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1. 发明授权

US08680102B2 Pyrrole derivatives, their preparation and their therapeutic application 失效
标题翻译：吡咯衍生物，其制备及其治疗应用
公开(公告)号：US08680102B2
公开(公告)日：2014-03-25
申请号：US12942780
申请日：2010-11-09
申请人： Francis Barth , Daniel Bichon , Murielle Rinaldi-Carmona , Christian Congy
发明人： Francis Barth , Daniel Bichon , Murielle Rinaldi-Carmona , Christian Congy
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译：本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。

2. 发明申请

US20110152320A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 失效
标题翻译：吡咯衍生物，其制备及其治疗应用
公开(公告)号：US20110152320A1
公开(公告)日：2011-06-23
申请号：US12942780
申请日：2010-11-09
申请人： Francis Barth , Daniel Bichon , Murielle Rinaldi-Carmona , Christian Congy
发明人： Francis Barth , Daniel Bichon , Murielle Rinaldi-Carmona , Christian Congy
IPC分类号： A61K31/4545 , C07D401/14 , C07D401/06 , A61K31/454 , A61P29/00 , A61P25/04 , A61P35/00 , A61P1/00 , A61P19/02 , A61P25/16 , A61P25/28
CPC分类号： C07D401/14 , C07D401/06
摘要： The subject of the invention is compounds of formula (I): in which R1-R10 are as defined within, the method of preparation and therapeutic application as cannabinoid CB1 receptor antagonists.
摘要翻译：本发明的主题是式（I）化合物：其中R 1 -R 10如上所定义，作为大麻素CB1受体拮抗剂的制备方法和治疗应用。

3. 发明授权

US07674821B2 N-[(4,5-diphenyl-3-alkyl-2-thienyl)methyl]amine [amide, sulfonamide, carbamate and urea) derivatives as cannabinoid CB1 receptor antagonists 失效
标题翻译： N - [（4,5-二苯基-3-烷基-2-噻吩基）甲基]胺[酰胺，磺酰胺，氨基甲酸酯和尿素）衍生物作为大麻素CB1受体拮抗剂
公开(公告)号：US07674821B2
公开(公告)日：2010-03-09
申请号：US11764378
申请日：2007-06-18
申请人： Francis Barth , Christian Congy , Jean-Phillipe Ducoux , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Jean-Phillipe Ducoux , Murielle Rinaldi-Carmona
IPC分类号： A61K31/381 , C07D333/22
CPC分类号： C07D333/20
摘要： The invention concerns compounds of formula (I), wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also concerns a method for preparing said compounds and their use as cannabinoid CB1 receptor antagonists.
摘要翻译：本发明涉及式（I）化合物，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。本发明还涉及制备所述化合物的方法及其作为大麻素CB1受体拮抗剂的用途。

4. 发明授权

US07381727B2 Pyrrole derivatives, their preparation and their therapeutic use 失效
标题翻译：吡咯衍生物，其制备及其治疗用途
公开(公告)号：US07381727B2
公开(公告)日：2008-06-03
申请号：US11625616
申请日：2007-01-22
申请人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： A61K31/4025 , A61K31/445 , A61K31/496 , C07D207/30 , C07D401/02 , C07D403/02
CPC分类号： C07D409/12 , C07D207/34 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds and their therapeutic use.
摘要翻译：本发明涉及式（I）的化合物：其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8和R 9，如本文所定义。本发明还涉及制备所述化合物的方法及其治疗用途。

5. 发明授权

US08410137B2 Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof 有权
标题翻译：噻吩-2-甲酰胺衍生物，其制备及其治疗用途
公开(公告)号：US08410137B2
公开(公告)日：2013-04-02
申请号：US13057043
申请日：2009-07-30
申请人： Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
发明人： Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
IPC分类号： A61K31/445 , C07D409/06
CPC分类号： C07D409/06 , C07D409/14
摘要： The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n′—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
摘要翻译：本发明的主题是对应于式（I）的化合物，其中：R 1和R 2与它们所连接的氮原子一起构成含有4至7个原子的饱和杂环基团，其优选被取代; 两个取代基R 3和R 6中的一个是Y-A-R 9基团; Y是氧原子或-S（O）n'-或-OSO 2基团; A是未取代的（C 1 -C 4）亚烷基; R9是-OR19，-CH3，-NR19R20，-CONR19R20，-NR15COR19，-S（O）nR21或-NR13SO2R21基团; -R10是氢原子或（C1-C4）烷基。本发明还涉及式（I）化合物的制备方法和治疗用途。

6. 发明授权

US07632852B2 (1,5-diphenyl-1H-pyrazol-3-yl)oxadiazole derivatives, preparation method thereof and use of same in therapeutics 失效
标题翻译：（1,5-二苯基-1H-吡唑-3-基）恶二唑衍生物及其制备方法及其在治疗中的应用
公开(公告)号：US07632852B2
公开(公告)日：2009-12-15
申请号：US11835670
申请日：2007-08-08
申请人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona , Didier Van Broeck
发明人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona , Didier Van Broeck
IPC分类号： A61K31/4155 , A61K31/4245 , C07D271/10 , C07D231/10
CPC分类号： C07D413/04
摘要： The invention relates to compounds having formula (I): Wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to a method of preparing said compounds and to the application thereof in therapeutics.
摘要翻译：本发明涉及具有式（I）的化合物：其中R1，R2，R3和R4如本文所定义。本发明还涉及制备所述化合物的方法及其在治疗中的应用。

7. 发明授权

US07618995B2 Derivatives of 4,5-diarylpyrrole, preparation method thereof and use of same in therapeutics 有权
标题翻译： 4,5-二芳基吡咯的衍生物，其制备方法及其在治疗中的应用
公开(公告)号：US07618995B2
公开(公告)日：2009-11-17
申请号：US11952224
申请日：2007-12-07
申请人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： A61K31/40 , C07D207/30
CPC分类号： C07D207/335 , C07D207/323
摘要： The invention relates to compounds having formula (I): Wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also relates to the preparation method thereof and the use of same in therapeutics.
摘要翻译：本发明涉及具有式（I）的化合物：其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。本发明还涉及其制备方法及其在治疗中的用途。

8. 发明授权

US07541361B2 N-[4,5-diphenylpyrimidin-2-yl)methyl]amine derivatives, the preparation thereof and their therapeutic use 失效
标题翻译： N - [（4,5-二苯基嘧啶-2-基）甲基]胺衍生物及其治疗用途
公开(公告)号：US07541361B2
公开(公告)日：2009-06-02
申请号：US11968855
申请日：2008-01-03
申请人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Patrick Gueule , Murielle Rinaldi-Carmona
IPC分类号： C07D239/26 , C07D403/12 , C07D403/14 , A61K31/505 , A61K31/506 , A61P3/04
CPC分类号： C07D405/12 , C07D239/26 , C07D403/12 , C07D409/12
摘要： The invention relates to compounds of formula (I): Wherein X, R1, R2, R3, R4 and R5 are as defined herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.
摘要翻译：本发明涉及式（I）化合物：其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。本发明还涉及一种制备上述化合物及其治疗用途的方法。

9. 发明授权

US07345059B2 Diphenylpyridine derivatives, preparation and therapeutic application thereof 失效
标题翻译：二苯基吡啶衍生物，其制备及治疗应用
公开(公告)号：US07345059B2
公开(公告)日：2008-03-18
申请号：US11316510
申请日：2005-12-22
申请人： Francis Barth , Laurent Hortala , Murielle Rinaldi-Carmona
发明人： Francis Barth , Laurent Hortala , Murielle Rinaldi-Carmona
IPC分类号： A61K31/445 , C07D213/02 , C07D405/02
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12
摘要： The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I): where: R1 represents hydrogen or a (C1-C4)alkyl; R2 represents: a monoazo saturated heterocycle of 5 to 7 atoms, the nitrogen atom being substituted with a (C1-C4)alkanoyl; NR10R11; a nonaromatic (C3-C10) carbocycle more than tri-substituted with (C1-C4)alkyl; a nonaromatic (C11-C12) carbocycle unsubstituted or mono- or polysubstituted with (C1-C4)alkyl; a monooxygenated saturated heterocycle with 5 to 7 atoms, more than tri-substituted with (C1-C4)alkyl; or R1 and R2, together with the nitrogen atom to which the above are bonded, form a 4-disubstituted piperidin-1-yl group; the salts, solvates and hydrates thereof. The invention further relates to a method for production and therapeutic application thereof.
摘要翻译：本发明涉及通式（I）的5,6-二苯基吡啶-3-甲酰胺衍生物：其中：R 1表示氢或（C 1 -C 3 -C > 4个）烷基; R 2表示：5至7个原子的单偶氮饱和杂环，氮原子被（C 1 -C 4 -C 4）烷酰基 ; NR 11 R 11; 与（C 1 -C 4 -C 4）三取代的非芳族（C 3 -C 10 - ）碳环，）烷基; 未取代或未被取代的（C 1 -C 4 -C 12）碳环的非芳族（C 1 -C 12 -C 12）碳环 >）烷基; 具有5至7个原子的单加成饱和杂环，多于（C 1 -C 4 -C 4）烷基的三取代基; 或R 1和R 2 2与上述键合的氮原子一起形成4-二取代的哌啶-1-基; 其盐，溶剂合物和水合物。本发明还涉及其生产方法及其治疗应用。

10. 发明授权

US07297710B1 Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics 失效
标题翻译： N - [（1,5-二苯基-1H-吡唑-3-基）甲基]磺酰胺的衍生物及其制备及其在治疗中的应用
公开(公告)号：US07297710B1
公开(公告)日：2007-11-20
申请号：US11457014
申请日：2006-07-12
申请人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
发明人： Francis Barth , Christian Congy , Serge Martinez , Philippe Pointeau , Murielle Rinaldi-Carmona
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D213/12 , C07D213/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
摘要翻译：本发明涉及对应于式（I）的化合物：其中R 1，R 2，R 3，R 3， 4和R 5 5如本文所述。本发明还涉及所述化合物的制备方法及其在治疗中的应用。

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