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1. 发明授权

US5736355A Self contained biological indicator 失效
标题翻译：自包含生物指标
公开(公告)号：US5736355A
公开(公告)日：1998-04-07
申请号：US645259
申请日：1996-05-13
申请人： Denis G. Dyke , Paul S. Malchesky , Raymond C. Kralovic , Donna M. Richardson , Joseph J. Switka
发明人： Denis G. Dyke , Paul S. Malchesky , Raymond C. Kralovic , Donna M. Richardson , Joseph J. Switka
IPC分类号： C12M1/28 , C12Q1/18 , C12Q1/22 , C12M1/34
CPC分类号： C12Q1/18 , C12M23/32 , C12M23/38 , C12M25/02 , C12M25/06 , C12M37/04 , C12Q1/22
摘要： A self contained biological indicator (A) determines an effectiveness of a microbial decontamination process. A dart (68) has a seal (80) engaged by rim (58) in detents (50C) in fins (36A-36F) of a cap (C). The dart has a cutting edge (76) aligned just above a foil seal (86) sealing a growth medium (F) in a medium housing (D). The dart has a chamber (72) in which challenge spores or other microorganisms on a paper disk (74) are housed. A microporous membrane (G) traps the challenge spores in the chamber while allowing a microbial decontamination fluid to flow through to contact the spores. The housing is lodged by a flange (56) in detents (50A) in fins (36A-36F). After the microbial decontamination process is complete, the cap is forced toward medium housing causing the rim and the flange to dislodge from their respective detents and lodge in detents (50B) resulting in the puncturing of the foil seal, the sealing of the dart within the medium housing and the immersion of the dart and the challenge spores into the growth medium.
摘要翻译：自给自足的生物指示剂（A）确定微生物净化过程的有效性。飞镖（68）具有在盖（C）的翅片（36A-36F）中的掣子（50C）中与轮辋（58）接合的密封件（80）。飞镖具有在密封培养基壳体（D）中的生长介质（F）的箔密封件（86）正上方对准的切割边缘（76）。飞镖具有容纳在纸盘（74）上的挑战孢子或其他微生物的室（72）。微孔膜（G）捕获腔室中的挑战孢子，同时允许微生物去污染液体流过以接触孢子。壳体通过翼片（36A-36F）中的棘爪（50A）中的凸缘（56）放置。微生物净化过程完成后，盖被迫朝向中等壳体，导致轮缘和凸缘从它们各自的棘爪上移开，并且卡在掣子（50B）中，导致穿刺箔片密封件，将飞镖密封在中等住房和镖的浸入和挑战孢子进入生长培养基。

2. 发明授权

US4914034A Disposable biological indicator test pack for monitoring steam and ethylene oxide sterilization cycles 失效
标题翻译：一次性生物指示剂测试包用于监测蒸汽和环氧乙烷灭菌循环
公开(公告)号：US4914034A
公开(公告)日：1990-04-03
申请号：US288362
申请日：1988-12-22
申请人： Jon D. Welsh , Denis G. Dyke
发明人： Jon D. Welsh , Denis G. Dyke
IPC分类号： C12Q1/22
CPC分类号： C12Q1/22
摘要： Disposable test packs for monitoring the efficacy of steam or ethylene oxide sterilization cycles includes a fiber board housing for a biological indicator. The housing includes two end sections and a midsection. Each end section includes an outer tube and a longer inner tube. The open end of the outer tubes abut the opposing open ends of the midsection to define a seam or gap. The inner tube extends past the seam and telescopes into the midsection. The seam and the close tolerance between the inner tube and the midsection provide a tortuous path for the entry of sterilant into the interior of the housing. The tortuous path has a moisture absorbent surface and is dimensioned to promote intimate contact between the sterilant and the absorbent surface. A second path of entry is provided in the embodiment adapted for use in monitoring ethylene oxide sterilization processes only. A midsection can be made of a transparent, sterilant impermeable material to permit observation of the interior of the housing.
摘要翻译：用于监测蒸汽或环氧乙烷灭菌循环功效的一次性测试包括用于生物指示剂的纤维板外壳。外壳包括两个端部和一个中部。每个端部包括一个外管和一个较长的内管。外管的开口端与中间部分的相对开口端相接，以限定接缝或间隙。内管延伸穿过缝和望远镜进入中部。接缝和内管和中间部分之间的紧密公差提供了用于将消毒剂进入壳体内部的曲折路径。曲折路径具有吸湿表面，其尺寸被设计成促进消毒剂和吸收表面之间的紧密接触。在仅适用于监测环氧乙烷灭菌工艺的实施例中提供了第二条入口路径。中央部分可以由透明的灭菌剂不渗透材料制成，以便观察外壳的内部。

3. 发明授权

US4594223A Device for detecting the presence of noncondensable gas in steam sterilizers 失效
标题翻译：用于检测蒸汽灭菌器中不可冷凝气体的存在的装置
公开(公告)号：US4594223A
公开(公告)日：1986-06-10
申请号：US683818
申请日：1984-12-20
申请人： Denis G. Dyke , David A. Oshlag
发明人： Denis G. Dyke , David A. Oshlag
IPC分类号： A61L2/24 , A61L2/28 , G01N25/14 , G01N31/22
CPC分类号： A61L2/24 , A61L2/28 , G01N25/142
摘要： A device for indicating the presence of unacceptable levels of noncondensable gas, such as air, in a stream sterilization chamber. The device includes an insulated heat sink having an upper end and a lower end. The upper end of the heat sink is in such open communication with the sterilization chamber that the steam enters the heat sink. The device also includes a chamber proximate the lower end of the heat sink. The heat sink defines a path through which the steam travels from the upper end toward the chamber. The path is adapted to provide sufficient exposure of the steam to the heat sink so that the steam condenses within the path, releasing any noncondensable gas associated with the steam and forcing it toward the chamber. The chamber includes means for indicating the presence of noncondensable gas accumulated therein. The device also includes means for preventing the condensate from effecting the indicating means.
摘要翻译：用于指示在流消毒室中存在不可接受水平的不可冷凝气体（例如空气）的装置。该装置包括具有上端和下端的绝缘散热器。散热器的上端与灭菌室开口连通，蒸汽进入散热器。该装置还包括邻近散热器的下端的腔室。散热器限定了蒸汽从上端朝向室行进的路径。该路径适于提供足够的蒸汽暴露于散热器，使得蒸汽在路径内冷凝，释放与蒸汽相关联的任何不可冷凝气体并迫使其朝向室。该室包括用于指示积聚在其中的不可冷凝气体的存在的装置。该装置还包括用于防止冷凝物影响指示装置的装置。

4. 发明授权

US4515841A Pore forming sterilization bag 失效
标题翻译：孔成型消毒袋
公开(公告)号：US4515841A
公开(公告)日：1985-05-07
申请号：US567234
申请日：1983-12-30
申请人： Denis G. Dyke
发明人： Denis G. Dyke
IPC分类号： A61L2/26 , B65D33/00 , B65D65/42 , B32B1/02
CPC分类号： B65D33/00 , A61L2/26 , B65D65/42 , Y10S428/913 , Y10T428/1341 , Y10T428/268
摘要： A receptacle for handling contaminated waste for sterilization and subsequent disposal which is a pore forming sterilization bag made from a thermoplastic resin which has been embedded with either soluble materials or melt materials which respond to the temperature and moisture of steam sterilization to form pores in the bag, thus permitting the entrance of sterilant and the exit of air for sterilization of the waste. The melt materials are low molecular weight polymers such as carbowaxes. The soluble materials can be either organic or inorganic materials such as polyvinyl alcohol, polyvinyl acetate, polyvinyl pyrrolidone and various inorganic salts, such as sodium chloride.
摘要翻译：一种用于处理受污染废物进行灭菌和后续处置的容器，其是由热塑性树脂制成的成孔灭菌袋，其中已经嵌入了可溶材料或熔体材料，所述溶解材料或熔体材料响应蒸汽灭菌的温度和湿度以在袋中形成孔，从而允许消毒剂的入口和空气的出口用于废物的灭菌。熔融材料是低分子量聚合物，如碳蜡。可溶性材料可以是有机或无机材料，如聚乙烯醇，聚乙酸乙烯酯，聚乙烯吡咯烷酮和各种无机盐，如氯化钠。

5. 发明授权

US4874090A Self-seal sterilization pouch 失效
标题翻译：自密封灭菌袋
公开(公告)号：US4874090A
公开(公告)日：1989-10-17
申请号：US261197
申请日：1988-10-24
申请人： Denis G. Dyke
发明人： Denis G. Dyke
IPC分类号： A61B19/02 , A61J1/10 , A61L2/26 , B65D33/16
CPC分类号： A61L2/26 , A61B50/30 , B65D33/1691 , A61B2050/002 , A61B2050/314
摘要： A sterilizable pouch for holding items during sterilization and for storing such items in a sterile condition following sterilization. The pouch includes a first member and a second opposing member. The first member extends outwardly beyond one edge of the second member to define a flap. An opening is defined between the one edge of the second member and the flap. The remaining edges of the first and second members are sealed to one another to define the pouch. An adhesive backed strip having a removable liner over the adhesive is connected along one edge to the second member adjacent to or spaced from the opening and is dimensioned to cover the opening and the flap when the liner is removed and the adhesive backed strip is pressed against the opening and the flap.
摘要翻译：用于在灭菌期间保持物品的灭菌袋，并且在灭菌后将其贮存在无菌状态下。袋包括第一构件和第二相对构件。第一构件向外延伸超过第二构件的一个边缘以限定翼片。在第二构件的一个边缘和翼片之间限定开口。第一和第二构件的剩余边缘彼此密封以限定袋。在粘合剂上具有可移除衬垫的粘合剂背衬条带沿着一个边缘连接到与开口相邻或间隔开的第二构件，并且尺寸设计成当衬垫被移除并且粘合剂背衬的条被压靠时覆盖开口和襟翼开口和襟翼。

6. 发明授权

US4003382A Retention catheter and method of manufacture 失效
标题翻译：保留导管及其制造方法
公开(公告)号：US4003382A
公开(公告)日：1977-01-18
申请号：US599293
申请日：1975-07-25
申请人： Denis G. Dyke
发明人： Denis G. Dyke
IPC分类号： A61F2/958 , A61M25/00
CPC分类号： A61M25/1029 , A61M25/10 , A61M25/1027 , A61M25/1034
摘要： An all plastic retention catheter of the Foley type having a body of a thermoplastic polyurethane and a balloon of a thermosetting polyurethane. The catheter may be fabricated by a method wherein the thermosetting polyurethane balloon sleeve is molded with integral bands of a thermoplastic polyurethane polymer spaced at either end of the sleeve and subsequently sealed to the catheter body by fusing the thermoplastic bands to the body material with heat or solvent.
摘要翻译：具有热塑性聚氨酯主体和热固性聚氨酯球囊的Foley型全塑塑料保持导管。导管可以通过以下方法制造：其中热固性聚氨酯球囊套筒被模制成在套管的任一端分开的热塑性聚氨酯聚合物的整体带，随后通过将热塑性带通过热量融合到身体材料而密封到导管主体，溶剂。

7. 发明授权

US5507813A Shaped materials derived from elongate bone particles 失效
标题翻译：衍生自细长骨颗粒的成型材料
公开(公告)号：US5507813A
公开(公告)日：1996-04-16
申请号：US164152
申请日：1993-12-09
申请人： Michael Dowd , Denis G. Dyke
发明人： Michael Dowd , Denis G. Dyke
IPC分类号： A61L27/00 , A61F2/28 , A61F2/30 , A61L27/36 , A61F2/02
CPC分类号： A61L27/3847 , A61F2/28 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61F2002/2839 , A61F2002/30677
摘要： Surgically implantable shaped materials, e.g., sheets, are fabricated from elongate bone particles, advantageously those that have been demineralized. The materials when applied to a bone repair site enhance or accelerate new bone ingrowth by any one of a variety of biological and/or mechanical mechanisms.
摘要翻译：手术可植入的成形材料，例如片材由细长的骨颗粒制成，有利地是已被去矿化的那些。施加到骨修复部位时的材料通过各种生物和/或机械机制中的任何一种增强或加速新骨向内生长。

8. 发明授权

US5478749A Method and article for providing an indication of the presence of air in steam 失效
标题翻译：用于提供蒸汽中空气存在的指示的方法和制品
公开(公告)号：US5478749A
公开(公告)日：1995-12-26
申请号：US139465
申请日：1993-10-20
申请人： Denis G. Dyke
发明人： Denis G. Dyke
IPC分类号： A61L2/28 , G01N31/22
CPC分类号： A61L2/28 , G01N31/226 , Y10T436/20 , Y10T436/209163
摘要： A method and apparatus for evaluating the efficacy of prevacuum steam sterilizers by separating, collecting and detecting the presence of air in association with steam. A receptacle containing an adsorbent directly separates air from steam without changing the physical state of the steam. The apparatus has a portal communicating with the sterilizing environment and a defined path for the steam to traverse from the portal to a distal end of the apparatus. The distal end of the apparatus is attached to an air collection chamber which contains an air indicator. The indicator can be chemical or biological, and indicated whether any air pockets existed in the steam.
摘要翻译：一种通过分离，收集和检测与蒸汽相关的空气的存在来评估先前真空蒸汽灭菌器的功效的方法和装置。容纳吸附剂的容器直接从蒸汽中分离空气，而不改变蒸汽的物理状态。该设备具有与消毒环境通信的入口和用于蒸汽从入口到设备的远端的限定路径。装置的远端附接到包含空气指示器的空气收集室。指示器可以是化学的或生物的，并且指示蒸汽中是否存在任何气穴。

9. 发明授权

US4839291A Disposable biological indicator test pack for monitoring steam and ethylene oxide sterilization cycles 失效
标题翻译：一次性生物指示剂测试包用于监测蒸汽和环氧乙烷灭菌循环
公开(公告)号：US4839291A
公开(公告)日：1989-06-13
申请号：US50585
申请日：1987-05-15
申请人： Jon D. Welsh , Denis G. Dyke
发明人： Jon D. Welsh , Denis G. Dyke
IPC分类号： C12Q1/22
CPC分类号： A61L2/28 , C12Q1/22
摘要： A disposable test pack for monitoring the efficacy of steam or ethylene oxide sterilization cycles includes a fiber board housing for a bioligical indicator. The housing includes an outer tube and a shorter inner tube. The outer tube has upper and lower portions which define a seam or gap at their adjoining open ends. The inner tube extends past the seam and telescopes into the upper and lower portions. The seam and the close tolerance between the inner tube and the upper and lower portions of the outer tube provide a tortuous path for the entry of sterilant into the interior of the housing. The tortuous path has a moisture absorbent surface and is dimensioned to promote intimate contact between the sterilant and the absorbent surface. The exterior of the housing can be lined with foil to prevent sterilant from permeating the housing, thereby preventing entry of the steam by any path other than through the seam. A hole covered by an optionally removable tab is provided at the end of the upper portion of the outer tube for use in monitoring ethylene oxide sterilization cycles.
摘要翻译：用于监测蒸汽或环氧乙烷灭菌循环功效的一次性测试包包括用于生物指示剂的纤维板外壳。壳体包括外管和较短的内管。外管具有在其相邻的开口端限定接缝或间隙的上部和下部。内管延伸穿过接缝并望远镜进入上部和下部。内管和外管的上部和下部之间的接缝和紧密公差提供了用于将灭菌剂进入壳体内部的曲折路径。曲折路径具有吸湿表面，其尺寸被设计成促进消毒剂和吸收表面之间的紧密接触。外壳的外部可以衬有箔，以防止消毒剂渗透到壳体中，从而防止蒸汽通过除了接缝之外的任何路径进入。在外管的上部的端部设置有可选择地移除的突出部覆盖的孔，用于监测环氧乙烷灭菌循环。

10. 发明授权

US5270217A Method and article for providing an indication of the presence of air in steam 失效
标题翻译：用于提供蒸汽中空气存在的指示的方法和制品
公开(公告)号：US5270217A
公开(公告)日：1993-12-14
申请号：US13147
申请日：1993-02-01
申请人： Denis G. Dyke
发明人： Denis G. Dyke
IPC分类号： A61L2/28 , G01N31/22
CPC分类号： A61L2/28 , G01N31/226 , Y10T436/20 , Y10T436/209163
摘要： A device for evaluating the efficacy of prevacuum steam sterilizers by separating, collecting and detecting the presence of air in association with the steam. The device includes a receptacle containing an adsorbent for directly separating air from steam without requiring a change of state, from gas to liquid, of the steam. During sterilizer evacuation, the interstices of the adsorbent and the device offer a challenge to air removal. The receptacle has a portal to provide communication with the sterilizer environment and a defined path for the steam to traverse, in a progressive manner, moving to the distal end of the receptacle. The adsorbent retains the moisture during sterilization. At the distal end of the column is an opening into an air collecting chamber. Within this chamber is located an article that indicates the presence of air in the steam. The indicator can be chemical or biological, and indicates whether any air pockets existed which prevented complete contact between the steam and the indicator.
摘要翻译：用于通过分离，收集和检测与蒸汽相关联的空气的存在来评估先前真空蒸汽灭菌器的功效的装置。该装置包括容纳有用于直接从蒸汽中分离空气的吸附剂的容器，而不需要蒸汽状态从气体到液体的状态的改变。在灭菌器排空过程中，吸附剂和装置的间隙对排气的挑战是一个挑战。容器具有门口以提供与灭菌器环境的通信以及用于使蒸汽以渐进的方式移动到容器的远端的限定路径。吸附剂在灭菌期间保持水分。在塔的远端是进入集气室的开口。在该室内设有一个表示蒸汽中存在空气的物品。指示器可以是化学的或生物的，并且指示是否存在阻止蒸汽和指示器之间完全接触的任何气穴。

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