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1. 发明申请

US20090192493A1 IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR REFILLING THE DEVICES 审中-公开
标题翻译：可植入药物递送装置，以及用于重新装备装置的装置和方法
公开(公告)号：US20090192493A1
公开(公告)日：2009-07-30
申请号：US12348178
申请日：2009-01-02
申请人： Ellis Meng , Mark Humayun , Ronalee Lo , Po-Ying Li , Saloomeh Saati
发明人： Ellis Meng , Mark Humayun , Ronalee Lo , Po-Ying Li , Saloomeh Saati
IPC分类号： A61M5/42 , A61M5/32 , A61M5/00
CPC分类号： A61M5/427 , A61F9/0017 , A61M5/14276 , A61M5/158 , A61M5/46 , A61M39/0208 , A61M2005/14284 , A61M2039/0238 , A61M2205/3523 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/6054 , A61M2205/6063 , A61M2209/045 , A61M2210/0612
摘要： In various embodiments, a needle is employed in refilling drug-delivery devices.
摘要翻译：在各种实施方案中，使用针来重新填充药物递送装置。

2. 发明授权

US08308686B2 MEMS device and method for delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的MEMS装置和方法
公开(公告)号：US08308686B2
公开(公告)日：2012-11-13
申请号：US12790240
申请日：2010-05-28
申请人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61F7/12
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。套管被成形为便于将其插入患者眼球。

3. 发明申请

US20080039792A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20080039792A1
公开(公告)日：2008-02-14
申请号：US11686310
申请日：2007-03-14
申请人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M5/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： An implantable device for delivering a therapeutic agent to a patient is provided. The device includes a reservoir configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.
摘要翻译：提供了一种用于将治疗剂递送至患者的可植入装置。该装置包括构造成容纳包含治疗剂的液体的储存器。该装置还包括与储存器流体连通的套管。套管具有被配置成与患者流体连通的出口。该装置还包括第一电极和第二电极，第一电极和第二电极中的至少一个是平面的。该装置还包括与第一和第二电极电连通的材料。施加在第一电极和第二电极之间的电压从材料产生气体，气体迫使液体从储存器流出到出口。

4. 发明申请

US20100305550A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20100305550A1
公开(公告)日：2010-12-02
申请号：US12790240
申请日：2010-05-28
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M35/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。套管被成形为便于将其插入患者眼球。

5. 发明申请

US20110144619A1 MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送治疗剂的MEMS装置和方法
公开(公告)号：US20110144619A1
公开(公告)日：2011-06-16
申请号：US13026121
申请日：2011-02-11
申请人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis MENG , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61M5/152 , A61M5/14
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. A valve for maintaining a constant flow rate through the cannula independent of the pressure applied to the device may be included.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体的储存器和与储存器流体连通的套管。可以包括不依赖于施加到装置的压力来保持通过套管的恒定流速的阀。

6. 发明授权

US07887508B2 MEMS device and method for delivery of therapeutic agents 有权
标题翻译：用于递送治疗剂的MEMS装置和方法
公开(公告)号：US07887508B2
公开(公告)日：2011-02-15
申请号：US11686310
申请日：2007-03-14
申请人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
发明人： Ellis Meng , Yu-Chong Tai , Mark S. Humayun , Rajat Agrawal , Ronalee Lo , Jason Shih , Kenrick Kuwahara , Po-Ying Li , Damien Rodger , Po-Jui Chen
IPC分类号： A61F7/12
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： Embodiments of an implantable device for delivering a therapeutic agent to a patient includes a reservoir configured to contain a liquid comprising the therapeutic agent and a cannula in fluid communication with the reservoir. The device and related methods may provide such features as constant-flow operation, an electrolytic mode of pumping, and/or wireless communication.
摘要翻译：用于将治疗剂递送到患者的可植入装置的实施例包括构造成容纳包含治疗剂的液体和与储存器流体连通的插管的储存器。该装置和相关方法可以提供诸如恒流操作，电解抽吸模式和/或无线通信之类的特征。

7. 发明申请

US20120017423A1 INTERCONNECT FOR MEMS DEVICE INCLUDING A VISCOELASTIC SEPTUM 失效
标题翻译：用于包括粘弹性体的MEMS器件的互连
公开(公告)号：US20120017423A1
公开(公告)日：2012-01-26
申请号：US13251959
申请日：2011-10-03
申请人： Ellis Meng , Ronalee Lo
发明人： Ellis Meng , Ronalee Lo
IPC分类号： H01S4/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0816 , B01L2300/0858 , B01L2300/0887 , B01L2400/046 , G01N35/1079
摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.
摘要翻译：提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件隔膜腔。隔膜元件由粘弹性材料形成。隔膜元件限定隔膜入口表面和隔膜出口表面，其中隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。还提供了与MEMS器件的制造和相互作用的方法。

8. 发明授权

US08087310B2 Interconnect for MEMS device including a viscoelastic septum 有权
标题翻译：用于MEMS器件的互连，包括粘弹性隔膜
公开(公告)号：US08087310B2
公开(公告)日：2012-01-03
申请号：US12357330
申请日：2009-01-21
申请人： Ellis Meng , Ronalee Lo
发明人： Ellis Meng , Ronalee Lo
IPC分类号： G01N1/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0816 , B01L2300/0858 , B01L2300/0887 , B01L2400/046 , G01N35/1079
摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.
摘要翻译：提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件隔膜腔。隔膜元件由粘弹性材料形成。隔膜元件限定隔膜入口表面和隔膜出口表面，隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。还提供了与MEMS器件的制造和相互作用的方法。

9. 发明授权

US08518481B2 Interconnect for MEMS device including a viscoelastic septum 失效
标题翻译：用于MEMS器件的互连，包括粘弹性隔膜
公开(公告)号：US08518481B2
公开(公告)日：2013-08-27
申请号：US13251959
申请日：2011-10-03
申请人： Ellis Meng , Ronalee Lo
发明人： Ellis Meng , Ronalee Lo
IPC分类号： B05D7/00
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0816 , B01L2300/0858 , B01L2300/0887 , B01L2400/046 , G01N35/1079
摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.
摘要翻译：提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件隔膜腔。隔膜元件由粘弹性材料形成。隔膜元件限定隔膜入口表面和隔膜出口表面，其中隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。还提供了与MEMS器件的制造和相互作用的方法。

10. 发明申请

US20090183555A1 INTERCONNECT FOR MEMS DEVICE INCLUDING A VISCOELASTIC SEPTUM 有权
标题翻译：用于包括粘弹性体的MEMS器件的互连
公开(公告)号：US20090183555A1
公开(公告)日：2009-07-23
申请号：US12357330
申请日：2009-01-21
申请人： Ellis Meng , Ronalee Lo
发明人： Ellis Meng , Ronalee Lo
IPC分类号： G01N1/00 , B05D5/12
CPC分类号： B01L3/502715 , B01L2200/027 , B01L2300/044 , B01L2300/0816 , B01L2300/0858 , B01L2300/0887 , B01L2400/046 , G01N35/1079
摘要： Provided is a micro electro mechanical systems (MEMS) device for use with an elongate structure. The MEMS device includes a generally planar substrate, a device wall layer formed upon the substrate, a septum cavity formed in the device wall layer, a channel formed in the device wall layer in fluid communication with the septum cavity, and a septum element disposed in the septum cavity. The septum element is formed of a viscoelastic material. The septum element defines a septum entry surface and a septum exit surface with the septum exit surface being exposed to the channel and disposed between the septum entry surface and the channel. The septum element is without any openings formed through the septum element extending between the septum entry and exit surfaces. Methods of manufacturing and interacting with the MEMS device are also provided.
摘要翻译：提供了一种用于细长结构的微机电系统（MEMS）装置。 MEMS器件包括大致平面的衬底，形成在衬底上的器件壁层，形成在器件壁层中的隔膜腔，形成在与隔膜腔流体连通的器件壁层中的通道和设置在隔膜腔中的隔膜元件隔膜腔。隔膜元件由粘弹性材料形成。隔膜元件限定隔膜入口表面和隔膜出口表面，其中隔膜出口表面暴露于通道并且设置在隔膜入口表面和通道之间。隔膜元件没有通过在隔膜入口和出口表面之间延伸的隔膜元件形成的任何开口。还提供了与MEMS器件的制造和相互作用的方法。

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