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1. 发明授权

US07344562B2 AAA low profile support structure 有权
标题翻译： AAA低调支持结构
公开(公告)号：US07344562B2
公开(公告)日：2008-03-18
申请号：US11188498
申请日：2005-07-25
申请人： Frederick Feller , David C. Majercak , Jin S. Park , Diana M. Sanchez
发明人： Frederick Feller , David C. Majercak , Jin S. Park , Diana M. Sanchez
IPC分类号： A61F2/06
CPC分类号： A61F2/856 , A61F2/07 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0016 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2250/0037
摘要： An endoprosthesis for repairing and treating abdominal aortic aneurysms. The endoprosthesis features an anchoring and sealing component and low profile bifurcated legs. A biocompatible graft material is secured to at least the bifurcated legs in order to provide two endoleg fluid flow lumens or conduits. The bifurcated legs have staggered stent elements that nest to contribute to the low profile nature of the device and additional longitudinal struts between pair of the staggered stent elements to increase the longitudinal stiffness of the bifurcated legs while maintaining the patency of the lumen created thereby.
摘要翻译：用于修复和治疗腹主动脉瘤的内假体。内假体具有锚固和密封部件和低剖面分叉的腿部。将生物相容的移植物材料固定到至少分叉的腿以便提供两个内流体流体流动管腔或导管。分叉的腿具有交错的支架元件，其嵌套以有助于装置的低调性质以及一对交错的支架元件之间的另外的纵向支柱，以增加分叉腿的纵向刚度，同时保持由此产生的内腔的通畅。

2. 发明申请

US20070156222A1 Adjustable and detached stent deployment device 有权
标题翻译：可调和分离的支架展开装置
公开(公告)号：US20070156222A1
公开(公告)日：2007-07-05
申请号：US11321582
申请日：2005-12-29
申请人： Frederick Feller , Huisun Wang
发明人： Frederick Feller , Huisun Wang
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/9517
摘要： The present disclosure is directed to a device for housing and retaining a delivery system for a self-expanding implant while providing means for actuating the delivery system.
摘要翻译：本公开涉及一种用于容纳和保持用于自膨胀植入物的输送系统的装置，同时提供用于致动输送系统的装置。

3. 发明授权

US08163006B2 Reduced profile AAA device 有权
标题翻译：缩减配置文件AAA设备
公开(公告)号：US08163006B2
公开(公告)日：2012-04-24
申请号：US11190367
申请日：2005-07-27
申请人： Frederick Feller , David C. Majercak , Jin S. Park
发明人： Frederick Feller , David C. Majercak , Jin S. Park
IPC分类号： A61F2/82
CPC分类号： C25F3/16 , A61F2/07 , A61F2/856 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0016 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2250/0037 , A61F2250/0039
摘要： An abdominal aortic aneurysm endoprosthesis having a reduced profile for percutaneous delivery of the endoprosthesis. The endoprosthesis provides a cranial section supported by a stent, and a bifurcated caudal section having at least two legs each of which are supported by individual stents. The individual stents of each leg of the caudal section are staggered so as not to line up with one another. Altering the lengths of the legs permits nesting of the endoprosthesis. Optimizing the expansion ratio and radial strength of the endoprosthesis is achieved by altering the dimensions of the starting material from which the stent segments are fabricated, by altering the final austentite temperature of the starting materials, or by changing the structural configuration of the stent segments. A graft material is attached to at least a portion of the cranial section and to all of the caudal section of the endoprosthesis.
摘要翻译：腹主动脉瘤内用假体具有减少的内皮假体经皮递送的轮廓。内假体提供由支架支撑的颅面部分和具有至少两个腿的分叉尾部，每个腿由各个支架支撑。尾部各腿的个体支架交错排列，以免彼此排列。改变腿部的长度允许内置假体嵌套。通过改变制造支架段的起始材料的尺寸，通过改变起始材料的最终奥氏体温度，或通过改变支架段的结构构造来实现内部假体的膨胀比和径向强度的优化。移植材料附着到颅部的至少一部分和内置假体的所有尾部。

4. 发明申请

US20080213433A1 Fluid compositions comprising polyphenols and methods for making and packaging the same 审中-公开
标题翻译：包含多酚的流体组合物及其制备和包装方法
公开(公告)号：US20080213433A1
公开(公告)日：2008-09-04
申请号：US11818193
申请日：2007-06-13
申请人： Frederick Feller , Jay S. Yadav , Gregory Lamps
发明人： Frederick Feller , Jay S. Yadav , Gregory Lamps
IPC分类号： A23L2/52 , A23L2/00 , A23F3/00 , A23C9/123 , A23F5/00 , C12G3/00 , A23L1/48 , B65D83/00 , B65D85/00
CPC分类号： B65D51/2828 , A23L2/52 , A23L33/105 , A23V2002/00 , A23V2250/2132 , A23V2250/708
摘要： The present invention provides a number of compositions, including non-alcoholic and non-fermented aqueous solutions comprising trans-resveratrol and/or other polyphenols. In one aspect, the present invention provides retail or commercially available beverages comprising trans-resveratrol and/or other polyphenols.
摘要翻译：本发明提供了许多组合物，包括包含反式白藜芦醇和/或其它多酚的非酒精和非发酵水溶液。一方面，本发明提供了包含反式白藜芦醇和/或其它多酚的零售或市售饮料。

5. 发明申请

US20060069428A1 Thin film medical device and delivery system 审中-公开
标题翻译：薄膜医疗器械和输送系统
公开(公告)号：US20060069428A1
公开(公告)日：2006-03-30
申请号：US11231088
申请日：2005-09-20
申请人： Frederick Feller
发明人： Frederick Feller
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/075
摘要： The present invention relates to an intraluminal thin film medical device particularly well suited for occlusion of an aneurysm, vessel side branch or dissection of a body lumen or duct, such as an artery or vein. The medical device has a thin film tube capable of being longitudinally stretched by the application of mechanical energy to achieve a smaller circumferential profile, and self-expand to the pre-stretched length and diameter upon release of the mechanical energy. To assist the thin film during expansion a plurality of slots are incised in the tube wall. The slots open and assist the thin film tube to longitudinally stretch, and substantially close when the thin film tube self-expands to the pre-stretched length and diameter.
摘要翻译：本发明涉及一种特别适用于闭塞动脉瘤，血管侧分支或体腔或管道如动脉或静脉的解剖的管腔内薄膜医疗装置。该医疗装置具有能够通过施加机械能纵向拉伸以获得更小的圆周轮廓并且在释放机械能时自扩张至预拉伸长度和直径的薄膜管。为了在膨胀期间辅助薄膜，多个槽被切割在管壁中。狭缝打开并帮助薄膜管纵向拉伸，并且当薄膜管自膨胀至预拉伸长度和直径时基本上闭合。

6. 发明申请

US20060025846A1 AAA low profile support structure 有权
标题翻译： AAA低调支持结构
公开(公告)号：US20060025846A1
公开(公告)日：2006-02-02
申请号：US11188498
申请日：2005-07-25
申请人： Frederick Feller , David Majercak , Jin Park , Diana Sanchez
发明人： Frederick Feller , David Majercak , Jin Park , Diana Sanchez
IPC分类号： A61F2/90
CPC分类号： A61F2/856 , A61F2/07 , A61F2/89 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/065 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0016 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2250/0037
摘要： An endoprosthesis for repairing and treating abdominal aortic aneurysms. The endoprosthesis features an anchoring and sealing component and low profile bifurcated legs. A biocompatible graft material is secured to at least the bifurcated legs in order to provide two endoleg fluid flow lumens or conduits. The bifurcated legs have staggered stent elements that nest to contribute to the low profile nature of the device and additional longitudinal struts between pair of the staggered stent elements to increase the longitudinal stiffness of the bifurcated legs while maintaining the patency of the lumen created thereby.
摘要翻译：用于修复和治疗腹主动脉瘤的内假体。内假体具有锚固和密封部件和低剖面分叉的腿部。将生物相容的移植物材料固定到至少分叉的腿以便提供两个内流体流体流动管腔或导管。分叉的腿具有交错的支架元件，其嵌套以有助于装置的低调性质以及一对交错的支架元件之间的另外的纵向支柱，以增加分叉腿的纵向刚度，同时保持由此产生的内腔的通畅。

7. 发明申请

US20080161936A1 Remodeling Device for Aneurysms 有权
标题翻译：动脉瘤改造装置
公开(公告)号：US20080161936A1
公开(公告)日：2008-07-03
申请号：US11663489
申请日：2005-10-14
申请人： Frederick Feller , Donald K. Jones , Darren R. Sherman
发明人： Frederick Feller , Donald K. Jones , Darren R. Sherman
IPC分类号： A61F2/02
CPC分类号： A61B17/12022 , A61B17/12118 , A61B17/12172 , A61B2017/12054 , A61F2002/823
摘要： A method of occluding a defect in the wall of a body vessel is provided. An outlet portion of a microcatheter is delivered to the defect, then at least a body portion of a thin film occlusion device is radially expanded from a collapsed orientation to a deployed orientation for engaging the microcatheter and covering at least a portion of the defect. Thereafter, an embolic media is released into the defect from the microcatheter for facilitating thrombosis. The body portion of the occlusion device is substantially porous in the collapsed orientation, but substantially non-porous in the deployed orientation for preventing prolapse of the embolic media into the body vessel.
摘要翻译：提供了一种在身体容器的壁中闭塞缺陷的方法。微导管的出口部分被输送到缺陷，然后薄膜闭塞装置的至少主体部分从收缩方向径向扩张到展开方向，以便与微导管接合并覆盖缺陷的至少一部分。此后，栓塞介质从微导管释放到缺陷中以便于血栓形成。闭塞装置的主体部分在塌缩方向上基本上是多孔的，但是在展开方向上基本上是无孔的，以防止栓塞介质向身体容器脱垂。

8. 发明申请

US20080097508A1 Expandable Vascular Occlusion Device 有权
标题翻译：可扩张血管闭塞装置
公开(公告)号：US20080097508A1
公开(公告)日：2008-04-24
申请号：US11662847
申请日：2005-09-16
申请人： Donald Jones , Robert Slazas , Frederick Feller
发明人： Donald Jones , Robert Slazas , Frederick Feller
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12172 , A61B2017/00867
摘要： A vascular occlusion device that includes an inner embolic member at least partially covered by an expandable generally tubular mesh. The expandable tubular mesh typically comprises a unitary wall with apertures through the wall to assist in the expansion of the generally tubular mesh.
摘要翻译：一种血管闭塞装置，其包括至少部分被可扩张的大体管状网状物覆盖的内部栓塞构件。可膨胀的管状网通常包括具有穿过壁的孔的整体壁，以有助于大体上管状的网状物的膨胀。

9. 发明申请

US20080195136A1 Thin Film Devices for Temporary or Permanent Occlusion of a Vessel 有权
标题翻译：用于临时或永久闭塞血管的薄膜装置
公开(公告)号：US20080195136A1
公开(公告)日：2008-08-14
申请号：US11662816
申请日：2005-09-16
申请人： Frederick Feller , Donald K. Jones , Darren R. Sherman
发明人： Frederick Feller , Donald K. Jones , Darren R. Sherman
IPC分类号： A61M29/02
CPC分类号： A61B17/12022 , A61B17/12036 , A61B17/12109 , A61B17/12172 , A61B2017/00867 , A61B2017/1205 , A61B2017/12054
摘要： Thin film devices implantable within a human subject for occlusion of an aneurysm or body vessel are provided. The devices are movable from an elongated, collapsed configuration for delivery to a deployed configuration within the body. Open slots in selected portions of the device telescope as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while also decreasing in porosity for preventing blood flow. Closed slits in other portions of the device open as the device moves to its deployed configuration, which causes the associated portions to longitudinally foreshorten and radially expand, while remaining open for fluid flow or endothelialization. The occlusion devices may be either self-supporting or supported by a strut structure. Additionally, the occlusion devices may comprise a plurality of mesh layers having unaligned pore systems which further reduce porosity in desired portions of the deployed configuration.
摘要翻译：提供了植入人体受试者内用于闭塞动脉瘤或体内血管的薄膜装置。这些装置可以从细长的，折叠的构型移动，以便输送到主体内的展开构型。当设备移动到其展开的构型时，在设备望远镜的选定部分中开放狭槽，这导致相关部分纵向缩短并且径向膨胀，同时孔隙度也降低以防止血液流动。当装置移动到其展开构型时，装置的其它部分中的封闭狭缝打开，这导致相关部分纵向缩短并径向膨胀，同时保持开放以用于流体流动或内皮化。闭塞装置可以是自支撑的或由支柱结构支撑。另外，闭塞装置可以包括具有未对准孔系统的多个网眼层，其进一步降低展开构型的期望部分中的孔隙率。

10. 发明申请

US20070162109A1 Intraluminal stent graft 审中-公开
标题翻译：腔内支架移植
公开(公告)号：US20070162109A1
公开(公告)日：2007-07-12
申请号：US11329567
申请日：2006-01-11
申请人： Luis Davila , Frederick Feller
发明人： Luis Davila , Frederick Feller
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/067 , A61F2230/0067
摘要： A modular intraluminal stent graft. The intraluminal stent graft is bifurcated having a primary section and a secondary section extending therefrom. The primary section tapers from a larger diameter at an upstream end to a smaller diameter at a downstream end. The downstream end of the primary section has a pair of independent openings each having an expanded diameter. The secondary section provides a first endoleg having an upstream end that is received through the expanded diameter of one opening of the primary section, and a second endoleg having an upstream end that is received through the second opening of the primary section. The upstream ends of each endoleg, in its expanded state, is larger than the downstream portion of the respective endolegs and expands within the primary section to help assemble the graft in situ. The first and second endolegs also expand within the respective openings each is received within to assemble the stent graft in situ as well. The primary section is positioned within a blood vessel trunk, whereas the endolegs of the secondary section are positioned within a blood vessel branched from the blood vessel trunk. A typical application would be to place the primary section within the abdominal aorta infrarenally, with the endolegs positioned in the ipsilateral and contralaterial iliacs, respectively. By minimizing the number of stent segments in the primary section of the stent graft a lower delivery profile is achieved.
摘要翻译：模块化腔内支架移植物。管腔内支架移植物分叉具有从其延伸的初级部分和次级部分。初级部分从上游端的较大直径到下游端的较小直径变细。初级部分的下游端具有一对独立的开口，各自具有扩大的直径。次级部分提供第一内燃，其具有通过主部分的一个开口的扩展直径接收的上游端，以及具有通过主部分的第二开口接收的上游端的第二内燃。在其膨胀状态下，每个内燃料的上游端大于相应内固体的下游部分，并且在初级部分内膨胀以帮助原位组装移植物。第一和第二内固定体还在相应的开口内扩张，每个开口都被接收在内，以便在现场组装支架移植物。主要部分位于血管干内，而第二部分的内固定体位于从血管干线分支的血管内。典型的应用是将主要部分置于腹主动脉内，腹内主动脉分别位于同侧和对侧髂骨中。通过最小化在支架移植物的主要部分中的支架段的数量，实现较低的输送曲线。

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