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1. 发明授权

US07935102B2 Method and apparatus for prevention of catheter air intake 有权
标题翻译：用于预防导管进气的方法和装置
公开(公告)号：US07935102B2
公开(公告)日：2011-05-03
申请号：US12317127
申请日：2008-12-19
申请人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
发明人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
IPC分类号： A61M31/00 , A61M1/00
CPC分类号： A61M5/36
摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.
摘要翻译：一种用于防止空气进入多导管系统的第一导管的系统。通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。空气通过靠近室的中心线的端口移除。用空气除去的液体返回到室中，以最小化在该过程中的液体损失。插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

2. 发明授权

US08235943B2 Method and apparatus for prevention of catheter air intake 有权
标题翻译：用于预防导管进气的方法和装置
公开(公告)号：US08235943B2
公开(公告)日：2012-08-07
申请号：US13099084
申请日：2011-05-02
申请人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
发明人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
IPC分类号： A61M1/00
CPC分类号： A61M5/36 , A61M1/3627 , A61M25/0097
摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.
摘要翻译：一种用于防止空气进入多导管系统的第一导管的系统。通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。空气通过靠近室的中心线的端口移除。用空气除去的液体返回到室中，以最小化在该过程中的液体损失。插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

3. 发明申请

US20090163864A1 Method and apparatus for prevention of catheter air intake 有权
标题翻译：用于预防导管进气的方法和装置
公开(公告)号：US20090163864A1
公开(公告)日：2009-06-25
申请号：US12317127
申请日：2008-12-19
申请人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
发明人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
IPC分类号： A61M5/36
CPC分类号： A61M5/36
摘要： A system is disclosed for preventing air from entering a first catheter or cannula of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The first catheter is affixed at an offset location, near the periphery of the chamber. The impeller is driven by a motor drive and imparts rotational energy to the fluid within the chamber forcing any air within the chamber to migrate to the center of the chamber by buoyancy effects. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. Hemostasis valves or seals can be provided at the entrance and the exit of the chamber. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. The first catheter can be a cannula or an introduction sheath, devices suited for endovascular access into the mammalian cardiovascular system where pressures may fall below ambient room pressure, a condition, which could encourage the possibility of air embolism to a patient. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.
摘要翻译：公开了一种用于防止空气进入多导管系统的第一导管或套管的系统。通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。第一导管固定在靠近腔室周边的偏移位置处。叶轮由马达驱动器驱动，并向腔室内的流体施加旋转能量，迫使腔室内的任何空气通过浮力作用迁移到腔室的中心。空气通过靠近室的中心线的端口移除。用空气除去的液体返回到室中，以最小化在该过程中的液体损失。可以在腔室的入口和出口设置止血阀或密封件。插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。第一导管可以是插管或引入护套，适合于血管内进入哺乳动物心血管系统的装置，其中压力可能低于室内空气压力，这种情况可能鼓励患者空气栓塞的可能性。来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

4. 发明申请

US20130053693A1 METHOD AND APPARATUS FOR PREVENTION OF CATHETER AIR INTAKE 审中-公开
标题翻译：用于预防导管空气摄入的方法和装置
公开(公告)号：US20130053693A1
公开(公告)日：2013-02-28
申请号：US13568778
申请日：2012-08-07
申请人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
发明人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
IPC分类号： A61M5/36 , A61B6/00
CPC分类号： A61M5/36 , A61M1/3627 , A61M25/0097 , A61M39/0613
摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.
摘要翻译：一种用于防止空气进入多导管系统的第一导管的系统。通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。空气通过靠近室的中心线的端口移除。用空气除去的液体返回到室中，以最小化在该过程中的液体损失。插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

5. 发明申请

US20110270182A1 Method and Apparatus for Prevention of Catheter Air Intake 有权
标题翻译：用于预防导管吸气的方法和装置
公开(公告)号：US20110270182A1
公开(公告)日：2011-11-03
申请号：US13099084
申请日：2011-05-02
申请人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
发明人： Eugene M. Breznock , Jay A. Lenker , David W. Wieting
IPC分类号： A61M5/36
CPC分类号： A61M5/36 , A61M1/3627 , A61M25/0097
摘要： A system for preventing air from entering a first catheter of a multi-catheter system. Air is prevented from entering the proximal end of the first catheter by an axially elongate chamber having an impeller, the chamber being affixed to the proximal end of the first catheter. The air is removed through a port near the centerline of the chamber. Liquid removed with the air is returned to the chamber to minimize liquid loss during the procedure. A second catheter inserted through the chamber and into the first catheter is unable to entrain gas into the first catheter because any gas that enters the chamber is routed to the centerline of the chamber where it is removed. Inflow of fluid from an external pump scrubs the second catheter shaft of air bubbles attached by surface tension.
摘要翻译：一种用于防止空气进入多导管系统的第一导管的系统。通过具有叶轮的轴向细长室防止空气进入第一导管的近端，该腔室固定到第一导管的近端。空气通过靠近室的中心线的端口移除。用空气除去的液体返回到室中，以最小化在该过程中的液体损失。插入通过腔室并进入第一导管的第二导管不能将气体夹带到第一导管中，因为进入腔室的任何气体被引导到其被移除的腔室的中心线。来自外部泵的流体的流入通过表面张力擦拭附着的气泡的第二导管轴。

6. 发明授权

US06821263B2 Method and apparatus for venous drainage and retrograde coronary perfusion 失效
标题翻译：静脉引流和逆行冠状动脉灌注的方法和装置
公开(公告)号：US06821263B2
公开(公告)日：2004-11-23
申请号：US10759310
申请日：2004-01-16
申请人： Jay A. Lenker , Eugene M. Breznock
发明人： Jay A. Lenker , Eugene M. Breznock
IPC分类号： A61M3700
CPC分类号： A61M1/3653 , A61M1/3613 , A61M1/3656 , A61M1/3659 , A61M1/3664 , A61M2025/1013 , A61M2202/047
摘要： A system is disclosed for cannulating the vena cava of a patient during cardiopulmonary bypass procedures. Such cannulation is necessary for drainage of venous blood from the patient so that it may be oxygenated and pumped back to the patient to perfuse tissues during cardiac surgery and, more specifically, during periods of ischemic cardiac arrest or dysfunction. The device of the present invention not only provides venous drainage for cardiopulmonary bypass, but also performs the function of routing cardioplegic solution through the heart in the retrograde direction. Such cardioplegia provides protection to the heart during periods of ischemic cardiac arrest. This invention replaces a plurality of cannulae currently used for open-heart surgery, thus simplifying the surgical field and improving visibility of the heart. The device allows for the delivery of retrograde cardioplegia to the coronary circulation of both the right and the left side of the heart. The device further includes protection mechanisms to prevent overinflation or excessive pressurization of the right atrium during retrograde delivery of cardioplegia solution.
摘要翻译：公开了一种用于在体外循环手术期间插入患者的腔静脉的系统。这种插管对于从患者排出静脉血液是必需的，使得其可以被氧合并泵送回患者以在心脏手术期间，更具体地，在缺血性心脏骤停或功能障碍期间灌注组织。本发明的装置不仅提供用于体外循环的静脉引流，而且还执行沿逆行方向通过心脏路由心脏停搏溶液的功能。这种心脏停跳在缺血性心脏骤停期间为心脏提供保护。本发明代替目前用于开心手术的多个套管，从而简化了手术领域并提高了心脏的可见度。该装置允许将逆行心麻痹递送到心脏右侧和左侧的冠状动脉循环。该装置还包括用于在逆行递送心麻痹液期间防止右心房过度充气或过度加压的保护机制。

7. 发明授权

US07695467B2 Method and apparatus for chest drainage 有权
标题翻译：胸部引流方法和装置
公开(公告)号：US07695467B2
公开(公告)日：2010-04-13
申请号：US11417410
申请日：2006-05-03
申请人： Eugene M. Breznock , Jay A. Lenker
发明人： Eugene M. Breznock , Jay A. Lenker
IPC分类号： A61M1/00 , A61M27/00
CPC分类号： A61M27/00 , A61M35/00 , A61M2210/1039
摘要： The present invention describes a device for placement in the thoracic cavity of a patient. The device is a cannula, tube or catheter for chest drainage. The device serves as a conduit for drainage of excessive fluid or air buildup in the chest to a receptacle outside the body. The device also serves to prevent influx of fluid or air into the chest cavity, thus preventing pneumothorax or infection. The device incorporates systems for anchoring the chest drainage cannula to the chest and for steering the chest drainage cannula into the thoracic cavity.
摘要翻译：本发明描述了一种用于放置在患者的胸腔中的装置。该装置是用于胸部引流的插管，管或导管。该装置用作将胸部中过量的液体或积聚物排出体外的容器的导管。该装置还用于防止流体或空气流入胸腔，从而防止气胸或感染。该装置包括用于将胸部引流套管锚定到胸部并用于将胸腔引流套管转向胸腔的系统。

8. 发明授权

US07326197B2 Method and apparatus for chest drainage 有权
标题翻译：胸部引流方法和装置
公开(公告)号：US07326197B2
公开(公告)日：2008-02-05
申请号：US10694510
申请日：2003-10-27
申请人： Eugene M. Breznock , Jay A. Lenker
发明人： Eugene M. Breznock , Jay A. Lenker
IPC分类号： A61M1/00 , A61M27/00 , A61M37/00
CPC分类号： A61M27/00 , A61M35/00 , A61M2210/1039
摘要： The present invention describes a device for placement in the thoracic cavity of a patient. The device is a cannula, tube or catheter for chest drainage. The device serves as a conduit for drainage of excessive fluid or air buildup in the chest to a receptacle outside the body. The device also serves to prevent influx of fluid or air into the chest cavity, thus preventing pneumothorax or infection. The device incorporates systems for anchoring the chest drainage cannula to the chest and for steering the chest drainage cannula into the thoracic cavity.
摘要翻译：本发明描述了一种用于放置在患者的胸腔中的装置。该装置是用于胸部引流的插管，管或导管。该装置用作将胸部中过量的液体或积聚物排出体外的容器的导管。该装置还用于防止流体或空气流入胸腔，从而防止气胸或感染。该装置包括用于将胸部引流套管锚定到胸部并用于将胸腔引流套管转向胸腔的系统。

9. 发明授权

US07824356B2 Method and apparatus for removal of gas bubbles from blood 有权
标题翻译：从血液中除去气泡的方法和装置
公开(公告)号：US07824356B2
公开(公告)日：2010-11-02
申请号：US12322594
申请日：2009-02-04
申请人： David W. Wieting , Jay A. Lenker
发明人： David W. Wieting , Jay A. Lenker
IPC分类号： A61M37/00 , A61M1/00 , B01D21/26 , B01D33/15 , B01D33/27
CPC分类号： A61M1/3633 , A61M1/1658 , A61M1/3626 , A61M1/3627 , A61M1/3666 , A61M1/3667 , A61M5/36 , A61M2205/75 , A61M2205/7527 , A61M2206/16 , B01D19/0031 , B01D19/0057 , B01D19/0094 , B01D2247/10 , B01D2247/101 , B01D2247/108 , B04C3/00 , B04C3/06 , B04C5/02 , B04C5/04 , B04C5/08 , B04C5/107 , B04C9/00 , B04C2009/004 , B04C2009/007
摘要： A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Filters are used in the line to remove particulates and bubbles from the blood before they are pumped back to the patient but current filters are inefficient at removing small bubbles and debris that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter element.
摘要翻译：公开了一种在循环辅助过程中从血液中除去气泡的系统。这些气泡与颗粒物质一起通过泵，氧合器和其它组分在体外循环旁路系统中产生。在使用过滤器从血液中除去颗粒和气泡之前，将其抽回患者，但是当前的过滤器在除去可能导致神经缺陷和患者的肾脏和其他器官衰竭的小气泡和碎屑时效率低下。公开了一种有源过滤装置和方法，其将气泡迫使系统的中心，在血液离开过滤器之前将其从血液中取出。过滤器包括具有血液入口，血液出口和气体出口的轴向细长的圆柱形壳体。马达驱动的叶轮将壳体内的血液旋转并通过向心力将气体推向中心，利用血液中气泡的浮力作用，从而可以在过滤元件的中心排出气泡。

10. 发明申请

US20090173695A1 Method and apparatus for removal of gas bubbles from blood 有权
标题翻译：从血液中除去气泡的方法和装置
公开(公告)号：US20090173695A1
公开(公告)日：2009-07-09
申请号：US12322594
申请日：2009-02-04
申请人： David W. Wieting , Jay A. Lenker
发明人： David W. Wieting , Jay A. Lenker
IPC分类号： B01D21/26
CPC分类号： A61M1/3633 , A61M1/1658 , A61M1/3626 , A61M1/3627 , A61M1/3666 , A61M1/3667 , A61M5/36 , A61M2205/75 , A61M2205/7527 , A61M2206/16 , B01D19/0031 , B01D19/0057 , B01D19/0094 , B01D2247/10 , B01D2247/101 , B01D2247/108 , B04C3/00 , B04C3/06 , B04C5/02 , B04C5/04 , B04C5/08 , B04C5/107 , B04C9/00 , B04C2009/004 , B04C2009/007
摘要： A system is disclosed for removing gas bubbles from blood during circulatory assist procedures. Such bubbles are generated, along with particulate matter, in an extracorporeal circulatory bypass system by the pump, oxygenator and other components. Filters are used in the line to remove particulates and bubbles from the blood before they are pumped back to the patient but current filters are inefficient at removing small bubbles and debris that can cause neurological defects and renal and other organ failures in the patient. An active filter apparatus and method is disclosed that forces the bubbles to the center of the system where they are removed from the blood before the blood exits the filter. The filter comprises an axially elongate cylindrical shell with a blood inlet, a blood outlet and a gas outlet. A motor driven impeller spins the blood within the shell and forces the gas toward the center by centripetal force, utilizing the buoyancy effects of the bubbles in blood, whereby the bubbles can be bled off at the center of the filter element.
摘要翻译：公开了一种在循环辅助过程中从血液中除去气泡的系统。这些气泡与颗粒物质一起通过泵，氧合器和其它组分在体外循环旁路系统中产生。在使用过滤器从血液中除去颗粒和气泡之前，将其抽回患者，但是当前的过滤器在除去可能导致神经缺陷和患者的肾脏和其他器官衰竭的小气泡和碎屑时效率低下。公开了一种有源过滤装置和方法，其将气泡迫使系统的中心，在血液离开过滤器之前将其从血液中取出。过滤器包括具有血液入口，血液出口和气体出口的轴向细长的圆柱形壳体。马达驱动的叶轮将壳体内的血液旋转并通过向心力将气体推向中心，利用血液中气泡的浮力作用，从而可以在过滤元件的中心排出气泡。

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