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1. 发明授权

US08275457B1 Cardiac monitoring system for paced patients having paced and non-paced ischemia detection thresholds 有权
标题翻译：心律监护系统对于有节奏和非节奏的缺血检测阈值的起搏患者
公开(公告)号：US08275457B1
公开(公告)日：2012-09-25
申请号：US12624496
申请日：2009-11-24
申请人： David R. Fischell , Michael Sasha John , Bruce Hopenfeld , David Keenan
发明人： David R. Fischell , Michael Sasha John , Bruce Hopenfeld , David Keenan
IPC分类号： A61N1/362
CPC分类号： A61B5/686 , A61B5/0031 , A61B5/0452 , A61B5/4836 , A61N1/368 , A61N1/3702 , A61N1/37247 , A61N1/37258 , G16H40/63
摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as ventricularly paced beats and supraventricular beats. The processor applies different ischemia tests to the two different beat types, and generates alert when it detects ischemia.
摘要翻译：公开了一种用于检测心脏缺血的装置。该装置包括处理器，其被配置为区分两种不同的心跳类型，例如心室起搏节拍和室上搏动。处理器对两种不同的节拍类型应用不同的缺血试验，并在检测到缺血时产生警报。

2. 发明申请

US20070208263A1 Systems and methods of medical monitoring according to patient state 有权
标题翻译：根据患者状况进行医疗监测的系统和方法
公开(公告)号：US20070208263A1
公开(公告)日：2007-09-06
申请号：US11710902
申请日：2007-02-27
申请人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
发明人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/024 , A61B5/7232 , A61B5/7264 , G06F19/00
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal. The systems receives data regarding the patient's state (e.g. asleep, exercising). Patient state information is stored in a patient state array, thereby enabling the system to track the patient's state over time, and to select an appropriate test for detecting a cardiac event based on both past and present data regarding the patient's state.
摘要翻译：提供了一种用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号。系统接收关于患者状态的数据（例如睡眠，锻炼）。患者状态信息被存储在患者状态阵列中，从而使得系统能够随着时间跟踪患者的状态，并且基于关于患者状态的过去和现在数据来选择用于检测心脏事件的适当测试。

3. 发明授权

US08224430B2 Baseline processing for a cardiac event detection system 有权
标题翻译：心脏事件检测系统的基线处理
公开(公告)号：US08224430B2
公开(公告)日：2012-07-17
申请号：US12585861
申请日：2009-09-28
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
IPC分类号： A61N1/00
CPC分类号： A61B5/0456 , A61B5/0006 , A61B5/0031 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal and a patient alarm means is further provided and electrically coupled to the electrical signal processor. The electrical signal is acquired in the form of electrogram segments, which are categorized according to heart rate, ST segment shift and type heart rhythm (normal or abnormal). Baseline electrogram segments are tracked over time.
摘要翻译：提供了一种用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号，并且还提供患者报警装置并电耦合到电信号处理器。电信号是以心律，ST段移位和心律（正常或异常）分为心电图段的形式获得的。基线电描绘片段随时间跟踪。

4. 发明申请

US20080188763A1 System and methods for sliding-scale cardiac event detection 有权
标题翻译：用于滑动式心脏事件检测的系统和方法
公开(公告)号：US20080188763A1
公开(公告)日：2008-08-07
申请号：US12068776
申请日：2008-02-12
申请人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
发明人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/024 , A61B5/7232
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal. The system determines the presence of a cardiovascular condition by applying a sliding scale rule to heart signal feature values. When the cardiovascular condition is ischemia, the ST segment may be analyzed. A sliding scale is applied to ST segment shifts such that when the magnitudes of ST segment shifts are relatively small, a larger number of beats is required to detect ischemia compared to the case when the magnitudes of ST shifts are large.
摘要翻译：提供了一种用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号。该系统通过将滑动比例规则应用于心脏信号特征值来确定心血管疾病的存在。当心血管疾病缺血时，ST段可能被分析。将滑动刻度应用于ST段移位，使得当ST段移位的幅度相对较小时，与ST移位量大的情况相比，需要较大数量的搏动来检测缺血。

5. 发明申请

US20100087745A1 Baseline processing for a cardiac event detection system 有权
标题翻译：心脏事件检测系统的基线处理
公开(公告)号：US20100087745A1
公开(公告)日：2010-04-08
申请号：US12585861
申请日：2009-09-28
申请人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
发明人： David R. Fischell , Tim A. Fischell , Jonathan Harwood , Robert E. Fischell , Steven R. Johnson , Bruce Hopenfeld , Michael Sasha John
IPC分类号： A61B5/0452
CPC分类号： A61B5/0456 , A61B5/0006 , A61B5/0031 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal and a patient alarm means is further provided and electrically coupled to the electrical signal processor. The electrical signal is acquired in the form of electrogram segments, which are categorized according to heart rate, ST segment shift and type heart rhythm (normal or abnormal). Baseline electrogram segments are tracked over time.
摘要翻译：提供了一种用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号，并且还提供患者报警装置并电耦合到电信号处理器。电信号是以心律，ST段移位和心律（正常或异常）分为心电图段的形式获得的。基线电描绘片段随时间跟踪。

6. 发明授权

US08838215B2 Systems and methods of medical monitoring according to patient state 有权
标题翻译：根据患者状况进行医疗监测的系统和方法
公开(公告)号：US08838215B2
公开(公告)日：2014-09-16
申请号：US11710902
申请日：2007-02-27
申请人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
发明人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
IPC分类号： A61B5/04 , A61B5/0452 , A61B5/00 , A61B5/024
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/024 , A61B5/7232 , A61B5/7264 , G06F19/00
摘要： A system for the detection of cardiac events occurring in a human patient. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal. The system receives data regarding the patient's state (e.g. asleep, exercising). Patient state information is stored in a patient state array, thereby enabling the system to track the patient's state over time, and to select an appropriate test for detecting a cardiac event based on both past and present data regarding the patient's state.
摘要翻译：用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号。系统接收关于患者状态的数据（例如睡眠，锻炼）。患者状态信息被存储在患者状态阵列中，从而使得系统能够随着时间跟踪患者的状态，并且基于关于患者状态的过去和现在数据来选择用于检测心脏事件的适当测试。

7. 发明授权

US08676304B2 Ischemia monitoring system for patients having periods of left bundle branch block 有权
标题翻译：患有左束支传导阻滞期的患者缺血监测系统
公开(公告)号：US08676304B2
公开(公告)日：2014-03-18
申请号：US12791327
申请日：2010-06-01
申请人： David R. Fischell , Bruce Hopenfeld , Michael Sasha John , David Keenan
发明人： David R. Fischell , Bruce Hopenfeld , Michael Sasha John , David Keenan
IPC分类号： A61B5/02 , A61B5/04 , A61N1/00
CPC分类号： A61B5/04525 , A61B5/0031 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/1112 , A61N1/365
摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as left bundle branch block beats and normal sinus beats. The processor applies different ischemia tests to the two different beat types, and generates alert when it detects ischemia.
摘要翻译：公开了一种用于检测心脏缺血的装置。该装置包括处理器，其被配置为区分两种不同的心跳类型，例如左束支阻滞搏动和正常窦搏动。处理器对两种不同的节拍类型应用不同的缺血试验，并在检测到缺血时产生警报。

8. 发明申请

US20080188762A1 Systems and methods for cardiac segmentation analysis 审中-公开
标题翻译：心脏分割分析的系统和方法
公开(公告)号：US20080188762A1
公开(公告)日：2008-08-07
申请号：US12068767
申请日：2008-02-12
申请人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
发明人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
IPC分类号： A61B5/0408
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/024 , A61B5/7232 , A61B5/7264
摘要： A system for the detection of cardiac events occurring in a human patient is provided. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal. Electrical signals are acquired in segments and segment score rules are applied to the segments to classify them. To detect an abnormal cardiovascular condition, diagnostic rules are applied to the classification data. Patient state information modulates the acquisition of electrical data, the application of segment score rules, and the application of diagnostic rules.
摘要翻译：提供了一种用于检测在人类患者中发生的心脏事件的系统。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号。电子信号是以片段获取的，片段分数规则被应用于片段以对它们进行分类。为了检测心血管疾病异常，将诊断规则应用于分类数据。患者状态信息调节电数据的采集，段评分规则的应用以及诊断规则的应用。

9. 发明授权

US08903487B1 Pacemaker enabled ischemia detection with selective ischemia tests 有权
标题翻译：起搏器能够通过选择性缺血试验进行缺血检测
公开(公告)号：US08903487B1
公开(公告)日：2014-12-02
申请号：US12624521
申请日：2009-11-24
申请人： David R. Fischell , Michael Sasha John , Bruce Hopenfeld
发明人： David R. Fischell , Michael Sasha John , Bruce Hopenfeld
IPC分类号： A61N1/00 , A61N1/368
CPC分类号： A61N1/3702 , A61B5/0452 , A61B5/0472 , A61B5/4836 , A61B5/7282 , A61N1/025 , A61N1/362 , A61N1/368 , A61N1/3684
摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to distinguish between two different heart beats types such as ventricularly paced beats and supraventricular beats. The processor collects separate reference data for a first one of the beat types indicative of the normal values of a cardiac feature. The processor performs an ischemia test to beats of the first type by first checking whether valid reference data exists for that beat type. If so, the ischemia test is based on this reference data. If no valid reference data exists for the first beat type, the processor applies an ischemia test that is not based on reference data for the first beat type.
摘要翻译：公开了一种用于检测心脏缺血的装置。该装置包括处理器，其被配置为区分两种不同的心跳类型，例如心室起搏节拍和室上搏动。处理器针对指示心脏特征的正常值的节拍类型中的第一个收集单独的参考数据。处理器通过首先检查是否存在针对该节拍类型的有效参考数据来执行第一类型的缺血测试。如果是这样，缺血试验基于该参考数据。如果第一节拍类型没有有效的参考数据，则处理器应用不基于第一节拍类型的参考数据的缺血测试。

10. 发明授权

US08781566B2 System and methods for sliding-scale cardiac event detection 有权
标题翻译：用于滑动式心脏事件检测的系统和方法
公开(公告)号：US08781566B2
公开(公告)日：2014-07-15
申请号：US12068776
申请日：2008-02-12
申请人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
发明人： Michael Sasha John , David R. Fischell , Bruce Hopenfeld
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/024 , A61B5/7232
摘要： A system for the detection of cardiac events occurring in a human patient is disclosed to include at least two electrodes for obtaining an electrical signal from a patient's heart. At least two electrodes are included in the system for obtaining an electrical signal from a patient's heart. An electrical signal processor is electrically coupled to the electrodes for processing the electrical signal. The system determines the presence of a cardiovascular condition by applying a sliding scale rule to heart signal feature values. When the cardiovascular condition is ischemia, the ST segment may be analyzed. A sliding scale is applied to ST segment shifts such that when the magnitudes of ST segment shifts are relatively small, a larger number of beats is required to detect ischemia compared to the case when the magnitudes of ST shifts are large.
摘要翻译：公开了一种用于检测在人类患者中发生的心脏事件的系统，以包括用于从患者心脏获得电信号的至少两个电极。系统中包括至少两个电极，以从患者的心脏获得电信号。电信号处理器电耦合到电极以处理电信号。该系统通过将滑动比例规则应用于心脏信号特征值来确定心血管疾病的存在。当心血管疾病缺血时，ST段可能被分析。将滑动刻度应用于ST段移位，使得当ST段移位的幅度相对较小时，与ST移位量大的情况相比，需要较大数量的搏动来检测缺血。

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