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1. 发明申请

US20060240560A1 Microsphere optical ion sensors based on doped silica gel templates 审中-公开
标题翻译：基于掺杂硅胶模板的微球光离子传感器
公开(公告)号：US20060240560A1
公开(公告)日：2006-10-26
申请号：US11345553
申请日：2006-01-31
申请人： Eric Bakker , Chao Xu , Katarzyna Wygladacz
发明人： Eric Bakker , Chao Xu , Katarzyna Wygladacz
IPC分类号： G01N33/20
CPC分类号： G01N33/54313 , B01J2219/005 , B01J2219/00524 , B01J2219/00648 , B01J2219/00704 , G01N15/1459 , G01N21/6428 , G01N21/6458 , G01N21/7703 , G01N31/22 , G01N33/6872 , G01N33/84 , G01N2015/0092 , G01N2015/1486 , G01N2021/6434 , G01N2021/6439 , G01N2021/6484 , G01N2021/7759 , G01N2021/7786
摘要： A sensor for determining the concentration of a target ion in a liquid sample having a particulate silica doped with: an ionophore capable of binding the target ion; and an indicator capable of producing a detectable signal in response to binding by the ionophore of the target ion. The detectable signal is related to the target ion concentration in the liquid sample.
摘要翻译：一种用于确定具有掺杂有能够结合目标离子的离子载体的颗粒状二氧化硅的液体样品中的靶离子的浓度的传感器; 以及能够产生响应于靶离子的离子载体结合的可检测信号的指示剂。可检测信号与液体样品中的目标离子浓度有关。

2. 发明申请

US20080182056A1 Hollow Microsphere Particles 审中-公开
标题翻译：中空微球颗粒
公开(公告)号：US20080182056A1
公开(公告)日：2008-07-31
申请号：US11669085
申请日：2007-01-30
申请人： Eric Bakker , Katarzyna Wygladacz , Nan Ye , Chao Xu
发明人： Eric Bakker , Katarzyna Wygladacz , Nan Ye , Chao Xu
IPC分类号： G01N33/00 , B29D22/00 , B32B27/00
CPC分类号： B01J13/04 , A61K9/5089 , Y10T428/1352 , Y10T428/1386
摘要： Disclosed herein are novel monodispersed hollow microsphere particles having a general shell-core structure with a monodispersity of from about 0.1% to about 50%, a diameter in the range of from about 3 μm to about 30 μm and a shell thickness of from about 0.1 μm to about 5 μm. The particles generally have a hydrophobic exterior shell matrix and a hydrophilic interior core, wherein the interior core may further comprise a number of materials or a cargo. Also disclosed are micro sensors comprising the hollow microsphere particles, methods for forming the sensors, as well as methods for using the sensors.
摘要翻译：本文公开了新颖的单分散中空微球颗粒，其具有单分散度为约0.1％至约50％，直径范围为约3μm至约30μm，壳厚度为约0.1μm的一般壳芯结构妈妈到大约5个妈妈。颗粒通常具有疏水性外壳基质和亲水性内部芯，其中内芯可以进一步包含许多材料或货物。还公开了包括中空微球颗粒的微传感器，用于形成传感器的方法以及使用传感器的方法。

3. 发明授权

US07678252B2 Long lived anion-selective sensors based on a covalently attached metalloporphyrin as anion receptor 失效
标题翻译：基于共价连接的金属卟啉作为阴离子受体的长寿命阴离子选择性传感器
公开(公告)号：US07678252B2
公开(公告)日：2010-03-16
申请号：US11424185
申请日：2006-06-14
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： G01N27/26
CPC分类号： C07D487/22 , G01N27/3335
摘要： A graft copolymer having metalloporphyrin ionophores covalently attached in a manner that prevents dimer formation is provided. A method of making the graft copolymer comprises polymerizing a functionalized metalloporphyrin monomer, which includes a polymerizable group, with a co-monomer. Methods for synthesizing the polymerizable metalloporphyrin monomers are provided. The graft copolymer can be incorporated into anion-selective membranes for use in anion-detecting sensors, which have improved longevity and response times.
摘要翻译：提供了以防止二聚体形成的方式共价连接的具有金属卟啉离子载体的接枝共聚物。制备接枝共聚物的方法包括使包含可聚合基团的官能化金属卟啉单体与共聚单体聚合。提供合成可聚合金属卟啉单体的方法。接枝共聚物可以并入用于阴离子检测传感器的阴离子选择性膜中，其具有改善的寿命和响应时间。

4. 发明授权

US07553403B2 Reversible electrochemical sensors for polyions 失效
标题翻译：用于多边形的可逆电化学传感器
公开(公告)号：US07553403B2
公开(公告)日：2009-06-30
申请号：US10887251
申请日：2004-07-08
申请人： Eric Bakker , Alexey Shvarev
发明人： Eric Bakker , Alexey Shvarev
IPC分类号： G01N27/327 , G01N27/333
CPC分类号： G01N27/3335
摘要： The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration.
摘要翻译：本发明涉及一种用于聚阴离子的可逆电化学传感器。传感器使用主动提取和离子剥离，电化学控制。通过使用不含离子交换性质的含有高亲脂性电解质的膜来抑制自发的聚阴离子提取。通过跨膜的固定持续时间的恒定电流脉冲诱导聚阴离子的可逆萃取。随后，通过施加恒定的剥离电势除去多边形。传感器提供优异的稳定性和可逆性，并允许通过鱼精蛋白滴定测量全血样品中的肝素浓度。

5. 发明授权

US07651858B2 Ion-detecting microspheres 失效
标题翻译：离子检测微球及其使用方法
公开(公告)号：US07651858B2
公开(公告)日：2010-01-26
申请号：US11779173
申请日：2007-07-17
申请人： Eric Bakker , Martin Telting-Diaz , Mike Bell
发明人： Eric Bakker , Martin Telting-Diaz , Mike Bell
IPC分类号： G01N33/20 , G01N33/52
CPC分类号： G01N33/84
摘要： This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.
摘要翻译：本发明提供了在临床实验室仪器中使用含有离子光谱和chromoionphore的离子检测微球的方法，如流式细胞仪进行样品分析。在一个实施方案中，使微球与允许离子选择性离子载体与样品中的离子络合的条件和样品的流动流接触，并引起染色质团的去质子化。然后将复合物暴露于适合于激发去质子化的染色体以发射荧光信号图案的激发波长光源。检测由含有复合物的微球中去质子化的染色体发射的荧光信号图案可以测定样品中目标离子的存在。在一个实施方案中，提供可以以几分钟的响应时间检测纳摩尔含量的铅离子的铅离子检测微球。

6. 发明授权

US07247489B2 Ion-detecting microspheres and methods of use thereof 失效
标题翻译：离子检测微球及其使用方法
公开(公告)号：US07247489B2
公开(公告)日：2007-07-24
申请号：US10384082
申请日：2003-03-07
申请人： Eric Bakker , Martin Telting-Diaz , Mike Bell
发明人： Eric Bakker , Martin Telting-Diaz , Mike Bell
IPC分类号： G01N33/20 , G01N33/52
CPC分类号： G01N33/84
摘要： This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.
摘要翻译：本发明提供了在临床实验室仪器中使用含有离子光谱和chromoionphore的离子检测微球的方法，如流式细胞仪进行样品分析。在一个实施方案中，使微球与允许离子选择性离子载体与样品中的离子络合的条件和样品的流动流接触，并引起染色质团的去质子化。然后将复合物暴露于适合于激发去质子化的染色体以发射荧光信号图案的激发波长光源。检测由含有复合物的微球中去质子化的染色体发射的荧光信号图案可以测定样品中目标离子的存在。在一个实施方案中，提供可以以几分钟的响应时间检测纳摩尔含量的铅离子的铅离子检测微球。

7. 发明申请

US20120118762A1 SENSING DEVICE AND METHOD 审中-公开
标题翻译：感应装置和方法
公开(公告)号：US20120118762A1
公开(公告)日：2012-05-17
申请号：US13201158
申请日：2010-02-12
申请人： Eric Bakker
发明人： Eric Bakker
IPC分类号： G01N27/333
CPC分类号： G01N27/333 , G01N27/3277
摘要： A sensing device for the determination of ions in a thin layer sample (32) comprising: a first (12) and second (14) ion selective electrode, each having a first (16) and second layer (20); the first layer (16) of the first ion selective electrode (12) being a polymeric membrane layer in electrical contact with the second layer (20) of the first ion selective electrode (12), and the first layer (18) of the second ion selective electrode (14) being a polymeric membrane layer in electrical contact with the second layer (20) of the second ion selective electrode (14); the first and second ion selective electrodes being positioned in opposing arrangement such that, the respective polymeric membrane layers are in direct contact with a thin layer sample (32) containing ions, located between the first and second electrodes; and a detector (28) in electrical connection with the first (12) and second (14) ion selective electrodes.
摘要翻译：一种用于确定薄层样品（32）中的离子的感测装置，包括：第一（12）和第二（14）离子选择性电极，每个具有第一层（16）和第二层（20）; 第一离子选择电极（12）的第一层（16）是与第一离子选择电极（12）的第二层（20）电接触的聚合物膜层，第二离子选择电极的第一层（18）离子选择性电极（14）是与第二离子选择电极（14）的第二层（20）电接触的聚合物膜层; 第一和第二离子选择性电极被定位成相对的布置，使得相应的聚合物膜层与位于第一和第二电极之间的含有离子的薄层样品（32）直接接触; 以及与所述第一（12）和第二（14）离子选择性电极电连接的检测器（28）。

8. 发明申请

US20050011760A1 Ion-detecting sensors comprising plasticizer-free copolymers 有权
标题翻译：离子检测传感器包括不含增塑剂的共聚物
公开(公告)号：US20050011760A1
公开(公告)日：2005-01-20
申请号：US10856665
申请日：2004-05-28
申请人： Eric Bakker , Yu Qin
发明人： Eric Bakker , Yu Qin
IPC分类号： C07C69/52 , C07F5/02 , C08F220/14 , C08F220/18 , C08F265/04 , G01N20060101 , G01N21/64 , G01N27/26 , G01N27/333 , G01N33/20
CPC分类号： C08F220/18 , C08F220/14 , C08F265/04 , C08F230/06
摘要： Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through covalent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.
摘要翻译：提供了用于检测样品中的目标离子的无增塑剂离子检测传感器。该传感器包括由聚合单元的甲基丙烯酸酯单体和可聚合离子交换剂组成的不含增塑剂的共聚物，其中所述甲基丙烯酸酯化单体具有不同长度的侧链烷基，并且其中所述官能化离子交换剂通过共价键接枝到所述共聚物中。离子交换剂包含具有可聚合部分的卤代十六烷基硼烷阴离子的C-衍生物。本发明的传感器包括基于载体的离子选择性电极或光电极，例如薄膜离子特异性光电极，基于粒子的光电极或体光电极。

9. 发明授权

US5470453A Reference electrode with ion barrier for electrochemical measuring systems 失效
标题翻译：用于电化学测量系统的具有离子屏障的参比电极
公开(公告)号：US5470453A
公开(公告)日：1995-11-28
申请号：US971870
申请日：1993-06-28
申请人： Andre Nipkow , Eric Bakker
发明人： Andre Nipkow , Eric Bakker
IPC分类号： G01N27/30 , G01N27/36 , G01N27/401
CPC分类号： G01N27/401
摘要： A reference electrode (2) which features an ion barrier (20) based on the redox principle and which is fashioned as an independent unit or as part of a combination electrode, for instance a single-rod measuring chain. Metal ions to be blocked and contained in the reference electrolyte (24) and the material forming the ion barrier (20) together form a redox system. The ion barrier (20) is preferably a reduction agent which reduces the metal ions to the respective metal, and its properties are such that it will not cause contamination of the diaphragm (6) in oxidized state.
摘要翻译： PCT No.PCT / CH92 / 00095 Sec。 371日期：1993年6月28日 102（e）日期1993年6月28日PCT提交日期为1992年5月15日PCT公布。出版物WO92 / 21960 日期：1992年12月10日。参考电极（2），其特征在于基于氧化还原原理的离子屏障（20），其形成为独立单元或组合电极的一部分，例如单杆测量链。待封闭并包含在参考电解质（24）中的金属离子和形成离子屏障（20）的材料一起形成氧化还原体系。离子屏障（20）优选是还原剂，其将金属离子还原成各自的金属，并且其性质使得不会在氧化状态下引起隔膜（6）的污染。

10. 发明申请

US20080173846A1 ION-DETECTING MICROSPHERES AND METHODS OF USE THEREOF 失效
标题翻译：离子检测微球及其使用方法
公开(公告)号：US20080173846A1
公开(公告)日：2008-07-24
申请号：US11779173
申请日：2007-07-17
申请人： Eric Bakker , Martin Telting-Diaz , Mike Bell
发明人： Eric Bakker , Martin Telting-Diaz , Mike Bell
IPC分类号： G01N33/20
CPC分类号： G01N33/84
摘要： This invention provides methods of using ion-detecting microspheres containing an ionphore and a chromoionphore in clinical laboratory instrumentation such as flow cytometry for sample analysis. In one embodiment, the microspheres are contacted with a flowing stream of a sample under conditions that allow the ion-selective ionophores to complex with the ions in the sample, and to cause deprotonation of the chromoionophore. The complexes are then exposed to an excitation wavelength light source suitable for exciting the deprotonated chromoionophore to emit a fluorescence signal pattern. Detection of the fluorescence signal pattern emitted by the deprotonated chromoionophore in microspheres containing the complexes allows for determination of the presence of the target ions in the sample. In one embodiment, lead ion-detecting microspheres are provided that can detect nanomolar levels of lead ions with response times on the order of minutes.
摘要翻译：本发明提供了在临床实验室仪器中使用含有离子光谱和chromoionphore的离子检测微球的方法，如流式细胞仪进行样品分析。在一个实施方案中，使微球与允许离子选择性离子载体与样品中的离子络合的条件和样品的流动流接触，并引起染色质团的去质子化。然后将复合物暴露于适合于激发去质子化的染色体以发射荧光信号图案的激发波长光源。检测由含有复合物的微球中去质子化的染色体发射的荧光信号图案可以测定样品中目标离子的存在。在一个实施方案中，提供可以以几分钟的响应时间检测纳摩尔含量的铅离子的铅离子检测微球。

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