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1. 发明授权

US08053568B2 Bacterial packaging strains useful for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof 有权
标题翻译：用于产生和产生重组双链RNA核衣壳的细菌包装菌株及其用途
公开(公告)号：US08053568B2
公开(公告)日：2011-11-08
申请号：US11284817
申请日：2005-11-23
申请人： David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
发明人： David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
IPC分类号： C12N15/11 , C07H21/04 , A61K38/16
CPC分类号： C12N1/20 , C07K14/25
摘要： Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
摘要翻译：提供用于产生重组双链RNA核衣壳（rdsRN）的细菌包装菌株。包装菌株可用于在真核细胞或组织中产生编码疫苗抗原，生物活性蛋白质，免疫调节蛋白，反义RNA和催化RNA的RNA。将重组ssRNA引入菌株并包装以从头形成rdsRN。

2. 发明申请

US20080107683A1 Bacterial Packaging Strains Useful for Generation and Production of Recombinant Double-Stranded RNA Nucleocapsids and Uses Thereof 审中-公开
标题翻译：用于生成和生产重组双链RNA核衣壳的细菌包装菌株及其用途
公开(公告)号：US20080107683A1
公开(公告)日：2008-05-08
申请号：US11755440
申请日：2007-05-30
申请人： David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
发明人： David Hone , John Fulkerson , Jerald C. Sadoff , David Onyabe , Michele Stone
IPC分类号： A61K39/295 , A61P43/00 , C12N15/74 , C12N7/00
CPC分类号： C12N15/88 , A61K39/04 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/57 , C12N15/86 , C12N2770/24211 , C12N2770/36143 , C12N2840/203
摘要： Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo. The packaging strains and rdsRNs may also comprise nucleic acid sequences that stabilize a closed loop eukaryotic translation complex; nucleic acid sequences encoding one or more proteins that interfere with a host cell type I interferon (IFN) response; as well as recombinant alphavirus replicons encoding a protein complex specific for plus strand RNA-dependent synthesis of minus strand RNA
摘要翻译：提供用于产生重组双链RNA核衣壳（rdsRN）的细菌包装菌株。包装菌株可用于在真核细胞或组织中产生编码疫苗抗原，生物活性蛋白，免疫调节蛋白，反义RNA和催化RNA的RNA。将重组ssRNA引入菌株并包装以从头形成rdsRN。包装菌株和rdsRN还可以包含稳定闭环真核翻译复合物的核酸序列; 编码一种或多种干扰宿主细胞I型干扰素（IFN）应答的蛋白质的核酸序列; 以及编码特异于负链RNA依赖性合成负链RNA的蛋白质复合物的重组甲病毒复制子

3. 发明申请

US20060115493A1 Bacterial packaging strains useful for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof 有权
标题翻译：用于产生和产生重组双链RNA核衣壳的细菌包装菌株及其用途
公开(公告)号：US20060115493A1
公开(公告)日：2006-06-01
申请号：US11284817
申请日：2005-11-23
申请人： David Hone , John Fulkerson , Jerald Sadoff , David Onyabe , Michele Stone
发明人： David Hone , John Fulkerson , Jerald Sadoff , David Onyabe , Michele Stone
IPC分类号： A61K39/02 , C12N15/74 , C12N1/21
CPC分类号： C12N1/20 , C07K14/25
摘要： Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
摘要翻译：提供用于产生重组双链RNA核衣壳（rdsRN）的细菌包装菌株。包装菌株可用于在真核细胞或组织中产生编码疫苗抗原，生物活性蛋白，免疫调节蛋白，反义RNA和催化RNA的RNA。将重组ssRNA引入菌株并包装以从头形成rdsRN。

4. 发明申请

US20100322951A1 Replication-proficient dsRNA capsids and uses thereof 审中-公开
标题翻译：复制熟练的dsRNA衣壳及其用途
公开(公告)号：US20100322951A1
公开(公告)日：2010-12-23
申请号：US12521768
申请日：2007-12-31
申请人： David Hone , David Onyabe
发明人： David Hone , David Onyabe
IPC分类号： A61K39/00 , A61P35/00 , A61P33/06 , A61P31/18 , A61P31/06 , C12N15/63 , C12N5/00 , C12N1/00
CPC分类号： C12N7/00 , C12N2770/24223 , C12N2840/203
摘要： Compositions and methods useful in the production of proteins in vitro and in vivo are provided. In particular, this invention provides bionanoparticles comprised of replication-proficient, double-stranded RNA (dsRNA) capsids which are capable of transfecting, for example, target bacterial, yeast, plant and mammalian cells, and causing expression of genes of interest in said transfected cells. The bionanoparticles comprised of replication-proficient, dsRNA capsids are also capable of expressing genes of interest in vitro. The genes of interest can encode proteins that are useful, for example, as research reagents, therapeutics and vaccines. Also described are methods that enable the construction of bionanoparticles comprised of replication-proficient dsRNA capsids and methods for transfecting cells with said bionanoparticles and expressing said genes of interest in transfected cells and in vitro.
摘要翻译：提供了在体外和体内生产蛋白质中有用的组合物和方法。特别地，本发明提供了由能够转染例如靶细菌，酵母，植物和哺乳动物细胞以及在所述转染的细胞，酵母，植物和哺乳动物细胞中引起感兴趣的基因表达的复制精通双链RNA（dsRNA）衣壳组成的生物纳米颗粒细胞。由复制熟练的dsRNA衣壳组成的生物纳米颗粒也能够体外表达感兴趣的基因。感兴趣的基因可以编码可用于例如研究试剂，治疗剂和疫苗的蛋白质。还描述了能够构建由复制熟练的dsRNA衣壳组成的生物纳米颗粒的方法以及用所述生物纳米颗粒转染细胞并在转染细胞中体外表达所述目的基因的方法。

5. 发明申请

US20070014814A1 Webbed HIV envelope immunogens, methods for production and use of same 有权
标题翻译： Webbed HIV信封免疫原，生产和使用方法
公开(公告)号：US20070014814A1
公开(公告)日：2007-01-18
申请号：US11445455
申请日：2006-06-02
申请人： David Hone , David Onyabe
发明人： David Hone , David Onyabe
IPC分类号： A61K39/21 , C07K14/16
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/53 , A61K2039/55544 , C07K14/43522 , C07K2319/00 , C07K2319/735 , C12N2730/10122 , C12N2740/16122 , C12N2760/14122 , C12N2795/10122 , Y02A50/472
摘要： HIV envelope immunogens that display multivalent epitopes are provided. The immunogens are aggregated, “webbed” HIV envelope immunogens in which native envelope structures are stabilized due to interactions with multimeric derivatives of M9 scorpion toxin.
摘要翻译：提供显示多价表位的HIV信封免疫原。免疫原被聚集，“网状”HIV包膜免疫原，其中天然包膜结构由于与M9蝎毒素的多聚衍生物的相互作用而稳定。

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