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1. 发明授权

US07491413B2 Compositions and methods for treating and preventing virus infections 有权
标题翻译：用于治疗和预防病毒感染的组合物和方法
公开(公告)号：US07491413B2
公开(公告)日：2009-02-17
申请号：US11241744
申请日：2005-09-30
申请人： D. James Morré , Dorothy M. Morré
发明人： D. James Morré , Dorothy M. Morré
IPC分类号： A61K36/82 , A61K36/81 , A61K31/35 , A61K31/05
CPC分类号： A61K36/81 , A61K36/82 , Y02A50/387 , A61K2300/00
摘要： Provided are compositions comprising a vanilloid and tea catechins in amounts and proportions which combat virus infections in a human or animal. The vanilloid can be provided in the form of a dried pepper preparation and the tea catechins can be provided in the form of a green tea extract (or concentrate). These active ingredients can be provided separately or in combination. The administration of a such nutritional or other composition, desirably oral administration (in an amount effect) results in reduced virus infection or ameliorated symptoms of virus infection in a human or an animal in need of such a composition.
摘要翻译：提供的组合物包含与人或动物中的病毒感染相抗衡的量和比例的香草酸和茶儿茶素。香草醇可以以干胡椒制剂的形式提供，茶儿茶素可以以绿茶提取物（或浓缩物）的形式提供。这些活性成分可以单独或组合提供。施用这样的营养或其它组合物，期望地口服给药（量的作用）导致需要这种组合物的人或动物中病毒感染或病毒感染症状的改善。

2. 发明授权

US06652890B2 Tea catechins as cancer specific proliferation inhibitors 失效
公开(公告)号：US06652890B2
公开(公告)日：2003-11-25
申请号：US10102502
申请日：2002-03-19
申请人： Dorothy M. Morré , D. James Morré
发明人： Dorothy M. Morré , D. James Morré
IPC分类号： A61K3578
CPC分类号： A61K31/35 , A61K31/353 , A61K36/82 , A61K45/06 , Y10S514/964 , A61K31/00 , A61K2300/00
摘要： The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.

3. 发明授权

US06878514B1 Methods for identifying agents that inhibit serum aging factors and uses and compositions thereof 失效
公开(公告)号：US06878514B1
公开(公告)日：2005-04-12
申请号：US09536551
申请日：2000-03-28
申请人： Dorothy M. Morré , D. James Morré
发明人： Dorothy M. Morré , D. James Morré
IPC分类号： A61K31/122 , C12Q1/00 , A61K49/00 , A61K37/18 , A01N37/18
CPC分类号： A61K31/122 , Y02A50/411
摘要： The invention described herein encompasses methods of preventing or treating disorders caused by oxidative damage by an aging-specific isoform of NADH oxidase (AR-NOX). The invention encompasses methods of assaying, screening, and identifying agents that inhibit AR-NOX, as well as methods using ubiquinone to inhibit the ability of AR-NOX to generate reactive oxygen species. These agents may be formulated into pharmaceutical compositions in the prevention and treatment of disorders caused by oxidative damage.

4. 发明授权

US07192612B2 Compositions and methods based on synergies between capsicum extracts and tea catechins for prevention and treatment of cancer 失效
标题翻译：基于辣椒提取物和茶儿茶素之间协同作用的组合物和方法，用于预防和治疗癌症
公开(公告)号：US07192612B2
公开(公告)日：2007-03-20
申请号：US10886159
申请日：2004-07-06
申请人： D. James Morré , Dorothy M. Morré
发明人： D. James Morré , Dorothy M. Morré
IPC分类号： A51K36/82 , A61K36/81 , A61K9/22 , A61K31/35 , A61K31/05
CPC分类号： A61K36/81 , A61K31/05 , A61K31/35 , A61K36/82 , A61K2300/00
摘要： The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of therapeutically effective amount of catechins, a group of polyphenols found in green tea, and Capsicum extracts. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins and Capsicum extracts, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.
摘要翻译：本文描述的发明包括预防或治疗癌症的方法和组合物，包括施用治疗有效量的儿茶素，一组在绿茶中发现的多酚和辣椒提取物的组合。儿茶素的组合物包括但不限于表没食子儿茶素没食子酸酯（EGCg），表儿茶素（EC），表儿茶素没食子酸酯（ECG），表没食子儿茶素（EGC））。本发明的独特组合包含儿茶素和辣椒提取物的各种组合，彼此组合或其它治疗剂，并用于治疗人类的原发性和转移性癌症。本发明还包括治疗化合物的不同给药方式，包括可用作治疗癌症的治疗化合物或用作预防癌症的膳食补充剂的制剂。

5. 发明申请

US20120207862A1 ORAL INHIBITORS OF AGE-RELATED NADH OXIDASE (arNOX), COMPOSITIONS AND NATURAL SOURCES 审中-公开
标题翻译：与年龄相关的NADH氧化酶（arNOX），组合物和天然来源的口腔抑制剂
公开(公告)号：US20120207862A1
公开(公告)日：2012-08-16
申请号：US13224317
申请日：2011-09-01
申请人： D. James Morré , Dorothy M. Morré , Thomas Shelton
发明人： D. James Morré , Dorothy M. Morré , Thomas Shelton
IPC分类号： A61K36/45 , A61K36/53 , A61K36/537 , A61K36/00
CPC分类号： A61K36/53 , A61K36/235 , A61K36/282 , A61K36/537 , A61K2300/00
摘要： Described are compositions and agents for blocking serum and other aging factors, especially arNOX in serum, skin or other body fluid or tissue and/or on the cell surface, and methods for using the same. More particularly, the invention relates to agents comprising any one of several naturally-occurring arNOX inhibitors capable of reducing occurrence or severity of or treating disorders and complications of disorders resulting from cell damage caused by aging-related isoforms of NADH oxidase (arNOX). In one exemplary embodiment, nutraceutical, cosmeceutical or pharmaceutical compositions comprise at least one naturally occurring arNOX inhibitor or inhibitor source. Such naturally occurring inhibitors also are capable of augmenting the anti-arNOX effect of other naturally occurring arNOX inhibitory agents. The discovery of multiple inhibitors with significantly different kinetics of inhibition that when combined provide long term arNOX inhibition is one of the unique and non-obvious features of the present methods and compositions.
摘要翻译：描述了用于阻断血清和其它老化因子，特别是血清，皮肤或其它体液或组织中和/或细胞表面上的arNOX的组合物和试剂，以及使用它们的方法。更具体地，本发明涉及能够减少由NADH氧化酶（arNOX）的老化相关同种型引起的细胞损伤引起的疾病的发生或严重程度的障碍和并发症的几种天然存在的arNOX抑制剂中的任一种的药剂。在一个示例性实施方案中，营养药物，药妆组合物或药物组合物包含至少一种天然存在的arNOX抑制剂或抑制剂来源。这些天然存在的抑制剂也能够增强其它天然存在的arNOX抑制剂的抗-ArNOX作用。发现具有显着不同的抑制动力学的多种抑制剂，当组合时提供长期的arNOX抑制是本方法和组合物的独特和非显而易见的特征之一。

6. 发明授权

US06759064B2 Compositions based on vanilloid-catechin synergies for prevention and treatment of cancer 失效
标题翻译：基于香草素 - 儿茶素协同作用的组合物，用于预防和治疗癌症
公开(公告)号：US06759064B2
公开(公告)日：2004-07-06
申请号：US10081903
申请日：2002-02-22
申请人： Dorothy M. Morré , D. James Morré
发明人： Dorothy M. Morré , D. James Morré
IPC分类号： A61K3578
CPC分类号： A61K31/35 , A61K36/82 , A61K2300/00
摘要： The invention described herein encompasses methods and compositions of preventing or treating cancer comprising the administration of a combination of catechins and vanilloids. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). In a preferred embodiment the catechins have been treated with tannase. Compositions of vanilloids include, but are not limited to vanillylamine, the head group of capsaicin. The unique compositions of the invention contain various combinations of the catechins and vanilloids, in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses various modes of administration of the therapeutic compounds, including formulations which may be used as a dietary or nutritional supplement or as a therapeutic compound.
摘要翻译：本文描述的发明包括预防或治疗癌症的方法和组合物，其包括给予儿茶素和香草素的组合。儿茶素的组合物包括但不限于表没食子儿茶素没食子酸酯（EGCg），表儿茶素（EC），表儿茶素没食子酸酯（ECG），表没食子儿茶素（EGC））。在优选的实施方案中，儿茶素已经用鞣酸酶处理。香草素的组合物包括但不限于香草胺，辣椒素的头基。本发明的独特组合包含儿茶素和香草素的各种组合，彼此组合或其它治疗剂，并且用于治疗人类中的原发性和转移性癌症。本发明还包括治疗化合物的各种施用模式，包括可用作膳食或营养补充剂或作为治疗化合物的制剂。

7. 发明授权

US06428818B1 Tea catechin formulations and processes for making same 失效
标题翻译：茶儿茶素制剂及其制备方法
公开(公告)号：US06428818B1
公开(公告)日：2002-08-06
申请号：US09640768
申请日：2000-08-17
申请人： Dorothy M. Morré , D. James Morré , Raymond Cooper , Howard Sun , Qing Ye
发明人： Dorothy M. Morré , D. James Morré , Raymond Cooper , Howard Sun , Qing Ye
IPC分类号： A61K3578
CPC分类号： A61K36/82 , A61K31/35 , A61K31/353 , A61K45/06 , A61K2300/00
摘要： The invention described herein encompasses methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins with reduced levels of EGCg, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds.
摘要翻译：本文描述的发明包括治疗癌症或实体肿瘤的方法和组合物，包括向需要这种治疗的哺乳动物施用治疗有效量的儿茶素（一组在绿茶中发现的多酚）。儿茶素的组合物包括但不限于表没食子儿茶素没食子酸酯（EGCg），表儿茶素（EC），表儿茶素没食子酸酯（ECG），表没食子儿茶素（EGC））。本发明独特的组合物含有儿茶素类与EGCg水平的各种组合，单独或彼此组合或其它治疗剂，并用于治疗人类原发性和转移性癌症。本发明还包括治疗化合物的不同给药方式。

8. 发明授权

US06410052B1 Tea catechins in sustained release formulations as cancer specific proliferation inhibitors 有权
标题翻译：持久释放制剂中的茶儿茶素作为癌症特异性增殖抑制剂
公开(公告)号：US06410052B1
公开(公告)日：2002-06-25
申请号：US09637840
申请日：2000-08-10
申请人： Dorothy M. Morré , D. James Morré , Raymond Cooper , Michael N. Chang
发明人： Dorothy M. Morré , D. James Morré , Raymond Cooper , Michael N. Chang
IPC分类号： A61K922
CPC分类号： A61K36/82 , A23L33/105 , A61K9/2081 , A61K9/5047 , A61K31/35 , A61K31/353 , A61K45/06 , A61K2300/00
摘要： The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of such therapy. Compositions of catechins include but not limited to, epigallocatechin gallate (EGCg), epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC). The unique compositions of the invention contain various combinations of the catechins, alone or in combination with each other or other therapeutic agents and are used to treat primary and metastatic cancers in humans. The invention also encompasses the varying modes of administration of the therapeutic compounds, including a sustained release formulation which may be used as a therapeutic compound for the treatment of cancer or as a dietary supplement for the prevention of cancer.
摘要翻译：本文描述的发明包括治疗癌症或实体肿瘤的方法和组合物，包括向需要这种治疗的哺乳动物施用治疗有效量的儿茶素（一组在绿茶中发现的多酚）。儿茶素的组合物包括但不限于表没食子儿茶素没食子酸酯（EGCg），表儿茶素（EC），表儿茶素没食子酸酯（ECG），表没食子儿茶素（EGC））。本发明的独特组合包含儿茶素的单独或彼此组合或其它治疗剂的各种组合，并且用于治疗人类的原发性和转移性癌症。本发明还包括治疗化合物的不同给药方式，包括可用作治疗癌症的治疗化合物或作为预防癌症的膳食补充剂的持续释放制剂。

9. 发明申请

US20120034626A1 Neoplasia-Specific Autoantibodies and Methods 审中-公开
标题翻译：新生儿特异性自身抗体和方法
公开(公告)号：US20120034626A1
公开(公告)日：2012-02-09
申请号：US13040232
申请日：2011-03-03
申请人： D. James Morré , Xiaoyu Tang
发明人： D. James Morré , Xiaoyu Tang
IPC分类号： G01N33/577 , C07K19/00 , G01N33/573 , C07K16/40
CPC分类号： G01N33/57484 , C07K16/30 , C07K16/40 , C07K16/4241 , C07K2317/622 , G01N33/564
摘要： ENOX2 proteins are growth-related cell surface proteins expressed specifically by cancer cells; they catalyze NADH oxidation and protein disulfide-thiol interchange reactions. Taught herein are IgM class autoantibodies specific to ENOX2 (tNOX) in a variety of cancer patient sera. Early cancer patients produce these autoantibodies as a possible defense mechanism. Because ENOX2 is bound to autoantibodies in patients, it is unavailable to bind conventional ENOX2-specific antibodies in standard ELISA assays, but two-dimensional gel electrophoresis dissociates ENOX2 protein from autoantibodies, allowing detection. Probing ENOX2 using cancer sera as a source of ENOX2 autoantibodies followed by horseradish peroxidase-coupled anti-human IgM allows visualization and detection of the ENOX2 autoantibody. ENOX2 autoantibodies from breast cancer sera reacts with the ENOX2 isoforms from, e.g., lung and ovarian cancer patient sera. ENOX2 autoantibodies enable cancer screening based both on autoantibody detection and autoantibody dissociation to allow for standard ELISA development as well as therapy.
摘要翻译： ENOX2蛋白是癌细胞特异性表达的生长相关细胞表面蛋白; 它们催化NADH氧化和蛋白质二硫键 - 硫醇交换反应。本文教导了各种癌症患者血清中特异于ENOX2（tNOX）的IgM类自身抗体。早期癌症患者产生这些自身抗体作为可能的防御机制。由于ENOX2与患者中的自身抗体结合，因此在标准ELISA测定中不能结合常规的ENOX2特异性抗体，但二维凝胶电泳可以从自身抗体中分离出ENOX2蛋白，从而进行检测。使用癌症血清作为ENOX2自身抗体的来源，然后用辣根过氧化物酶偶联的抗人IgM检测ENOX2，可以显示和检测ENOX2自身抗体。来自乳腺癌血清的ENOX2自身抗体与来自例如肺癌和卵巢癌患者血清的ENOX2同种型反应。 ENOX2自身抗体能够基于自身抗体检测和自身抗体解离进行癌症筛查，以实现标准ELISA的发展和治疗。

10. 发明授权

US08465939B2 Aging-related circulating particle-associated lipoprotein B oxidase (apoBNOX) and inhibitors thereof 有权
标题翻译：老化相关循环颗粒相关脂蛋白B氧化酶（apoBNOX）及其抑制剂
公开(公告)号：US08465939B2
公开(公告)日：2013-06-18
申请号：US13039170
申请日：2011-03-02
申请人： D. James Morré
发明人： D. James Morré
IPC分类号： G01N33/53 , C12Q1/00 , C12N9/00
CPC分类号： C12N9/0036 , A61K31/05 , A61K36/87 , C12Q1/26 , G01N33/92
摘要： Provided is an age-related apolipoprotein B oxidase (apoBNOX) found tightly associated with the low-density lipoprotein particles and believed to be responsible for oxidizing lipoprotein particles and initiating atherogenesis. It causes damage by directly oxidizing the apolipoprotein B protein and indirectly oxidizing the lipids in the particles due to superoxide formation by the apoBNOX and its conversion into hydrogen peroxide. apoBNOX activity is inhibited by tyrosol and hydroxytyrosol and components of white wine, important components of French and Mediterranean diets, which seem to be a very good source of inhibitors of the apolipoprotein B oxidase. Agents comprising at least one naturally-occurring apoBNOX inhibitor and compositions lessen, ameliorate or treat disorders and complications resulting from cell damage caused by oxidation of apolipoprotein B. Also provided is an assay system comprising recombinant apoBNOX or an equivalent peptide and apolipoprotein B purified from human sera as a model to screen for agents and supplements that lower apoBNOX activity when administered orally.
摘要翻译：提供与年龄相关的载脂蛋白B氧化酶（apoBNOX），其发现与低密度脂蛋白颗粒紧密相关，并被认为负责氧化脂蛋白颗粒并引发动脉粥样硬化形成。它通过直接氧化载脂蛋白B蛋白并间接氧化颗粒中的脂质而引起损伤，这是由于通过apoBNOX的超氧化物形成及其转化为过氧化氢。 apoBNOX活性被酪醇和羟基酪醇以及白葡萄酒的成分，法国和地中海饮食的重要组成部分所抑制，这似乎是载脂蛋白B氧化酶抑制剂的非常好的来源。包含至少一种天然存在的apoBNOX抑制剂的药剂和减轻，改善或治疗由载脂蛋白B的氧化引起的细胞损伤引起的疾病和并发症的组合物。还提供了包含重组apoBNOX或从人体纯化的等效肽和载脂蛋白B的测定系统血清作为模型，用于筛选当口服给药时降低apoBNOX活性的药剂和补充剂。

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