专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050087685A1 Desalting plate for maldi mass spectrometry 有权
标题翻译：用于maldi质谱的脱盐板
公开(公告)号：US20050087685A1
公开(公告)日：2005-04-28
申请号：US10478399
申请日：2002-05-24
申请人： Edouard Bouvier , Bruce Compton , Dominic Gostick , Jeffrey Brown
发明人： Edouard Bouvier , Bruce Compton , Dominic Gostick , Jeffrey Brown
IPC分类号： G01N27/62 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/0418 , G01N1/405 , Y10T436/24 , Y10T436/25
摘要： A novel Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) desalting sample support plate is described. The plate comprises a sample presentation surface, wherein the sample presentation surface comprises at least one receiving surface of an absorbent layer, wherein the absorbent layer retains selected molecules on the receiving surface. Methods for making and using the sample support plate in conventional and automated MALDI-MS are also described.
摘要翻译：描述了一种新型的矩阵辅助激光解吸/电离质谱（MALDI-MS）脱盐样品支撑板。所述板包括样品呈现表面，其中所述样品呈现表面包括吸收层的至少一个接收表面，其中所述吸收层将选定的分子保持在所述接收表面上。还描述了在常规和自动化的MALDI-MS中制备和使用样品支持板的方法。

2. 发明申请

US20080073512A1 METHODS, COMPOSITIONS AND DEVICES FOR PERFORMING IONIZATION DESORPTION ON SILICON DERIVATIVES 审中-公开
标题翻译：用于对硅衍生物进行离子沉淀的方法，组合物和装置
公开(公告)号：US20080073512A1
公开(公告)日：2008-03-27
申请号：US11829170
申请日：2007-07-27
申请人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
发明人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
IPC分类号： C01B33/113 , C07F7/02 , H01J49/16
CPC分类号： B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/12 , H01J49/0418
摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1, or O—SiR1, R2, R3 wherein R1, R2, and R3 are selected from the group consisting of alkyl, alkenyl, alkynyl, aromatic, amino alkyl, amino alkenyl, amino alkynyl, pyridinyl, pyrridonyl, and carbonyl, alcohol and carboxylic acid derivatives thereof having one to twenty five atoms, and hydroxyl, amino, amide, carboxyl, ester, carbonyl, sulfhydryl, sulfonyl, phosphoral, bromo, iodo, chloro and fluoro derivatives. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.
摘要翻译：本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基或-OR 1，或O-SiR 1，R 2，R 3，其中R 1， R 1，R 2，R 3和R 3选自烷基，烯基，炔基，芳族，氨基烷基，氨基烯基，氨基炔基，吡啶基，吡咯基和羰基，具有一至二十五个原子的醇和羧酸衍生物，以及羟基，氨基，酰胺，羧基，酯，羰基，巯基，磺酰基，磷酰基，溴，碘，氯和氟衍生物。字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

3. 发明申请

US20060057659A1 Destructible surfactants and uses thereof 有权
公开(公告)号：US20060057659A1
公开(公告)日：2006-03-16
申请号：US10516418
申请日：2003-05-30
申请人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
发明人： Edouard Bouvier , Bruce Compton , John Gebler , Martin Gilar , Ying-Qing Yu , Peter Lee , Elizabeth Brown
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C12P21/06 , G01N27/44726 , G01N27/44747 , G01N33/5306
摘要： The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

4. 发明申请

US20060157648A1 Methods, compositions and devices for performing ionization desorption on silicon derivatives 审中-公开
标题翻译：用于在硅衍生物上进行电离解吸的方法，组合物和装置
公开(公告)号：US20060157648A1
公开(公告)日：2006-07-20
申请号：US11288590
申请日：2005-11-29
申请人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
发明人： Gary Siuzdak , Eden Go , Zhouxin Shen , Bruce Compton , Edouard Bouvier , Grace Credo
IPC分类号： H01J49/00
CPC分类号： H01J49/0418 , B01L3/5085 , B01L3/5088 , B01L2300/069 , B01L2300/0819 , B01L2300/0829 , B01L2300/12 , G01N1/22
摘要： Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1 or O—SiR1,R2,R3 wherein R1,R2, and R3 are selected from the group consisting C1 to C6 straight, cyclic, or branched alkyl, aryl, or alkoxy group, a hydroxyl group, or a siloxane group, and R6 may be a C1 to C36 straight, cyclic, or branched alkyl (e.g., C18, cyanopropyl), aryl, or alkoxy group, where the groups of R6 are unsubstituted or substituted with one or more moieties such as halogen, cyano, amino, diol, nitro, ether, carbonyl, epoxide, sulfonyl, cation exchanger, anion exchanger, carbamate, amide, urea, peptide, protein, carbohydrate, and nucleic acid functionalities. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.
摘要翻译：本发明的实施例涉及用于在多孔硅上进行电离解吸的基板，用于进行这种电离解吸的方法和制造基板的方法。涉及用于在硅上进行离子解吸的衬底的一个实施方案包括具有下式的表面的衬底：如上所用，X为H或Y，其中X至少为二十五摩尔百分数为Y，Y为羟基或-OR 1或O-SiR 1，R 2，R 3，其中R 1 R 2，R 3和R 3选自C 1至C 6 - ， - 直链，环状或支链烷基，芳基或烷氧基，羟基或硅氧烷基，R 6可以是C 1〜 36个直链，环状或支链烷基（例如C 18，氰基丙基），芳基或烷氧基，其中R 6基团是未取代的或被一个或多个部分取代，例如卤素，氰基，氨基，二醇，硝基，醚，羰基，环氧化物，磺酰基，阳离子交换剂，阴离子交换剂，氨基甲酸酯，酰胺，脲，肽，蛋白质，碳水化合物和核酸功能。字母“n”表示从1到无穷大的整数，任何空位是硅原子，氢或杂质。

5. 发明申请

US20070023627A1 Adsorption, detection and identification of components of ambient air with desorption/ionization on silicon mass spectrometry (dios-ms) 有权
标题翻译：通过硅质谱分析（dios-ms）解吸/电离的环境空气组分的吸附，检测和鉴定
公开(公告)号：US20070023627A1
公开(公告)日：2007-02-01
申请号：US10545332
申请日：2004-02-09
申请人： Jeffrey Finch , Chris Stumpf , Bruce Compton
发明人： Jeffrey Finch , Chris Stumpf , Bruce Compton
IPC分类号： B01D59/44
CPC分类号： G01N1/2214 , H01J49/0418 , H01J49/0422 , Y10T428/24802 , Y10T428/249953 , Y10T428/29 , Y10T428/2913 , Y10T436/24 , Y10T436/25
摘要： The present invention provides a device, system, and associated methods to actively or passively sample air by directing it onto the surface of a porous light-absorbing semiconductor, for example, a desorption/ionization on porous silicon (“DIOS”) chip. Upon adsorption of an analyte, the surface may be analyzed directly by laser desorption/ionization time-of-flight mass spectrometry. Because the process of laser desorption/ionization and subsequent mass detection does not require elevated temperatures, thermal degradation of analytes is avoided.
摘要翻译：本发明提供了一种通过将空气引导到多孔光吸收半导体的表面上，例如在多孔硅（“DIOS”）芯片上的解吸/电离来主动或被动地对空气进行取样的装置，系统和相关方法。在分析物吸附后，可以通过激光解吸/电离飞行时间质谱直接分析表面。由于激光解吸/电离和随后的质量检测过程不需要升高的温度，因此避免了分析物的热降解。

6. 发明申请

US20060104966A1 Transglutaminase linkage of agents to tissue 审中-公开
标题翻译：试剂与组织的转谷氨酰胺酶连接
公开(公告)号：US20060104966A1
公开(公告)日：2006-05-18
申请号：US11144372
申请日：2005-06-03
申请人： Howard Green , Bruce Compton , George Corey , Philippe Djian
发明人： Howard Green , Bruce Compton , George Corey , Philippe Djian
IPC分类号： A61K38/48
CPC分类号： A61K8/49 , A61K8/0208 , A61K8/37 , A61K8/602 , A61K8/64 , A61K8/66 , A61K38/45 , A61K38/465 , A61K47/557 , A61K47/65 , A61K47/665 , A61K2800/57 , A61K2800/70 , A61K2800/88 , A61K2800/94 , A61Q5/12 , A61Q17/04 , A61Q19/00 , B82Y5/00 , C07K14/685 , C07K14/78 , C07K17/02 , C12N9/16 , C12N9/18 , C12Y203/02013 , C12Y301/01007 , Y10S530/812
摘要： Methods, products and kits are provided for attaching agents to body tissues using transglutaminase.
摘要翻译：提供方法，产品和试剂盒用于使用转谷氨酰胺酶将试剂连接到人体组织。

7. 发明申请

US20050233464A1 Methods and apparatus for identifying compounds in a sample 审中-公开
标题翻译：用于鉴定样品中化合物的方法和装置
公开(公告)号：US20050233464A1
公开(公告)日：2005-10-20
申请号：US11099891
申请日：2005-04-06
申请人： Bruce Compton , Robert Plumb
发明人： Bruce Compton , Robert Plumb
IPC分类号： G01N30/02 , G01N30/72 , G01N30/74 , G01N30/78 , G01N30/88
CPC分类号： G01N30/78 , G01N30/72 , G01N30/74 , G01N2030/8813 , Y10T436/24
摘要： Embodiments of the present invention provide methods and apparatus for comparing the proteome and or metabonome of an organism or culture to standard values, over time, or after a change has taken place, a pertubation, with respect to the organinsm or culture.
摘要翻译：本发明的实施方案提供了用于将生物体或培养物的蛋白质组学和/或代谢组分与标准值进行比较的方法和装置，随着时间的推移，或在发生变化后，相对于组织或培养物的渗透。

8. 发明申请

US20060110379A1 Linkage of agents using microparticles 审中-公开
标题翻译：使用微粒的试剂连接
公开(公告)号：US20060110379A1
公开(公告)日：2006-05-25
申请号：US11125830
申请日：2005-05-10
申请人： Howard Green , Bruce Compton , George Corey , Philippe Djian
发明人： Howard Green , Bruce Compton , George Corey , Philippe Djian
IPC分类号： A61K38/48 , A61K9/14
CPC分类号： C07K17/08 , A61K8/11 , A61K8/64 , A61K9/167 , A61K2800/412 , A61K2800/57 , A61K2800/94 , A61Q19/00 , Y10S530/812
摘要： Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.
摘要翻译：提供方法，产品和试剂盒用于通过使用内源或外源转谷氨酰胺酶的微粒将试剂附着到皮肤表面。

9. 发明授权

US06919076B1 Conjugates of agents and transglutaminase substrate linking molecules 失效
标题翻译：试剂和转谷氨酰胺酶底物连接分子的结合物
公开(公告)号：US06919076B1
公开(公告)日：2005-07-19
申请号：US09359920
申请日：1999-07-22
申请人： Howard Green , Bruce Compton , George Corey , Philippe Djian
发明人： Howard Green , Bruce Compton , George Corey , Philippe Djian
IPC分类号： A61K8/02 , A61K8/37 , A61K8/49 , A61K8/60 , A61K8/64 , A61K8/66 , A61K38/00 , A61K38/45 , A61K38/48 , A61K47/48 , A61Q5/12 , A61Q17/04 , A61Q19/00 , C07K17/02 , C12N11/02
CPC分类号： A61K8/49 , A61K8/0208 , A61K8/37 , A61K8/602 , A61K8/64 , A61K8/66 , A61K38/45 , A61K38/465 , A61K47/557 , A61K47/65 , A61K47/665 , A61K2800/57 , A61K2800/70 , A61K2800/88 , A61K2800/94 , A61Q5/12 , A61Q17/04 , A61Q19/00 , B82Y5/00 , C07K14/685 , C07K14/78 , C07K17/02 , C12N9/16 , C12N9/18 , C12Y203/02013 , C12Y301/01007 , Y10S530/812
摘要： Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase. In another embodiment a linking molecule containing multiple glutamines is covalently bonded to tissue in the presence of transglutaminase, and an agent containing multiple lysines is covalently bonded to the linking molecule in the presence of transglutaminase. Alternatively, the linking molecule contains multiple lysines and the agent contains multiple glutamines. Two tissues can be sealed together by holding the tissues in contact with each other in the presence of transglutalinase.
摘要翻译：提供方法，产品，组合物和试剂盒用于在转谷氨酰胺酶存在下用连接分子将试剂连接到组织。连接分子和/或试剂是转谷氨酰胺酶的底物。该试剂可以是非蛋白质或酶如胆碱酯酶或磷酸二酯酶。转谷氨酰胺酶可外源性加入或在组织中是内源性的。在具体实施方案中，所述试剂不是转谷氨酰胺酶底物，并且所述连接分子是含有至少两个相邻连接的谷氨酰胺或至少三个连续相连的赖氨酸的转谷氨酰胺酶的底物，并且可以是聚合物。试剂和连接分子的缀合物可以施用于组织，并且在通过连接分子共价键合到组织的转谷氨酰胺酶的存在下。富含赖氨酸的互补连接分子可以在转谷氨酰胺酶存在下首先连接到组织上，然后在转谷氨酰胺酶存在下共价键合到缀合物的含谷氨酰胺的连接分子。在另一个实施方案中，含有多个谷氨酰胺的连接分子在转谷氨酰胺酶的存在下共价结合到组织上，并且含有多个赖氨酸的试剂在转谷氨酰胺酶存在下共价键合到连接分子上。或者，连接分子含有多个赖氨酸，并且该试剂含有多个谷氨酰胺。在转谷氨酰胺酶的存在下，通过保持组织彼此接触将两个组织密封在一起。

10. 发明申请

US20080027234A1 Destructible surfactants and uses thereof 审中-公开
标题翻译：可破坏的表面活性剂及其用途
公开(公告)号：US20080027234A1
公开(公告)日：2008-01-31
申请号：US11811696
申请日：2007-06-11
申请人： Peter Lee , Bruce Compton
发明人： Peter Lee , Bruce Compton
IPC分类号： C07D319/06 , C07D317/14
CPC分类号： B01F17/0057 , B01D15/203 , G01N27/44747 , G01N30/02 , G01N30/04 , B01D15/366
摘要： Destructible surfactants and methods of using same are provided. The invention includes anionic surfactants having a dioxolane or dioxane functional group which enables the surfactant to be broken down under acidic conditions. The invention also includes methods of making anionic surfactants and methods of using anionic surfactants in a variety of applications.
摘要翻译：提供了可破坏的表面活性剂及其使用方法。本发明包括具有二氧戊环或二恶烷官能团的阴离子表面活性剂，其使表面活性剂在酸性条件下分解。本发明还包括制备阴离子表面活性剂的方法和在各种应用中使用阴离子表面活性剂的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式