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    • 1. 发明申请
    • Imaging apparatus
    • 成像设备
    • US20020051512A1
    • 2002-05-02
    • US09984854
    • 2001-10-31
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • G21K001/12
    • A61B5/0066A61B5/0084
    • An compact imaging apparatus having an OCT function is provided. An image formed of the illuminating-light reflected from a examination area is displayed on a monitor. A signal-light for obtaining an optical tomographic image is guided in a fiber through an insertion portion and projected onto a living tissue measurement area by an illuminating lens. The measurement area is scanned with the signal-light by a Piezo actuator moving the output face of the fiber. An OCT obtaining-portion obtains and displays on a monitor an optical tomographic image by using the interference caused by the signal-light reflected from the measurement area and a reference-light. By performing the scanning with the signal-light using an image-obtaining lens, the need to insert a probe for obtaining an optical tomographic image through a forceps port is eliminated. Therefore, the number of required forceps ports is reduced, and the insertion portion can be made thin.
    • 提供具有OCT功能的紧凑型成像装置。 从检查区域反射的照明光形成的图像被显示在监视器上。 用于获得光学断层图像的信号光通过插入部分在纤维中被引导,并通过照明透镜投影到生物体组织测量区域。 通过移动光纤的输出面的压电致动器用信号光扫描测量区域。 OCT获取部通过使用从测量区域反射的信号光和参考光引起的干扰,在监视器上获取并显示光学断层图像。 通过使用图像获取透镜通过信号光进行扫描,消除了通过钳子端口插入用于获得光学断层图像的探针的需要。 因此,所需的钳子端口的数量减少,并且插入部分可以变薄。
    • 2. 发明申请
    • Light source device and image capturing device
    • 光源装置和摄像装置
    • US20030007087A1
    • 2003-01-09
    • US10189001
    • 2002-07-05
    • FUJI PHOTO FILM CO., LTD.
    • Kazuo HakamataMasahiro Toida
    • H04N005/222
    • H04N5/2256A61B1/0638A61B1/0653A61B1/07H04N2005/2255
    • A light source device for use in an image capturing device such as an endoscope capable of reducing size and cost, and preventing heat generation at an illuminated position. An illumination unit of the endoscope includes LED light sources for emitting ultraviolet light, fluorescent fibers for generating red, green and blue light respectively by irradiation of the ultraviolet light, a sampling light source, and an excitation light source. Upon capturing a normal image, the ultraviolet light is emitted sequentially from the LED light sources to cause the fluorescent fibers to generate the red, green and blue light. The light of each color is passed through a light guide and irradiated on an observation area of a living body. Thereafter, reflected images attributable to the light of each color are captured with a CCD image capturing element of a charge multiplying type, and captured images are displayed on a monitor.
    • 一种用于诸如内窥镜的图像捕获装置的光源装置,其能够减小尺寸和成本,并且防止在照明位置产生热量。 内窥镜的照明单元包括用于发射紫外光的LED光源,分别通过紫外线照射产生红,绿和蓝光的荧光纤维,采样光源和激发光源。 在捕获正常图像时,从LED光源顺序地发射紫外线,以使荧光纤维产生红色,绿色和蓝色光。 每种颜色的光通过光导并照射在活体的观察区域上。 此后,利用电荷倍增类型的CCD图像捕获元件捕获归因于每种颜色的光的反射图像,并且将捕获的图像显示在监视器上。
    • 3. 发明申请
    • Optical tomographic imaging apparatus
    • 光学层析成像装置
    • US20030055342A1
    • 2003-03-20
    • US10246395
    • 2002-09-19
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • A61B006/00
    • A61B3/102A61B3/1225A61B5/0066G01N21/4795
    • Low coherence light emitted from a light source is separated by a fiber coupler into a signal light, which is to be projected onto a target subject, and a reference light, which is to be modulated by a piezoelectric element. The signal light reflected from a predetermined depth of the target subject is synthesized with the reference light. The intensity of the interference light obtained thereby is detected by a balance differential detector, subjected to signal process by a signal processor, and displayed as a tomographic image on a display. The spectral width of the pulse light emitted from a pulse light source formed of an Er doped fiber is expanded in a zero dispersion fiber having a negative dispersion property, whereby the coherence length is shortened. The conventionally employed KTM Ti sapphire laser becomes unnecessary, and the light source becomes compact and inexpensive.
    • 从光源发射的低相干光由光纤耦合器分离成被投影到目标物体上的信号光和被压电元件调制的参考光。 从参考光合成从目标物体的预定深度反射的信号光。 由此获得的干涉光的强度由平衡差分检测器检测,由信号处理器进行信号处理,并在显示器上显示为断层图像。 从由Er掺杂光纤形成的脉冲光源发射的脉冲光的光谱宽度在具有负色散特性的零色散光纤中扩展,从而缩短了相干长度。 常规使用的KTM Ti蓝宝石激光器变得不必要,并且光源变得紧凑和便宜。
    • 4. 发明申请
    • Method and apparatus for outputting optical tomographic image diagnostic data
    • 用于输出光学层析图像诊断数据的方法和装置
    • US20020028010A1
    • 2002-03-07
    • US09945749
    • 2001-09-05
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • G06K009/68G06K009/00
    • G06T7/0012G06T7/70G06T2207/30024
    • A fiber coupler separates, the low-coherence light emitted from a light source into a signal-light to be projected onto a target subject and a reference-light whose wavelength is shifted by a Piezo element, and combines the signal-light reflected from a predetermined depth within the target subject with the reference-light. A balance differential detector detects the signal strength of the interference-light after said combining, and said signal is processed by the signal processor; whereby an optical tomographic image of the target subject is obtained, and output to a monitor and to the diagnostic data output portion. The diagnostic data output portion performs pattern-matching between the optical tomographic image of the target subject and the pattern of a prerecorded standard optical tomographic image obtained of a normal tissue. If the two patterns substantially match, that the target subject is in the normal state is output to the monitor and displayed.
    • 光纤耦合器将从光源发射的低相干光分离成投影到目标物体上的信号光和波长被压电元件偏移的参考光,并将从 具有参考光的目标对象内的预定深度。 平衡差分检测器检测所述组合之后的干涉光的信号强度,并且所述信号由信号处理器处理; 从而获得目标对象的光学断层图像,并将其输出到监视器和诊断数据输出部分。 诊断数据输出部分执行目标对象的光学断层图像与由正常组织获得的预先记录的标准光学断层图像的图案之间的图案匹配。 如果两个图案基本匹配,则目标被摄体处于正常状态,则输出到监视器并显示。
    • 5. 发明申请
    • Laser annealing apparatus and laser annealing method
    • 激光退火装置和激光退火方法
    • US20040241923A1
    • 2004-12-02
    • US10853116
    • 2004-05-26
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • H01L021/00H01L021/324H01L021/477
    • H01L21/268B23K26/0604B23K26/0619B23K26/067
    • A temperature distribution which is of the sum of the temperature distribution generated by a laser beam emitted from above and the temperature distribution generated by the laser beam emitted from below at the same irradiation position in a film which is of a subject of laser annealing is caused to be substantially constant in a thickness direction of the subject to be annealed. Therefore, a solid-liquid interface is formed substantially perpendicular to a surface direction of the subject to be annealed, crystal growth in a lateral direction is promoted, and a large crystal grain can be formed. As a result, even if the subject to be annealed has a thin film thickness, the annealing process can be performed by utilizing input energy without waste of the input energy.
    • 引起由激光退火对象的薄膜中的同一照射位置产生的温度分布与从上方发射的激光束产生的温度分布和由下面发射的激光束产生的温度分布之和的温度分布, 在待退火对象的厚度方向上基本恒定。 因此,固体 - 液体界面基本上垂直于待退火对象的表面方向形成,促进横向晶体生长,并且可以形成大的晶粒。 结果,即使被退火对象具有薄膜厚度,也可以通过利用输入能量而不浪费输入能量来进行退火处理。
    • 6. 发明申请
    • Laser annealing method and apparatus
    • 激光退火方法和装置
    • US20040241922A1
    • 2004-12-02
    • US10852155
    • 2004-05-25
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • H01L021/00H01L021/324H01L021/477
    • H01L21/268B23K26/0613B23K26/064B23K26/0643B23K26/0676B23K26/083
    • A laser beam emitted from a laser light source is transmitted plural times through an a-Si layer on a substrate to be annealed by irradiating the a-Si layer with the laser beam so that a direction of the laser beam is reversed along an optical path along which the laser beam is transmitted through the a-Si layer. Since an operation in which energy is absorbed is repeated plural times when the laser beam is transmitted through the a-Si layer, input energy of the laser beam can be utilized without waste. Further, in an area of the a-Si layer that the laser beam is transmitted plural times, crystal growth in a lateral direction can be realized to form a large crystal grain in such a manner that an energy absorption distribution generated in a transmission direction is made constant to cause a solid-liquid interface to be flat along the optical path.
    • 从激光光源发射的激光束通过用激光束照射a-Si层,通过a-Si层在待退火的基板上透射多次,使得激光束的方向沿光路反转 沿着该激光束透过a-Si层。 由于当激光束通过a-Si层传输时,多次吸收能量的操作,所以可以无浪费地使用激光束的输入能量。 此外,在a-Si层的多个区域中激光束被透射多次,可以实现沿横向的晶体生长,从而形成大的晶粒,使得在透射方向上产生的能量吸收分布为 使得固 - 液界面沿光路平坦。
    • 7. 发明申请
    • Dynamic change detecting method, dynamic change detecting apparatus and ultrasonic diagnostic apparatus
    • 动态变化检测方法,动态变化检测装置和超声波诊断装置
    • US20020009103A1
    • 2002-01-24
    • US09859460
    • 2001-05-18
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • H01S003/10
    • G01H9/00G01H9/002G01H9/004G01N2291/044
    • A dynamic change detecting apparatus allows canceling the influence of environmental change or an individual difference between a plurality of laser elements so as to perform a stable detection. This apparatus has a laser, including a laser resonator, for emitting a laser beam while causing frequency modulation in accordance with dimensional change of the laser resonator; a partial reflection mirror for splitting the laser beam emitted by the laser into a plurality of split-beams and guiding the plurality of split-beams to a plurality of optical paths having mutually different optical path lengths respectively; a frequency shifter for causing frequency shift in at least one of the plurality of split-beams; a lens for combining the plurality of split-beams with each other to obtain interference light; an photodetector for detecting the interference light to obtain an intensity signal; a demodulation unit for demodulating the intensity signal to generate a demodulated signal; and an integration processing unit for obtaining a signal corresponding to the dynamic change on the basis of the demodulated signal.
    • 动态变化检测装置允许消除环境变化的影响或多个激光元件之间的个体差异,从而进行稳定的检测。 该装置具有包括激光谐振器的激光器,用于发射激光束,同时根据激光谐振器的尺寸变化进行频率调制; 部分反射镜,用于将由激光器发射的激光束分成多个分束,并将多个分束引导到分别具有不同光程长度的多个光路; 用于在所述多个分束中的至少一个中引起频率偏移的频移器; 用于将所述多个分割光束彼此组合以获得干涉光的透镜; 用于检测干涉光以获得强度信号的光电检测器; 解调单元,用于解调强度信号以产生解调信号; 以及积分处理单元,用于基于解调信号获得与动态变化相对应的信号。
    • 8. 发明申请
    • Endoscope apparatus
    • 内窥镜装置
    • US20020052547A1
    • 2002-05-02
    • US09984511
    • 2001-10-30
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • A61B005/05
    • A61B5/6852A61B1/0005A61B1/00096A61B1/00172A61B1/0125A61B5/0066
    • An endoscope apparatus that has an OCT function and can efficiently obtain an optical tomographic image is provided. An image of an area within a body cavity is displayed on a monitor, and an operator uses a pen-type input to specify a point thereon. An aiming-light is projected onto the body cavity and displayed on said monitor as a bright point, and a coated tube of an OCT probe is slid and rotated by a scanning controller so as to align the aiming-light with the point. A scanning-area setting means sets a ring shaped scanning area when the aiming-light and point are aligned. The scanning area is scanned with a signal-light, and an optical tomographic image is obtained and displayed on a monitor. An optical tomographic image can be efficiently and expediently obtained without the need to manually direct the irradiation position of the signal-light to a desired scanning area.
    • 提供具有OCT功能并可以有效获得光学断层图像的内窥镜装置。 体腔内的区域的图像显示在监视器上,并且操作者使用笔式输入来指定其上的点。 将瞄准光投射到体腔上并作为亮点显示在所述监视器上,并且通过扫描控制器滑动并旋转OCT探针的涂覆管,以使瞄准光与点对准。 扫描区域设定装置在对准光和点对齐时设定环形扫描区域。 用信号光扫描扫描区域,并获得光学断层图像并将其显示在监视器上。 可以有效且方便地获得光学断层图像,而无需手动地将信号光的照射位置指向期望的扫描区域。
    • 9. 发明申请
    • Method and apparatus for obtaining an optical tomographic image of a sentinel lymph node
    • 用于获得前哨淋巴结的光学断层图像的方法和装置
    • US20020037252A1
    • 2002-03-28
    • US09962195
    • 2001-09-26
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • A61K049/00
    • A61K49/0034A61B5/0066A61B5/0071A61B5/418G01B9/02003G01B9/0203G01B9/02031G01B9/02091
    • An apparatus for obtaining a cellular image to be used in performing a test for pathology of the sentinel lymph node, which is the first lymph node a cancer metastasizes to. The gamma radiation emitted from a near-infrared fluorescent colorant injected in advance into the vicinity of a tumor is detected by use of a gamma-probe. A fiber coupler separates the low-coherence light emitted from the light source of an OCT portion (Optical Coherence Tomography) into a signal-light to be projected onto the sentinel lymph node and a reference-light whose wavelength is slightly shifted. The signal-light is projected onto the sentinel lymph node, and interference is caused between the signal-light reflected from a predetermined depth within the sentinel lymph node and the reference-light. A balance differential detector measures the intensity of the interference-light, and a cellular level ultra high-resolution optical tomographic image of the sentinel lymph node is obtained.
    • 一种用于获得用于进行前哨淋巴结的病理学检查的细胞图像的装置,其是癌症转移的第一淋巴结。 通过使用γ探针检测从预先注射到肿瘤附近的近红外荧光着色剂发射的γ射线。 光纤耦合器将从OCT部分(光学相干断层扫描)的光源发射的低相干光分离成要投影到前哨淋巴结的信号光和其波长稍微偏移的参考光。 信号光投射到前哨淋巴结上,并且在从前哨淋巴结中的预定深度反射的信号光与参照光之间引起干扰。 平衡差分检测器测量干涉光的强度,并获得前哨淋巴结的细胞水平的超高分辨率光学断层图像。
    • 10. 发明申请
    • Optical coherence tomography apparatus using optical-waveguide structure which reduces pulse width of low-coherence light
    • 使用减少低相干光的脉冲宽度的光波导结构的光学相干断层摄影装置
    • US20010043332A1
    • 2001-11-22
    • US09849294
    • 2001-05-07
    • FUJI PHOTO FILM CO., LTD.
    • Masahiro Toida
    • G01B009/02
    • G01N21/4795A61B5/0066A61B5/0073G01B9/02003G01B9/02014G01B9/02091G02B6/02085G02B6/2861
    • In an optical coherence tomography apparatus: low-coherence light from a light source is split into signal light and reference light; at least one of the frequencies of the signal light and the reference light is shifted so as to produce a predetermined frequency difference between the frequencies; the reference light and a portion of the signal light reflected from the object are optically multiplexed so as to produce interference light; and the optical intensity of the interference light is detected in order to obtain a tomographic image of the object. In the light source, the pulse width of pulsed light emitted from a pulsed light source unit is reduced by an optical-waveguide structure. The optical-waveguide structure is made of a material having a normal dispersion characteristic, and includes a structure which realizes an anomalous dispersion characteristic so as to reduce the pulse width of the pulsed light.
    • 在光学相干断层摄影装置中:来自光源的低相干光被分成信号光和参考光; 信号光和参考光的频率中的至少一个被移动,以产生频率之间的预定频率差; 将参考光和从物体反射的信号光的一部分光学多路复用以产生干涉光; 并且检测干涉光的光强度以获得物体的断层图像。 在光源中,通过光波导结构减少从脉冲光源单元发射的脉冲光的脉冲宽度。 光波导结构由具有正常色散特性的材料制成,并且包括实现异常色散特性以减小脉冲光的脉冲宽度的结构。