/003
摘要： An installation for producing a parenteral nutrition is described. The installation includes a pump with which liquids can be transferred from a plurality of source containers into a target container. The installation has a modular construction and includes a weighing module and a main module with the pump.

8. 发明公开

US20240033183A1 VALVE UNIT FOR A SYSTEM FOR PRODUCING A MEDICAL PREPARATION 审中-公开
公开(公告)号：US20240033183A1
公开(公告)日：2024-02-01
申请号：US18378592
申请日：2023-10-10
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Biehl , Michael Hock , Lothar Tiedemann , Klaus Buettner
IPC分类号： A61J3/00 , A61J1/20
CPC分类号： A61J3/002 , A61J1/2062 , A61J1/2089 , A61J1/2096
摘要： A valve unit for a system for producing a medical preparation for parenteral nutrition is described. The valve unit includes a housing having a duct extending along a longitudinal access of housing, upper inlets and lower inlets, and an outlet in fluid communication with each of the inlets via the duct. The valve unit includes valves that alternately connect a respective upper inlet of the upper inlets and a respective lower inlet of the lower inlets to the duct. Each of the valves have a first passage that fluidly connects the respective upper inlet and the duct, and a second passage that fluidly connects the respective lower inlet and the duct.

9. 发明授权

US11793722B2 Valve unit for a system for producing a medical preparation 有权
公开(公告)号：US11793722B2
公开(公告)日：2023-10-24
申请号：US16641293
申请日：2018-08-22
申请人： Fresenius Kabi Deutschland GmbH
发明人： Martin Biehl , Michael Hock , Lothar Tiedemann , Klaus Buettner
IPC分类号： A61J3/00 , A61J1/20
CPC分类号： A61J3/002 , A61J1/2062 , A61J1/2089 , A61J1/2096
摘要： The invention relates to a valve unit for a system for producing a parenteral nutrition, in which a three-way valve is used for respectively two connections to a source container. The valve unit is a component which is mounted on the system and can be removed again following use. The valve unit is in particular provided as a replaceable disposable component.

10. 发明授权

US10966906B2 Method for producing a medical preparation 有权
公开(公告)号：US10966906B2
公开(公告)日：2021-04-06
申请号：US16084396
申请日：2017-03-15
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Martin Biehl , Michael Hock , Henrik Schaake , Ulla Schöbel , Martin Bohm
IPC分类号： A61J3/00 , F04B43/12
摘要： The invention relates to a method and a system for synthesizing a medical preparation, a peristaltic pump being used for pumping liquid from a plurality of source containers. According to the invention, the individual metering steps are verified by a weighing process, even the metering of micro-amounts being verifiable.

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