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1. 发明授权

US07125434B2 Deep gradient-density filter device 有权
标题翻译：深度梯度密度滤波器
公开(公告)号：US07125434B2
公开(公告)日：2006-10-24
申请号：US10324774
申请日：2002-12-19
申请人： David P. Yavorsky , Jonathan Royce , Matthew Alexander Tomasko , Ven Anantha Raman
发明人： David P. Yavorsky , Jonathan Royce , Matthew Alexander Tomasko , Ven Anantha Raman
IPC分类号： B01D46/10
CPC分类号： B01D39/1623 , B01D39/18 , B01D2201/182
摘要： A deep gradient-density filter device capable of effectively filtering a fluid containing a distribution of particles in the range of approximately 25 microns to approximately 0.2 micron at a fluid velocity of at least approximately 100 cm/hr and an initial hydraulic permeability of greater than approximately 10 cm/hr/psi. The deep gradient-density filter device includes several layers of filtration material, each having specific predetermined particle retention properties. In one product embodiment, the deep gradient-density filter device uses “loose” fibrillated cellulose fiber material as a primary filter element. In a method aspect, the deep gradient-density filter device is used for either the secondary clarification of industrial-scale volumes of cultured or fermented protein-containing biopharmaceutical fluids or the primary clarification of pilot-scale volumes.
摘要翻译：一种深度梯度密度过滤装置，其能够以至少约100cm / hr的流体速度和大于约100cm / hr的初始水力渗透率有效过滤含有约25微米至约0.2微米范围内的颗粒分布的流体 10厘米/小时/磅。深度梯度密度过滤装置包括几层过滤材料，每层具有特定的预定颗粒保留性能。在一个产品实施例中，深梯度密度过滤装置使用“松散”原纤化纤维素纤维材料作为主要过滤元件。在方法方面，深度梯度密度过滤装置用于工业规模体积的培养或发酵的含蛋白质的生物药物流体的二次澄清或中试规模体积的初步澄清。

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