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1. 发明授权

US07932503B2 Method for pre-identification of spectral overlaps within fluorescent dye and detector combinations used in flow cytometry 有权
标题翻译：在荧光染料中预先鉴定光谱重叠的方法和用于流式细胞术的检测器组合
公开(公告)号：US07932503B2
公开(公告)日：2011-04-26
申请号：US12467662
申请日：2009-05-18
申请人： David R. Parks , Wayne Moore , Stephen Meehan
发明人： David R. Parks , Wayne Moore , Stephen Meehan
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： This invention relates to the field of flow cytometry. It provides methods for identifying important dye-detector spectral overlaps for use in designing flow cytometry experiments. It further provides methods for quantifying the impact of spectral overlaps on dye selection and detector selection, the methods including the steps of: a) obtaining spectra of a dye; b) obtaining a laser configuration and an optical filter configuration of a detector; c) obtaining a spectrum yield value; and d) ranking the spectrum yield value.
摘要翻译：本发明涉及流式细胞仪领域。它提供了用于鉴定重要的染料检测器光谱重叠的方法，用于设计流式细胞术实验。它进一步提供了用于量化光谱重叠对染料选择和检测器选择的影响的方法，所述方法包括以下步骤：a）获得染料的光谱; b）获得检测器的激光配置和滤光器配置; c）获得频谱收益值; 和d）对频谱产量值进行排序。

2. 发明申请

US20100012853A1 METHOD FOR PRE-IDENTIFICATION OF SPECTRAL OVERLAPS WITHIN FLUORESCENT DYE AND DETECTOR COMBINATIONS USED IN FLOW CYTOMETRY 有权
标题翻译：在荧光染料中用于预先鉴定荧光染料和在流式细胞仪中使用的检测器组合的方法
公开(公告)号：US20100012853A1
公开(公告)日：2010-01-21
申请号：US12467662
申请日：2009-05-18
申请人： David R. Parks , Wayne Moore , Stephen Meehan
发明人： David R. Parks , Wayne Moore , Stephen Meehan
IPC分类号： G01J1/58 , G01N21/47
CPC分类号： G01N21/6428 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： This invention relates to the field of flow cytometry. It provides methods for identifying important dye-detector spectral overlaps for use in designing flow cytometry experiments. It further provides methods for quantifying the impact of spectral overlaps on dye selection and detector selection, the methods including the steps of: a) obtaining spectra of a dye; b) obtaining a laser configuration and an optical filter configuration of a detector; c) obtaining a spectrum yield value; and d) ranking the spectrum yield value.
摘要翻译：本发明涉及流式细胞仪领域。它提供了用于鉴定重要的染料检测器光谱重叠的方法，用于设计流式细胞术实验。它进一步提供了用于量化光谱重叠对染料选择和检测器选择的影响的方法，所述方法包括以下步骤：a）获得染料的光谱; b）获得检测器的激光配置和滤光器配置; c）获得频谱收益值; 和d）对频谱产量值进行排序。

3. 发明申请

US20100161561A1 METHOD AND SYSTEM FOR DATA ARCHIVING 有权
标题翻译：数据存档的方法和系统
公开(公告)号：US20100161561A1
公开(公告)日：2010-06-24
申请号：US12470215
申请日：2009-05-21
申请人： Wayne Moore , David R. Parks , Leonore A. Herzenberg
发明人： Wayne Moore , David R. Parks , Leonore A. Herzenberg
IPC分类号： G06F12/16 , G06F17/30 , G06F15/16
CPC分类号： G06F17/30091
摘要： Disclosed is a method and system for archiving data. A server computer (or any computing device) receives data transmitted over a network from a client computer, wherein at least some of the data was previously collected by a scientific instrument during an experiment. After receiving the data, the server computer updates (e.g., creates) an index for the received data, archives the received data, and automatically transmits a notification to the client computer that the received data has been archived.
摘要翻译：公开了一种用于归档数据的方法和系统。服务器计算机（或任何计算设备）从客户计算机接收通过网络发送的数据，其中至少一些数据在实验期间由科学仪器先前收集。在接收到数据之后，服务器计算机更新（例如，创建）接收到的数据的索引，归档所接收的数据，并且自动向客户端计算机发送已经存档了所接收的数据的通知。

4. 发明授权

US08548950B2 Method and system for data archiving 有权
标题翻译：数据归档方法和系统
公开(公告)号：US08548950B2
公开(公告)日：2013-10-01
申请号：US12470215
申请日：2009-05-21
申请人： Wayne Moore , David R. Parks , Leonore A. Herzenberg
发明人： Wayne Moore , David R. Parks , Leonore A. Herzenberg
IPC分类号： G06F17/30
CPC分类号： G06F17/30091
摘要： Disclosed is a method and system for archiving data. A server computer (or any computing device) receives data transmitted over a network from a client computer, wherein at least some of the data was previously collected by a scientific instrument during an experiment. After receiving the data, the server computer updates (e.g., creates) an index for the received data, archives the received data, and automatically transmits a notification to the client computer that the received data has been archived.
摘要翻译：公开了一种用于归档数据的方法和系统。服务器计算机（或任何计算设备）从客户计算机接收通过网络发送的数据，其中至少一些数据在实验期间由科学仪器先前收集。在接收到数据之后，服务器计算机更新（例如，创建）接收到的数据的索引，归档所接收的数据，并且自动向客户端计算机发送已经存档了所接收的数据的通知。

5. 发明授权

US4987539A Apparatus and method for multidimensional characterization of objects in real time 失效
标题翻译：实时多维表征物体的装置和方法
公开(公告)号：US4987539A
公开(公告)日：1991-01-22
申请号：US082254
申请日：1987-08-05
申请人： Wayne A. Moore , Tom Nozaki, Jr. , David R. Parks , Richard T. Stovel , Gary Breitbard
发明人： Wayne A. Moore , Tom Nozaki, Jr. , David R. Parks , Richard T. Stovel , Gary Breitbard
IPC分类号： B07C5/342 , G01N15/14
CPC分类号： B07C5/3427 , G01N15/14 , G01N2015/149
摘要： A system for characterizing objects to be sorted in real time and making sorting decisions using lasers to excite fluorescing dyes used to tag objects such as cells which flow through the laser beam in a stream of conductive fluid. The scattered light and fluorescent light at various frequencies define a multidimensional space. These light characteristics are sensed and digitized. The data so gathered is buffered and then compared to a binary classification tree. The individual parameters cause a certain path through the binary decision tree to be taken while the cell is passing from the point in the stream where the light characteristics are gathered to a point where electrostatically charged electrodes deflect individual statically charged drops containing cells to be sorted into various sorting bins. When the decision tree has been traversed, the sorting decision for the drop containing the cell which had those parameters is done. This sorting decision is buffered until the time the drop reaches the charged electrodes. The sort decision is then accessed and used to properly charge the electrodes so that the drop is diverted into the proper bin.
摘要翻译：用于表征要实时分类的对象的系统，并且使用激光器进行排序决定，以激发用于标记诸如在导电流体流中流过激光束的细胞的物体的荧光染料。各种频率的散射光和荧光灯定义了多维空间。这些光特性被感测和数字化。如此收集的数据被缓冲，然后与二进制分类树进行比较。单个参数导致通过二进制决策树的特定路径，同时单元从光聚合的流中的点通过到静电充电电极偏转包含待分类的单元的静态电荷的液滴的点各种分拣箱。当决策树已经遍历时，对包含具有这些参数的单元的分支的排序决定完成。这种排序决定被缓冲，直到液滴到达带电电极。然后访问排序决定并将其用于适当地对电极充电，使得液滴转入适当的料仓。

6. 发明授权

US06954722B2 Methods and systems for data analysis 有权
标题翻译：数据分析方法和系统
公开(公告)号：US06954722B2
公开(公告)日：2005-10-11
申请号：US10688868
申请日：2003-10-17
申请人： David R. Parks , Wayne A. Moore
发明人： David R. Parks , Wayne A. Moore
IPC分类号： G01N15/14 , G06F15/00 , G06F19/00 , H03F1/26
CPC分类号： G06F19/26 , G01N2015/1472 , G01N2015/1488 , G06F19/24
摘要： The present invention provides methods of analyzing and/or displaying data. In one aspect, the invention provides methods for visualizing or displaying high dynamic range data obtained from flow cytometry analyses. Related systems and computer programs products are also provided.
摘要翻译：本发明提供了分析和/或显示数据的方法。一方面，本发明提供了用于可视化或显示从流式细胞术分析获得的高动态范围数据的方法。还提供了相关系统和计算机程序产品。

7. 发明授权

US4667830A Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like 失效
标题翻译：将各种颗粒分离到用于培养，克隆，分析等的容器中的方法和装置
公开(公告)号：US4667830A
公开(公告)日：1987-05-26
申请号：US273750
申请日：1981-06-15
申请人： Tom Nozaki, Jr. , Richard G. Sweet , Richard T. Stovel , David R. Parks
发明人： Tom Nozaki, Jr. , Richard G. Sweet , Richard T. Stovel , David R. Parks
IPC分类号： B07C5/342 , G01N15/14
CPC分类号： B07C5/3427 , G01N2015/149
摘要： Method and apparatus for sorting individual particles into containers, such as the wells of a microculture tray, are disclosed. The particles may comprise, for example, individual biological cells which then may be cultured, cloned, analyzed, or the like. The particles are incorporated into a flow stream which is jetted from a nozzle which is vibrated in the direction of the stream to break the jet stream into discrete drops. A particle sensor senses particles in the stream, and a signal processor in response to the particle sensor output produces an output when the sensed particle is of the type to be sorted from the stream. A pulse charger, responsive to the signal processor, is included for charging the drops as they break from the vibrating jet stream. The drops pass between charged deflection plates where they are deflected an amount related to the drop charge. For individual cell sorting, the signal processor is in normal inopertive condition to prevent sorting of drops from the drop stream. During this time all drops contained in the stream are caught by a stream catcher, and none are allowed to enter a tray well. When armed, by manual actuation of an arming switch, the circuit is conditioned to sort a single particle from the drop stream, at which time the circuit returns to normal inoperative condition. A tray support is provided for movable support of the multiwell tray along perpendicular X and Y directions, and a releasable detent releasably lock the tray support at any desired X-Y position. The tray support is provided with a target for use in initial alignment of the tray support relative to drops separated from the stream to assure entry of such drops into a tray well during subsequent operation of the cell sorter.
摘要翻译：公开了将各种颗粒分离成容器的方法和装置，例如微型培养皿的孔。颗粒可以包括例如可以培养，克隆，分析等的单个生物细胞。将颗粒结合到从喷嘴喷射的流中，该喷嘴在流动方向上振动以将喷射流破裂成离散的液滴。粒子传感器感测流中的粒子，并且响应于粒子传感器输出的信号处理器当感测到的粒子是从流中排序的类型时产生输出。包括响应于信号处理器的脉冲充电器，用于在液滴从振动喷射流中分离时对其充电。液滴在带电偏转板之间通过，在它们之间偏转与滴落电荷相关的量。对于单个细胞分选，信号处理器处于正常的无效状态，以防止液滴从滴流中分选。在此期间，流中包含的所有液滴都被流捕获器捕获，并且不允许任何进入盘。当装备时，通过手动启动布防开关，电路被调节为从液滴流中分离单个颗粒，此时电路恢复到正常的不工作状态。提供了托盘支撑件，用于沿着垂直X和Y方向的多孔托盘的可移动支撑件，以及可释放的止动件将托盘支撑件可释放地锁定在任何期望的X-Y位置。托盘支撑件设置有用于托盘支撑件相对于从流分离的液滴的初始对准中的目标，以确保在细胞分选器的后续操作期间将这些液滴进入托盘孔。

8. 发明申请

US20210245817A1 VEHICLE HAVING MULTIFUNCTIONAL TAILGATE 有权
公开(公告)号：US20210245817A1
公开(公告)日：2021-08-12
申请号：US17158076
申请日：2021-01-26
申请人： Robert J. Gibbs , Christopher J. Sytek , Clifford L. Eberle, JR. , Eric Ghoukasian , Piyush Agarwal , Sean E. Whelan , David R. Parks , Michael C. Gillam , Paul Van Norman , Christopher J. Duke
发明人： Robert J. Gibbs , Christopher J. Sytek , Clifford L. Eberle, JR. , Eric Ghoukasian , Piyush Agarwal , Sean E. Whelan , David R. Parks , Michael C. Gillam , Paul Van Norman , Christopher J. Duke
IPC分类号： B62D33/027 , B62D33/037 , B62D33/03
摘要： A vehicle includes a vehicle body, a door and a handle assembly. A door is coupled to the vehicle body and is pivotable about a horizontal axis between a closed position and a horizontal open position. The door is also pivotable about a vertical axis between the closed position and a vertical open position. The handle assembly includes a housing, a first release switch and a second release switch. The housing extends at least partially into a cavity of the door and includes a lower wall and an upper wall that cooperate to define a pocket. The first release switch is disposed along the upper wall of the housing and is configured to be actuated to pivot the door about the horizontal axis. The second release switch is disposed along the lower wall of the housing and is configured to be actuated to pivot the door about the vertical axis.

9. 发明申请

US20180018386A1 SYSTEMS AND METHODS FOR CLUSTER MATCHING ACROSS SAMPLES AND GUIDED VISUALIZATION OF MULTIDIMENSIONAL CYTOMETRY DATA 审中-公开
公开(公告)号：US20180018386A1
公开(公告)日：2018-01-18
申请号：US15652194
申请日：2017-07-17
申请人： Darya Y. Orlova , Stephen W. Meehan , Wayne A. Moore , Guenther Walther , David R. Parks , Leonore A. Herzenberg
发明人： Darya Y. Orlova , Stephen W. Meehan , Wayne A. Moore , Guenther Walther , David R. Parks , Leonore A. Herzenberg
IPC分类号： G06F17/30 , G01N15/14 , G06F3/0484 , G06T11/20 , G06F3/0482 , G01N15/10 , G01N15/00
摘要： Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.

10. 发明授权

US06178382B1 Methods for analysis of large sets of multiparameter data 失效
标题翻译：大量多参数数据分析方法
公开(公告)号：US06178382B1
公开(公告)日：2001-01-23
申请号：US09103284
申请日：1998-06-23
申请人： Mario Roederer , Adam S. Treister , Martin Bigos , David R. Parks , Wayne A. Moore , Leonore A. Herzenberg
发明人： Mario Roederer , Adam S. Treister , Martin Bigos , David R. Parks , Wayne A. Moore , Leonore A. Herzenberg
IPC分类号： G01N3350
CPC分类号： G06T11/206 , G01N33/50
摘要： This invention relates a series of methods for the visual representation and subsequent application of analyses on complex data sets. In particular, this invention is useful for the analysis of multiple sample sets that share common features, for which similar types of analyses are desired. Three concepts are embodied to aid in this analysis: “Functional equivalence by Algorithmic Polymorphism” (FEAP), in which an analysis algorithm is abstracted through the use of an associated name; a genealogical metaphor for the representation of successive or parallel analysis steps, in which “families” of analyses can be easily copied between different sample data sets; and batch analysis through the creation of multi-sample analysis surrogates (MSAS), which are groups of samples wherein analyses applied to an MSAS is then applied to every sample within the MSAS group. This invention has particular utility in the analysis of data derived from flow cytometers, the analysis of complex demographic data, and other similar data sets.
摘要翻译：本发明涉及用于在复杂数据集上的分析的视觉表示和后续应用的一系列方法。特别地，本发明对于分析共享共同特征的多个样本集是有用的，对于类似的分析类型是期望的。三个概念被体现为帮助分析：“通过算法多态性的功能等同”（FEAP），其中分析算法通过使用关联名称被抽象; 用于表示连续或平行分析步骤的系谱比喻，其中分析的“家庭”可以容易地在不同样本数据集之间复制; 并通过创建多样本分析代理（MSAS）进行批量分析，这些代码是MSAS组中每个样本的样本组，其中分析应用于MSAS。本发明在分析流式细胞仪获得的数据，复杂人口统计学数据分析和其他类似数据集方面具有特别的实用价值。

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