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1. 发明申请

US20100198350A1 COATING WITH ANTIMICROBIAL AGENTS 有权
标题翻译：涂抹抗微生物剂
公开(公告)号：US20100198350A1
公开(公告)日：2010-08-05
申请号：US12723580
申请日：2010-03-12
申请人： Eric P. Berg , Rita Stella
发明人： Eric P. Berg , Rita Stella
IPC分类号： A61F2/12 , A61L31/10 , B32B27/06 , B05D1/00
CPC分类号： C09D5/14 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , A61L2430/04 , Y10T428/31663 , C08L83/04
摘要： A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.
摘要翻译：具有用于医疗装置的抗微生物剂的涂层。在一种方法中，相关方法包括用室温硫化分散体涂覆高温硫化硅酮材料。

2. 发明申请

US20100076113A1 COATING WITH ANTIMICROBIAL AGENTS 有权
公开(公告)号：US20100076113A1
公开(公告)日：2010-03-25
申请号：US12233949
申请日：2008-09-19
申请人： Eric P. Berg , Rita Stella
发明人： Eric P. Berg , Rita Stella
IPC分类号： A61L27/50 , B05D3/00
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/406 , A61L2300/606 , Y10T428/31663 , C08L83/04
摘要： A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.

3. 发明授权

US08419793B2 Coating with antimicrobial agents 有权
标题翻译：用抗菌剂涂覆
公开(公告)号：US08419793B2
公开(公告)日：2013-04-16
申请号：US12723580
申请日：2010-03-12
申请人： Eric P. Berg , Rita Stella
发明人： Eric P. Berg , Rita Stella
IPC分类号： A61F2/12 , A61L31/10 , B32B27/06 , B05D1/00
CPC分类号： C09D5/14 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , A61L2430/04 , Y10T428/31663 , C08L83/04
摘要： A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.
摘要翻译：具有用于医疗装置的抗微生物剂的涂层。在一种方法中，相关方法包括用室温硫化分散体涂覆高温硫化硅酮材料。

4. 发明授权

US08420153B2 Coating with antimicrobial agents 有权
公开(公告)号：US08420153B2
公开(公告)日：2013-04-16
申请号：US12233949
申请日：2008-09-19
申请人： Eric P. Berg , Rita Stella
发明人： Eric P. Berg , Rita Stella
IPC分类号： A61L31/10 , B32B27/06 , B05D1/00 , A61F2/12
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/406 , A61L2300/606 , Y10T428/31663 , C08L83/04
摘要： A coating with antimicrobial agents for use with medical devices. In one approach, a related method involves coating high temperature vulcanized silicone material with a room temperature vulcanized dispersion.

5. 发明授权

US08465537B2 Encapsulated or coated stent systems 有权
标题翻译：封装或涂层支架系统
公开(公告)号：US08465537B2
公开(公告)日：2013-06-18
申请号：US10871946
申请日：2004-06-17
申请人： David B. Masters , Eric P. Berg
发明人： David B. Masters , Eric P. Berg
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/0077 , A61F2/064 , A61F2/852 , A61F2/90 , A61F2/91 , A61F2002/826 , A61F2250/0063 , A61F2250/0067 , A61L31/043 , A61L31/16 , C08L89/00
摘要： A stent system having zero or more inner stents inserted into an outer stent. The inner stents and outer stent are separated and/or encapsulated by a protein-based material of a protein matrix and/or a set biocoacervate, each one or more biocompatible proteins and one or more biocompatible solvents. The protein-based material may also include one or more carbohydrates and one or more pharmacologically active agents.
摘要翻译：具有插入到外支架中的具有零个或多个内支架的支架系统。内部支架和外支架由蛋白质基质和/或凝集生物封闭物，每种一种或多种生物相容性蛋白质和一种或多种生物相容性溶剂的基于蛋白质的材料分离和/或封装。基于蛋白质的材料还可以包括一种或多种碳水化合物和一种或多种药理活性剂。

6. 发明授权

US5464650A Intravascular stent and method 失效
标题翻译：血管内支架和方法
公开(公告)号：US5464650A
公开(公告)日：1995-11-07
申请号：US52878
申请日：1993-04-26
申请人： Eric P. Berg , Ronald J. Tuch , Michael Dror , Rodney G. Wolff
发明人： Eric P. Berg , Ronald J. Tuch , Michael Dror , Rodney G. Wolff
IPC分类号： A61F2/00 , A61F2/02 , A61F2/82 , A61K31/57 , A61L31/00 , A61L31/10 , A61L31/14 , A61L31/16 , B05D1/02 , B05D1/18 , B05D1/38
CPC分类号： A61F2/82 , A61L31/10 , A61L31/146 , A61L31/16 , A61F2/958 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L2300/222 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/608
摘要： A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
摘要翻译：一种通过向支架体施用包括溶剂，溶解在溶剂中的聚合物和分散在溶剂中然后蒸发溶剂的治疗物质的溶液来制备血管内支架的方法。包含聚合物与支架上的药物紧密接触允许药物在支架扩张期间保留在支架上，并且还控制植入后药物的给药。可以通过选择合适的生物可吸收或生物稳定的聚合物和溶液中药物与聚合物的比例来控制涂层的粘附和药物递送速率。通过该方法，可以将药物如地塞米松施用于支架，在支架扩张期间保留在支架上并以受控的速率洗脱。

7. 发明申请

US20190014766A1 FISHING SYSTEM 审中-公开
公开(公告)号：US20190014766A1
公开(公告)日：2019-01-17
申请号：US16032636
申请日：2018-07-11
申请人： Eric P. Berg
发明人： Eric P. Berg
IPC分类号： A01K91/06 , A01K91/04 , A01K91/047 , A01K91/053 , A01K95/00
摘要： A fishing system is disclosed. In one aspect, the fishing system includes a first fishing line segment terminating with a hook and a second fishing line segment terminating with a sinker. An attachment point can also be provided, wherein a first eyelet of the attachment point is slidably arranged on the first fishing line segment and a second eyelet of the attachment point is attached to the second fishing line segment. The fishing system can also include an immovable stopper attached to the first fishing line segment and a rigid or non-collapsing flexible tube spaced between the hook and the immovable stopper. In one aspect, the hook, stopper, and tube can move distally away from the first eyelet. The fishing system can also include a spherical ball spacer situated between the stopper and the first eyelet.

8. 发明授权

US08153591B2 Protein biomaterials and biocoacervates and methods of making and using thereof 有权
标题翻译：蛋白质生物材料和生物胶囊及其制备和使用方法
公开(公告)号：US08153591B2
公开(公告)日：2012-04-10
申请号：US10929117
申请日：2004-08-26
申请人： David B. Masters , Eric P. Berg
发明人： David B. Masters , Eric P. Berg
IPC分类号： A61K38/39 , A61K31/715 , A61K31/722 , A61K31/726 , A61K31/727 , A61K31/728 , A61K31/737 , A61K31/738
CPC分类号： A61L27/24 , A61K8/64 , A61K8/65 , A61K31/70 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/728 , A61K35/545 , A61K38/00 , A61K38/39 , A61K45/06 , A61K2800/91 , A61L27/20 , A61L27/22 , A61L27/227 , A61L27/34 , A61L27/48 , A61L27/507 , A61L31/10 , A61L33/12 , A61M25/0045 , A61Q19/08 , C08L89/00 , C08L5/00
摘要： The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.
摘要翻译：本发明涉及蛋白质生物凝聚物和生物材料以及制备和使用蛋白质生物凝聚物和生物材料的方法。更具体地，本发明涉及可用于各种医学应用的蛋白质生物凝聚物和生物材料，包括但不限于用于药理学活性剂的控制释放的药物递送装置，涂覆的医疗装置（例如支架，瓣膜等），血管，管状移植物，血管移植物，包括蛋白质缝合生物材料和生物组织的伤口愈合装置，牙科插入物和植入物，皮肤/骨/组织移植物，组织填充剂，蛋白质生物材料粘附防止屏障，细胞支架和其它生物相容性生物封装或生物材料装置。

9. 发明授权

US07419696B2 Medical devices for delivering a therapeutic agent and method of preparation 失效
公开(公告)号：US07419696B2
公开(公告)日：2008-09-02
申请号：US11292171
申请日：2005-11-30
申请人： Eric P. Berg , Ronald J. Tuch , Michael Dror , Rodney G. Wolff
发明人： Eric P. Berg , Ronald J. Tuch , Michael Dror , Rodney G. Wolff
IPC分类号： A61L33/00 , B05D1/02 , B05D1/18 , B05D1/36
CPC分类号： A61F2/88 , A61F2/82 , A61F2/958 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L29/041 , A61L29/044 , A61L29/06 , A61L29/145 , A61L29/146 , A61L29/16 , A61L31/042 , A61L31/043 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/146 , A61L31/16 , A61L2300/236 , A61L2300/42 , A61L2300/432
摘要： A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.

10. 发明授权

US6106454A Medical device for delivering localized radiation 失效
标题翻译：用于递送局部辐射的医疗设备
公开(公告)号：US6106454A
公开(公告)日：2000-08-22
申请号：US877426
申请日：1997-06-17
申请人： Eric P. Berg , Thomas Q. Dinh
发明人： Eric P. Berg , Thomas Q. Dinh
IPC分类号： A61M36/04 , A61N5/10 , A61B17/00 , A61B5/00
CPC分类号： A61N5/1002
摘要： A medical device useful for localized delivery of radiation in vivo is provided. The medical device includes a structure including a porous material; and a plurality of discrete particles including a water-insoluble radioactive salt dispersed throughout a substantial portion of the porous material. The water-insoluble radioactive salt is formed by contacting an aqueous radioactive salt solution with a heavy metal water-soluble salt dispersed throughout a substantial portion of the porous material. The heavy metal water-soluble salt can be dispersed in the porous material so that the device can be sterilized and the radioactive material can be loaded in the device in situ, for example, just prior to implantation.
摘要翻译：提供了可用于体内局部放射辐射的医疗装置。医疗装置包括包括多孔材料的结构; 以及包括分散在多孔材料的大部分中的水不溶性放射性盐的多个离散颗粒。通过使放射性水溶液与分散在多孔材料的大部分中的重金属水溶性盐接触而形成水不溶性放射性盐。重金属水溶性盐可以分散在多孔材料中，使得该装置可以被灭菌，并且放射性物质可以在植入之前就地装载在装置中。

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