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1. 发明授权

US08444687B2 Implantable vascular device 有权
公开(公告)号：US08444687B2
公开(公告)日：2013-05-21
申请号：US12393819
申请日：2009-02-26
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame using heat or pressure welding crimping, adhesive, or other techniques to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.

2. 发明申请

US20090048662A1 IMPLANTABLE VASCULAR DEVICE 有权
标题翻译：可植入血管装置
公开(公告)号：US20090048662A1
公开(公告)日：2009-02-19
申请号：US12258757
申请日：2008-10-27
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

3. 发明申请

US20090157169A1 IMPLANTABLE VASCULAR DEVICE 有权
标题翻译：可植入血管装置
公开(公告)号：US20090157169A1
公开(公告)日：2009-06-18
申请号：US12393819
申请日：2009-02-26
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame using heat or pressure welding crimping, adhesive, or other techniques to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或胶原基材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以使用热或压力焊接压接，粘合剂或形成闭塞装置，支架移植物或可植入的腔内瓣膜的其它技术，例如用于矫正小腿和脚部的无能力的静脉。

4. 发明授权

US07520894B2 Implantable vascular device 有权
公开(公告)号：US07520894B2
公开(公告)日：2009-04-21
申请号：US11165600
申请日：2005-06-22
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame using heat or pressure welding crimping, adhesive, or other techniques to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.

5. 发明授权

US07452371B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07452371B2
公开(公告)日：2008-11-18
申请号：US09777091
申请日：2001-02-05
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller , John A. DeFord , Joseph W. Roberts
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

6. 发明授权

US08613763B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08613763B2
公开(公告)日：2013-12-24
申请号：US12258757
申请日：2008-10-27
申请人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
发明人： Dusan Pavcnik , Frederick S. Keller , Josef Rosch , Thomas A. Osborne , Brian L. Bates , John A. DeFord , Christopher G. Dixon , Andrew K. Hoffa , Raymond B. Leonard, II , Joseph F. Obermiller
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095 , Y10S623/901
摘要： A multiple-sided medical device comprises a frame comprising wire or other resilient material and having a series of bends and interconnecting sides. The device has both a flat configuration and a second, folded configuration which a generally serpentine shape. The device is pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material such as DACRON, PTFE, or a collagen-based material such as small intestinal submucosa (SIS), may be sutured or attached to the frame to form an occlusion device, a stent graft, or an implantable, intraluminal valve such as for correcting incompetent veins in the lower legs and feet.
摘要翻译：多面医疗装置包括包括线或其它弹性材料并具有一系列弯曲和互连侧的框架。该装置具有扁平构型和第二折叠构造，其大致蛇形形状。该装置从输送导管推入管道或容器的内腔，并且可以包括用于锚定目的的一个或多个倒钩。织物或其他柔性材料如DACRON，PTFE或基于胶原的材料如小肠粘膜下层（SIS）的全部或部分覆盖物可以被缝合或附着到框架上以形成闭塞装置，支架移植物，或可植入的管腔内瓣膜，例如用于矫正小腿和脚部的无能力的静脉。

7. 发明授权

US06494824B1 Medical, radiotherapy source vial 有权
标题翻译：医疗放射源小瓶
公开(公告)号：US06494824B1
公开(公告)日：2002-12-17
申请号：US09253310
申请日：1999-02-20
申请人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
发明人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot , James D. Purdy , Joseph P. Lane , Delbert C. Miller , Gregory A. Frankland
IPC分类号： A61N0500
CPC分类号： A61N5/1002 , A61M5/1785 , A61M5/31511 , A61M5/31515 , A61M25/10184 , A61M25/104 , A61N2005/1021
摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. A radiotherapy source vial (700) includes a fluid container (701) of radioactive fluid with a seal (702,731) disposed about the container. Seal (702,731) is moveable with respect to container (701) to change the contained volume therein. A radioactive fluid transport site (703) is in communication with the contained volume and with an exterior (726) of the container (701), and may include a septum (707) or a valve (711). An engagement mechanism (704) is connectable to an external control mechanism (706) whereby the contained volume in the radioactive fluid container can be decreased and increased by actuation of the external control mechanism.
摘要翻译：导管装置和放射剂量测定单元指示器，用于向患者输送规定的辐射剂量。放射治疗源小瓶（700）包括具有围绕容器设置的密封件（702,731）的放射性流体的流体容器（701）。密封件（702,731）能够相对于容器（701）移动以改变其中的容纳体积。放射性流体输送部位（703）与所容纳的容积和容器（701）的外部（726）连通，并且可以包括隔膜（707）或阀（711）。接合机构（704）可连接到外部控制机构（706），由此可以通过外部控制机构的致动来减小和增加放射性液体容器中的容纳量。

8. 发明授权

US06251059B1 Medical radiation treatment delivery apparatus 有权
标题翻译：医疗放射治疗仪器
公开(公告)号：US06251059B1
公开(公告)日：2001-06-26
申请号：US09262620
申请日：1999-03-04
申请人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
发明人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
IPC分类号： A61N500
CPC分类号： A61M25/1011 , A61M2025/1047 , A61M2025/1072 , A61N5/1002 , A61N5/1048
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.
摘要翻译：导管装置（20）和辐射剂量测定单元指示器（21），用于向患者输送规定的辐射剂量。导管填充有辐射载体材料，例如惰性放射性气体（12），用于治疗例如血管成形术后的再狭窄和恶性肿瘤。膨胀的导管包括多个分立的腔室，例如用于运送放射性载体材料的气囊部分（22,24,26）和多个离散的腔室（32,34,36），其能够在治疗过程中使大量血液流过动脉，规定的辐射。充气导管还可以包括一个单一的气囊。特定的金属涂层增强了传递给靶的辐射剂量。充气腔的壁（25）衰减通过导管装置的中空内腔循环的血液的透射剂量。该系统还产生增加的副产物辐射，从β粒子和γ质子向腔壁行进的影响。辐射剂量测量单元指示器（21）被定位，设置或固定到校准的导管上，以帮助医师规定辐射活动和暴露时间。

9. 发明授权

US06162165A Medical radiation treatment device 失效
标题翻译：医疗放射治疗装置
公开(公告)号：US06162165A
公开(公告)日：2000-12-19
申请号：US203947
申请日：1998-12-02
申请人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
发明人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
IPC分类号： A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61N2005/1021
摘要： A catheter apparatus and radiation dosimetry unit indicator for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers for transporting the radioactive carrier material, and a plurality of discrete chambers enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.
摘要翻译：导管装置和放射剂量测定单元指示器，用于向患者输送规定的辐射剂量。导管填充有诸如惰性放射性气体的辐射载体材料，用于治疗例如血管成形术后的再狭窄和恶性肿瘤。充气导管包括用于运输放射性载体材料的多个离散室，以及多个分立的腔室，其能够在用规定的辐射治疗期间使血液能够通过动脉。充气导管还可以包括一个单一的气囊。特定的金属涂层增强了传递给靶的辐射剂量。充气腔的壁衰减通过导管装置的中空内腔循环的血液的透射剂量。该系统还产生增加的副产物辐射，从β粒子和γ质子向腔壁行进的影响。放射剂量测定单元指示器被定位，设置或固定到校准的导管上，以帮助医生规定辐射活动和暴露时间。

10. 发明授权

US6159141A Medical radiation treatment delivery apparatus 失效
标题翻译：医疗放射治疗仪器
公开(公告)号：US6159141A
公开(公告)日：2000-12-12
申请号：US150814
申请日：1998-09-11
申请人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
发明人： Marc G. Apple , Brian L. Bates , John A. DeFord , Neal E. Fearnot
IPC分类号： A61B1/00 , A61F2/958 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61M25/1011 , A61N5/1002 , A61N5/1048 , A61M2025/1047 , A61M2025/1072
摘要： A catheter apparatus (20) and radiation dosimetry unit indicator (21) for delivery of a prescribed radiation dose to a patient. The catheter is filled with a radiation carrier material such as an inert radioactive gas (12) for the treatment of, for example, restenosis after angioplasty, and malignancies. The inflated catheter includes a plurality of discrete chambers such as balloon sections (22, 24, 26) for transporting the radioactive carrier material, and a plurality of discrete chambers (32, 34, 36) enabling substantial blood flow through the artery during treatment with the prescribed radiation. The inflated catheter can also comprise a one-unit balloon. A specific metal coating enhances the radiation dose delivered to the target. The wall (25) of the inflation lumen attenuates transmission dose to the blood circulating through the hollow inner lumen of the catheter device. The system also creates increased by-product radiation, from the impact of beta particles and gamma protons traveling toward the lumen wall. A radiation dosimetry unit indicator (21) is positioned, disposed, or affixed to a calibrated catheter to assist the physician in prescribing radiation activity and exposure times.
摘要翻译：导管装置（20）和辐射剂量测定单元指示器（21），用于向患者输送规定的辐射剂量。导管填充有辐射载体材料，例如惰性放射性气体（12），用于治疗例如血管成形术后的再狭窄和恶性肿瘤。膨胀的导管包括多个分立的腔室，例如用于运送放射性载体材料的气囊部分（22,24,26）和多个离散的腔室（32,34,36），其能够在治疗过程中使大量血液流过动脉，规定的辐射。充气导管还可以包括一个单一的气囊。特定的金属涂层增强了传递给靶的辐射剂量。充气腔的壁（25）衰减通过导管装置的中空内腔循环的血液的透射剂量。该系统还产生增加的副产物辐射，从β粒子和γ质子向腔壁行进的影响。辐射剂量测量单元指示器（21）被定位，设置或固定到校准的导管上，以帮助医师规定辐射活动和暴露时间。

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