专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07363169B2 Simulating microarrays using a parameterized model 失效
标题翻译：使用参数化模型模拟微阵列
公开(公告)号：US07363169B2
公开(公告)日：2008-04-22
申请号：US10501848
申请日：2003-01-21
申请人： Edward R. Dougherty , Yoganand Balagurunathan , Yidong Chen
发明人： Edward R. Dougherty , Yoganand Balagurunathan , Yidong Chen
IPC分类号： G06F17/00
CPC分类号： G06T7/0012 , G06T2207/30072
摘要： Simulating a microarray includes defining a number of parameters. A microarray is generated according to the parameters using an imaging procedure. The microarray is compared to a known value, and the imaging procedure is evaluated in response to the comparison. A simulated microarray image can be generated based on parameters. The simulated microarray can be associated with known values. An imaging procedure is applied to the simulated microarray image to generate observed values. The known values (e.g., intensities) can be compared to the observed values to evaluate the imaging procedure.
摘要翻译：模拟微阵列包括定义多个参数。使用成像程序根据参数产生微阵列。将微阵列与已知值进行比较，并且响应于比较来评估成像过程。可以基于参数生成模拟微阵列图像。模拟的微阵列可以与已知值相关联。将成像过程应用于模拟微阵列图像以产生观察值。可以将已知值（例如，强度）与观察值进行比较以评估成像过程。

2. 发明申请

US20050164187A1 Simulating microarrays using a parameterized model 失效
标题翻译：使用参数化模型模拟微阵列
公开(公告)号：US20050164187A1
公开(公告)日：2005-07-28
申请号：US10501848
申请日：2003-01-21
申请人： Edward Dougherty , Yoganand Balagurunathan , Yidong Chen
发明人： Edward Dougherty , Yoganand Balagurunathan , Yidong Chen
IPC分类号： C12P19/34 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00 , G06T7/00
CPC分类号： G06T7/0012 , G06T2207/30072
摘要： Simulating a microarray includes defining a number of parameters. A microarray is generated according to the parameters using an imaging procedure. The microarray is compared to a known value, and the imaging procedure is evaluated in response to the comparison. A simulated microarray image can be generated based on parameters. The simulated microarray can be associated with known values. An imaging procedure is applied to the simulated microarray image to generate observed values. The known values (e.g., intensities) can be compared to the observed values to evaluate the imaging procedure.
摘要翻译：模拟微阵列包括定义多个参数。使用成像程序根据参数产生微阵列。将微阵列与已知值进行比较，并且响应于比较来评估成像过程。可以基于参数生成模拟微阵列图像。模拟的微阵列可以与已知值相关联。将成像过程应用于模拟微阵列图像以产生观察值。可以将已知值（例如，强度）与观察值进行比较以评估成像过程。

3. 发明授权

US07003403B1 Quantifying gene relatedness via nonlinear prediction of gene 失效
标题翻译：通过基因的非线性预测量化基因相关性
公开(公告)号：US07003403B1
公开(公告)日：2006-02-21
申请号：US09595580
申请日：2000-06-15
申请人： Edward R. Dougherty , Seungchan Kim , Michael L. Bittner , Yidong Chen
发明人： Edward R. Dougherty , Seungchan Kim , Michael L. Bittner , Yidong Chen
IPC分类号： G01N33/48 , G06G7/00 , C12Q1/68
CPC分类号： G06F19/24 , G06F19/20
摘要： Relatedness between genes is quantified by constructing nonlinear models predicting gene expression. Effectiveness of the model is evaluated to provide a measurement of the relatedness of genes associated with the model. Various types of models, including full-logic or neural networks can be constructed. A graphical user interface presents results of the analysis to allow evaluation by a user. Each gene's contribution to the measurement of relatedness can be shown on a graph, and graphical representations of models used to predict gene expression can be displayed.
摘要翻译：通过构建预测基因表达的非线性模型来量化基因之间的相关性。评估模型的有效性，以提供与模型相关的基因的相关性的测量。可以构建各种类型的模型，包括全逻辑或神经网络。图形用户界面显示分析结果，以便用户进行评估。每个基因对相关性测量的贡献可以显示在图上，并且可以显示用于预测基因表达的模型的图形表示。

4. 发明授权

US06245517B1 Ratio-based decisions and the quantitative analysis of cDNA micro-array images 有权
标题翻译：基于比例的决策和cDNA微阵列图像的定量分析
公开(公告)号：US06245517B1
公开(公告)日：2001-06-12
申请号：US09407021
申请日：1999-09-28
申请人： Yidong Chen , Edward R. Dougherty , Michael L. Bittner
发明人： Yidong Chen , Edward R. Dougherty , Michael L. Bittner
IPC分类号： C12Q168
CPC分类号： G06F19/20
摘要： Gene expression can be quantitatively analyzed by hybridizing fluor-tagged mRNA to targets on a cDNA micro-array. Comparison of gene expression levels arising from co-hybridized samples is achieved by taking ratios of average expression levels for individual genes. In an image-processing phase, a method of image segmentation identifies cDNA target sites in a cDNA micro-array image. The resulting cDNA target sites are analyzed based on a hypothesis test and confidence interval to quantify the significance of observed differences in expression ratios. In particular, the probability density of the ratio and the maximum-likelihood estimator for the distribution are derived, and an iterative procedure for signal calibration is developed.
摘要翻译：通过将荧光标记的mRNA与cDNA微阵列上的靶杂交，可以定量分析基因表达。通过获取单个基因的平均表达水平的比例来实现来自共杂交样品的基因表达水平的比较。在图像处理阶段，图像分割的方法识别cDNA微阵列图像中的cDNA靶位点。基于假设检验和置信区间分析得到的cDNA靶位点，以量化观察到的差异表达率的显着性。特别地，导出比率的概率密度和分布的最大似然估计量，并且开发用于信号校准的迭代过程。

5. 发明授权

US07247426B2 Classifying cancers 失效
标题翻译：分类癌症
公开(公告)号：US07247426B2
公开(公告)日：2007-07-24
申请号：US09921406
申请日：2001-08-02
申请人： Zohar Yakhini , Michael Bittner , Jeff Trent , Amir Ben-Dor , Paul Meltzer , Yidong Chen , Ashani Weeraratna , Yuan Jiang , Nick Sampas , Edward Dougherty
发明人： Zohar Yakhini , Michael Bittner , Jeff Trent , Amir Ben-Dor , Paul Meltzer , Yidong Chen , Ashani Weeraratna , Yuan Jiang , Nick Sampas , Edward Dougherty
IPC分类号： C12Q1/68
CPC分类号： G01N33/5743 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136
摘要： The overexpression of certain marker genes including Wnt5a has been found useful in the identification of more aggressive forms of malignant melanoma. Therefore, the overexpression of these genes in tumor samples of malignant melanoma may be useful in the diagnosis, profiling, and treatment of patients suffering from this disease. Inhibitors of Wnt5a activity may be useful in the treatment of aggressive forms of malignant melanoma. Inhibition of Wnt5a activity may be effected by any method including anti-sense therapy, gene therapy, and pharmaceutical intervention.
摘要翻译：已经发现某些标记基因（包括Wnt5a）的过表达可用于鉴定更具攻击性的恶性黑素瘤。因此，这些基因在恶性黑素瘤肿瘤样本中的过表达可能用于诊断，分析和治疗患有这种疾病的患者。 Wnt5a活性抑制剂可用于治疗侵袭性恶性黑色素瘤。 Wnt5a活性的抑制可以通过任何方法进行，包括反义治疗，基因治疗和药物干预。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式